Series of preclinical studies demonstrate the therapeutic potential of PAT-DX1, a first-in-class, synthetically lethal DNA-binding antibody in primary brain cancers and brain metastases.

Patrys Limited (ASX:PAB), a therapeutic antibody development company, has announced the publication of preclinical data for its therapeutic antibody candidate PAT-DX1 in The Journal of Clinical Investigation—Insight. Patrys is developing PAT-DX1 for use in DDR-deficient cancers, including a range of primary brain cancers and metastases.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210616005355/en/

The antibody PAT-DX1 acts by a unique mechanism to cross the blood brain barrier and kill brain cancer cells and metastases, reducing tumor size and increasing survival. (Graphic: Business Wire)

PAT-DX1 is a cell-penetrating autoantibody that localizes into live cell nuclei, inhibits DNA repair, and is synthetically lethal to cancer cells with defects in DNA damage repair (DDR) processes.

Researchers led by Dr James Hansen of the Yale School of Medicine found that the transporter ENT2 facilitates both brain endothelial cell penetration and crossing of the blood brain barrier (BBB) by PAT-DX1. Efficacy studies conducted in three mouse models of human cancer showed that PAT-DX1 is able to cross the BBB and suppress both orthotopic glioblastoma and metastatic triple negative breast cancer. The suppression of glioblastoma growth or brain metastasis resulted in statistically significant survival benefits.

Most antibodies are unable to cross either cell membranes or the BBB which limits their use for applications such as treating cancers in the brain and intracellular targeting of therapeutic payloads. Patrys believes the unique ability of PAT-DX1 and other deoxymabs to be transported intact across cell membranes and the BBB has potential to provide much-needed, new therapeutic options for the treatment of cancers located in the brain.

Patrys Chief Executive Officer and Managing Director, Dr. James Campbell said: “We continue to be impressed with the robust scientific evidence and rationale that is backing the development of our deoxymab drug platform. Glioblastoma and TNBC brain metastases are very difficult to treat, and the prognosis for patients with these cancers is generally poor. We are excited by the potential that PAT-DX1 shows in animal models of these cancers and are on track for the first-in-human study of our lead deoxymab asset, PAT-DX1, in mid 2022.”

  • Media Contact: H^CK Director, Haley Chartres. M. +61 423 139 163 E. haley@hck.digital
  • Interviews: CEO and MD Dr James Campbell (in AU) and Yale School of Medicine’s / inventor of the deoxymab technology, Dr James Hansen (in US) are available for interviews.
  • Link to JCI Research paper: “ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody”

About Patrys Limited

Based in Melbourne, Australia, Patrys (ASX:PAB) is focused on the development of its deoxymab platform of cell-penetrating antibodies as therapies for a range of different cancers. More information can be found at www.patrys.com.

For more information about Patrys, please visit www.patrys.com and follow us on Twitter (@PatrysLtd) and LinkedIn.

Media Contact: H^CK Director Haley Chartres M. +61 423 139 163 E. haley@hck.digital

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