SQZ SQZ Biotechnologies Company

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

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SQZ Biotechnologies Company Important Notice Regarding the Availability of Proxy Materials SQZBIOTECH P.O. BOX 8016, CARY, NC 27512-9903 Stockholders Meeting to be held on June 14, 2023 For Stockholders of record as of April 17, 2023 This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting. To view the Proxy Statement, Notice, and Annual Report, and to obtain directions to attend the meeting, go to: www.proxydocs.com/SQZ To vote your proxy while visiting this site, you will need the 12 digit control number in the box below. Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet. For a convenient way to view proxy materials and VOTE go to www.proxydocs.com/SQZ Have the 12 digit control number located in the shaded box above available when you access the website and follow the instructions. If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year's meeting, you must make this request on or before June 02, 2023. To order paper materials, use one of the following methods. INTERNET www.investorelections.com/SQZ TELEPHONE (866) 648-8133 * E-MAIL paper@investorelections.com When requesting via the Internet or telephone you will need the 12 digit control number located in the shaded box above. * If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located above) in the subject line. No other requests, instructions OR other inquiries should be included with your e-mail requesting material. SQZ Biotechnologies Company Meeting Type: Date: Time: Place: Annual Meeting of Stockholders Wednesday, June 14, 2023 9:30 AM, Eastern Time Annual Meeting to be held live via Internet - please visit www.proxydocs.com/SQZ for more details. You must register to attend the meeting online and/or participate at www.proxydocs.com/SQZ SEE REVERSE FOR FULL AGENDA

SQZ Biotechnologies Company Annual Meeting of Stockholders THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote on these important matters. THE BOARD OF DIRECTORS RECOMMENDS A VOTE: FOR ON PROPOSALS 1, 2 AND 3 PROPOSAL 1 To elect three Class III Directors to serve until the 2026 Annual Meeting of Stockholders, and until their respective successors have been duly elected and qualified 1.01 Howard Bernstein, M.D., Ph. D. 1.02 Paul Bolno, M.D. 1.03 Marc Schegerin, M.D. 2. To approve amendments to the Company's restated certificate of incorporation, as amended, to effect a reverse stock split of the Company's common stock at a ratio ranging from any whole number between 1-for-10 and 1-for-20, as determined by the Board of Directors in its discretion, subject to the Board of Directors' authority to abandon such amendments 3. To ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2023

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