FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Zeronda Tyler		 2. Date of Event Requiring Statement (MM/DD/YYYY)
6/18/2021 

 3. Issuer Name and Ticker or Trading Symbol

VYNE Therapeutics Inc. [VYNE]
(Last)        (First)        (Middle)

C/O VYNE THERAPEUTICS, INC., 520 U.S. HIGHWAY 22, SUITE 204		 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Interim CFO /
(Street)

BRIDGEWATER, NJ 08807      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		2. Amount of Securities Beneficially Owned
(Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 23395 (1)D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option  (2)5/16/2029 Common Stock 13504 $5.92 D  
Stock Option  (3)3/19/2030 Common Stock 4375 $10.68 D  
Stock Option  (4)5/6/2030 Common Stock 9375 $7.80 D  
Stock Option  (5)3/4/2031 Common Stock 18834 $6.68 D  
Explanation of Responses:
(1) This amount includes 18,853 shares underlying unvested restricted stock units that will vest over four years following the date of grant.
(2) The shares subject to the option vest over a period of 4 years. 25% of the shares subject to the option vested on June 30, 2020 and 6.25% of the shares vest on the last day of each quarter thereafter.
(3) The shares subject to the option vest over a period of 4 years. 25% of the shares subject to the option vested on March 31, 2021 and 6.25% of the shares will vest on the last day of each quarter thereafter.
(4) The shares subject to the option vest over a period of 4 years. 25% of the shares subject to the option will vest on June 30, 2021 and 6.25% of the shares will vest on the last day of each quarter thereafter.
(5) The shares subject to the option vest over a period of 4 years. 25% of the shares subject to the option will vest on March 31, 2022 and 6.25% of the shares will vest on the last day of each quarter thereafter.

Remarks:
The reporting person was not granted any additional awards in connection with his appointment as interim CFO of the Issuer.
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Zeronda Tyler
C/O VYNE THERAPEUTICS, INC.
520 U.S. HIGHWAY 22, SUITE 204
BRIDGEWATER, NJ 08807

Interim CFO
Signatures
/s/ Mutya Harsch, attorney-in-fact for Tyler Zeronda6/21/2021
**Signature of Reporting PersonDate
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