By Tess Stynes 

AbbVie Inc. said its first-quarter earnings rose 4.3% as the biopharmaceutical company posted broad sales growth.

Shares rose 1.5% to $65.50 in recent premarket trading as per-share earnings, excluding items, beat expectations and AbbVie raised its full-year per-share earnings estimate to $4.10 to $4.30, from its previous estimate for $4.05 to $4.25.

AbbVie last month agreed to acquire cancer biotech company Pharmacyclics Inc. in a $21 billion deal that returned AbbVie to deal-making after backing away from a big tax-lowering takeover last year.

The North Chicago, Ill., drug company had reached a $54 billion agreement to buy Irish drug company Shire PLC last year before abruptly walking away after the Obama administration took steps to deter such tax-lowering deals.

Overall, AbbVie reported a profit of $1.02 billion, or 63 cents a share, up from $980 million, or 61 cents a share, a year earlier. Excluding separation-related costs and other items, per-share earnings rose to 94 cents from 71 cents. The company expected per-share earnings of 82 cents to 84 cents.

Revenue increased 10% to $5.04 billion, but excluding currency effects rose 18%.

Global Humira sales rose 18% and climbed 26% excluding currency impacts.

Write to Tess Stynes at tess.stynes@wsj.com

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