TIDMMPH

RNS Number : 3369M

Mereo BioPharma Group plc

13 September 2019

Mereo BioPharma Group plc

("Mereo" or the "Company" or the "Group")

Directors' details - Update

London and Redwood City, Calif., September 13, 2019 - Mereo BioPharma Group plc (NASDAQ: MREO, AIM: MPH), a clinical stage biopharmaceutical company focused on rare diseases, today announces the additional details on Directors' disclosures in the Appendix below.

Further Enquiries:

 
 Mereo                                            +44 (0)333 023 7300 
 Denise Scots-Knight, Chief Executive Officer 
 Richard Jones, Chief Financial Officer 
 
 Cantor Fitzgerald Europe (Nominated Adviser 
  and Broker to Mereo)                            +44 (0)20 7894 7000 
 Phil Davies 
 Will Goode 
 
 FTI Consulting (Public Relations Adviser 
  to Mereo)                                       +44 (0)20 3727 1000 
 Simon Conway 
 Brett Pollard 
 Ciara Martin 
 
 Burns McClellan (US Public Relations Adviser 
  to Mereo)                                      +01 (0) 212 213 0006 
 Lisa Burns 
 Steve Klass

Appendix

Directors' disclosures

The Company makes the following disclosures pursuant to Rule 17 and Schedule Two (g) of the AIM Rules for Companies

Anders Ekblom, Non-Executive Director of Mereo, was at the time of the publication of the Company's admission document dated 3 June 2016 ("Admission Document"), a director of NXT Science AB, Sallheten Invest AB and TFS Trial Form Support International AB.

Deepa Pakianathan, Non-Executive Director of Mereo, was at the time of her appointment as a director of the Company on 23 April 2019, a director of Serplus Technology LLC. This disclosure corrects the name Serplus Bio, previously disclosed by the Company on 23 April 2019.

Kunal Kashyap, Non-Executive Director of Mereo, had in the five years prior to publication of the Admission Document, been a director of Bharti Life Ventures Pvt Limited and Bharti General Ventures Pvt Limited.

Michael Wyzga, Non-Executive Director of Mereo, was at the time of his appointment as a director of Mereo on 23 April 2019, a Director of International Institute of New England Inc. and, in addition, Mr Wyzga was a director of Altus Pharmaceuticals, Inc. in 2009 when it filed for Chapter 7 bankruptcy. The assets of Altus Pharmaceuticals, Inc. were later sold.

Paul Blackburn, Non-Executive Director of Mereo, was, at the time of publication of the Admission Document, a director of Manawatu Management Company (Beaconsfield) Limited.

Richard Jones, Chief Financial Officer of the Company, had in the five years prior to announcement of his appointment as a director of Mereo on 7 November 2016, been a director of The Cambridge Crystallographic Data Centre.

The Admission Document or, where relevant, the announcement of director appointment, omitted the directorship details above.

There are no further disclosures to be made pursuant to Rule 17 of the AIM Rules for Companies.

About Mereo BioPharma

Mereo BioPharma is a biopharmaceutical company focused on the development and commercialization of innovative therapeutics that aim to improve outcomes for patients with rare diseases. Mereo's strategy is to selectively acquire product candidates for rare diseases that have already received significant investment from pharmaceutical and large biotechnology companies and that have substantial preclinical, clinical and manufacturing data packages. Mereo's existing portfolio consists of six clinical stage product candidates.

-- Setrusumab for osteogenesis imperfecta (OI). In October 2018, the Company announced completion of enrollment of 112 adult patients in a Phase 2b dose ranging study with initial positive 6-month open label data announced in May 2019 and top-line 12-month blinded dose ranging data expected in Q4 2019. A pediatric Phase 3 study design has also been approved by the EMA. Setrusumab has orphan designation in the U.S. and the EU and has been accepted into the PRIME and Adaptive Pathways in EU;

   --      Alvelestat for alpha-1 antitrypsin deficiency (AATD). The Company has initiated a Phase 2 proof-of-concept clinical trial in patients with severe AATD in the United States and the EU and expects to report top-line data from this trial around the end of 2019;

-- Acumapimod for severe exacerbations of COPD. The Company announced positive Phase 2 data in May 2018 and recently announced the outline of the pivotal Phase 3 study including the primary and key secondary endpoints following the successful end of Phase 2 Type B meeting with the FDA;

-- Leflutrozole for hypogonadotropic hypogonadism (HH). The Company announced positive top-line Phase 2b data in March 2018 and positive results from the Phase 2b safety extension study in December 2018;

-- Navicixizumab has completed a Phase 1a single-agent clinical trial in patients with advanced solid tumors and is currently in a Phase 1b trial in combination with a standard paclitaxel regimen in patients with platinum-resistant ovarian cancer. This study recently completed enrollment and the Company has held a successful Type B meeting with the FDA outlining a path for Accelerated Approval; and

-- Etigilimab has completed a single-agent Phase 1a trial in patients with advanced or metastatic solid tumors and the Phase 1b combination study with nivolumab has fully enrolled and is currently in the safety monitoring phase.

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