TIDMOMH 
 
RNS Number : 4329S 
Osmetech PLC 
18 May 2009 
 

Form TR-1 with annex. FSA Version 2.1 updated April 2007 
 
 
+-----------------------------------------+ 
| For filings with the FSA include the    | 
| annex                                   | 
| For filings with issuer exclude the     | 
| annex                                   | 
+-----------------------------------------+ 
 
 
+-----------------------------------------------------------------------------+ 
| TR-1: Notifications of Major Interests in Shares                            | 
+-----------------------------------------------------------------------------+ 
 
 
+----------------------------------------+---------------+---------------+----------+ 
| 1. Identity of the issuer or the underlying issuer of  | Osmetech Plc             | 
| existing shares to which voting rights are attached:   |                          | 
+--------------------------------------------------------+--------------------------+ 
| 2. Reason for notification (yes/no)                                               | 
+-----------------------------------------------------------------------------------+ 
| An acquisition or disposal of voting rights                            | Yes      | 
+------------------------------------------------------------------------+----------+ 
| An acquisition or disposal of financial instruments which may result   |          | 
| in the acquisition of shares already issued to which voting rights are |          | 
| attached                                                               |          | 
+------------------------------------------------------------------------+----------+ 
| An event changing the breakdown of voting rights                       |          | 
+------------------------------------------------------------------------+----------+ 
| Other (please specify):______________                                  |          | 
+------------------------------------------------------------------------+----------+ 
| 3. Full name of person(s) subject to   | Polar Capital Healthcare Opportunities   | 
| notification obligation:               | Fund                                     | 
+----------------------------------------+------------------------------------------+ 
| 4. Full name of shareholder(s) (if     |                                          | 
| different from 3):                     |                                          | 
+----------------------------------------+------------------------------------------+ 
| 5. Date of transaction (and date on    | 13th May 2009                            | 
| which the threshold is crossed or      |                                          | 
| reached if different):                 |                                          | 
+----------------------------------------+------------------------------------------+ 
| 6. Date on which issuer notified:      | 18th May 2009                            | 
+----------------------------------------+------------------------------------------+ 
| 7. Threshold(s) that is/are crossed or | From 7% to below 4%                      | 
| reached:                               |                                          | 
+----------------------------------------+---------------+---------------+----------+ 
 
 
 
 
 
 
 
 
 
+------------+----------+----------+----------+----------+----------+----------+----------+ 
| 8: Notified Details                                                                     | 
+-----------------------------------------------------------------------------------------+ 
| A: Voting rights attached to shares                                                     | 
|                                                                                         | 
+-----------------------------------------------------------------------------------------+ 
| Class/type | Situation previous  | Resulting situation after the triggering transaction | 
| of shares  | to the triggering   |                                                      | 
| If         | transaction         |                                                      | 
| possible   |                     |                                                      | 
| use ISIN   |                     |                                                      | 
| code       |                     |                                                      | 
+            +---------------------+------------------------------------------------------+ 
|            | Number   | Number   | Number   | Number of voting    | Percentage of       | 
|            | of       | of       | of       | rights              | voting rights       | 
|            | shares   | voting   | shares   |                     |                     | 
|            |          | rights   |          |                     |                     | 
+            +          +          +          +---------------------+---------------------+ 
|            |          |          |          | Direct   | Indirect | Direct   | Indirect | 
+------------+----------+----------+----------+----------+----------+----------+----------+ 
| B0K29R564,151,936 32,881,7733.687%                                                      | 
+-----------------------------------------------------------------------------------------+ 
|                                                                                         | 
+------------+----------+----------+----------+----------+----------+----------+----------+ 
 
 
+---------------+---------------+---------------+----------------------+---------------+ 
| B: Financial Instruments                                                             | 
|                                                                                      | 
+--------------------------------------------------------------------------------------+ 
| Resulting situation after the triggering transaction                                 | 
|                                                                                      | 
+--------------------------------------------------------------------------------------+ 
| Type of       | Expiration    | Exercise/     | No. of voting        | Percentage of | 
| financial     | date          | conversion    | rights that          | voting rights | 
| instrument    |               | period/date   | may be               |               | 
|               |               |               | acquired (if         |               | 
|               |               |               | the                  |               | 
|               |               |               | instrument           |               | 
|               |               |               | exercised/converted) |               | 
+---------------+---------------+---------------+----------------------+---------------+ 
|               |               |               |                      |               | 
+---------------+---------------+---------------+----------------------+---------------+ 
 
 
 
 
+--------------------------------------+--------------------------------------+ 
| Total (A+B)                                                                 | 
|                                                                             | 
+-----------------------------------------------------------------------------+ 
| Number of voting rights              | Percentage of voting rights          | 
+--------------------------------------+--------------------------------------+ 
| 32,881,773                           | 3.687%                               | 
+--------------------------------------+--------------------------------------+ 
 
 
 
 
 
+-----------------------------------------------------------------------------+ 
| 9. Chain of controlled undertakings through which the voting rights and /or | 
| the financial instruments are effectively held, if applicable:              | 
+-----------------------------------------------------------------------------+ 
|                                                                             | 
+-----------------------------------------------------------------------------+ 
 
 
+--------------------------------------+--------------------------------------+ 
| Proxy Voting:                                                               | 
|                                                                             | 
+-----------------------------------------------------------------------------+ 
| 10. Name of proxy holder:            |                                      | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
| 11. Number of voting rights proxy    |                                      | 
| holder will cease to hold:           |                                      | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
| 12. Date on which proxy holder will  |                                      | 
| cease to hold voting rights:         |                                      | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
 
 
+--------------------------------------+--------------------------------------+ 
| 13. Additional information:          |                                      | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
| 14 Contact name:                     | Polar Capital LLP - Operations       | 
|                                      | Department                           | 
+--------------------------------------+--------------------------------------+ 
| 15. Contact telephone name:          | +44 (0)207 227 2700                  | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
 
 
For notes on how to complete form TR-1 please see the FSA website. 
Note: Annex should only be submitted to the FSA not the issuer 
 
 
+-----------------------------------------------------------------------------+ 
| Annex: Notification of major interests in shares                            | 
+-----------------------------------------------------------------------------+ 
 
 
 
 
+--------------------------------------+--------------------------------------+ 
| A: Identity of the persons or legal entity subject to the notification      | 
| obligation                                                                  | 
+-----------------------------------------------------------------------------+ 
| Full name                            | Polar Capital Healthcare             | 
| (including legal form of legal       | Opportunities Fund                   | 
| entities)                            |                                      | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
| Contact address                      | c/o Northern Trust International     | 
| (registered office for legal         | Fund Administration Services         | 
| entities)                            | 54-62 Townsend Street                | 
|                                      | Dublin 2                             | 
|                                      | Ireland                              | 
+--------------------------------------+--------------------------------------+ 
| Phone number & email                 | +44 (0) 207 227 2700                 | 
|                                      | operations@polarcapital.co.uk        | 
+--------------------------------------+--------------------------------------+ 
| Other useful information             |                                      | 
| (at least legal representative for   |                                      | 
| legal persons)                       |                                      | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
 
 
+--------------------------------------+--------------------------------------+ 
| B: Identity of the notifier, if applicable                                  | 
+-----------------------------------------------------------------------------+ 
| Full name                            | Gopal Bharj                          | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
| Contact address                      | Polar Capital LLP                    | 
|                                      | 4 Matthew Parker street              | 
|                                      | London SW1H 9NP                      | 
+--------------------------------------+--------------------------------------+ 
| Phone number & email                 | +44 (0)207 227 2700                  | 
|                                      |                                      | 
+--------------------------------------+--------------------------------------+ 
| Other useful information             |                                      | 
| (e.g. functional relationship with   |                                      | 
| the person or legal entity subject   |                                      | 
| to the notification obligation)      |                                      | 
+--------------------------------------+--------------------------------------+ 
 
 
+-----------------------------------------------------------------------------+ 
| C: Additional information                                                   | 
+-----------------------------------------------------------------------------+ 
|                                                                             | 
+-----------------------------------------------------------------------------+ 
 
 
 
This information is provided by RNS 
            The company news service from the London Stock Exchange 
   END 
 
 HOLSFUFDASUSEEI 
 

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