KZIA Kazia Therapeutics Ltd

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Novogen Limited (Registrant)

Kate Hill

Kate Hill

Company Secretary

Date 11 September 2017

An emerging oncology drug developer with two clinical-stage programs Novogen Limited September 2017 NRT NVGN

Forward-Looking Statements 1 This presentation contains “forward-looking statements” within the meaning of the “safe-harbor” provisions of the Private Securities Litigation Reform Act of 1995. Such statements involve known and unknown risks, uncertainties and other factors that could cause the actual results of the Company to differ materially from the results expressed or implied by such statements, including changes from anticipated levels of customer acceptance of existing and new products and services and other factors. Accordingly, although the Company believes that the expectations reflected in such forward-looking statements are reasonable, there can be no assurance that such expectations will prove to be correct. The Company has no obligation to sales, future international, national or regional economic and competitive conditions, changes in relationships with customers, access to capital, difficulties in developing and marketing new products and services, marketing existing products and services update the forward-looking information contained in this presentation.

Executive Summary •Novogen is an oncology-focused biotechnology company, listed on ASX and NASDAQ •Lead asset is GDC-0084 for GBM, an orally-administered small molecule PI3K inhibitor licensed from Genentech –PI3K class is well-validated, with one commercial product on market: Zydelig (idelalisib) from Gilead –PI3K / Akt / mTOR pathway shown to be upregulated in 85-90% of GBM tumours –GDC-0084 well differentiated from class; able to cross blood-brain barrier –Genentech has successfully completed a large (n=47) phase I study in recurrent GBM patients, demonstrative a favourable safety profile and promising indications of clinical efficacy –GDC-0084 is ready to begin phase II studies in first-line GBM, with protocol concept developed, experienced clinical sites enthusiastic to participate, and 45kg of drug substance already manufactured and on hand •Cantrixil, lead asset from in-house discovery programs, is currently in a phase I clinical trial in ovarian cancer in United States and Australia •Company strategy is to build a diversified pipeline over the medium term by in-licensing undervalued assets that have been deprioritised by pharmaceutical companies and developing them to value inflection    2

Agenda •Corporate Overview •GDC-0084 •Cantrixil •Investment Hypothesis    3

Novogen has a well-diversified portfolio of assets, stretching from preclinical to mid-stage clinical 4 Lead Optimisation Preclinical Proof-of-Concept IND-Enabling Tox & CMC Phase I Clinical Trials Phase II Clinical Trials Patent Expiry SBP TRXE-002-1 Cantrixil 2035 SBP TRXE-009 Trilexium 2035 PI3K GDC-0084 2032 Ovarian Cancer Solid Tumours Glioblastoma Multiforme Phase II 2H 2017 CLINICAL DEVELOPMENT Data 1H 2018 PRECLINICAL DEVELOPMENT & DISCOVERY ATM Next-Gen ATM Solid Tumours TBD Pipeline Licensed from Genentech in late 2016 after completion of phase I clinical trial Derived from historical in-house discovery program Discovery program largely co-funded by Australian Government grant of AU$ 3 million over three years

A strong team brings international experience in big pharma and biotech 5 Board Management Team Scientific Advisory Board Board & Management Dr James Garner Chief Executive Officer & Executive Director Physician / MBA; Extensive drug development experience Dr Gordon Hirsch Chief Medical Officer Physician / MBA; 20 years of pharma industry experience Dr Peng Leong Chief Business Officer 18 years of BD and investment banking experience Kate Hill Company Secretary Chartered accountant, and former audit partner at Deloitte Iain Ross Chairman Executive and Board roles in pharma and small biotech Bryce Carmine Deputy Chairman 36 years executive experience in Eli Lilly Steven Coffey Non-Executive Director Chartered accountant with extensive governance experience Dr James Garner Chief Executive Officer & Executive Director Physician / MBA; Extensive drug development experience Professor Sir Murray Brennan Emeritus Chairman of Cancer Surgery at Memorial Sloan Kettering Hospital, New York Dr Karen Ferrante Former Chief Medical Officer at Millennium Pharmaceuticals Professor Peter Gunning Head of School of Medical Sciences at University of New South Wales Professor Alex Matter Former Global Head of Oncology Research at Novartis

Agenda •Corporate Overview •GDC-0084 •Cantrixil •Investment Hypothesis    6

Glioblastoma Multiforme (GBM) is the most common form of primary brain cancer 7 GDC-0084 Lung 14 million cancer cases per annum Breast Colon Prostate Stomach No clear cause or strong risk factors 3-4 months untreated survival 12-15 months average survival with treatment Any age, but most common in 60s Five-year survival 3 – 5% ( breast cancer: 90%) Most common drug treatment is temozolomide (Temodar®), used after surgery and radiotherapy Ineffective in approximately two-thirds of patients Glioblastoma Multiforme 133,000 cases per annum worldwide Indicative Market Opportunity US$ 1 billion

Current GBM standard of care is ineffective in ~65% of patients 8 Source: ME Hegi, A-C Diserens, T Gorlia, et al. (2005). N Engl J Med 352:997-1003 Standard of Care (‘Stupp Regimen’) Debulking surgery where possible Radiotherapy + temozolomide Temozolomide maintenance therapy 6 weeks 4w 6 x 28-day cycles Temozolomide is clearly efficacious… …but only in ~35% with a methylated MGMT promotor GDC-0084

The PI3K pathway is highly relevant to GBM; GDC-0084 is differentiated within the class 9 1CW Brennan et al, Cell (2013), 155(2):462-477; 2Y Suzuki, et al. J Radiat Res (2010), 51(3):343 PI3K Activation in GBM PI3K Inhibitor Class is Diverse GDC-0084 PI3K dysregulation is associated with a worse prognosis2 PI3K pathway upregulated in ~90% of GBM cases per Cancer Genome Atlas1 0% 24% 0% 10% 20% 30% pAkt positive pAkt negative 2-Year Survival Rate GDC-0084 is a pan-PI3K inhibitor, active against all four isoforms (a b g d) Idelalisib (Gilead) – d IPI-549 (Infinity) – g Umbalisib (TG)—d a & b isoforms likely more relevant to solid tumors Differentiation Comparators Relevance GDC-0084 is a dual PI3K / mTOR inhibitor Taselisib (Genentech) – PI3K only Dual mechanism reduces bypass signalling GDC-0084 penetrates the blood-brain barrier (1:1 brain / plasma ratio) Buparsilib (Novartis) – also brain-penetrant but mood disturbances Brain / plasma ratio ³ 1 necessary, given diffuse nature of GBM Rich preclinical data set supporting clinical development in GBM Buparsilib (Novartis) – lead indication is breast cancer GDC-0084 developed from ground up as a GBM drug

Previous GBM failures are understood and can inform development of new therapies 10 GDC-0084 Pharmacokinetic Failure •Many small-molecule kinase inhibitors are not well brain-penetrant, and so reach insufficient concentration at the tumour    Tumour Genetics & Heterogeneity •Many driver mutations for GBM, but few constitutive (e.g. EGFR disordered in ~40% of cases) •Profound heterogeneity in the tumour, and rapid evolution Immunological Environment •Brain is ‘immunologically privileged’, with profoundly different set of immunological responses, so immuno-oncology therapies and cancer vaccines are likely to face hurdles    Clinical Trial Design •Positioning in advanced treatment failures entails an extremely ‘hard-to-treat’ group with limited life expectancy, creating very high bar for new therapies •Combination therapy tends to be limited by significant toxicity, and some monotherapies can be impeded by higher levels of toxicity in this population    Compensatory Mechanisms •Inhibition of some downstream targets may lead to upregulation elsewhere (e.g. pure mTOR inhibitors have been associated with worse clinical outcomes)

Genentech’s phase I study established a dose of 45mg and demonstrated acceptable safety 11 GDC-0084 Efficacy Signals Safety •Phase I safety trial conducted by Genentech •47 patients enrolled with advanced glioma (grade 3/4) •Most common adverse events were oral mucositis and hyperglycemia (common effects of PI3K inhibitors) •No evidence of liver, bone marrow, kidney toxicity, or mood disturbances •Data presented at American Society for Clinical Oncology annual meeting in Chicago, June 2016 GDC-0084 40% Achieved ‘stable disease’ Arresting Tumour Growth 21% Remained on study for >3 months Potentially Delaying Progression 26% Showed ‘metabolic partial response’ on FDG-PET Slowing Tumour Metabolism

40% of patients achieved stable disease, with response increasing in higher doses 12 Best % change from baseline of target lesions CR / PR: 0 SD: 19 (40%) PD: 26 (55%) GDC-0084 Disease stabilisation is consistent with a primarily cytostatic mechanism, and highly relevant for use in post-resection setting

First-line phase II study design is supported by preclinical data and KOL consultation 13 GDC-0084 Debulking surgery prior to study entry Radiotherapy + temozolomide Maintenance temozolomide Maintenance GDC-0084 R Approximately 60 sites in 5-6 countries Will target patients who are resistant to temozolomide (approximately two-thirds of glioblastoma patients) Duration: 18 months recruitment 12 months follow-up Number of patients: approx. 228 (114 per arm) prior to entering study during study Regulatory Strategy •Designed to provide robust evidence of clinical efficacy, using an endpoint, progression-free survival (PFS), that could potentially be approvable •Goal is to seek accelerated approval prior to completion of a definitive phase III study. Avastin (bevacizumab) was approved for recurrent GBM in this way •In the interim, Novogen aims special designations (ODD, FTD, etc.) to provide enhanced opportunities for regulatory engagement    n = 114 n = 114

Brain metastases from non-CNS tumors represent long-term upside potential 14 Source: E Lim & N Lim (2012). Oncology. 26(7):652-9; PK Brastianos, SL Carter, S Santagata, et al. (2015). Discovery 5:1164 •Estimated 100,000—200,000 cases/year in US •~10-25% adult cancer patients develop symptomatic brain mets •Lung, breast and melanoma represent the majority of brain mets •Frequency of brain mets increasing with better systemic control and longer survival •Few (if any) drugs available to treat brain metastasis    •Use GBM as a ‘gateway indication’, with the potential to explore registration post-phase II via accelerated approval / breakthrough designation, subject to clinical results •Meanwhile, conduct preclinical exploration of brain metastases in partnership with identified researchers to demonstrate preclinical proof-of-concept and augment economic value of the asset    •~30-44% of metastatic HER2-positive metastatic breast cancer patients have brain metastases •Brain metastases represent the cause of death in ~50% of HER2-positive breast cancer patients •~40-50% of breast cancer brain metastases have disordered PI3K pathway •Therapies that are effective for the primary tumor (e.g. Herceptin) are often ineffective for brain metastases    Overview Example: Breast Cancer Next Steps GDC-0084

Agenda •Corporate Overview •GDC-0084 •Cantrixil •Investment Hypothesis 15

Ovarian cancer remains a disease of high unmet medical need 16 Source: GLOBOCAN; Holschneider & Berek (2000), Sem Surg Onc 19(1):3-10; Decision Resources Cantrixil Cause of death for 1 in 100 women 10% of cases are primarily genetic in origin Lung 14 million cancer cases per annum Breast Colon Prostate Stomach >60% of patients have disease spread at diagnosis 80% of patients are over 50 years of age Five-year survival 45% ( breast cancer: 90%) Chemotherapy only curative in ~20% of ovarian cancers More than half of patients with advanced disease will recur within 1-4 years Ovarian Cancer 239,000 cases per annum worldwide Indicative Market Opportunity US$ 1.5 billion

Cantrixil (TRX-E-002-1) is a novel small molecule optimized to kill tumor-initiating cells 17 First-in-class agent that kills the ‘tumor-initiating cells’ thought to be responsible for tumor recurrence and metastasis Prevents recurrence post-chemotherapy Combination treatment of TRX-E-002- 1 and paclitaxel reduces tumour recurrence in a model of disseminated, chemoresistant ovarian cancer Potentiates the destruction of ovarian cancer stem cell spheroids which are linked to migration and enhanced chemo-resistance Survival benefit over 47 days of treatment compared with the respective monotherapy controls Ref: Mol Can Ther; 15(6) June 2016 Spheroid Degraded 0 20 40 60 80 100 Number per image Control TRX 0.245 μM TRX 2.45 μM Number of spheroids after 48 hours of treatment with Cantrixil Cantrixil kills chemo-resistant cancer cells resulting in improved survival compared to cisplatin alone in tumour-bearing athymic nude mice Cantrixil

Phase I study is designed to establish safety and tolerability, and explore potential efficacy 18 Trial Sites •~6 hospitals in United States and Australia •Investigators are generally specialist gynaecological oncologists with clinical trial experience    Patient Population •Women with confirmed ovarian cancer •Resistant or refractory to at least one prior line of therapy (generally a platinum compound)    Study Design •Standard dose escalation to establish maximally tolerated dose (MTD) •Expansion phase at MTD to explore signals of clinical activity    Completion •Forecast 18 month study duration •Actual duration will depend on how many dose cohorts are required to establish MTD Study performed under Investigational New Drug (IND) application with United States Food & Drug Administration (FDA) – provides careful validation and supports eventual product approval in United States In addition to standard efficacy measures (via CT scan), study will measure exploratory biomarkers to seek signals of clinical activity Cantrixil

Agenda •Corporate Overview •GDC-0084 •Cantrixil •Investment Hypothesis 19

20 2017 2018 2019 2020 GDC-0084 Other Programs 2H Phase I study publication 2H FDA meeting re: GBM phase II program 2H Initiation of GBM study 2H Maximum Tolerated Dose (MTD) from TRXE-002-1 phase I study in ovarian cancer 1H Planned FDA ODD approval 1H Potential exploratory clinical studies with partners 1H Completion of TRXE-002-1 phase I study in ovarian cancer 1H Initital data from GBM study 1H Data from FDG-PET subgroup of GBM study 2H Completion of ATM discovery program and potential progression to clinic Calendar Year Basis Milestones and Newsflow

Financial Overview 21 * Adjusted for change in ASX / NASDAQ consolidation ratio on 14 July 2017 Market Capitalisation 0.00 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 Mar-17 May-17 Jul-17 Sep-17 NVGN US$ 16.2 million Shares on Issue 483 million (35% US, 65% Australia) Cash at Bank ~US$ 11.1 million Listing ASX: NRT NASDAQ: NVGN (1:100 ratio) Share Price (US$)* Outstanding Options / Warrants ~60 million Average Daily Volume ASX: 0.1% /day NASDAQ: 0.2% /day Debt Nil Average Daily Value ASX: AU$ 44K /day NASDAQ: US$ 54K /day As at 30 June 2017

•Multiple value-driving catalysts between now and 2Q 2019    •Two active clinical programs providing diversification    •Board and management brings international big pharma experience    •Ambition to source additional assets and to aggressively seek partnering opportunities with big pharma    •Lead asset in-licensed from Genentech after successful phase I Investment Summary 22 High-Quality Pipeline Clear Development Plans Careful Risk Management Proven Team Sustainable Corporate Strategy

NOVOGEN