By Chelsey Dulaney 

Walgreen Co. said strong pharmacy sales and cost cuts helped drive a 16% rise in profit in its latest quarter.

Shares in Walgreen, the largest U.S. drugstore chain by number of stores, rose 3% to $76.51 Tuesday.

The upbeat results come less than a week before a shareholder vote on Walgreen's deal to buy the rest of European drugstore chain Alliance Boots GmbH--a move that would expand Walgreen from a U.S. operation with 8,200 locations to a global one, doing business in more than 10 countries with more than 11,000 total locations.

Walgreen, worried about the possible public reaction, decided not to move its headquarters offshore to lower its tax bill as part of the deal.

Shareholders are set to vote on the deal on Monday, and prominent shareholder advisory firms Glass, Lewis & Co. and Institutional Shareholder Services Inc. have given the deal their blessing. Walgreen Chief Executive Greg Wasson will step down after the merger is completed.

The combination is aimed at giving the companies greater scale and purchasing power at a time that lower drug-reimbursement rates and higher costs for generic drugs are hurting profits.

Walgreen shocked investors in August when it cut its long-term profit forecast because it had failed to account for a rapid rise in the price of generics as it negotiated contracts to offer prescription drugs under Medicare's Part D program.

The bungled generics forecast led to the departure of two top executives, including Chief Financial Officer Wade Miquelon.

Walgreen is also relying on higher margin from selling items such as beauty products in the front end of the stores as well as cost cuts to offset the pressure its pharmacy division is facing.

For the fiscal first quarter ended Nov. 30, the company's selling, general and administrative expenses edged up 1.8% from a year earlier. Overall, Walgreen posted a profit of $809 million, or 85 cents a share, up from a profit of $695 million, or 72 cents a share, a year earlier. Revenue rose 6.7% to $19.6 billion.

Excluding one-time items, per-share earnings were 81 cents, compared with 72 cents a year earlier. Analysts polled by Thomson Reuters had projected 75 cents a share in earnings and $19.5 billion in revenue. Customer traffic fell 2.7%, and basket size increased 4.2%.

Sales, excluding newly opened or closed locations, rose 5.7%, including a 1.5% increase for front-of-the-store sales. Pharmacy sales, excluding newly opened or closed locations, increased 8.1% as the stores filled 4.1% more prescriptions.

Write to Chelsey Dulaney at Chelsey.Dulaney@wsj.com

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