NITE Nightstar Therapeutics Plc ADS

Knight Capital Group, Inc. (Nasdaq: NITE) and the International Securities Exchange (ISE) are pleased to announce that Knight Equity Markets, L.P. will become a Competitive Market Maker (CMM) on ISE’s options exchange, effective in the first quarter 2010. Knight purchased ten CMM trading rights from TD Options, LLC that cover every options class listed on the exchange.

“Knight is developing options market making capabilities as an extension of our equities and fixed income trade execution services for broker-dealers,” said Thomas M. Joyce, Chairman and Chief Executive Officer, Knight Capital Group, Inc. “ISE is one of the most advanced, efficient and transparent options markets for investors. We look forward to joining as a market maker and generating additional liquidity for the benefit of all market participants.”

“ISE is very excited to welcome Knight to its family of world class liquidity providers,” said Gary Katz, President and Chief Executive Officer of ISE. “Knight will bring its advanced trading systems and expertise as a global liquidity provider to its new market making role at ISE. As a CMM, Knight will play a key role in providing competitive quotes and deep liquidity for all options products traded on ISE.”

Knight will maintain its Electronic Access Member (EAM) trading rights on the exchange.

About Knight

Knight Capital Group, Inc. (Nasdaq: NITE) is a global capital markets firm that provides market access and trade execution services across multiple asset classes to buy- and sell-side firms. Knight’s hybrid market model features complementary electronic and voice trade execution services in global equities and fixed income as well as foreign exchange, futures and options. The firm is consistently ranked as the leading source of off-exchange liquidity in U.S. equities. Knight also provides capital markets services to corporate issuers. Knight is headquartered in Jersey City, NJ with a growing global presence across North America, Europe and the Asia-Pacific region. For more information, please go to www.knight.com.

About International Securities Exchange

The International Securities Exchange (ISE) operates the world’s largest equity options exchange and offers options trading on over 2,000 underlying equity, ETF, index, and FX products. As the first all-electronic options exchange in the U.S., ISE transformed the options industry by creating efficient markets through innovative market structure and technology. Regulated by the Securities and Exchange Commission (SEC) and a member-owner of The Options Clearing Corporation (OCC), ISE provides investors with a transparent marketplace for price and liquidity discovery on centrally cleared options products. ISE continues to expand its marketplace through the ongoing development of enhanced trading functionality, new products, and market data services. As a complement to its options business, ISE has expanded its reach into multiple asset classes through strategic investments in financial marketplaces that foster technology innovation and market efficiency. Through minority investments, ISE participates in the securities lending and equities markets. ISE also licenses its proprietary Longitude technology for trading in event-driven derivatives markets.

ISE is a wholly owned subsidiary of Eurex, a leading global derivatives exchange. Eurex itself is jointly operated by Deutsche B�rse AG (Ticker: DB1) and SIX Swiss Exchange AG. Together, Eurex and ISE are the global market leader in individual equity and equity index derivatives. For more information, visit www.ise.com.

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