RNS Number:0736Q
Alizyme PLC
23 September 2003


Immediate Release                                             23 September 2003


                                  ALIZYME PLC


                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


Cambridge, UK, 23 September 2003: Alizyme plc (London Stock Exchange: AZM)
announces that it received, today, the following "Notification of Interest" from
ISIS Asset Management plc.



"In accordance with the provisions of Sections 198-202 of the Companies Act
1985, we give notice that, as a result of a purchase of 750,000 and a sale of
100,000 ordinary shares of 2p each in the relevant share capital of your company
("Shares") on 19th and 22nd September 2003 the following fund management
companies in the Friends Provident group are interested in the Shares referred
to below through client holdings:


ISIS Asset Management plc is interested in the following shares:

No. of Shares                   %
15,625,555                      11.41


Such interest includes the material interests of the clients of ISIS Asset
Management plc referred to below:

Name of Client           No. of Shares         %   Name of Registered Holder
Discovery Trust                  450,000    0.33   Chase Nominees Ltd
The AIM VCT Trust              1,547,344    1.13   Chase Nominees Ltd
Active Capital Trust           7,637,039    5.58   Chase Nominees Ltd


Such interest includes the material interest of the client of Friends Provident
Unit Managers referred to below:

Name of Client                      No. of            %   Name of Registered
                                    Shares                Holder
ISIS Inst Inv Fund ICVC Inst UK         191,850    0.14   Chase Nominees Ltd
Equity
Fund
ISIS Inv Funds ICVC II UK Smaller     1,202,615    0.88   Chase Nominees Ltd
Co Fund
ISIS Inst Inv Funds ICVC Inst UK      4,203,416    3.07   Chase Nominees Ltd
Smaller
Co Fund


Such interest includes the material interest of the client of ISIS Managed
Pension Funds referred to below:

Name of Client                No. of Shares       %   Name of Registered
                                                      Holder
ISIS MPF UK Smaller                 393,291    0.29   Citifriends
Companies


In addition, ISIS Asset Management plc, as the holding company of the company(s)
referred to in the paragraph(s) above is also interested in those Shares.
Furthermore, Friends Provident Life Office, as the holding company of ISIS Asset
Management plc is also interested in the Shares referred to above.


This notification supersedes all previous notifications given by members of the
Friends Provident group in relation to Shares. (It also supersedes all previous
notifications given by members of the Friends Provident group on behalf of the
client(s) named above in relation to Shares)."



For further information, please contact:



Mr Tim McCarthy, Finance Director          Tel No: + 44 (0)1223 896000
ALIZYME plc

Lisa Baderoon                              Tel No: + 44 (0) 20 7466 5000
BUCHANAN COMMUNICATIONS



Further information on Alizyme can be found on the Company's website:
www.alizyme.com







                      This information is provided by RNS
            The company news service from the London Stock Exchange

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