Advanced Proteome Therapeutics Announces Achievement of a Milestone
02 Maio 2008 - 11:23AM
Marketwired
VANCOUVER, BRITISH COLUMBIA , a subsidiary of Advanced Proteome
Therapeutics Corporation (TSX VENTURE: APC) is pleased to announce
the achievement of a significant milestone. Application of its
kinetic labeling library technology has led to the development of
chemical methods that enable the site-selective attachment of
entities to human growth hormone, an established protein
therapeutic. The methodology would thus far appear to be a general
way of linking entities to proteins that can be used to modify
their properties and lead to new, improved therapeutics.
This discovery provides examples of molecules that are capable
of selectively attaching to a natural protein. Selective attachment
of polymers, such as polyethylene glycol (PEG) has been shown to
enhance the therapeutic properties of several proteins and dominate
markets, since they represent superior versions of the
corresponding unpegylated proteins. However, it has been difficult
to modify natural proteins chemically without producing complex
mixtures that would complicate drug development. Unlike other
methods, APT's site-selective technology does not require altering
the protein from its natural state to enable site-selective
attachments, which APT believes represents a competitive
advantage.
Alexander (Allen) Krantz, President and CEO of APT, stated that,
"These discoveries involving site-selective labeling of a
challenging target, human growth hormone, and the characterization
of sites of attachment, represent what we believe to be a
significant advance in the field of protein modification and
attachment strategies. Our technology provides a basis for
functional mapping of proteins for commercially valuable sites of
attachment and for the development of novel drugs, and sets the
stage for business development based on these advances."
About APT and APC
APC's primary corporate mission is to apply its proprietary drug
delivery and drug redevelopment technologies to produce new,
improved versions of therapeutic proteins and pioneer the emerging
field of protein-site targeting by discovering valuable targetable
sites on the surface of proteins. The market for diagnostics and
therapeutic proteins and peptides is expected to surpass more than
50 Billion USD by the year 2010 and is the fastest growing segment
of the pharmaceutical market. Future growth however depends largely
on the industry overcoming a number of hurdles, including drug and
site delivery challenges that APT is addressing.
Except for historical information contained herein, this press
release contains forward-looking statements that involve risks and
uncertainties. Actual results may differ materially. Factors that
might cause a difference include, but are not limited to, those
relating to the possibility of our products infringing patents and
other intellectual property of third parties, and costs of product
development. APT nor Atreus will not update these forward-looking
statements to reflect events or circumstances after the date
hereof. More detailed information about potential factors that
could affect APT's financial results is included in the documents
APT files from time to time with the Securities and Exchange
Commission and Canadian securities regulatory authorities including
APT's Registration Statement on Form F-10.
The forward-looking statements contained in this news release
involve risks and uncertainties, and are subject to change based on
various important factors including timely development and
acceptance of new products, gaining product approval, successful
entry into new markets, changes in financing conditions, and
changes in FDA regulations.
Contacts: Encompass Communications Inc. (604) 630-0770 or Toll
Free: 1-877-566-6592
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