SECURITY AND PLEDGE AGREEMENT dated as of February 9, 2024 (as amended, restated,
amended and restated, supplemented or otherwise modified from time to time, this Agreement) by and among the Grantors listed on the signature pages hereof and those additional Persons that hereafter become parties hereto by
executing a Joinder (the Grantors, as more fully set forth in Section 1), and The Bank of New York Mellon Trust Company, N.A., successor to Wilmington Trust, National Association, as collateral agent for
the Secured Parties (in such capacity, the Collateral Agent, as more fully set forth in Section 1).
W I T N E S E T H:
WHEREAS,
reference is made to that certain Indenture dated as of June 9, 2021 (the Issue Date) (as supplemented and amended by that certain First Supplement Indenture, dated as of February 9, 2024, and as it may be further
amended, restated, amended and restated, supplemented or otherwise modified from time to time, the Indenture) between UpHealth, Inc.., a Delaware corporation (the Company), the Subsidiary Guarantors from time to
time party thereto and The Bank of New York Mellon Trust Company, N.A., successor to Wilmington Trust, National Association, a national banking association, as trustee (in such capacity, the Trustee) and the Collateral Agent;
WHEREAS, pursuant to the Indenture, the Company has issued $160,000,000 principal amount of its 6.25% Convertible Senior Notes due 2026
(together with any additional notes issued pursuant to Section 2.10 of the Indenture, the Notes) upon the terms and subject to the conditions set forth therein;
WHEREAS, Wilmington Trust, National Association has been appointed to serve as Collateral Agent under the Indenture and, in such capacity, to
enter into this Agreement;
WHEREAS, pursuant to the Indenture, each Subsidiary Guarantor has unconditionally and irrevocably guaranteed,
as primary obligor and not merely as surety, to the Collateral Agent, for the benefit of the Secured Parties, the prompt and complete payment and performance when due (whether at the stated maturity, by acceleration or otherwise) of the Secured
Obligations;
WHEREAS, each Subsidiary Guarantor is a Subsidiary of the Company and, as such, will receive substantial benefits from the
execution, delivery and performance of the obligations under the Indenture and the Secured Obligations and each is, therefore, willing to enter into this Agreement; and
WHEREAS, this Agreement is made by the Grantors in favor of the Collateral Agent for the benefit of the Secured Parties to secure the payment
and performance in full when due of the Secured Obligations.
NOW, THEREFORE, for and in consideration of the recitals made above and
other good and valuable consideration, the receipt, sufficiency and adequacy of which are hereby acknowledged, the parties hereto agree as follows:
1. Defined Terms. All initially capitalized terms used herein (including in the preamble and recitals hereof) without definition shall
have the meanings ascribed thereto in the Indenture. Any terms (whether capitalized or lower case) used in this Agreement that are defined in the Code (including, without limitation, Account, Account Debtor, Chattel Paper, Commercial Tort Claims,
Commodities Account, Deposit Account, Drafts, Documents, Equipment, Farm Products, Fixtures, General Intangibles, Inventory, Instruments, Letters of Credit, Letter of Credit Rights, Promissory Notes, Proceeds, Securities Account and Supporting
Obligations) shall be construed and defined as set forth in the Code unless otherwise defined herein or in the Indenture; provided, that to the extent that the Code is used to define any term used herein and if such term is defined
differently in different Articles of the Code, the definition of such term contained in Article 9 of the Code shall govern. The terms defined in this Section 1 include the plural as well as the singular. In addition to
those terms defined elsewhere in this Agreement, as used in this Agreement, the following terms shall have the following meanings:
Account means an account (as that term is defined in Article 9 of the Code).
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