TIDMAMYT 
 
 
   Grant of Options and Notification of Transactions by Persons Discharging 
Managerial Responsibilities 
 
   DUBLIN, Ireland, and Boston MA, March 8, 2021, Amryt (Nasdaq: AMYT, AIM: 
AMYT), a global, commercial-stage biopharmaceutical company focussed on 
acquiring, developing and commercializing novel treatments for rare 
diseases, today announces that the Remuneration Committee has approved 
the grant of 3,431,350 share options ("Options") to subscribe for 
ordinary shares in the Company ("Shares") under the Employee Share 
Option Plan 2019 (the "Plan") to Joe Wiley, CEO, and Rory Nealon, CFO, 
details of which are set out in the table below. 
 
   The Options have an exercise price of US$2.804 per Share ($14.02 per ADS 
equivalent) ("Exercise Price"). These options may be exercised as 
follows: 
 
 
 
 
--  25% of the total Options granted may be exercised 12 months 
     after the date of grant; 
--  a further 25% of the total Options granted may be exercised 
     24 months after the date of grant; and 
--  the balance of the Options may be exercised 36 months after 
     the date of grant. 
 
 
   All Options are subject to change of control provisions and expire on 
the seventh anniversary of their grant. 
 
   Following the grants of these options, the following Director and 
Company Secretary have the following options: 
 
 
 
 
Director / Company Secretary   Options granted  Total Options now held 
-----------------------------  ---------------  ---------------------- 
Joe Wiley                            2,031,350               8,468,810 
-----------------------------  ---------------  ---------------------- 
Rory Nealon                          1,400,000               6,226,823 
-----------------------------  ---------------  ---------------------- 
 
 
   PDMR Dealings 
 
   The notification of dealing forms for each Director/Company Secretary 
can be found below.  This announcement is made in accordance with 
Article 19 of the EU Market Abuse Regulation 596/2014. 
 
 
 
 
     Details of the person discharging managerial responsibilities 
1.    / person closely associated 
---  ----------------------------------------------------------------------- 
a)   Name                      Joe Wiley 
---  ------------------------  --------------------------------------------- 
2.   Reason for the notification 
---  ----------------------------------------------------------------------- 
a)   Position / status         Director 
---  ------------------------  --------------------------------------------- 
     Initial notification 
b)    / amendment              Initial notification 
---  ------------------------  --------------------------------------------- 
     Details of the issuer, emission allowance market participant, 
3.    auction platform, auctioneer or auction monitor 
---  ----------------------------------------------------------------------- 
a)   Name                      Amryt Pharma plc 
---  ------------------------  --------------------------------------------- 
b)   Legal entity identifier   213800YNUJEOJ84L4T95 
---  ------------------------  --------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
4.    where transactions have been conducted 
---  ----------------------------------------------------------------------- 
     Description of the 
      financial instrument, 
a)    type of instrument       Ordinary shares of GBP0.06 each 
     Identification code       ISIN: GB00BKLTQ412 
---  ------------------------  --------------------------------------------- 
                               Grant of options under the Employee 
                                Share Option Plan 2019 with an 
     Nature of the              exercise price of US$2.804 to purchase 
b)   transaction                2,031,350 ordinary shares. 
---  ------------------------  --------------------------------------------- 
c)   Currency                  US Dollar 
---  ------------------------  --------------------------------------------- 
d)   Price(s) and volume(s)     Price(s)                   Volume(s) 
---  ------------------------   -------------------  --------------------- 
   N/A                                                           2,031,350 
   ------------------------------------------------  --------------------- 
e)   Aggregated information 
      Aggregated volume          2,031,350 
      Aggregated price           N/A 
---  ------------------------  --------------------------------------------- 
f)   Date of the transaction   8 March 2021 
---  ------------------------  --------------------------------------------- 
g)   Place of the transaction  Outside a trading venue 
---  ------------------------  --------------------------------------------- 
 
 
 
 
 
 
     Details of the person discharging managerial responsibilities 
1.    / person closely associated 
---  ----------------------------------------------------------------------- 
a)   Name                     Rory Nealon 
---  -----------------------  ---------------------------------------------- 
2.   Reason for the notification 
---  ----------------------------------------------------------------------- 
a)   Position / status        PDMR -- CFO and Company Secretary 
---  -----------------------  ---------------------------------------------- 
     Initial notification 
b)    / amendment             Initial notification 
---  -----------------------  ---------------------------------------------- 
     Details of the issuer, emission allowance market participant, 
3.    auction platform, auctioneer or auction monitor 
---  ----------------------------------------------------------------------- 
a)   Name                     Amryt Pharma plc 
---  -----------------------  ---------------------------------------------- 
b)   Legal entity identifier  213800YNUJEOJ84L4T95 
---  -----------------------  ---------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place where 
4.    transactions have been conducted 
---  ----------------------------------------------------------------------- 
     Description of the 
      financial instrument, 
a)    type of instrument      Ordinary shares of GBP0.06 each 
     Identification code      ISIN: GB00BKLTQ412 
---  -----------------------  ---------------------------------------------- 
                              Grant of options under the Employee 
                               Share Option Plan 2019 with an exercise 
     Nature of the             price of US$2.804 to purchase 1,400,000 
b)   transaction               ordinary shares. 
---  -----------------------  ---------------------------------------------- 
c)   Currency                 US Dollar 
---  -----------------------  ---------------------------------------------- 
d)   Price(s) and volume(s)    Price(s)                    Volume(s) 
---  -----------------------   --------------------  --------------------- 
   N/A                                                           1,400,000 
   ------------------------------------------------  --------------------- 
e)   Aggregated information 
      Aggregated volume         1,400,000 
      Aggregated price          N/A 
---  -----------------------  ---------------------------------------------- 
f)   Date of the transaction  8 March 2021 
---  -----------------------  ---------------------------------------------- 
g)   Place of the             Outside a trading venue 
      transaction 
---  -----------------------  ---------------------------------------------- 
 
   About Amryt 
 
   Amryt is a global commercial-stage biopharmaceutical company focused on 
acquiring, developing and commercializing innovative treatments to help 
improve the lives of patients with rare and orphan diseases.  Amryt 
comprises a strong and growing portfolio of commercial and development 
assets. 
 
   Amryt's commercial business comprises two orphan disease products -- 
metreleptin (Myalept(R)/ Myalepta(R)) and lomitapide (Juxtapid(R)/ 
Lojuxta(R)). 
 
   Myalept(R) / Myalepta(R) (metreleptin) is approved in the US (under the 
trade name Myalept(R)) as an adjunct to diet as replacement therapy to 
treat the complications of leptin deficiency in patients with congenital 
or acquired generalized lipodystrophy (GL) and in the EU (under the 
trade name Myalepta(R)) as an adjunct to diet for the treatment of 
leptin deficiency in patients with congenital or acquired GL in adults 
and children two years of age and above and familial or acquired partial 
lipodystrophy (PL) in adults and children 12 years of age and above for 
whom standard treatments have failed to achieve adequate metabolic 
control.  For additional information, please follow this 
https://www.globenewswire.com/Tracker?data=e2ZYWajWFEbMEAC92Qw2Xp1CS3UPbpYUoygGhO3FyW1Q_wjPG7dnzV5TljxchVDDoqpaiLr25-4kb5wsZIMfVPqooRfAlnr7-PIRa-DtKe0li3zwCzDJbKIzuVbKfkNmsOxawOAAFLj6dsNmgeGE6Rg20QwN54Vf1tyWoedxHWs= 
link. 
 
   Juxtapid(R)/ Lojuxta(R) (lomitapide) is approved as an adjunct to a 
low-fat diet and other lipid-lowering medicinal products for adults with 
the rare cholesterol disorder, Homozygous Familial Hypercholesterolaemia 
("HoFH") in the US, Canada, Columbia, Argentina and Japan (under the 
trade name Juxtapid(R)) and in the EU, Israel and Brazil (under the 
trade name Lojuxta(R)).  For additional information, please follow this 
https://www.globenewswire.com/Tracker?data=e2ZYWajWFEbMEAC92Qw2XpZF9xBNB_4j-FN5aKdQVihrNr47EaIvwHvClW_xUzY8Gyk3PEzh6lE3mtVFzfdJerFLOIbhTb-r9rZv8m58KRA= 
link. 
 
   Amryt's lead development candidate, Filsuvez(R) (Oleogel-S10) is a 
potential treatment for the cutaneous manifestations of Junctional and 
Dystrophic Epidermolysis Bullosa ("EB"), a rare and distressing genetic 
skin disorder affecting young children and adults for which there is 
currently no approved treatment.  Filsuvez(R) has been selected as the 
brand name for Oleogel-S10. The product does not currently have 
regulatory approval to treat EB. 
 
   Amryt's pre-clinical gene therapy platform, AP103, offers a potential 
treatment for patients with Dystrophic EB, and is also potentially 
relevant to other genetic disorders. 
 
   For more information on Amryt, including products, please visit 
www.amrytpharma.com. 
 
   This announcement contains inside information for the purposes of 
article 7 of the Market Abuse Regulation (EU) 596/2014.  The person 
making this notification on behalf of Amryt is Rory Nealon, CFO/COO and 
Company Secretary. 
 
   Financial Advisors 
 
   Shore Capital (Edward Mansfield, Daniel Bush, John More) are NOMAD and 
Joint Broker to Amryt in the UK. Stifel (Ben Maddison) are Joint Broker 
to the company in the UK.  Davy (John Frain, Daragh O'Reilly) act as 
Joint Broker to the company. 
 
   Forward-Looking Statements 
 
   This press release may contain forward-looking statements containing the 
words "expect", "anticipate", "intends", "plan", "estimate", "aim", 
"forecast", "project" and similar expressions (or their negative) 
identify certain of these forward-looking statements. The 
forward-looking statements in this announcement are based on numerous 
assumptions and Amryt's present and future business strategies and the 
environment in which Amryt expects to operate in the future. 
Forward-looking statements involve inherent known and unknown risks, 
uncertainties and contingencies because they relate to events and depend 
on circumstances that may or may not occur in the future and may cause 
the actual results, performance or achievements to be materially 
different from those expressed or implied by such forward-looking 
statements. These statements are not guarantees of future performance or 
the ability to identify and consummate investments. Many of these risks 
and uncertainties relate to factors that are beyond each of Amryt's 
ability to control or estimate precisely, such as future market 
conditions, the course of the COVID-19 pandemic, currency fluctuations, 
the behaviour of other market participants, the outcome of clinical 
trials, the actions of regulators and other factors such as Amryt's 
ability to obtain financing, changes in the political, social and 
regulatory framework in which Amryt operates or in economic, 
technological or consumer trends or conditions. Past performance should 
not be taken as an indication or guarantee of future results, and no 
representation or warranty, express or implied, is made regarding future 
performance. No person is under any obligation to update or keep current 
the information contained in this announcement or to provide the 
recipient of it with access to any additional relevant information that 
may arise in connection with it. Such forward-looking statements reflect 
the Company's current beliefs and assumptions and are based on 
information currently available to management. 
 
   Contacts 
 
   Joe Wiley, CEO / Rory Nealon, CFO/COO, +353 (1) 518 0200, 
https://www.globenewswire.com/Tracker?data=Y2ZYBxdBKEJhF41HUcO4C7SdKpcxXtu7kSuPhgJmpRcR2zXzeyFrnsofKSiqLkRNYazO0xsBXD97zO1qu57h7HpjnCLCHqNz2pLC4WOXoWQ= 
ir@amrytpharma.com 
 
   Edward Mansfield, Shore Capital, NOMAD, +44 (0) 207 468 7906, 
edward.mansfield@shorecap.co.uk 
 
   Tim McCarthy, LifeSci Advisors, LLC, +1 (212) 915 2564, 
tim@lifesciadvisors.com 
 
   Amber Fennell, Consilium Strategic Communications, +44 (0) 203 709 5700, 
https://www.globenewswire.com/Tracker?data=IEeOje_BbyggFJCrjiyLfzAOc5RBe0u1gStMi5Ohxp13nrG29VBKhlFRk0W62zj0kS6Yp8lKKVyrwmTsCWXCfOhuLPg4QEc9wspbNUqO1i_AOsMqridP_N2Mhoys5r5E 
fennell@consilium-comms.com 
 
 
 
 

(END) Dow Jones Newswires

March 08, 2021 13:00 ET (18:00 GMT)

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