MorphoSys and Galapagos Advance Joint Antibody Program in Inflammatory Diseases into Preclinical Development
23 Julho 2014 - 2:41AM
MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX;
OTC: MPSYY) and Galapagos NV (Euronext: GLPG; OTC:
GLPYY) announced today that the first program from
their strategic alliance has advanced into preclinical development.
MOR106 was realized based on a novel Galapagos target and
MorphoSys' next-generation antibody library Ylanthia and will now
be jointly developed in inflammatory diseases.
"It is gratifying that the first development program from our
alliance with Galapagos has entered the preclinical development
stage. The novel mode of action for MOR106 remains
undisclosed. Furthermore, we are applying Ylanthia in a growing
number of existing and new alliances and an increasing proportion
of our pipeline is based on this next-generation platform,"
commented Dr. Marlies Sproll, Chief Scientific Officer of MorphoSys
AG.
"Our SilenceSelect target discovery platform delivered the novel
target against which this antibody is directed. MOR106 is the
first antibody in the pipeline of Galapagos, and we are excited to
develop this program further in close collaboration with our
friends at MorphoSys," commented Onno van de Stolpe, CEO of
Galapagos.
MOR106 arises from the alliance initiated by Galapagos and
MorphoSys in 2008, in which both companies contribute their core
technologies and expertise. Galapagos provides the disease-related
biology including the target and cellular assays. The targets are
discovered using Galapagos' SilenceSelect adenoviral target
discovery platform. MorphoSys contributes its Ylanthia antibody
technology to generate fully human antibodies directed against the
target. Galapagos and MorphoSys will continue to share equally the
research and development costs, as well as all future revenues.
About MorphoSys
MorphoSys developed HuCAL, the most successful antibody library
technology in the pharmaceutical industry. By successfully applying
this and other patented technologies, MorphoSys has become a leader
in the field of therapeutic antibodies, one of the fastest-growing
drug classes in human healthcare. Together with its
pharmaceutical partners, MorphoSys has built a therapeutic pipeline
of more than 80 human antibody drug candidates for the treatment of
cancer, rheumatoid arthritis, and Alzheimer's disease, to name just
a few. With its ongoing commitment to new antibody technology and
drug development, MorphoSys is focused on making the healthcare
products of tomorrow. MorphoSys is listed on the Frankfurt Stock
Exchange under the symbol MOR. For regular updates about MorphoSys,
visit http://www.morphosys.com.
About Galapagos
Galapagos (Euronext: GLPG; OTC: GLPYY) is specialized in novel
modes-of-action, with a large pipeline comprising five Phase 2
studies (two led by GSK), two Phase 1 studies, four pre-clinical,
and 20 discovery small-molecule and antibody programs in cystic
fibrosis, inflammation, antibiotics, metabolic disease, and other
indications. In the field of inflammation, AbbVie and
Galapagos signed a worldwide license agreement whereby AbbVie will
be responsible for further development and commercialization of
GLPG0634 after Phase 2B. GLPG0634 is an orally-available,
selective inhibitor of JAK1 for the treatment of rheumatoid
arthritis and potentially other inflammatory diseases, currently in
Phase 2B studies in RA and in Phase 2 in Crohn's disease.
Galapagos has another selective JAK1 inhibitor in Phase 2 in
ulcerative colitis and psoriasis, GSK2586184 (formerly GLPG0778,
in-licensed by GlaxoSmithKline in 2012). GLPG0974 is the
first inhibitor of FFA2 to be evaluated clinically for the
treatment of IBD; this program has completed a Proof-of-Concept
Phase 2 study. GLPG1205 is a first-in-class molecule that
targets inflammatory disorders and has completed Phase 1.
GLPG1690 is a first-in-class compound that targets pulmonary
diseases and is currently in a Phase 1 study. AbbVie and
Galapagos signed an agreement in CF whereby they work
collaboratively to develop and commercialize oral drugs that
address two mutations in the CFTR gene, the G551D and F508del
mutation. Potentiator GLPG1837 is at the pre-clinical
candidate stage. The Galapagos Group, including
fee-for-service subsidiary Fidelta, has around 400 employees,
operating from its Mechelen, Belgium headquarters and facilities in
The Netherlands, France, and Croatia. Further information at:
www.glpg.com
For more information, please contact:
MorphoSys AG |
Galapagos NV |
Dr. Claudia
Gutjahr-Löser Head of Corporate Communications & IR Mario
Brkulj Associate Director Corporate Communications & IR
Alexandra Goller Specialist Corporate Communications & IR
Jessica Rush Specialist Corporate Communications & IR
Tel: +49 (0) 89 / 899 27-404
investors@morphosys.com |
Elizabeth
Goodwin, Head of Corporate Communications & IR Tel. +31
6 2291 6240 ir@glpg.com |
HuCAL®, HuCAL GOLD®, HuCAL PLATINUM®, CysDisplay®, RapMAT®,
arYla®, Ylanthia® and 100 billion high potentials® are registered
trademarks of MorphoSys AG. Slonomics® is a registered trademark of
Sloning BioTechnology GmbH, a subsidiary of MorphoSys AG.
SilenceSelect® is a registered trademark of Galapagos NV
This communication contains certain forward-looking statements
concerning the MorphoSys group of companies. The forward-looking
statements contained herein represent the judgment of MorphoSys as
of the date of this release and involve risks and uncertainties.
Should actual conditions differ from the Company's assumptions,
actual results and actions may differ from those anticipated.
MorphoSys does not intend to update any of these forward-looking
statements as far as the wording of the relevant press release is
concerned.
This release may contain forward-looking statements of Galapagos
NV, including, without limitation, statements containing the words
"believes," "anticipates," "expects," "intends," "plans," "seeks,"
"estimates," "may," "will," "could," "stands to," and "continues,"
as well as similar expressions. Such forward-looking statements may
involve known and unknown risks, uncertainties and other factors
which might cause the actual results, financial condition,
performance or achievements of Galapagos, or industry results, to
be materially different from any historic or future results,
financial conditions, performance or achievements expressed or
implied by such forward-looking statements. Given these
uncertainties, the reader is advised not to place any undue
reliance on such forward-looking statements. These forward-looking
statements speak only as of the date of publication of this
document. Galapagos expressly disclaims any obligation to update
any such forward-looking statements in this document to reflect any
change in its expectations with regard thereto or any change in
events, conditions or circumstances on which any such statement is
based, unless required by law or regulation.
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