FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

ZERCHER MICHAEL		 2. Issuer Name and Ticker or Trading Symbol

22nd Century Group, Inc. [ XXII ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
President and COO
(Last)          (First)          (Middle)

500 SENECA STREET, SUITE 507		 3. Date of Earliest Transaction (MM/DD/YYYY)

12/14/2021
(Street)

BUFFALO, NY 14204
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 12/14/2021  S  23147 (1)D$2.1617 (2)1064985 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock option (right to buy) $3.2            (3)3/19/2031 Common Stock 85000  85000 D  
Stock option (right to buy) $1.07           8/24/2019 8/24/2026 Common Stock 250000  250000 D  
Stock option (right to buy) $1.07           9/9/2019 8/24/2026 Common Stock 300000  300000 D  
Stock option (right to buy) $1.07           9/9/2019 8/24/2026 Common Stock 100000  100000 D  
Stock option (right to buy) $1.39           4/1/2020 5/24/2027 Common Stock 68000  68000 D  
Stock option (right to buy) $2.76           3/6/2021 3/6/2028 Common Stock 77875  77875 D  
Explanation of Responses:
(1) Represents shares sold to satisfy taxes resulting from the vesting of restricted stock units.
(2) The price reported in Column 4 is a weighted average price. The prices actually received ranged from $2.15 to $2.185. The reporting person has provided to the issuer, and will provide to any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range for all transactions reported in this Form 4 utilizing a weighted average price.
(3) Options vest 1/3 per year on the anniversary of the date of grant, subject to continued service with the Company.
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
ZERCHER MICHAEL
500 SENECA STREET, SUITE 507
BUFFALO, NY 14204

President and COO
Signatures
/s/ John J. Wolfel, Attorney-in-Fact for Michael Zercher12/16/2021
**Signature of Reporting PersonDate
22nd Century (AMEX:XXII)
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