FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Sagrolikar Ashish M		 2. Issuer Name and Ticker or Trading Symbol

ZOGENIX, INC. [ ZGNX ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
EVP & CHIEF COMMERCIAL OFFICER
(Last)          (First)          (Middle)

C/O ZOGENIX, INC., 5959 HORTON STREET, SUITE 500		 3. Date of Earliest Transaction (MM/DD/YYYY)

7/2/2021
(Street)

EMERYVILLE, CA 94608
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 7/2/2021  M  3500 A$0 (1)17259 (2)D  
Common Stock 7/2/2021  F  1114 (3)D$17.74 16145 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Restricted Stock Units  (1)7/2/2021  M     3750   (4) (5)Common Stock 3750.0 $0 3750 D  
Explanation of Responses:
(1) Each restricted stock unit (RSU) represents a contingent right to receive one share of the Company's common stock.
(2) Includes 1,018 shares acquired under the Company's Employee Stock Purchase Plan since the last Section 16 filing by the Reporting Person.
(3) Represents shares withheld to satisfy tax withholding obligations in connection with the vesting of shares of RSUs granted to the Reporting Person.
(4) The RSUs were granted on July 2, 2018 and vest as to 1/4th of the original number of shares subject to the RSU award on the one-year anniversary of the date of grant, and thereafter as to 1/4th of the original number of shares subject to the RSU award on each of the following three anniversaries, subject to the Reporting Person's continued service to the Company on the applicable vesting dates.
(5) Not applicable.
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Sagrolikar Ashish M
C/O ZOGENIX, INC.
5959 HORTON STREET, SUITE 500
EMERYVILLE, CA 94608

EVP & CHIEF COMMERCIAL OFFICER
Signatures
/s/ Michael P. Smith, Attorney-in-fact for Ashish Sagrolikar7/6/2021
**Signature of Reporting PersonDate
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