RNS Number:1422O
Alizyme PLC
30 July 2003


Immediate Release                                                  30 July 2003



                                  ALIZYME PLC

                  NOTIFICATION OF MAJOR INTERESTS IN SHARES



Cambridge, UK, 30 July 2003: Alizyme plc (London Stock Exchange: AZM) announces
that it received, today, the following "Notification of Interest" from ISIS
Asset Management plc.



'As the result of the merger of two of ISIS Asset Management's clients on 29th
July 2003, we give notice that ISIS Asset Management plc is interested in the
following shares:


No. of shares                                        %
14,975,555                                          10.93



Such interest includes the material interests of the clients of ISIS Asset
Management plc referred to below:


Name of Client                                     No. of                        Name of Registered
                                                   Shares              %         Holder
Active Capital Trust                               7,437,039           5.43      Chase Nominees Ltd
The AIM VCT Trust                                  1,547,344           1.13      Chase Nominees Ltd



Such interest includes the material interest of the clients of Friends Provident
Unit Managers referred to below:


Name of Client                                     No. of                        Name of Registered
                                                   Shares              %         Holder
UK Mid/Small Cap Fund                              4,146,874           3.03      Citifriends
ISIS UK Smaller Companies Fund                     900,000             0.66      Littledown Nominees
UK Equity Fund                                     207,112             0.15      Citifriends
FISIS ICVC UK Smaller Markets
Fund                                               302,615             0.22      Citifriends



Such interest includes the material interest of the client of Friends Provident
Managed Pensions referred to below:


Name of Client                                     No. of                        Name of Registered
                                                   Shares              %         Holder
ISIS MPF UK Smaller                                434,571             0.32      Citifriends



Please amend your records such that:


Name of Client                                     No. of                        Name of Registered
                                                   Shares              %         Holder
Active Capital Trust                               7,437,039           5.43      Chase Nominees Ltd



replace the records for the following clients:


Name of Client                                     No. of                        Name of Registered
                                                   Shares              %         Holder
The Aim Trust                                      5,294,896           3.8677    Chase Nominees Ltd
3PC Investment Trust                               2,142,143           1.5647    Chase Nominees Ltd





This notification supersedes all previous notifications given by members of the
Friends Provident Group in relation to Shares for these clients.'




For further information, please contact:




Mr Tim McCarthy, Finance Director
ALIZYME plc                                          Tel No: + 44 (0)1223 896000

Lisa Baderoon
BUCHANAN COMMUNICATIONS                            Tel No: + 44 (0) 20 7466 5000



Further information on Alizyme can be found on the Company's website:
www.alizyme.com


                      This information is provided by RNS
            The company news service from the London Stock Exchange
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