By Jonathan D. Rockoff, Lauren Pollock and George Stahl 

Pfizer Inc. agreed to buy Hospira Inc., in a $16 billion, all-cash deal that would expand the New York pharmaceutical company's sales of injectable drugs and lower-priced versions of costly biotech drugs.

Hospira shareholders will receive $90 a share in cash, a 39% premium to Wednesday's close. Shares surged 35% to $87.51 in morning trading. The stock's previous high, set earlier this year, was $66.56 a share. Pfizer, meanwhile, gained 3.4%.

Pfizer Chief Executive Ian Read had said the company was open to doing a big deal after being rebuffed last year in its $120 billion bid to buy AstraZeneca PLC. Like its rivals, Pfizer is looking for new avenues of growth as key drugs lose patent protection.

Hospira is among the leading companies selling injectable drugs and biosimilars. In fact, Hospira is one of the first U.S. drug makers selling biosimilars in Europe and Australia. Hospira, of Lake Forest, Ill., had $4.4 billion in revenue last year, according to Pfizer.

The deal would give Pfizer, which has been trying to build up its own businesses in those areas, the opportunity to expand and take leading positions in fast-growing markets, according to Mr. Read. "The puzzle pieces come together in a very nice way," he said in an interview.

Pfizer estimates the global marketplace for generic sterile injectables is estimated to be $70 billion in 2020, while the marketplace for biosimilars is estimated to be about $20 billion by that time. Pfizer had $49.6 billion in sales last year.

Pfizer will add Hospira, which is based in Lake Forest, Ill., to its global established pharma business, which includes generic products as well as growth opportunities such as biosimilars and injectables. The business had $25.15 billion in revenue last year.

John Young, who heads the Pfizer established-products unit, said he expects further benefits from plugging Hospira's largely U.S.-based business into the New York company's world-wide commercial infrastructure.

"We think our commercial footprint can be a real enabler," Mr. Young said.

Pfizer expects the deal, which was announced Thursday, to close in the second half of this year and add to earnings immediately. The company expects the acquisition to add 10 cents to 12 cents in per-share earnings in the first full year. Pfizer also expects the acquisition to generate $800 million in cost savings within three years.

Executives indicated Pfizer would keep looking for deals, even bigger ones. "We have lots of remaining capacity" to do more transactions, Pfizer Chief Financial Officer Frank D'Amelio said.

As of Sept. 28, Pfizer had more than $33 billion in cash and short-term investments, sparking speculation about how it would put the money to work.

After walking away from AstraZeneca, Pfizer approached a number of other companies about a potential deal, The Wall Street Journal has reported. One of those companies was Actavis PLC, which later reached its own deal to buy Allergan Inc.

Pfizer and Hospira tagged the enterprise value of the deal, which likely includes the assumption of debt, at about $17 billion.

The deal comes as Hospira was facing challenges to a key business. Over the past couple of years, manufacturers of injectable drugs have benefited from product shortages that made it possible to raise prices. The shortages were often attributed to tougher inspections by the U.S. Food and Drug Administration, but these typically take about two years to resolve, suggesting the latest cycle of price hikes may be nearing an end.

Hospira had also looked to enter the deals fray in the pharmaceutical sector, emerging last year as a bidder for Danone SA's medical-nutrition unit, amid a flurry of so-called inversion deals designed to sidestep U.S. taxes. The deal never occurred, and Danone in December said it would keep its medical-nutrition business.

Hospira was expected to report its 2014 results next week. Pfizer, meanwhile, last month reported a 4% decline in 2014 revenue to $49.6 billion and a 58% drop in net income to $9.14 billion.

Pfizer is facing the loss of roughly $26 billion in sales between 2010 and this year from drugs losing patent protection. In December, its painkiller Celebrex began facing generic competition. To cope, the company has cut $5.5 billion in operating expenses over the past few years while trying to restock its research pipeline with heart and cancer drugs and vaccines.

Write to Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com, Lauren Pollock at lauren.pollock@wsj.com and George Stahl at george.stahl@wsj.com

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