UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

NOTICE OF EFFECTIVENESS

Effective Date:January 23, 2023
Accession Number:0000929638-23-000115
Submission Type:POS AM
CIK:0001797336
Company Name:Old Ayala, Inc
File Number:333-256793
Ayala Pharmaceuticals (NASDAQ:AYLA)
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