ImmuneRegen BioSciences(R) Reports Positive Results of Homspera(R) in Treating Highly Pathogenic Influenza
10 Novembro 2009 - 11:00AM
Marketwired
ImmuneRegen BioSciences Inc.®, a wholly owned subsidiary of IR
Biosciences Holdings Inc. (OTCBB: IRBS), today announced positive
results from a study that evaluated its lead anti-Influenza drug,
Homspera. The study in animals infected with H5N1 (or "Avian")
Influenza virus, which is highly lethal to humans and animals,
revealed that Homspera treatment starting 1 day following Influenza
infection dramatically reduced symptoms of Influenza infection and
increased survival by 60% over infected controls.
Performed at a public University under the guidance of a
world-renowned Influenza expert, the study utilized a 'real-world'
scenario of highly pathogenic Influenza infection by a clade 2.2
H5N1 virus (A/Whooperswan/Mongolia/244/2005); Homspera treatment
commenced 1 day following Influenza infection, which coincided with
the first signs of disease symptoms. The study also utilized the
most widely accepted model of Influenza infection, the ferret, and
2 different viral infectious doses (an approximate LD50 and 100x
LD50 dose) to evaluate differences relative to in initial infection
burden. Homspera treatment was found to increase survival by 60%
and reduce fever in both viral infectious dose groups.
Additionally, Homspera treatment reduced the decrease in body
weight seen in the lower viral infectious dose group to levels of
uninfected animals.
"We are excited by these findings," asserted ImmuneRegen CEO
Michael Wilhelm. "We had preliminary evidence in ferrets suggesting
a survival benefit against pandemic avian flu on co-administration,
but these studies, showing Homspera's ability to treat highly
pathogenic Influenza infection when administered at the onset of
symptoms -- reducing the symptoms of the disease and increasing
survival -- are validation that Homspera development should be
pursued as a stand-alone therapeutic. These studies support our
previous seasonal Influenza therapeutic studies, in which we saw
similar reductions of symptoms, as well as decreased viral titers,
coinciding with Homspera treatment. We believe we've gathered
enough convincing animal data to move this program to the
clinic."
About ImmuneRegen BioSciences, Inc.
ImmuneRegen BioSciences Inc., a wholly owned subsidiary of IR
BioSciences Holdings, Inc. (OTCBB: IRBS), is a development-stage
biotechnology company focused on the research, development and
licensing of Homspera® and its derivatives. Homspera is an adult
stem cell active compound that in study results has been shown to
regenerate and strengthen the immune system and enhance wound
healing. Viprovex®, a derivative of Homspera, is being developed
for potential use against infectious diseases as a stand-alone or
combination therapy and as a vaccine adjuvant. To advance its
mission, the Scottsdale, Arizona based company has forged numerous
study partnerships with industry and academic leaders, including
Celgene Cellular Therapeutics, HemoGenix, Lovelace Respiratory
Research Institute and Virion Systems. For more information, please
visit www.immuneregen.com.
Statements about ImmuneRegen's future expectations, including
statements about the potential use and scientific results for
ImmuneRegen's drug candidates, science and technology, and all
other statements in this press release other than historical facts,
are "forward-looking statements" within the meaning of Section 27A
of the Securities Act of 1933, Section 21E of the Securities
Exchange Act of 1934, and as that term is defined in the Private
Securities Litigation Reform Act of 1995. ImmuneRegen intends that
such forward-looking statements be subject to the safe harbors
created thereby. These future events may not occur as and when
expected, if at all, and, together with ImmuneRegen's business, are
subject to various risks and uncertainties. ImmuneRegen's actual
results could differ materially from expected results as a result
of a number of factors, including the uncertainties inherent in
research and development collaborations, pre-clinical and clinical
trials and product development programs (including, but not limited
to the fact that future results or research and development efforts
may prove less encouraging than current results or cause side
effects not observed in current pre-clinical trials), the
evaluation of potential opportunities, the level of corporate
expenditures and monies available for further studies, capital
market conditions, and others set forth in ImmuneRegen's periodic
report on Form 10-KSB for the year ended December 31, 2008 as filed
with the Securities and Exchange Commission. There are no
guarantees that any of ImmuneRegen's proposed products will prove
to be commercially successful. ImmuneRegen undertakes no duty to
update forward-looking statements.
Contact: Michael K. Wilhelm ImmuneRegen BioSciences Inc. Phone:
480-922-3926 Email: Email Contact John Fermanis ImmuneRegen
BioSciences Inc. Phone: 480-922-3926 Email: Email Contact
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