– A total of 17 accepted abstracts, including nine oral
presentations and eight posters, reinforce AbbVie's commitment
to produce a portfolio of products that aim to improve the lives of
patients living with inflammatory bowel diseases (IBD)
–
Oral data presentations include a new post-hoc analysis of clinical
and endoscopic outcomes from the SEQUENCE trial comparing
risankizumab (SKYRIZI®) versus ustekinumab, results from
the COMMAND Phase 3 study of risankizumab as a maintenance therapy
in adult patients with moderately to severely active ulcerative
colitis (UC), and long-term safety results from the U-ENDURE trial
of upadacitinib (RINVOQ®) in adult patients with
moderately to severely active Crohn's disease (CD)
–
Research accepted for presentation reiterates AbbVie's commitment
to understanding the needs of the gastroenterology community and
advance standards of care in IBD
NORTH
CHICAGO, Ill., Feb. 19,
2024 /PRNewswire/ -- AbbVie (NYSE: ABBV)
announced that 17 AbbVie-sponsored abstracts, including new data
from its inflammatory bowel disease (IBD) portfolio, have been
accepted for presentation at the 19th Congress of
European Crohn's and Colitis Organisation (ECCO) taking place in
Stockholm, Sweden from
February 21-24.
Among the accepted research are nine oral presentations and
eight posters. The research spans risankizumab
(SKYRIZI®) and upadacitinib (RINVOQ®) in both
Crohn's disease (CD) and ulcerative colitis (UC).
"Despite continued advancements, many patients are still
suffering from the debilitating effects of living with IBD,"
said Sofie Berg, Pharm.D, Ph.D., therapeutic area head,
international immunology, International Medical Affairs, AbbVie.
"Our collection of data at this year's congress is indicative of
our relentless quest to advance the standards of care in IBD by
including endoscopic outcomes, such as mucosal healing, as key
trial endpoints."
Key data presentations include:
- Several post-hoc analyses of data from the SEQUENCE trial
comparing risankizumab versus ustekinumab in CD
- OP36: Risankizumab versus ustekinumab for the
achievement of clinical outcomes and symptom improvement in
patients with moderate to severe Crohn's disease: Results from the
Phase 3b SEQUENCE trial (24 February 2024; 10:00-10:10 CET)
- DOP18: Risankizumab versus ustekinumab for the
achievement of endoscopic outcomes in patients with
moderate-to-severe Crohn's disease: Results from the Phase
3b SEQUENCE trial (22 February 2024; 18:33-18:39 CET)
- DOP64: Steroid-sparing effect of risankizumab versus
ustekinumab in patients with moderately to severely active Crohn's
disease: Post-hoc results from the Phase 3b SEQUENCE trial (23
February 2024; 17:40-17:46
CET)
- DOP10: Efficacy of risankizumab versus ustekinumab by
baseline Crohn's disease location: Post-hoc analysis of the
SEQUENCE head-to-head trial (22 February
2024; 17:45-17:51 CET)
- The primary safety and efficacy maintenance results from the
COMMAND Phase 3 study of risankizumab in adult patients with UC
- OP06: Risankizumab maintenance therapy in patients with
moderately to severely active ulcerative colitis: Efficacy and
safety in the randomised Phase 3 COMMAND study (22 February 2024; 15:30-15:40 CET)
- Post-hoc analyses of the risankizumab Phase 2b/3 trials in patients with UC
- P683: Economic impact of achieving mucosal healing on
ulcerative colitis-related hospitalisations and work productivity
in patients with moderately to severely active ulcerative colitis:
A post-hoc analysis of risankizumab Phase 2b/3 trials (23 February
2024; 12:40-13:40 CET)
- P593: Efficacy of risankizumab in patients with
moderately to severely active ulcerative colitis by prior advanced
therapy failure and mechanism of action: Post-hoc analysis of the
INSPIRE and COMMAND Phase 3 studies (23
February 2024; 12:40-13:40
CET)
- Long-term efficacy and safety data from Phase 3 maintenance
studies across the gastroenterology portfolio for CD
- OP10: Efficacy and safety of upadacitinib in patients
with moderately to severely active Crohn's disease: Results from
the U-ENDURE long-term extension (23
February 2024; 9:00-9:10
CET)
- DOP53: Long-term efficacy and safety of risankizumab in
patients with moderate to severe Crohn's disease up to 3 years of
treatment: Results from the FORTIFY open-label long-term extension
(23 February 2024; 18:22-18:28 CET)
- Retreatment with upadacitinib in patients with UC
- P1008: Efficacy and safety of retreatment with
upadacitinib after treatment interruption in ulcerative colitis:
Data from the Phase 3 long-term extension study U-ACTIVATE
(23 February 2024; 12:40-13:40 CET)
The full scientific program for ECCO 2024 is
available here.
"Research in IBD has resulted in new efficacious treatment
options over the past couple of years. However, we are still seeing
patients with uncontrolled disease," said Remo Panaccione, M.D., professor of medicine and
director of the IBD unit, University of
Calgary. "It is critically important that as the treatment
paradigm shifts, the gastroenterology community shifts with it.
Emerging data from studies in CD and UC from the AbbVie portfolio
provide insight on what may be possible, as we work with our
patients to set more ambitious treatment goals to help reduce the
burden of disease."
Risankizumab is not approved for the treatment of ulcerative
colitis.
SKYRIZI® (risankizumab) is part of a
collaboration between Boehringer Ingelheim and AbbVie, with AbbVie
leading development and commercialization globally.
About Inflammatory Bowel Disease (IBD)
Inflammatory
bowel disease (IBD) is a group of diseases characterized by chronic
inflammation of the gastrointestinal (GI) tract. Crohn's disease
(CD) and ulcerative colitis (UC) are the most common forms of IBD.
In both CD and UC, the immune system causes inflammation and damage
to the mucosa – or lining – of the gut.1-3 Specifically,
CD manifests as inflammation within the GI tract, most commonly in
the area between the small intestine (ileum) and the colon, causing
persistent diarrhea and abdominal pain.1,4 UC is a
chronic, idiopathic, immune-mediated IBD of the large intestine
that causes continuous mucosal inflammation extending, to a
variable extent, from the rectum to the more proximal
colon.3,5 The hallmark signs and symptoms of UC include
rectal bleeding, abdominal pain, bloody diarrhea, tenesmus (a sense
of pressure), urgency and fecal incontinence.3,5 CD and
UC are progressive diseases, meaning they get worse over time and
may lead to life-threatening complications or
surgery.6,7 Because the signs and symptoms of CD and UC
are unpredictable, they cause a significant burden on people living
with the disease—not only physically, but also emotionally and
economically.7,8
About Risankizumab (SKYRIZI®)
SKYRIZI is an interleukin-23 (IL-23) inhibitor that selectively
blocks IL-23 by binding to its p19 subunit. IL-23, a cytokine
involved in inflammatory processes, is thought to be linked to a
number of chronic immune-mediated
diseases.9-12 SKYRIZI is approved by the U.S. Food
and Drug Administration (FDA) and the European Medicines Agency for
the treatment of plaque psoriasis, psoriatic arthritis and Crohn's
disease.9,10
About RINVOQ® (upadacitinib)
Discovered and developed by AbbVie scientists, RINVOQ is a
selective JAK inhibitor that is being studied in several
immune-mediated inflammatory diseases. Based on enzymatic and
cellular assays, RINVOQ demonstrated greater inhibitory potency for
JAK-1 and JAK-2 relative to JAK-3, and TYK-2. The relevance of
inhibition of specific JAK enzymes to therapeutic effectiveness and
safety is not currently known.13-14
Phase 3 trials of RINVOQ in rheumatoid arthritis, atopic
dermatitis, psoriatic arthritis, axial spondyloarthritis, Crohn's
disease, ulcerative colitis, giant cell arteritis, Takayasu
arteritis, and systemic juvenile idiopathic arthritis are
ongoing.12
U.S. Indications and Important Safety Information about
SKYRIZI® (risankizumab-rzaa)9
SKYRIZI is a prescription medicine used to treat adults with:
- moderate to severe plaque psoriasis who may benefit from taking
injections or pills (systemic therapy) or treatment using
ultraviolet or UV light (phototherapy).
- active psoriatic arthritis (PsA).
- moderate to severe Crohn's disease.
IMPORTANT SAFETY INFORMATION
What is the most
important information I should know about
SKYRIZI® (risankizumab-rzaa)?
SKYRIZI is a prescription medicine that may cause serious
side effects, including:
Serious allergic reactions:
- Stop using SKYRIZI and get emergency medical help right
away if you get any of the following symptoms of a serious allergic
reaction:
– fainting, dizziness, feeling lightheaded (low blood pressure)
– swelling of your face, eyelids, lips, mouth, tongue, or
throat
– trouble breathing or throat tightness
– chest tightness
– skin rash, hives
– itching
Infections:
SKYRIZI may lower the ability of your
immune system to fight infections and may increase your risk of
infections. Your healthcare provider should check you for
infections and tuberculosis (TB) before starting treatment with
SKYRIZI and may treat you for TB before you begin treatment with
SKYRIZI if you have a history of TB or have active TB. Your
healthcare provider should watch you closely for signs and symptoms
of TB during and after treatment with SKYRIZI.
- Tell your healthcare provider right away if you have an
infection or have symptoms of an infection, including:
– fever, sweats, or chills
– cough
– shortness of breath
– blood in your mucus (phlegm)
– muscle aches
– warm, red, or painful skin or sores on your body different from
your psoriasis
– weight loss
– diarrhea or stomach pain
– burning when you urinate or urinating more often than normal
Do not use SKYRIZI if you are allergic to
risankizumab-rzaa or any of the ingredients in SKYRIZI. See the
Medication Guide or Consumer Brief Summary for a complete list of
ingredients.
Before using SKYRIZI, tell your healthcare provider about all
of your medical conditions,
including if you:
- have any of the conditions or symptoms listed in the
section "What is the most important information I should
know about SKYRIZI?"
- have an infection that does not go away or that keeps coming
back.
- have TB or have been in close contact with someone with
TB.
- have recently received or are scheduled to receive an
immunization (vaccine). Medicines that interact with the immune
system may increase your risk of getting an infection after
receiving live vaccines. You should avoid receiving live vaccines
right before, during, or right after treatment with SKYRIZI. Tell
your healthcare provider that you are taking SKYRIZI before
receiving a vaccine.
- are pregnant or plan to become pregnant. It is not known if
SKYRIZI can harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if
SKYRIZI passes into your breast milk.
- become pregnant while taking SKYRIZI. You are encouraged to
enroll in the Pregnancy Registry, which is used to collect
information about the health of you and your baby. Talk to your
healthcare provider or call 1-877-302-2161 to enroll in this
registry.
Tell your healthcare provider about all the medicines you
take, including prescription and over-the-counter
medicines, vitamins, and herbal supplements.
What are the possible side effects of SKYRIZI?
SKYRIZI may cause serious side effects. See "What is the most
important information I should know about SKYRIZI?"
Liver problems in Crohn's disease: A person with
Crohn's disease who received SKYRIZI through a vein in the arm
developed changes in liver blood tests with a rash that led to
hospitalization. Your healthcare provider will do blood tests to
check your liver before, during, and up to 12 weeks of treatment
and may stop treatment with SKYRIZI if you develop liver problems.
Tell your healthcare provider right away if you notice any of the
following symptoms: unexplained rash, nausea, vomiting, stomach
(abdominal) pain, tiredness (fatigue), loss of appetite, yellowing
of the skin and eyes (jaundice), and dark urine.
The most common side effects of SKYRIZI in people treated for
Crohn's disease include: upper respiratory infections,
headache, joint pain, stomach (abdominal) pain, injection site
reactions, low red blood cells (anemia), fever, back pain, and
urinary tract infection.
The most common side effects of SKYRIZI in people treated for
plaque psoriasis and psoriatic arthritis include: upper
respiratory infections, headache, feeling tired, injection site
reactions, and fungal skin infections.
These are not all the possible side effects of SKYRIZI. Call
your doctor for medical advice about side effects.
Use SKYRIZI exactly as your healthcare provider tells you to use
it.
SKYRIZI is available in a 150 mg/mL prefilled syringe and pen, a
600 mg/10 mL vial for intravenous infusion, and a 180 mg/1.2 mL or
360 mg/2.4 mL single-dose prefilled cartridge with on-body
injector.
You are encouraged to report negative side effects of
prescription drugs to the FDA.
Visit http://www.fda.gov/medwatch or call
1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie
may be able to help.
Visit AbbVie.com/myAbbVieAssist to learn more.
This is not a complete summary of all safety
information.
Please click here for Full Prescribing
Information and Medication Guide for
SKYRIZI.
Globally, prescribing information varies; refer to the
individual country product label for complete information.
U.S. Indications and Important Safety Information about
RINVOQ (upadacitinib) 13
USES
RINVOQ is a prescription medicine used to treat:
- Adults with moderate to severe rheumatoid arthritis
(RA) when 1 or more medicines called tumor necrosis factor
(TNF) blockers have been used, and did not work well or could not
be tolerated.
- Adults with active psoriatic arthritis (PsA) when 1
or more medicines called TNF blockers have been used, and did not
work well or could not be tolerated.
- Adults with active ankylosing spondylitis (AS) when
1 or more medicines called TNF blockers have been used, and did not
work well or could not be tolerated.
- Adults with active non-radiographic axial spondyloarthritis
(nr-axSpA) with objective signs of inflammation when a TNF
blocker medicine has been used, and did not work well or could not
be tolerated.
- Adults with moderate to severe ulcerative colitis
(UC) when 1 or more medicines called TNF blockers have
been used, and did not work well or could not be tolerated.
- Adults with moderate to severe Crohn's disease
(CD) when 1 or more medicines called TNF blockers have
been used, and did not work well or could not be tolerated.
It is not known if RINVOQ is safe and effective in children with
juvenile idiopathic arthritis, psoriatic arthritis, ankylosing
spondylitis, non-radiographic axial spondyloarthritis, ulcerative
colitis, or Crohn's disease.
- Adults and children 12 years of age and older with moderate
to severe eczema (atopic dermatitis [AD]) that did not
respond to previous treatment and their eczema is not well
controlled with other pills or injections, including biologic
medicines, or the use of other pills or injections is not
recommended.
RINVOQ is safe and effective in children 12 years of age and
older weighing at least 88 pounds (40 kg) with atopic
dermatitis.
It is not known if RINVOQ is safe and effective in children
under 12 years of age with atopic dermatitis.
IMPORTANT SAFETY INFORMATION
What is the most
important information I should know about RINVOQ?
RINVOQ may cause serious side effects, including:
- Serious infections. RINVOQ can lower your ability
to fight infections. Serious infections have happened while taking
RINVOQ, including tuberculosis (TB) and infections caused by
bacteria, fungi, or viruses that can spread throughout the body.
Some people have died from these infections. Your healthcare
provider (HCP) should test you for TB before starting RINVOQ and
check you closely for signs and symptoms of TB during treatment
with RINVOQ. You should not start taking RINVOQ if you have any
kind of infection unless your HCP tells you it is okay. If you get
a serious infection, your HCP may stop your treatment until your
infection is controlled. You may be at higher risk of developing
shingles (herpes zoster).
- Increased risk of death in people 50 years and older who
have at least 1 heart disease (cardiovascular) risk
factor.
- Cancer and immune system problems. RINVOQ may
increase your risk of certain cancers. Lymphoma and other cancers,
including skin cancers, can happen. Current or past smokers are at
higher risk of certain cancers, including lymphoma and lung cancer.
Follow your HCP's advice about having your skin checked for skin
cancer during treatment with RINVOQ. Limit the amount of time you
spend in sunlight. Wear protective clothing when you are in the sun
and use sunscreen.
- Increased risk of major cardiovascular (CV) events, such as
heart attack, stroke, or death, in people 50 years and older who
have at least 1 heart disease (CV) risk factor, especially if you
are a current or past smoker.
- Blood clots. Blood clots in the veins of the legs
or lungs and arteries can happen with RINVOQ. This may be
life-threatening and cause death. Blood clots in the veins of the
legs and lungs have happened more often in people who are 50 years
and older and with at least 1 heart disease (CV) risk factor.
- Allergic reactions. Symptoms such as rash (hives),
trouble breathing, feeling faint or dizzy, or swelling of your
lips, tongue, or throat, that may mean you are having an allergic
reaction have been seen in people taking RINVOQ. Some of these
reactions were serious. If any of these symptoms occur during
treatment with RINVOQ, stop taking RINVOQ and get emergency medical
help right away.
- Tears in the stomach or intestines. This happens
most often in people who take nonsteroidal anti-inflammatory drugs
(NSAIDs) or corticosteroids. Get medical help right away if you get
stomach-area pain, fever, chills, nausea, or vomiting.
- Changes in certain laboratory tests. Your HCP
should do blood tests before you start taking RINVOQ and while you
take it. Your HCP may stop your RINVOQ treatment for a period of
time if needed because of changes in these blood test results.
Do not take RINVOQ if you are allergic to upadacitinib or any
of the ingredients in RINVOQ. See the Medication Guide or
Consumer Brief Summary for a complete list of ingredients.
What should I tell my HCP BEFORE starting RINVOQ?
Tell your HCP if you:
- Are being treated for an infection, have an infection that
won't go away or keeps coming back, or have symptoms of an
infection such as:
- Fever, sweating, or chills
- Shortness of breath
- Warm, red, or painful skin or sores on your body
- Muscle aches
- Feeling tired
- Blood in phlegm
- Diarrhea or stomach pain
- Cough
- Weight loss
- Burning when urinating or urinating more often than normal
- Have TB or have been in close contact with someone with
TB.
- Are a current or past smoker.
- Have had a heart attack, other heart problems, or stroke.
- Have had any type of cancer, hepatitis B or C, shingles (herpes
zoster), blood clots in the veins of your legs or lungs,
diverticulitis (inflammation in parts of the large intestine), or
ulcers in your stomach or intestines.
- Have other medical conditions including liver problems, low red
or white blood cell counts, diabetes, chronic lung disease, HIV, or
a weak immune system.
- Live, have lived, or have traveled to parts of the country,
such as the Ohio and Mississippi River valleys and the
Southwest, that increase your risk of getting certain kinds of
fungal infections. If you are unsure if you've been to these types
of areas, ask your HCP.
- Have recently received or are scheduled to receive a vaccine.
People who take RINVOQ should not receive live vaccines.
- Are pregnant or plan to become pregnant. Based on findings in
animal studies, RINVOQ may harm your unborn baby. Your HCP will
check whether or not you are pregnant before you start RINVOQ. You
should use effective birth control (contraception) to avoid
becoming pregnant during treatment with RINVOQ and for 4 weeks
after your last dose.
- There is a pregnancy surveillance program for RINVOQ. The
purpose of the program is to collect information about the health
of you and your baby. If you become pregnant while taking RINVOQ,
you are encouraged to report the pregnancy by calling
1-800-633-9110.
- Are breastfeeding or plan to breastfeed. RINVOQ may pass into
your breast milk. Do not breastfeed during treatment with RINVOQ
and for 6 days after your last dose.
Tell your HCP about all the medicines you
take, including prescription and over-the-counter
medicines, vitamins, and herbal supplements. RINVOQ and other
medicines may affect each other, causing side effects.
Especially tell your HCP if you take:
- Medicines for fungal or bacterial infections
- Rifampicin or phenytoin
- Medicines that affect your immune system
If you are not sure if you are taking any of these medicines,
ask your HCP or pharmacist.
What should I avoid while taking RINVOQ?
Avoid food or drink containing grapefruit during treatment with
RINVOQ as it may increase the risk of side effects.
What should I do or tell my HCP AFTER starting
RINVOQ?
- Tell your HCP right away if you have any symptoms of an
infection. RINVOQ can make you more likely to get infections or
make any infections you have worse.
- Get emergency help right away if you have any symptoms of a
heart attack or stroke while taking RINVOQ, including:
- Discomfort in the center of your chest that lasts for more than
a few minutes or that goes away and comes back
- Severe tightness, pain, pressure, or heaviness in your chest,
throat, neck, or jaw
- Pain or discomfort in your arms, back, neck, jaw, or
stomach
- Shortness of breath with or without chest discomfort
- Breaking out in a cold sweat
- Nausea or vomiting
- Feeling lightheaded
- Weakness in one part or on one side of your body
- Slurred speech
- Tell your HCP right away if you have any signs or symptoms of
blood clots during treatment with RINVOQ, including:
- Swelling
- Pain or tenderness in one or both legs
- Sudden unexplained chest or upper back pain
- Shortness of breath or difficulty breathing
- Tell your HCP right away if you have a fever or stomach-area
pain that does not go away, and a change in your bowel habits.
What are other possible side effects of RINVOQ?
Common side effects include upper respiratory tract infections
(common cold, sinus infections), shingles (herpes zoster), herpes
simplex virus infections (including cold sores), bronchitis,
nausea, cough, fever, acne, headache, increased blood levels of
creatine phosphokinase, allergic reactions, inflammation of hair
follicles, stomach-area (abdominal) pain, increased weight, flu,
tiredness, lower number of certain types of white blood cells
(neutropenia, lymphopenia, leukopenia), muscle pain, flu-like
illness, rash, increased blood cholesterol levels, increased
liver enzyme levels, pneumonia, low number of red blood cells
(anemia), and infection of the stomach and intestine
(gastroenteritis).
A separation or tear to the lining of the back part of the eye
(retinal detachment) has happened in people with atopic dermatitis
treated with RINVOQ. Call your HCP right away if you have any
sudden changes in your vision during treatment with RINVOQ.
Some people taking RINVOQ may see medicine residue (a whole
tablet or tablet pieces) in their stool. If this happens, call your
healthcare provider.
These are not all the possible side effects of RINVOQ.
How should I take RINVOQ?
RINVOQ is taken once a day with or without food. Do not split,
crush, or chew the tablet. Take RINVOQ exactly as your HCP tells
you to use it. RINVOQ is available in 15 mg, 30 mg, and 45 mg
extended-release tablets.
This is the most important information to know about RINVOQ.
For more information, talk to your HCP.
You are encouraged to report negative side effects of
prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call
1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie
may be able to help.
Visit AbbVie.com/myAbbVieAssist to learn
more.
This is not a complete summary of all safety
information.
Please click here for the Full Prescribing
Information and Medication Guide.
Globally, prescribing information varies; refer to the
individual country product label for complete information.
About AbbVie in Gastroenterology
With a robust
clinical trial program, AbbVie is committed to cutting-edge
research to drive exciting developments in inflammatory bowel
diseases (IBD), like ulcerative colitis and Crohn's disease. By
innovating, learning and adapting, AbbVie aspires to eliminate the
burden of IBD and make a positive long-term impact on the lives of
people with IBD. For more information on AbbVie in
gastroenterology,
visit https://www.abbvie.com/our-science/therapeutic-focus-areas/immunology/immunology-focus-areas/gastroenterology.html.
About AbbVie
AbbVie's mission is to discover and
deliver innovative medicines and solutions that solve serious
health issues today and address the medical challenges of tomorrow.
We strive to have a remarkable impact on people's lives across
several key therapeutic areas – immunology, oncology, neuroscience,
and eye care – and products and services in our Allergan Aesthetics
portfolio. For more information about AbbVie, please visit us at
www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X
(formerly Twitter), and YouTube.
Forward-Looking Statements
Some statements in this
news release are, or may be considered, forward-looking statements
for purposes of the Private Securities Litigation Reform Act of
1995. The words "believe," "expect," "anticipate," "project" and
similar expressions and uses of future or conditional verbs,
generally identify forward-looking statements. AbbVie cautions that
these forward-looking statements are subject to risks and
uncertainties that may cause actual results to differ materially
from those expressed or implied in the forward-looking statements.
Such risks and uncertainties include, but are not limited to,
challenges to intellectual property, competition from other
products, difficulties inherent in the research and development
process, adverse litigation or government action, and changes to
laws and regulations applicable to our industry. Additional
information about the economic, competitive, governmental,
technological and other factors that may affect AbbVie's operations
is set forth in Item 1A, "Risk Factors," of AbbVie's 2022 Annual
Report on Form 10-K, which has been filed with the Securities and
Exchange Commission, as updated by its subsequent Quarterly Reports
on Form 10-Q. AbbVie undertakes no obligation, and specifically
declines, to release publicly any revisions to forward-looking
statements as a result of subsequent events or developments, except
as required by law.
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bowel diseases. Crohn's & Colitis Foundation. Published
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Crohn's & Colitis Foundation. Accessed June 16, 2021.
https://www.crohnscolitisfoundation.org/what-is-crohns-disease/overview
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Digestive and Kidney Diseases. Accessed August 13,
2021. https://www.niddk.nih.gov/health-information/digestive-diseases/ulcerative-colitis
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Clinic. Accessed June 16, 2021.
https://www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304
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Inc.; 2024.
- SKYRIZI [Summary of Product Characteristics]. AbbVie Ltd.
Available
at: https://www.ema.europa.eu/en/documents/product-information/skyrizi-epar-product-information_en.pdf.
Accessed on January 11, 2024.
- Duvallet E., Sererano L., Assier E., et al. Interleukin-23: a
key cytokine in inflammatory diseases. Ann Med. 2011. Nov
43(7):503-11.
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at: https://www.abbvie.com/our-science/pipeline.html. Accessed
on January 11, 2024.
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Inc.; 2023.
- RINVOQ [Summary of Product Characteristics]. AbbVie Deutschland
GmbH & Co KG. Available at: www.ema.europa.eu.
- A Multicenter, Randomized, Double-Blind, Placebo
Controlled Induction Study to Evaluate the Efficacy and Safety of
Risankizumab in Participants With Moderately to Severely Active
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Accessed on January 11, 2024.
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SOURCE AbbVie