M&T Bank Corp. said its profit inched higher in the second quarter as revenue and average total loans grew, but a key lending profitability metric narrowed.

Per-share earnings came in slightly above Wall Street estimates.

The Buffalo, N.Y.-based bank posted earnings of $286.7 million, up from $284.3 million in the prior-year period. On a per-share basis, earnings were flat at $1.98. Revenue rose 3.7% to $1.2 billion.

Analysts had expected $1.97 a share in earnings and $1.1 billion in revenue, according to FactSet.

Net interest margin, an important measure of lending profitability, fell to 3.17% from 3.4% a year earlier. Sequentially, though, it held steady. For many banks, the gauge has been under pressure amid continued low interest rates.

Chief Financial Officer René Jones highlighted growth in commercial loan portfolios during the quarter, where balances grew and the company benefited from higher loan syndication fees. Total loans and leases rose 5.3% from the year-earlier period, summing $68.1 billion.

M&T's results were hurt by the sale in April of its trade processing business and by a contribution to the bank's charitable foundation. Together those items took a penny off per-share earnings, the company said.

The bank, with about 650 branches across six eastern states plus Washington, D.C., has been struggling to close a deal to acquire Hudson City Bancorp Inc. for more than two years. The two lenders came to an agreement in August 2012, but have extended the deadline several times, most recently to Oct. 31. Two years ago, the Fed raised concerns about M&T's anti-money-laundering procedures, which the bank has been working to fix through increased spending in compliance and related hires.

During the latest quarter, M&T's efficiency ratio, which measures costs as a percentage of revenue, was little changed at 58.23%

Shares in the company, up about 2% this year, were inactive premarket.

Write to Lisa Beilfuss at lisa.beilfuss@wsj.com

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