SCIE SpectraScience Inc (CE)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D. C. 20549

FORM 12b-25

NOTIFICATION OF LATE FILING

SEC FILE NUMBER 33-24138-D

CUSIP NUMBER 45247F 104

(Check One) [ ] Form 10-K [ ] Form 20-F [ ] Form 11-K [X ] Form 10-Q

[ ] Form N-SAR [ ] Form N-CSR

For the Period Ended _ March 31, 2016 ______________

[ ] Transition Report on Form 10-K

[ ] Transition Report on Form 20-F

[ ] Transition Report on Form 11-K

[ ] Transition Report on Form 10-Q

[ ] Transition Report on Form N-SAR

For the Transition Period Ended ________________________

Nothing in this form shall be construed to imply that the Commission has verified any information contained herein.

If the notification relates to a portion of the filing checked above, identify the Item(s) to which the notification relates:

PART I - REGISTRANT INFORMATION

Full Name of Registrant: SPECTRASCIENCE, INC.

Former Name if Applicable: N/A

Address of Principal 11569-11 Sorrento Valley Road

Executive Office: San Diego, California 92121

PART II - RULES 12b-25 (b) and (c)

If the subject report could not be filed without unreasonable effort or expense, and the registrant seeks relief pursuant to Rule 12b-25(b), the following should be completed. (Check box if appropriate)

(a) The reasons described in reasonable detail in Part III of this form could not be eliminated without unreasonable effort or expense;

(b) (i) The subject annual report, semi-annual report, transition report on Form 10-K, Form 20-F, Form 11-K, Form N-SAR or Form N-CSR, or portion thereof will be filed on or before the fifteenth calendar day following the prescribed due date; or the subject quarterly report or transition report on Form 10-Q, or portion thereof, will be filed on or before the fifth calendar day following the prescribed due date.

(c) The accountant's statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.

PART III - NARRATIVE

As the result of the time required to calculate and review complex derivative accounting issues required to be included in the quarterly report on Form 10-Q, the registrant is not able to file the unaudited financial statements for the quarter ended March 31, 2016 until later this week. We believe that the subject Quarterly Report will be available for filing on or before May 20, 2016.

PART IV - OTHER INFORMATION

(1) Name and address of person to contact in regard to this notification:

Lowell W. Giffhorn, CFO

11569-11 Sorrento Valley Road

San Diego, CA 92121

Telephone: (858) 847-0200 x2019

(2) Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the Registrant was required to file such report(s) been filed? If the answer is no, identify report(s).

[X] Yes [ ] No

(3) Is it anticipated that any significant change in results of operations from the corresponding period for the last fiscal year will be reflected by the earnings statements to be included in the subject report or portion thereof?

[ ] Yes [X] No

If so, attach an explanation of the anticipated change, both narratively and quantitatively, and, if appropriate, state the reasons why a reasonable estimate of the results cannot be made.

SPECTRASCIENCE, INC. has caused this notification to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 16, 2016

By: /s/Lowell W. Giffhorn

       Lowell W. Giffhorn

       CFO

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