PTI Protherics

    


Lloyds TSB Group Plc



                                    FORM 8.3

    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE

                         (Rule 8.3 of the Takeover Code)

1. KEY INFORMATION

Name of person dealing (Note 1)            Lloyds TSB Group Plc and its Subsidiaries
------------------------------------------ ---------------------------------------------------------------
Company dealt in                           Protherics (PTI)
------------------------------------------ ---------------------------------------------------------------
Class of relevant security to which the    Ord GBP0.02
 dealings being disclosed relate (Note 2)
------------------------------------------ ---------------------------------------------------------------
Date of dealing                            26th September 2008
------------------------------------------ ---------------------------------------------------------------

2. INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a) Interests and short positions (following dealing) in the class of relevant
security dealt in (Note 3)

                                                   Long                                 Short
----------------------------------- ----------------------------------- --------------------------------------
                                         Number              (%)              Number               (%)
----------------------------------- ----------------- ----------------- ------------------ -------------------
(1) Relevant securities                 6,479,801           1.894
----------------------------------- ----------------- ----------------- ------------------ -------------------
(2) Derivatives (other than
 options)
----------------------------------- ----------------- ----------------- ------------------ -------------------
(3) Options and agreements to
 purchase/sell
----------------------------------- ----------------- ----------------- ------------------ -------------------
Total                                   6,479,801           1.894
----------------------------------- ----------------- ----------------- ------------------ -------------------

(3) Interests and short positions in relevant securities of the company, other
than the class dealt in (Note 3)

    Class of relevant security:                    Long                                 Short
----------------------------------- ----------------------------------- --------------------------------------
                                         Number              (%)              Number               (%)
----------------------------------- ----------------- ----------------- ------------------ -------------------
(3) Relevant securities
----------------------------------- ----------------- ----------------- ------------------ -------------------
(2) Derivatives (other than
 options)
----------------------------------- ----------------- ----------------- ------------------ -------------------
(3) Options and agreements to
 purchase/sell
----------------------------------- ----------------- ----------------- ------------------ -------------------
Total
----------------------------------- ----------------- ----------------- ------------------ -------------------

(3) �Rights to subscribe (Note 3)

Class of relevant security:                Details
------------------------------------------ ---------------------------------------------------------------

3. DEALINGS (Note 4)

(3) Purchases and sales

Purchase/sale                       Number of securities               Price per unit (Note 5)
----------------------------------- ---------------------------------- ------------------------------------
Purchase                            160,000                            0.45
----------------------------------- ---------------------------------- ------------------------------------
Transfer Out                        6,000                              N/A
----------------------------------- ---------------------------------- ------------------------------------

(b) Derivatives transactions (other than options)

Product name,        Long/short (Note 6)     Number of securities (Note 7)    Price per unit (Note 5)
e.g. CFD
-------------------- ----------------------- -------------------------------- -----------------------------

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Product name,       Writing,         Number of           Exercise   Type, e.g.    Expiry     Option money
e.g. call option     selling,         securities to      price       American,    date       paid/received
                     purchasing,      which the option               European                 per unit (Note
                     varying etc.     relates (Note 7)               etc.                     5)
------------------- ---------------- ------------------- ---------- ------------- ---------- ----------------

(ii) Exercising

Product name, e.g. call option      Number of securities               Exercise price per unit (Note 5)
----------------------------------- ---------------------------------- ------------------------------------

(d) Other dealings (including new securities) (Note 4)

                                                                       Price per unit (if applicable) (Note
Nature of transaction (Note 8)      Details                             5)
----------------------------------- ---------------------------------- ------------------------------------

4. OTHER INFORMATION

Agreements, arrangements or understandings relating to options or derivatives

Full details of any agreement, arrangement or understanding between the person disclosing and any other
 person relating to the voting rights of any relevant securities under any option referred to on this
 form or relating to the voting rights or future acquisition or disposal of any relevant securities to
 which any derivative referred to on this form is referenced. If none, this should be stated.
---------------------------------------------------------------------------------------------------------

Is a Supplemental Form 8 attached? (Note 9) YES/NO

Date of disclosure                                           29th September 2008
------------------------------------------------------------ ---------------------------------------------
Contact name                                                 Central Disclosure Unit
------------------------------------------------------------ ---------------------------------------------
Telephone number                                             01444 418336
------------------------------------------------------------ ---------------------------------------------
If a connected EFM, name of offeree/offeror with which
 connected                                                   N/A
------------------------------------------------------------ ---------------------------------------------
If a connected EFM, state nature of connection (Note 10)     N/A
------------------------------------------------------------ ---------------------------------------------

Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at
www.thetakeoverpanel.org.uk

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