Nektar Therapeutics Shares Rise 5% on Deal With Pfizer, Merck KGaA
21 Setembro 2021 - 02:44PM
Dow Jones News
By Chris Wack
Nektar Therapeutics shares were up 5% to $17.10 after the
company said it entered into a new oncology clinical collaboration
with Merck KGaA and Pfizer Inc.
The deal is for the company to evaluate the maintenance regimen
of NKTR-255, Nektar's interleukin-15 receptor agonist, in
combination with avelumab, a PD-L1 inhibitor, in patients with
locally advanced or metastatic urothelial carcinoma in a Phase II
study.
NKTR-255 is wholly owned by Nektar and is currently being
evaluated in two separate clinical studies in both liquid and solid
tumors. The novel IL-15 agonist is designed to activate the IL-15
pathway to expand both natural killer cells and memory CD8+ T cell
populations.
Avelumab, which is marketed in the U.S. as Bavencio, is
co-developed and co-commercialized by Merck KGaA and Pfizer
Inc.
Under the new collaboration, Merck KGaA and Pfizer Inc. will
include the combination of NKTR-255 plus avelumab in the study.
Nektar will supply NKTR-255 for the trial. Nektar and the Merck
KGaA-Pfizer alliance will each maintain existing global commercial
rights to their respective medicines. The study is expected to
begin enrolling patients in the first quarter of 2022.
Nektar stock hit its 52-week low of $12.92 on Aug. 20.
Write to Chris Wack at chris.wack@wsj.com
(END) Dow Jones Newswires
September 21, 2021 13:29 ET (17:29 GMT)
Copyright (c) 2021 Dow Jones & Company, Inc.
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