VSTM Verastem Inc

Delivering Novel Therapies for RAS/MAPK Pathway Driven Cancers January 2025 Corporate Presentation

2 Disclaimers Forward-Looking Statements This presentation includes forward-looking statements about, among other things, Verastem Oncology’s (the “Company”) programs and product candidates, strategy, future plans and prospects, including statements related to the anticipated timing of a potential launch of avutometinib and defactinib in Low-Grade Serous Ovarian Cancer, the expected outcome and benefits of collaborations, including with GenFleet Therapeutics (Shanghai), Inc. (GenFleet), including the timing of the IND for VS-7375 and the initiation of a Phase 1/2a study with respect to the same, the status of enrollments for and potential of the results of the RAMP 301 Phase 3 trial to expand the indication regardless of KRAS mutation status, the structure of our planned and pending clinical trials, the potential clinical value of various of the Company's clinical trials, including the RAMP 201, RAMP 205 and RAMP 301 trials, the timing of commencing and completing trials, including topline data reports, interactions with regulators, the timeline and indications for clinical development, regulatory submissions, the potential for and timing of commercialization of product candidates and potential for additional development programs involving the Company’s lead compound and the potential market opportunities of, and estimated addressable markets for, our drug candidates. The words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," “can,” “promising” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Each forward-looking statement is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statement. Applicable risks and uncertainties include the risks and uncertainties, among other things, regarding: the success in the development and potential commercialization of our product candidates, including avutometinib in combination with other compounds, including defactinib, LUMAKRAS and others; the uncertainties inherent in research and development, such as negative or unexpected results of clinical trials, the occurrence or timing of applications for our product candidates that may be filed with regulatory authorities in any jurisdictions; whether and when regulatory authorities in any jurisdictions may approve any such applications that may be filed for our product candidates, and, if approved, whether our product candidates will be commercially successful in such jurisdictions; our ability to obtain, maintain and enforce patent and other intellectual property protection for our product candidates; the scope, timing, and outcome of any legal proceedings; decisions by regulatory authorities regarding trial design, labeling and other matters that could affect the timing, availability or commercial potential of our product candidates; whether preclinical testing of our product candidates and preliminary or interim data from clinical trials will be predictive of the results or success of ongoing or later clinical trials; that the timing, scope and rate of reimbursement for our product candidates is uncertain; that the market opportunities of our drug candidates are based on internal and third-party estimates which may prove to be incorrect; that third-party payors (including government agencies) may not reimburse; that there may be competitive developments affecting our product candidates; that data may not be available when expected; that enrollment of clinical trials may take longer than expected, which may delay our development programs, including delays in review by the FDA of our NDA submission in recurrent KRAS mutant LGSOC if enrollment in our confirmatory trial is not well underway at the time of submission or that the FDA may require the company to enroll additional patients in the Company's ongoing RAMP 301 confirmatory Phase 3 clinical trial prior to Verastem submitting or the FDA taking action on our NDA seeking accelerated approval; risks associated with preliminary and interim data, which may not be representative of more mature data, including with respect to interim duration of therapy data; that our product candidates will cause adverse safety events and/or unexpected concerns may arise from additional data or analysis, or result in unmanageable safety profiles as compared to their levels of efficacy; that we may be unable to successfully validate, develop and obtain regulatory approval for companion diagnostic tests for our product candidates that require or would commercially benefit from such tests, or experience significant delays in doing so; that the mature RAMP 201 data and associated discussions with the FDA may not support the scope of our NDA submission for the avutometinib and defactinib combination in LGSOC, including with respect to KRAS wild type LGSOC; that our product candidates may experience manufacturing or supply interruptions or failures; that any of our third-party contract research organizations, contract manufacturing organizations, clinical sites, or contractors, among others, who we rely on fail to fully perform; that we face substantial competition, which may result in others developing or commercializing products before or more successfully than we do which could result in reduced market share or market potential for our product candidates; that we will be unable to successfully initiate or complete the clinical development and eventual commercialization of our product candidates; that the development and commercialization of our product candidates will take longer or cost more than planned, including as a result of conducting additional studies or our decisions regarding execution of such commercialization; that we may not have sufficient cash to fund our contemplated operations, including certain of our product development programs; that we may not attract and retain high quality personnel; that we or Chugai Pharmaceutical Co., Ltd. will fail to fully perform under the avutometinib license agreement; that our total addressable and target markets for our product candidates might be smaller than we are presently estimating; that we or Secura Bio, Inc. will fail to fully perform under the asset purchase agreement with Secura Bio, Inc., including in relation to milestone payments; that we will not see a return on investment on the payments we have and may continue to make pursuant to the collaboration and option agreement with GenFleet, or that GenFleet will fail to fully perform under the agreement; that we may not be able to establish new or expand on existing collaborations or partnerships, including with respect to in-licensing of our product candidates, on favorable terms, or at all; that we may be unable to obtain adequate financing in the future through product licensing, co-promotional arrangements, public or private equity, debt financing or otherwise; that we will not pursue or submit regulatory filings for our product candidates; and that our product candidates will not receive regulatory approval, become commercially successful products, or result in new treatment options being offered to patients. Other risks and uncertainties include those identified under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the year ended December 31, 2023, as filed with the Securities and Exchange Commission (SEC) on March 14, 2024, and in any subsequent filings with the SEC, which are available at www.sec.gov and www.verastem.com. The forward-looking statements in this presentation speak only as of the original date of this presentation, and we undertake no obligation to update or revise any of these statements whether as a result of new information, future events or otherwise, except as required by law. Use of Non-GAAP Financial Measures This presentation contains references to our non-GAAP operating expense, a financial measure that is not calculated in accordance with generally accepted accounting principles in the US (GAAP). This non-GAAP financial measure excludes certain amounts or expenses from the corresponding financial measures determined in accordance with GAAP. Management believes this non-GAAP information is useful for investors, taken in conjunction with the Company’s GAAP financial statements, because it provides greater transparency and period-over-period comparability with respect to the Company’s operating performance and can enhance investors’ ability to identify operating trends in the Company’s business. Management uses this measure, among other factors, to assess and analyze operational results and trends and to make financial and operational decisions. Non-GAAP information is not prepared under a comprehensive set of accounting rules and should only be used to supplement an understanding of the Company’s operating results as reported under GAAP, not in isolation or as a substitute for, or superior to, financial information prepared and presented in accordance with GAAP. In addition, this non-GAAP financial measure is unlikely to be comparable with non-GAAP information provided by other companies. The determination of the amounts that are excluded from non-GAAP financial measures is a matter of management judgment and depends upon, among other factors, the nature of the underlying expense or income amounts. Reconciliations between this non-GAAP financial measure and the most comparable GAAP financial measure are included in the footnotes to the slides in this presentation on which such non-GAAP number appears. Third-Party Sources Certain information contained in this presentation, including industry and market data and other statistical information, relates to or is based on studies, publications, surveys and other data obtained from third-party sources and the Company’s own internal estimates and research. While the Company believes these third-party sources to be reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, all of the market data included in this presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions.

3 Verastem Oncology: Preparing to Commercialize First Novel RAS/MAPK/FAK Combo Asset with Billion-Dollar Addressable Market Opportunity Avutometinib and defactinib combo has the potential to become the first and only FDA approved treatment for recurrent KRAS mutant Low-Grade Serous Ovarian Cancer (LGSOC) Discovery partnership with GenFleetTherapeutics on novel, potential best-in-class RAS pathway-related programs, including clinical stage KRAS G12D inhibitor, for additional value creation Market expansion opportunities with avutometinib + defactinib in first-line metastatic pancreatic cancer and advanced lung cancer Transitioning to commercial-stage company in 2025 focused on RAS/MAPK-driven cancers RAS: Rat Sarcoma; MAPK: Mitogen-activated protein kinases; FDA: Food and Drug Administration; LGSOC: Low-grade Serous Ovarian Cancer; PDUFA: Prescription Drug User Fee Act FDA granted Priority Review with June 30, 2025, PDUFA Date

4 Efficiently Scaled Launch Model to Deliver Best-in-Class Launch for Recurrent KRAS mutant LGSOC in Mid-2025 Mid-year Launch June 30, 2025 PDUFA Date Potential New Standard of Care Significant Market Opportunity Avutometinib plus defactinib is differentiated on multiple efficacy measures, favorable tolerability leading to relatively low rates of discontinuation due to AEs Novel/novel combination being reviewed under the Accelerated Approval pathway with Priority Review Concentrated Launch Focus Potential high market penetration in recurrent KRAS mt LGSOC in both prevalent and newly recurrent population Lean and focused field team for access, scientific exchange, and sales HCO/Key Accounts GPO Patients Surround Sound Support Programs

5 • 70% of LGSOC tumors are driven by RAS/MAPK pathway-associated mutations1-4 • 30% are KRAS mutant with other mutations including NRAS, BRAF, NF1, and other RAS pathway-associated gene mutations • Avutometinib is an oral RAF/MEK clamp that potently inhibits MEK kinase activity while also blocking the compensatory reactivation of MEK by upstream RAF5-7 • FAK is activated in response to MAPK pathway inhibition by avutometinib as well as by RAF inhibitors and MEK-only inhibitors8, 9 • Defactinib is an oral selective FAK inhibitor that inhibits parallel pathway signaling and FAK inhibition has been demonstrated to enhance the antitumor efficacy of avutometinib both preclinically and clinically10-12 • Together, avutometinib and defactinib have the potential to offer more complete blockade of the signaling that drives the growth of RAS/MAPK pathway-dependent tumors with the objective of deeper and more durable responses Avutometinib + Defactinib Aims to Inhibit Multiple Resistance Mechanisms in the RAS/MAPK Pathway to Improve Patient Outcomes Inhibition of RAF/MEK activates FAK adaptive resistance ERK; extracellular signal-regulated kinase; FAK, focal adhesion kinase; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated extracellular signal-regulated kinase; mTOR, mammalian target of rapamycin; P, phosphate; PI3K, phosphatidylinositol 3-kinase; RAF, rapidly accelerated fibrosarcoma; RAS, rat sarcoma virus; RhoA, Ras homolog family member A; RTK, receptor tyrosine kinase; YAP, Yes-associated protein. 1 AACR Genie v16.1; 2 Cheasley et al., J Pathol 2021; 3 Thomson et al., Gynecol Oncol 2023; 4 Gershenson et al., Gynecol Oncol 2022; 5 Coma et al., AACR 2022; 6 Ishii et al., Cancer Res, 2013; 7 Lito et al., Cancer Cell, 2014; 8 Lubrano et al., AACR 2024; 9 Banerji et al., AACR 2020; 10 Jones et al., Invest New Drugs 2015; 11 McNamara et al., Gynecol Oncol 2024; 12 Banerjee et al., ASCO 2023

6 Clinical Program Designed to Address LGSOC and Beyond Trial/Regimen Discovery Phase IND-Enabling/ Preclinical Phase 1 Phase 2 Phase 3 Anticipated Milestones Avutometinib + Defactinib: Recurrent LGSOC RAMP 301 RAF/MEK Clamp + FAKi vs ICT Complete enrollment in RAMP 301 by end of 2025 RAMP 201 RAF/MEK Clamp + FAKi PDUFA Action Date: June 30, 2025 Avutometinib ± Defactinib + Sotorasib (KRAS G12C Inhibitor): KRAS G12C NSCLC RAMP 203 RAF/MEK Clamp ± FAKi + KRAS G12Ci (sotorasib) Amgen Collaboration An interim update is planned to be presented at a medical meeting in the second half of 2025 Avutometinib + Defactinib + Chemotherapy: 1L Metastatic Pancreatic Cancer RAMP 205 RAF/MEK Clamp + FAKi + gemcitabine, nab-paclitaxel PanCAN Collaboration Expect to report updated safety and efficacy data in Q1 2025 and present data at medical meeting in mid-2025 GenFleet Collaboration of RAS/MAPK-Pathway Targeted Assets VS-7375/GFH375 KRAS G12D (ON/OFF) inhibitor Anticipate filing U.S. IND during Q1 2025; Expect to initiate Phase 1/2a trial in U.S. in mid-2025 Updated data from Phase 1 study by GenFleet in China expected in mid-2025 Undisclosed Undisclosed RAF: Rapidly Accelerated Fibrosarcoma; MEK: Mitogen-activated extracellular signal-regulated kinase FAKi: focal adhesion kinase inhibitor; KRAS: Kirsten Rat Sarcoma virus ICT: investigator choice of treatment; NSCLC: non-small cell lung cancer; NDA: New Drug Application

7 Anchor: Potential to bring avutometinib and defactinib combo as the first and only FDA approved treatment for recurrent KRAS mutant LGSOC in 2025 Maximize Potential: Expand market indications with avutometinib plus defactinib in first-line metastatic pancreatic cancer and advanced lung cancer Future Growth: Create additional value with GenFleet Therapeutics partnership on novel, potential best-in-class RAS pathway-related programs, including VS-7375, oral KRAS G12D (ON/OFF) inhibitor Broaden Reach: Expand indication and geographic reach with LGSOC and Mesonephric Value Time PDAC: pancreatic ductal adenocarcinoma cancer; NSCLC: non-small cell lung cancer Image for illustrative purposes only. Avutometinib Plus Defactinib Expected to Generate Near-Term Growth, while Pipeline Has Potential to Become Significant Driver for Long-Term Growth

8 Avutometinib and Defactinib in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) PDUFA Action Date: June 30, 2025 Potential Launch in Recurrent KRAS mutant LGSOC in mid-2025 Amanda, real patient living with recurrent LGSOC Diagnosed at 26 with LGSOC

9 Avutometinib + Defactinib Demonstrated Durable Results Across Various Efficacy Measures in Heavily Pretreated Patients in RAMP 201 • 31% Overall ORR, 44% in KRAS mt, 17% in KRAS wt • 82% of all patients had tumor shrinkage • 14.5 months estimated mean DoT, 18.3 months in KRAS mt and 10.7 months in KRAS wt • 12.9 months median PFS, 22 months in KRAS mt, 12.8 months in KRAS wt • 10% discontinuation rates due to adverse events Clear Regulatory Path for KRAS Mutant • Under the Accelerated Approval pathway received Priority Review and June 30, 2025 PDUFA Action Date for recurrent KRAS mutant LGSOC • RAMP 301 enrollment remains on track and will continue enrolling all comers • Committed to make the combination available to patients with KRAS wild-type in several ways, including a path for regulatory approval Verastem Aims to Deliver First FDA-Approved Treatment Specifically for Recurrent KRAS mutant LGSOC in mid-2025 Significant Market Opportunity in Area of High Unmet Need • SoC (Chemo/Hormonal) is associated with low response rates (6-13%) with PFS below 12 months and high discontinuation rates due to toxicity • Plan to be launch ready in first-half of 2025 to maximize market opportunity in recurrent KRAS mutant LGSOC • Plan to submit RAMP 201 for NCCN guideline review • NCCN guideline inclusion may enable patients with KRAS wild-type LGSOC to access therapy, if FDA-approved Source for all data: RAMP 201 data cut off as of June 30, 2024; LGSOC: Low-grade serous ovarian cancer; ORR: Objective Response Rate; KRAS, kirsten rat sarcoma virus; KRAS mt: mutant; KRAS wt: wild-type; PFS: Progression-free Survival; NDA: New Drug Application; SOC: Standard of Care; NCCN: National Comprehensive Cancer Network; The combination of Avutometinib and Defactinib is an investigational drug. It has not been proven to be safe or effective and has not been approved by FDA or any other comparable regulatory authority.

10 High Unmet Need for an Effective & Tolerable Therapy in Recurrent LGSOC “When you get told that you have a recurrence, the mental load is a lot. You’re thinking, okay, what did I have to do for treatment the first time? Now I have to repeat that. And will there even be something available for me to take for a second, or a third recurrence?” - Amanda, real patient living with recurrent LGSOC Diagnosed at 26 with LGSOC • U.S. Incidence / Prevalence: 1k-2k1 / 6k-8k2 / Worldwide: 80,000 • 70% of LGSOC tumors are driven by RAS/MAPK pathway-associated mutations3-6 • ~30% are KRAS mutant, with other mutations including NRAS, BRAF, NF1, and other RAS pathway-associated gene mutations • Affects younger population (20-30s) and disproportionately impacts health, fertility, and long-term quality of life7,8 • 80%+ of patients will experience a recurrence9 • Disease currently managed by NCCN guidelines, with no FDA approved treatments • Current SoC offer poor to moderate response rates (6-13%) and patients cycle through therapy10.11, 12 • Median OS of ~10 years from time of diagnosis13 • KRAS mt – ~12 years14 and KRAS wt – ~7 years14 1.Verastem DOF; 2. US Cancer Statistics. Accessed 2024. 3. AACR Genie v16.1; 4. Cheasley et al., J Pathol 2021; 5 Thomson et al., Gynecol Oncol 2023; 6 Gershenson et al., Gynecol Oncol 2022;7. Slomovitz Gynecol Oncol 2020; 8. Manning-Geist B et al. Clin Cancer Res 2022;28(20):4456-4465; 9. Babaier 2022/p1/para1/ln6,7; 10. Gershenson Gynecol Oncol 2022; 11. Slomovitz Gynecol Oncol 2020; 12. Monk 2020/p3758/table2/footnote-b; 13. Banerjee SN). J Clin Oncol. 41. No 16_suppl (June 1, 2023) 5515-5515; 14. Manning-Geist B et al. Clin Cancer Res 2022;28(20):4456-4465; Calculated using figures in Gershenson Gynecol Oncol 2022.

11 Key Inclusion Criteria • Recurrent LGSOC • Prior chemotherapy • Measurable disease (RECIST 1.1) • Prior MEKi allowed Avutometinib + Defactinib 3.2 mg BIW 200 mg BID KRAS mt (n=20) KRAS wt (n=22) Avutometinib + Defactinib 3.2 mg BIW 200 mg BID KRAS mt (n=22) KRAS wt (n=20) Avutometinib + Defactinib 1.6 mg BIW 200 mg BID KRAS mt (n=11) KRAS wt (n=16) Avutometinib + Defactinib 3.2 mg BIW 200 mg BID KRAS mt (n=16) KRAS wt (n=15) Go Forward Regimen Selection Criteria (Selection Phase): • Observed ORR is comparatively greater than the other regimen • Observed ORR of the leading regimen is ≥15% Primary Endpoint: ORR (BICR) Evaluation of ORR in Combination Arm: • In KRAS mt patients • All patients (KRAS mt & wt) Actual Enrollment at RP2D: 115 Treated Patients Avutometinib Mono 4.0 mg BIW KRAS mt (n=15) KRAS wt (n=22) Avutometinib Mono 4.0 mg BIW KRAS mt (n=16) KRAS wt (n=16) Part A Selection Phase Part B Expansion Phase Part C Expansion Phase Combo Part D Low-dose Avuto Combo ✓ ✓ ✓ ✓ Go Forward Regimen Numbers represent patients treated on study. RECIST: Response Evaluation Criteria in Solid Tumors; MEKi: Mitogen-activated extracellular signal-regulated kinase inhibitor; BICR, blinded independent central review; BID, twice daily; BIW, twice weekly; RP2D: Recommended Phase 2 Dose RAMP 201: Registration-Directed Phase 2 Trial of Avutometinib ± Defactinib in Patients with Recurrent LGSOC RAMP 201 (ENGOT-ov60/GOG-3052)

12 Avutometinib (3.2 mg BIW) + Defactinib (200 mg BID) Regimen Parts A+B+C ORR: 31% overall 44% in KRAS mt 17% in KRAS wt Low-Dose: Avutometinib (1.6 mg BIW) + Defactinib (200 mg BID) Part D • Disease progression by 4 months 22% in Low-Dose Part D • Disease progression by 4 months 12% with Go-Forward Regimen • TEAEs leading to discontinuation: 15% • Not lower than Go-Forward Regimen Monotherapy: Avutometinib (4.0 BIW) Part A+B • Protocol evaluated avutometinib 4 mg monotherapy vs avutometinib 3.2 mg + defactinib combination • ORR: 17% overall • 23% in KRAS mt and 13% in KRAS wt • Go-Forward Regimen demonstrated higher ORR • TEAEs leading to D/C was 16% Avutometinib + Defactinib Demonstrate Durable Results in Efficacy Measures & Low Discontinuation Rates Due to AEs, Regardless of KRAS Status Primary analysis of entire RAMP 201 dataset supports go-forward regimen as optimal dose Source for all data: RAMP 201 data cut off as of June 30, 2024; DOR: Duration of Response; TEAEs: treatment-emergent adverse events; AEs: adverse events • Patients with more prior regimens (>3) including prior bevacizumab and MEK-only therapy had lower response rates • The combination was well tolerated allowing for prolonged exposure to therapy • 10% discontinued due to adverse events Median PFS: 12.9 months overall 22.0 months in KRAS mt 12.8 months in KRAS wt DOR at 6 months: 81% overall 87% in KRAS mt 63% in KRAS wt The combination of Avutometinib and Defactinib is an investigational drug. It has not been proven to be safe or effective and has not been approved by FDA or any other comparable regulatory authority.

13 RAMP 201: Parts A+B+C Baseline Patient Characteristics Avutometinib + Defactinib Regimen 3.2 mg BIW + 200 mg BID 3 weeks on / 1 week off* All patients N=115 KRAS mt N=58 KRAS wt N=57 Age (years), Median (min, max) 54 (21, 87) 60 (29, 87) 45 (21, 80) ECOG PS, n (%) 0 78 (68) 42 (72) 36 (63) 1 37 (32) 16 (28) 21 (37) Median number of prior systemic regimens (min, max) 3 (1, 9) 3 (1, 9) 3 (1, 9) Prior platinum-based chemotherapy, n (%)* 114 (99) 58 (100) 56 (98) Prior Hormonal therapy, n (%) 99 (86) 49 (84) 50 (88) Prior Bevacizumab, n (%) 59 (51) 23 (40) 36 (63) Prior MEK inhibitor therapy, n (%) 25 (22) 12 (21) 13 (23) RAMP 201 Enrolled Heavily Pretreated Patients with a Median of 3 Prior Systemic Regimens • Most patients received prior platinum-based chemotherapy and endocrine therapy • 51% of all patients received prior bevacizumab and about 1 in 5 received prior MEK-only inhibitor therapy In the avutometinib + defactinib group: 77% of patients were White; 4% Asian; 4% Black or African American; 4% other; 11% not reported Source for all data: RAMP 201 data cut off as of June 30, 2024 *2 pts without prior platinum received anastrazole only (1 in the monotherapy and 1 in combination arm); ECOG PS, Eastern Cooperative Oncology Group performance status

14 Response Rate: Parts A, B, and C Avutometinib + Defactinib Regimen 3.2 mg BIW + 200 mg BID 3 weeks on / 1 week off All patients N=109 KRAS mt N=57 KRAS wt N=52 Confirmed* ORR, n (%) 34 (31) 25 (44) 9 (17) CR 2 (2) 2 (4) 0 PR 32 (29) 23 (40) 9 (17) SD† , n (%) 62 (57) 28 (49) 34 (65) PD, n (%) 9 (8) 2 (4) 7 (13) Not Evaluable, n (%) 4 (4) 2 (4) 2 (4) Source for all data: RAMP 201 data cut off as of June 30, 2024 ; * By RECIST 1.1 Objective Response by BICR: blinded independent central review 9primary endpoint); Includes Unconfirmed PR; SD (or unconfirmed PR) must occur at least 53 days after first dose date; ‡ PD, progressive disease; PR, partial response; SD, stable disease. • Overall: 31% ORR in all evaluable patients • 44% ORR in KRAS mt and 17% ORR in KRAS wt Mature Data from RAMP 201 Continue to Show Robust Responses Efficacy evaluable population includes patients who received at least one dose of study drug and had measurable disease at baseline by BICR. Patients not evaluable for response did not have a postbaseline assessment but are included in the denominator for the efficacy evaluable population.

15 Median time to response (range, 1.7-19.2) 3.7 MONTHS DOR for KRAS mt and 63% for KRAS wt at 6 months 87% Avutometinib + Defactinib 3.2 mg BIW + 200 mg BID 3 weeks on / 1 week off All Patients N=34 KRAS mt N=25 KRAS wt N=9 DOR (mo), median (range) 31.1 (14.8, 31.1) 31.1 (14.8, 31.1) 9.2 (5.5, NE) DOR >= 6 mo* (95% CI) 81% (62%, 91%) 87% (66%, 96%) 63% (23%, 86%) DOR >= 12 mo* (95% CI) 72% (54%, 89%) 82% (65%, 98%) NE 81% of Patients Achieved a Duration of Response of at Least 6 Months Avutometinib + Defactinib Regimen: Duration of Response Source for all data: RAMP 201 data cut off as of June 30, 2024 *KM estimates; NE = Could not be estimated based on number of patients with loss of response.

16 -100 -90 -80 -70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 Best Target Lesion Response Per IRC (% Change From Baseline) 110 120 Best Target Lesion Response Per IRC (% Change From Baseline) Avutometinib + Defactinib Regimen: Best Overall Response 82% of All Patients Had a Reduction in Target Lesions, Regardless of KRAS Status Source for all data: RAMP 201 data cut off as of June 30, 2024; Responses for 3 patients (KRAS wild type, n=1; KRAS mutant, n=2) were unknown. IRC, Independent Review Committee. Best Overall Confirmed Response (BICR) N (%) Complete Response (KRAS mt) 2 (2) Partial Response 32 (29) Stable Disease 62 (57) Progressive Disease 9 (8) KRAS wild-type KRAS mutant

17 Avutometinib + Defactinib Regimen: ORR by Key Subgroups Source for all data: RAMP 201 data cut off as of June 30, 2024; Bars show 95% confidence intervals Receiving Avutometinib and Defactinib Earlier in the Course of Therapy was Associated with Higher Rates of Response 0 10 20 30 40 50 60 n=63 n=46 n=54 n=55 n=84 n=25 24% (9%,45%) 33% (23%,44%) 20% (10%,33%) 43% (29%,57%) 24% (13%,39%) 37% (25%,50%) Prior Lines of Therapy Prior Bevacizumab Prior MEKi 1-3 >3 No Yes No Yes

18 88% in KRAS mt and 69% in KRAS wt 79% OVERALL 62% in KRAS mt and 53% in KRAS wt 58% OVERALL Patients Achieved an Overall mPFS of 12.9 Months Avutometinib + Defactinib Regimen: Progression Free Survival (PFS) PFS, median (95% CI) Total N=109 KRAS mt N=57 KRAS wt N=52 12.9 mos (10.9, 20.2) 22 mos (11.1, 36.6) 12.8 mos (7.4, 18.4) Source for all data: RAMP 201 data cut off as of June 30, 2024 At 12 Months At 6 Months

19 Median follow-up = 13.6 mo (range, 1.4 – 39.5) Source for all data: RAMP 201 data cut off as of June 30, 2024; *Other includes: clinical progression (n=8) and progression confirmed by biopsy/pathology report, progression by confirmation of cytology from pleural effusion showing malignant etiology, debulking surgery, patient noncompliance, patient withdrawal with agreement to follow-up, physician decision (1 each).; Low Discontinuation Rate of 10% Due to Adverse Events, No New Safety Signals Avutometinib + Defactinib Regimen 3.2 mg BIW + 200 mg BID 3 weeks on / 1 week off All patients KRAS mt KRAS wt Patients Treated 115 58 57 Patients on Treatment, n (%) 32 (28) 24 (41) 8 (14) Patients Discontinued Treatment, n (%) 83 (72) 34 (59) 49 (86) Primary Reason for Discontinuation RECIST v1.1 Disease Progression 46 (40) 18 (31) 28 (49) Adverse Event/Unacceptable Toxicity 12 (10) 4 (7) 8 (14) Withdrawal of Informed Consent 10 (9) 4 (7) 6 (11) Other* 10 (9) 5 (9) 5 (9) Clinical Deterioration 5 (4) 3 (5) 2 (4) Death 0 0 0

20 Avutometinib Plus Defactinib Continue to Demonstrate a Well-Tolerated Safety Profile Severe adverse events are generally uncommon and typically managed by a treatment pause 10% (12/115) discontinued for AEs (any cause); most common increased CPK (n=4) 80% (92/115) had AEs leading to dose interruption • 38% (44/115) for elevations in CPK 36.5% (42/115) had AEs leading to dose reduction • Mean relative dose intensity of 0.84 for avutometinib and 0.77 for defactinib 7% (8/115) of patients had serious AEs considered by the investigator to be related to study treatment: the only event occurring in more than 1 patient was abdominal pain 4 deaths (within 30 days of discontinuation) but were not considered related to the study treatment: • GI hemorrhage, large intestine perforation, clinical progression, clinical deterioration Treatment-Related Adverse Events (>20% of patients)* n (%) Avutometinib + Defactinib Regimen 3.2 mg BIW + 200 mg BID 3 weeks on/1 week off N= 115 Preferred term All Grades Grade ≥3 Non-laboratory AEs Nausea 77 (67.0) 3 (2.6) Diarrhea 67 (58.3) 9 (7.8) Oedema peripheral 61 (53.0) 1 (0.9) Fatigue 50 (43.5) 3 (2.6) Vomiting 49 (42.6) 3 (2.6) Vision blurred 47 (40.9) 0 Rash 41 (35.7) 2 (1.7) Dermatitis acneiform 39 (33.9) 5 (4.3) Dry skin 30 (26.1) 0 Anemia 26 (22.6) 6 (5.2) Laboratory-related AEs Increased blood CPK 69 (60.0) 28 (24.3) Increased blood bilirubin increased/ hyperbilirubinemia 38 (33.0) 5 (4.3) AST increased 36 (31.3) 2 (1.7) Source for all data: RAMP 201 data cut off as of June 30, 2024; *Most common adverse events (preferred term) considered by the investigator to be related to study drug (either avutometinib or defactinib); AE, adverse event; AST; aspartate aminotransferase; CPK, creatine phosphokinase; GI, gastrointestinal.

21 RAMP 301: First Randomized Prospective Study to Fully Characterize KRAS Status of all Enrolled LGSOC Patients • Patients enrolling are similar to patient population in RAMP 201, with recurrent KRAS mt and KRAS wt LGSOC; prior MEKi and bevacizumab use allowed and post one line of platinum chemotherapy • Primary Endpoint: PFS by BICR • Stratification Factors: KRAS mutation status (wt vs. mt) • Investigator choice of treatment • May crossover to avutometinib + defactinib arm upon BICR-confirmed PD • Study sites include the U.S., Australia, UK, Canada, and Europe RAMP 301: Phase 3 International Confirmatory Trial Enrollment is on track, targeting full enrollment by end of 2025

22 Changing the Treatment Paradigm in Recurrent LGSOC PDUFA Action Date: June 30, 2025 Potential Launch in Recurrent KRAS mutant LGSOC in mid-2025

23 Disproportionally affects younger women1 Pre-Diagnosis Nonspecific signs and symptoms2 Ultrasound and bloodwork3 Average delay up to 3 years4 Diagnosis Poor response rates of current treatments with high discontinuation rates 5,6 Treatment Symptom Progression &Testing Treatment After Recurrence Pathology report confirmation of disease3 Surgery3 of patients will receive ChemoTx7 frontline 95% Recurrent treatments include chemotherapy, hormonal therapy, MEK inhibitors or clinical trial3 Up to 60% of patients will be retreated with chemotherapy at initial recurrence7 After subsequent recurrence, doctors typically choose chemo or clinical trials over MEK-only inhibitors7 47% will be rechallenged with chemotherapy at subsequent recurrence7 80% of Patients with LGSOC Recur and Often Cycle Through Treatments 80% of patients will recur8 Driven by NCCN Guidelines 1. B. Slomovitz, C. Gourley, M.S. Carey, et al., Low-grade serous ovarian cancer: State of the science, Gynecologic Oncology, https://doi.org/10.1016/j.ygyno.2019.12.033; 2. Harvard Health 2017. https://www.health.harvard.edu/cancer/certain-symptoms-may-be-early-signs-of-ovarian-cancer. Assessed October 8, 2024; 3. NCCN Clinical Practice Guidelines in Oncology: (NCCN Guidelines®) for Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer V. 3.2024; 4. LGSOC Patient Impact Survey Research Findings, Harris Poll 2023. https://www.businesswire.com/news/home/20231107926726/en/; 5. Monk BJ et al. J Clin Oncol 2020 (MILO); 6. Gershenson DM et al. Lancet 2022 (GOG 281); 7. Verastem DOF. Demand Study March 2024.; 8. Gershenson et al J Clin Oncol 2015.

24 Trial Therapy Image assessment Response Rate ORR ORR KRAS mt ORR KRAS wt Median PFS Months (95% CI) mPFS KRAS mt mPFS KRAS wt Discontinuati on Rate due to AEs GOG 2811 SoC (n=130) (n=22 KRAS/NRAS/ BRAF mt; n=42 KRAS/NRAS/ BRAF wt) INV 6% 95% CI: (3%, 12%) 9.1%, 95% CI: (1.9%, 26.1%) 7.1%, 95% CI: (2.1%, 17.9%) 7.2 (5.6-9.9) 11.4 95% CI: (3.7, 13.3) 6.3 95% CI: (3.7, 9.9) 30% Trametinib (n=130) (n=22 KRAS/NRAS/ BRAF mt; n=42 KRAS/NRAS/ BRAF wt) INV 26% 95% CI: (19%, 35%) 50%, 95% CI: (30.2%, 69.8%) 8.3%, 95% CI: (2.9%, 18.6%) 13.0 (9.9-15.0) 13.2 95% CI: (9.4, 20.8) 7.3 95% CI: (5.6, 12.7) 36% MILO2 SoC (n=101) (n=24 KRAS mt; n=42 KRAS wt) BICR 13% 95% CI: (7%, 21%) 33%, 95% CI: (16%, 55%) 19% (8.6%, 34%) 10.6 (9.2 - 14.5) 14.6 (9.4, NA) 11.5 (5.7, 26.6) 17% Binimetinib2 (n=198) (n=45 KRAS mt; n=90 KRAS wt) BICR 16% 95% CI: (11%, 22%) 44%, 95% CI: (30%, 60%) 19%, 95% CI: (11%, 29%) 9.1 (7.3-11.3) 17.7 (12, NR) 10.8 (5.5, 16.7) 31% 1Study GOG 281 trial Gershenson et al., Lancet 2022; 2MILO Study. Grisham et al Clinical Cancer Research 2023, 3MILO Study Monk et al., J Clin Oncol 2020.; SoC = Standard of Care (endocrine / chemotherapy); INV = Investigator; BICR = Blinded Independent Central Review; PFS = Progression Free Survival; CI = Confidence Interval; NR = Not Reached Current Available Therapies Offer Relatively Poor Response Rates, High Discontinuation Rates • These studies started in 2013 and 2014 • Both MILO and GOG studies had low historical use of bevacizumab during trial conduct; % not reported • Mutation category is KRAS/BRAF/NRAS rather than just KRAS for GOG 281 • In both studies, not all patients had mutation status available • In the MILO study no more than 3 lines of prior chemotherapy • No prior MEK inhibitors were allowed in either GOG 281 or MILO • The number of prior systemic therapies median (range) were 2 (1-10) in GOG 281 and 2 (1-8) in MILO

25 To date, avutometinib + defactinib combination data in recurrent LGSOC show1 : Clinically meaningful response rates and durable benefit in both KRAS mutant and wild-type tumors Long progression-free survival and duration of treatment 1Data from RAMP 201 study June 30. 2024 cutoff; 2Chenard-Poirier, et al. ASCO 2017; References: Banerji, Q4 2020 report Avutometinib + Defactinib Combo Has the Potential to Address Key Treatment Needs Favorable tolerability profile, supported by novel intermittent dosing schedule, with oral treatments2 Low discontinuation rates due to adverse events

26 LGSOC Represents a Significant Market Opportunity 1. Estimated total addressable market opportunity based on incident / prevalent populations, average duration of therapy (as observed in VSTM clinical trials) and cost of therapy of $34,000 per month, consistent with other recent oncology drug launches (e.g. OJEMDA - $33,916 OGSIVEO - $29,000; www.dayonebio.com/wp-content/uploads/Ojemda-Connecticut_VF.pdf; www.hhs.texas.gov/sites/default/files/documents/apr-2024-durb-agenda-item8d.pdf) 2. Verastem DOF – Based on 30% KRAS mt and 70% KRAS wt in incident population assumed of 1,500 annually and 40% KRAS mt and 60% KRAS wt (calculation on file based on weighted average longer overall survival in KRAS mt compared to KRAS wt) initial prevalent population of 7,000; 3. RAMP 201 data cutoff as of June 30, 2024 KRAS mutant – Initial Launch KRAS wild-type Estimated Prevalent Addressable Opportunity1 (Target to Address in First 3-5 Years) Prevalent Population2 Avg. Duration of Therapy3 Estimated Annual Incident Addressable Opportunity1 Incident Population2 Avg. Duration of Therapy3 $1.7B+ $1.6B+ ~2,800 ~4,200 18 months 11 months $300M+ $374M+ ~500 ~1,000 18 months 11 months Total Addressable Market Opportunity Anticipate high market penetration in LGSOC KRAS mt population given: • No FDA approved therapies for LGSOC Plan to address prevalent population over 3-5 years from launch: • Patients cycle through therapies • Median of 3 prior therapies in RAMP 201 • Long overall survival in LGSOC patients at ~10 years • KRAS mt – ~12 years • KRAS wt – ~7 years

27 NCCN Category 1 NCCN Category 2a NCCN Category 2b NCCN Category 3 General % Commercial Payer Coverage Recurrent LGSOC Treatment NCCN Recommendations and Contemporary Clinical Data in LGSOC No category 1 recommendation • 6-13% ORR and 17-30% discontinuation rate due to AEs • Based on GOG 281 and MILO studies Trametinib (2-4% U.S, utilization rate1 ) Hormonal therapy (e.g., Anastrozole, Letrozole) & chemotherapy • 13 months PFS, 95% CI: (9.9-15.0) vs SoC • 26% ORR based on INV assessment of comparator arm of all patients not BICR • 36% discontinuation rate due to AEs • Based on GOG 2812 • Study stopped due to futility • PFS 12.5 vs 11.6 (HR 0.87) • 16% ORR based on BICR of comparator arm and 31% discontinuation rate due to AEs • Based on MILO study3 Binimetinib • Plan to submit RAMP 201, inclusive of entire patient population, for publication and NCCN consideration • There are no FDA-approved treatments and no standard sequencing of drugs for recurrent disease Current Treatments on NCCN Guidelines General source: NCCN; McGivney Global Advisory research and analysis; L.E.K. research and analysis. NCCN categories of preference: Preferred intervention, Other recommended intervention, Useful in certain circumstances. High-level of evidence generally means large randomized controlled Phased 3 trials; Pie charts represent coverage by all major commercial players; 1) Data on File 2) GOG 281 trial Gershenson et al., Lancet 2022 3) MILO Study Monk et al., J Clin Oncol 2020;.

28 • Patient support and access programs • Best-in-class multichannel marketing • NPP pull through and reinforcement to targeted customers and white space territories • Inside Sales Reps will bolster Field Force efforts • More than 2,500 patients have registered on disease education website2 • Robust program for ongoing education and resources HCO/Key Accounts GPO Patients Surround Sound Support Programs Efficiently Scaled Launch Model to Deliver Best-in-Class Launch for Recurrent KRAS mutant LGSOC Patient Focused • Top 100 commercial HCOs contribute 49.4% of patient claims1 • ~400 HCPs manage these patients1 • Deploy lean, focused field sales team (~14- 18 reps) for access and scientific exchange HCO/Key Account Focus • Ensuring inclusion in all relevant pathways and EMR systems • Access is based on group provided programs and/or opportunities GPO/Large Affiliated Practices 1VSTM DOF – Claims LGSOC Proxy; 2VSTM DOF. Self-identified patients with LGSOC registered via disease website; YTD: Year-to-date; NPP: Non-personal promotion

29 Current available therapies offer limited efficacy, relatively high discontinuation rates due to AEs; no FDA-approved therapies and no active promotion NCCN guidelines help to drive treatment decision; will submit entire RAMP 201 dataset for NCCN consideration Avutometinib in combination with defactinib is differentiated on multiple efficacy measures, relatively low rates of discontinuation due to AEs and favorable tolerability 1k-2k incidence with a prevalence of 6k-8k; potential for high market penetration in KRAS mutant at launch enriching overtime with the prevalent patient population Efficiently scaled launch model to deliver best-in-class launch for recurrent KRAS mutant LGSOC Potential to Change Treat Paradigm and Improve Patient Outcomes The combination of Avutometinib and Defactinib is an investigational drug. It has not been proven to be safe or effective and has not been approved by FDA or any other comparable regulatory authority.

30 Next Steps in LGSOC Clinical Program and NDA Complete enrollment in RAMP 301 Phase 3 confirmatory study by end of 2025 Report initial data from the RAMP 201J Phase 2 clinical trial being conducted in Japan in H2 2025 Publish RAMP 201 primary analysis for all patients and then submit for NCCN consideration in H1 2025 Present additional analyses from the RAMP 201 trial at a medical meeting in Q1 2025 Plan for FDA decision: June 30, 2025, PDUFA action date

Avutometinib ± Defactinib Potential Market Expansion Opportunities in First-line Metastatic Pancreatic Cancer and Advanced Lung Cancer

Topline Data from RAMP 205: Avutometinib + Defactinib + SOC in First-Line Metastatic Pancreatic Cancer

33 RAMP 205: Designed to Identify and Evaluate RP2D in Combination with Chemotherapy for Treatment of Newly Diagnosed mPDAC Inclusion Criteria Part A: Dose Evaluation (3+3 DLT Assessment) Part B: Dose Expansion (Primary Endpoint: ORR) • Histologic or cytologic confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) • Eligible for treatment in the first-line setting (no prior systemic therapy for advanced or metastatic disease) • Measurable by RECIST v1.1 by CT or MRI • ECOG Performance status of ≤1 • Part B only, adequate tissue sample to evaluate KRAS mutational status Avutometinib + Defactinib + Gemcitabine + Nab-paclitaxel Dose Finding Cohorts n=3-6 Avutometinib + Defactinib + Gemcitabine + Nab-paclitaxel DLT-Cleared Dose Level Expansion • Patients with PDAC treated at RP2D • Stage 1: 17 patients if ≥4 responders, then • Simon’s 2-stage design: expand to 29 patients Collaboration with PanCAN, NCT05669482 DLT: dose-limiting toxicity; n: number of patients; ORR: overall response rate; RP2D: recommended phase 2 dose; CT: computed tomography; ECOG: European Cooperative Oncology Group; MRI: magnetic resonance imaging RP2D Selection RAMP 205: Ongoing Phase 1/2 Evaluating Avutometinib + Defactinib with Gemcitabine and Nab-paclitaxel

34 RAMP 205: Initial Interim Safety and Efficacy Results • Encouraging early interim data from ongoing Phase 1/2 RAMP 205 study evaluating avutometinib + defactinib + gemcitabine + Nab-paclitaxel in first-line metastatic pancreatic cancer • As of data cutoff of May 14, 2024, Dose Level 1 mature with more than 6 months follow up o Confirmed ORR = 83% (5/6) o Cohort was DLT cleared, one DLT observed (neutropenic fever) • Evaluating additional dose/schedule combinations to optimize the dose for safety/tolerability and define RP2D for expansion cohort • 11 top academic sites currently enrolling and highly engaged • Presented RAMP 205 initial interim data at ASCO on June 1, 2024 Dose Level Avuto Defactinib Gem Nab-Pac Day 1, 8, 15 chemo dosing: -1 2.4 mg BIW 200 mg BID 800 mg/m2 100 mg/m2 1 2.4 mg BIW 200 mg BID 800 mg/m2 125 mg/m2 Day 1 and 15 chemo dosing: 1a 3.2 mg BIW 200 mg BID 800 mg/m2 125 mg/m2 2a 3.2 mg BIW 200 mg BID 1000 mg/m2 125 mg/m2 DLT: dose-limiting toxicity; ASCO: American Society of Clinical Oncology

35 Landmark Trials in First-Line Metastatic Pancreatic Cancer Trial/PI/Reported (# Patients) Intervention Comparator ORR by Investigator (95% CI) mPFS (95% CI) mOS (95% CI) MPACT Von Hoff 2013 (N=861) Gem/NabP* (n=431) Gem (n=430) Gem/NabP 5.5 months (4.5-5.9) 8.5 months (7.89-9.53) 29% (25-34) 23% (19-17) IRR** NAPOLI 3 O’Reilly 2023 (N=770) Nalirifox (n=383) Gem/NabP* (n=387) Gem/NabP 36.2% (31.4-41.2) 5.6 Months (5.3-5.8) 9.2 months (8.3-10.6) Nalirifox 41.8% (36.8-46.9) 7.4 months (6.0-7.7) 11.1 months (10-12.1) PRODIGE Conroy 2011 (N=342) Folfirinox (n=171) Gem (n=171) Folfirinox 31.6% (24.7-39.1) 6.4 months 11.1 months For Reference only: No cross-trial comparison made.*Dosing schedule in Gem/NabP arms above= 1000/125(mg/m2 ) D1,8,15 q 4w, **Secondary endpoint of ORR based on IRR (Independent Radiology Review), SOC Treatment Landscape: • ORR is between 23% - 36% for Gem/NabP • Median overall survival reported between 8.5 – 9.2 months

36 RAMP 205: Evaluating Multiple Regimens in Parallel to Efficiently Identify RP2D in First-Line mPC Duration of Treatment for All Patients; Safety Population (n=41) Data Cutoff Date:14 MAY 2024 In Dose Level 1: • 1 of 6 patients achieved objective response by month 2 • 2 of 6 patients achieved objective response by month 4 • 5 of 6 patients achieved objective response by month 6 Dose Level -1 1 1a 2a

37 RAMP 205: Best Percent Change in Target Lesion Sum of Diameters Includes Patients Who Have Had At Least First Scan (n=26) Data Cutoff Date:14 MAY 2024 Threshold for PR Dose Level Avuto Defactinib Gem Nab-Pac Day 1, 8, 15 chemo dosing: -1 2.4 mg BIW 200 mg BID 800 mg/m2 100 mg/m2 1 2.4 mg BIW 200 mg BID 800 mg/m2 125 mg/m2 Day 1 and 15 chemo dosing: 1a 3.2 mg BIW 200 mg BID 800 mg/m2 125 mg/m2 2a 3.2 mg BIW 200 mg BID 1000 mg/m2 125 mg/m2

38 • Any grade TEAEs occurring in ≥20% or grade ≥3 occurring in ≥5% of patients1 DL-1 (n=11) DL1 (n=6) DL1a (n=12) DL2a (n=12) Total (N=41) Any Grade, n (%) Grade ≥3, n (%) Any Grade, n (%) Grade ≥3, n (%) Any Grade, n (%) Grade ≥3, n (%) Any Grade, n (%) Grade ≥3, n (%) Any Grade, n (%) Grade ≥3, n (%) Nausea 6 (54.5) 0 (0) 5 (83.3) 0 (0) 7 (58.3) 0 (0) 6 (50.0) 0 (0) 24 (58.5) 0 (0) Fatigue 5 (45.5) 0 (0) 5 (83.3) 0 (0) 5 (41.7) 1 (8.3) 7 (58.3) 0 (0) 22 (53.7) 1 (2.4) Constipation 4 (36.4) 0 (0) 5 (83.3) 0 (0) 7 (58.3) 0 (0) 4 (33.3) 0 (0) 20 (48.8) 0 (0) Diarrhoea 1 (9.1) 0 (0) 4 (66.7) 0 (0) 6 (50.0) 0 (0) 6 (50.0) 0 (0) 17 (41.5) 0 (0) Alopecia 3 (27.3) 0 (0) 6 (100.0) 0 (0) 3 (25.0) 0 (0) 2 (16.7) 0 (0) 14 (34.1) 0 (0) Neutrophil count decreased 2 (18.2) 2 (18.2) 4 (66.7) 4 (66.7) 4 (33.3) 3 (25.0) 3 (25) 2 (16.7) 13 (31.7) 11 (26.8) Rash maculo-papular 4 (36.4) 0 (0) 5 (83.3) 0 (0) 3 (25.0) 0 (0) 1 (8.3) 0 (0) 13 (31.7) 0 (0) Vomiting 3 (27.3) 0 (0) 4 (66.7) 0 (0) 4 (33.3) 1 (8.3) 2 (16.7) 0 (0) 13 (31.7) 1 (2.4) Anaemia 2 (18.2) 1 (9.1) 2 (33.3) 2 (33.3) 2 (16.7) 2 (16.7) 3 (25.0) 1 (8.3) 9 (22.0) 6 (14.6) Decreased appetite 2 (18.2) 0 (0) 3 (50.0) 0 (0) 3 (50.0) 0 (0) 1 (8.3) 0 (0) 9 (22.0) 0 (0) Alanine aminotransferase increased 1 (9.1) 1 (9.1) 2 (33.3) 2 (33.3) 3 (25.0) 1 (8.3) 1 (8.3) 0 (0) 7 (17.1) 4 (9.8) 1. Lim et al. ASCO 2024 Abstract #4140; Data Cutoff: May 14, 2024, TEAEs were graded based on guidelines provided in CTCAE v5.0. CTCAE v5.0, Common Terminology Criteria for Adverse Events version 5.0; DL, dose level; TEAE, treatment emergent adverse event. RAMP 205: AE Profile Generally Comparable with Gem/Nab-P • Inclusion of avutometinib plus defactinib may increase rates of neutropenia and rash No head-to-head clinical trials have been conducted between avutometinib and defactinib combination and gemcitabine and Nab-paclitaxel.

39 Next Steps for RAMP 205 Plan to report updated data in Q1 2025 Determine RP2D for expansion cohort in H1 2025 Present data from RAMP 205 trial at a medical meeting in mid-year 2025

Avutometinib ± Defactinib with Sotorasib (G12Ci) in KRAS G12C mutant NSCLC

41 -100 0 100 200 300 400 Response at Day 10 Response @ Day 10 (% change from baseline) vehicle 10 PR avutometinib FAKi sotorasib sotorasib + avutometinib sotorasib + FAKi sotorasib + avutometinib + FAKi 1 SD 2 SD 1 SD 8 SD 2 PR 4 SD 3 PR 0 50 100 150 0 5 10 15 20 25 Days after first sotorasib dose Tumor volume (mm3 ) Sotorasib Sotorasib + Avutometinib + FAKi 0 50 100 150 0 5 10 15 20 Days after first sotorasib dose Tumor volume (mm3 ) Sotorasib Sotorasib + Avutometinib + FAKi Mouse #1 Mouse #2 Addition of FAKi + avutometinib reverses sotorasib resistance Addition of FAK inhibitor Augments the Efficacy of Sotorasib + Avutometinib and Reverses Sotorasib Resistance in KRAS G12C NSCLC Preclinical Models Collaboration Verastem & Mariano Barbacid, CNIO (Spain) Doses Tested Sotorasib: 30 mg/kg PO QD Avutometinib: 0.3 mg/kg PO QD FAKi: 50 mg/kg PO BID H2122 KRAS G12C NSCLC 0 50 100 150 0 10 20 30 40 50 60 Days after first sotorasib dose Tumor volume (mm3 ) Sotorasib Sotorasib + Avutometinib 0 50 100 150 0 5 10 15 20 25 Days after first sotorasib dose Tumor volume (mm3 ) Sotorasib Sotorasib + Avutometinib Mouse #3 Mouse #4 Addition of avutometinib is insufficient to reverse sotorasib resistance Avutometinib enhances sotorasib efficacy. Addition of FAK inhibitor induces deep tumor regressions in all treated mice

42 Cohort 1 Patients without Prior KRAS G12C Inhibitor Treatment Stage 1: ~20 patients Stage 2: expand to 54 Inclusion Criteria Part A: Dose Evaluation (3+3 DLT Assessment) Part B: Dose Expansion (Primary endpoint: ORR) • Documented KRAS G12C mutation determined using validated test • Treatment with 1 but no more than 3 prior systemic regimens for Stage 3B-C or 4 NSCLC* • May have received adjuvant chemotherapy for earlier-stage disease • Measurable disease per RECIST v1.1 • ECOG performance status ≤ 1 Avutometinib + Sotorasib Dose Finding Cohort RP2D Selected: 4 mg avutometinib / 960 mg sotorasib Avutometinib + Sotorasib + Defactinib Dose Finding Cohort Alt-RP2D Selection RAMP 203: Phase 1/2 Trial of Avutometinib + LUMAKRASTM (Sotorasib) Defactinib in KRAS G12C Advanced NSCLC DLT, dose-limiting toxicity; KRAS, kristen rat sarcoma virus; NSCLC, non-small cell lung cancer; ORR, objective response rate; RECIST v1.1, response evaluation criteria in solid tumours version 1.1; RP2D, recommended phase 2 dose. Now enrolling Collaboration with Amgen, NCT05074810 *may include patients with or without prior G12C therapy Treatment with RP2D and/or Alt-RP2D KRAS G12C inhibitor-naive Progressed on KRAS G12C inhibitor Cohort 2 Patients who Progressed on Prior KRAS G12C Inhibitor Treatment Stage 1: ~19 patients Stage 2: expand to 55 Cohort 1 Patients without Prior KRAS G12C Inhibitor Treatment Stage 1: ~20 patients Stage 2: expand to 54 Cohort 2 Patients who Progressed on Prior KRAS G12C Inhibitor Treatment Stage 1: ~19 patients Stage 2: expand to 55 Enrollment Complete for Stage 1 Now enrolling

43 RAMP 203: No DLTs Were Observed in the First Triplet Combination Cohort in Patients Previously Treated with a G12C Inhibitor Triplet Combination Update: • As of a November 21, 2024, data cutoff, 3 patients whose cancer previously progressed on a G12C inhibitor have been treated with the triplet combination of sotorasib 960 mg administered daily on a continuous schedule and avutometinib 3.2 mg twice-weekly (BIW) plus defactinib 200 mg twice-daily (BID). Avutometinib and defactinib are administered on a three out of four weeks schedule. • 2 of the 3 patients demonstrated initial tumor reductions of at least 20% at the first scan. As of the data cutoff, all three patients remain on treatment. • With no DLTs observed in the first triplet combination cohort, enrollment of additional patients to the triplet combination continues. Doublet Combination Update: • As previously reported, the doublet combination of avutometinib with sotorasib has completed enrollment (n=28) in the G12C inhibitor treatment-naïve Stage 1 Part B cohort. • The KRAS G12C inhibitor prior-treated Stage I Part B cohort is still enrolling patients and is anticipated to complete enrollment in early 2025. • Patients in both cohorts continue to be followed for safety and efficacy to determine if observed efficacy supports expanded enrollment. • Plan to complete enrollment and evaluate the safety and efficacy of the triplet combination before expanding either of the doublet cohorts.

44 Next Steps for RAMP 203 Complete enrollment in the KRAS G12C inhibitor prior-treated Stage 1 Part B doublet cohort in Q1 2025 Complete enrollment and evaluate the safety and efficacy of the triplet combination in H1 2025 Present an interim update at a medical meeting in H2 2025

Partnership with GenFleet Therapeutics on Novel, Potential Best-in-Class RAS Pathway Programs

46 KRAS G12D is the Most Frequent KRAS Mutation in Human Cancers Adapted from Hofmann et al., Cancer Discovery 2022 • The only approved KRAS inhibitors target KRAS G12C which is largely restricted to NSCLC • KRAS G12D accounts for 26% of all KRAS mutations • KRAS G12D mutations are especially prevalent in pancreatic and colorectal cancers • Targeting KRAS G12D has historically been challenging due to the shallow pocket for drug interaction and lack of a cysteine for covalent binding

47 Target Profile for a Best-in-Class KRAS G12D inhibitor Categories Criteria/Rationale ON/OFF Dual Inhibition Potent inhibition of both KRAS-GTP (ON) and KRAS-GDP (OFF) states for deep and durable inhibition of tumor growth Potency Inhibition of KRAS G12D signaling with sub-nanomolar potency KRAS G12D Selectivity Selectivity for KRAS G12D may enable avoidance of rash for dosing to maximal target inhibition and better combinability with other agents Oral Bioavailability Oral bioavailability to enable convenient round-the-clock target coverage Anti-Tumor Efficacy Deep tumor regressions in preclinical KRAS G12D models at low oral doses Blood Brain Barrier Activity in intracranial tumor models may indicate potential to treat brain metastases (e.g. in NSCLC) Target profile based on the Company’s internal analysis and framework

48 Importance of Inhibiting Both the Active (ON) & Inactive (OFF) States of KRAS for Deep and Durable Inhibition of Tumor Growth GEF GTP GDP GTP GDP RAS/MAPK pathway signaling GAP P KRAS OFF (inactive) KRAS ON (active) • KRAS-GTP is the active (ON) state which drives cancer growth • KRAS-GDP is the inactive (OFF) state and represents a KRAS pool that will cycle back to the active ON state • OFF-state selective agents (e.g., approved G12C inhibitors) may give sub-optimal efficacy because they do not target the active ON state • ON-state selective agents (e.g., RMC-6236) can also drive GTP hydrolysis to the OFF state which they can no longer bind* • May be ideal to have an inhibitor capable of targeting both the ON and OFF states of KRAS to maintain inhibition around the clock, aiming for maximum efficacy *Piro Lito, RAS Initiative Conference 2024; GEF: Guanine nucleotide exchange factor; GAP: GTPase-activating protein

49 GEF GTP GDP GTP GDP VS-7375 KRAS G12D (ON/OFF) inhibitor RAS/MAPK pathway signaling GAP P KRAS OFF (inactive) KRAS ON (active) KRAS G12D State VS-7375 IC50 (nM) (KRAS G12D binding) GppNp-bound (ON/active) 2 1 GDP-bound (OFF/inactive) 6 1 VS-7375 is a dual inhibitor of ON (GTP) and OFF (GDP) states of KRAS G12D* VS-7375 potently inhibits pERK signaling in KRAS G12D tumor cells* VS-7375 is an Oral KRAS G12D (ON/OFF) Inhibitor Non-covalent inhibitor of KRAS G12D (ON/OFF) with potent anti-tumor efficacy across preclinical models *Zhou et al., AACR 2024

50 VS-7375 Induces Tumor Regression in Multiple KRAS G12D Tumor Models via Oral Administration 0 2 4 6 8 10 12 14 16 0 200 400 600 800 1000 Days after first dose Tumor volume (mm 3 , mean ± SEM) 0 2 4 6 8 10 12 14 16 0 500 1000 1500 2000 Days after first dose Tumor volume (mm 3 , mean ± SEM) 0 2 4 6 8 10 12 14 16 18 20 22 0 500 1000 1500 2000 Days after first dose Tumor volume (mm 3 , mean ± SEM) 0 2 4 6 8 10 12 14 0 100 200 300 400 Days after first dose Tumor volume (mm 3 , mean ± SEM) AsPC-1 PDAC Panc 04.03 PDAC LS513 CRC GP2D CRC 5 mg/kg VS-7375, p.o., BID Vehicle, BID 10 mg/kg VS-7375, p.o., BID 30 mg/kg VS-7375, p.o., BID 100 mg/kg VS-7375, p.o., BID Source for all data: Zhou et al., AACR 2024 -100 -50 0 50 100 150 200 Response @ Day 14 (% change from baseline) vehicle VS-7375 10 mg/kgVS-7375 30 mg/kg VS-7375 10 mg/kg 4 PRs 2 SD2 6 PRs 1 SD 3 PRs -100 -50 0 50 100 150 200 250 300 350 Response @ Day 14 (% change from baseline) vehicle VS-7375 10 mg/kgVS-7375 30 mg/kg VS-7375 10 mg/kg 6 SDs 1 PR 5 SDs 8 PRs 8 PRs VS-7375 5 mg/kg -100 -50 0 50 100 150 200 250 300 350 Response @ Day 14 (% change from baseline) vehicle VS-7375 10 mg/kgVS-7375 30 mg/kg VS-7375 10 mg/kg VS-7375 5 mg/kg 1 SD 4 SDs 5 PRs 3SDs 8 PRs -100 0 100 200 300 500 1000 1500 Response @ Day 21 (% change from baseline) vehicle VS-7375 10 mg/kgVS-7375 30 mg/kgVS-7375 10 mg/kg 4 PRs 3 SDs 7 PRs 1 SD

51 VS-7375 Positively Addresses the Key Criteria for a Potential Best-in-Class G12D Inhibitor Categories Criteria/Rationale VS-7375* ON/OFF Dual Inhibition Potent inhibition of both KRAS-GTP (ON) and KRAS-GDP (OFF) states for deep and durable inhibition of tumor growth Yes IC50 = 2 nM (KRAS G12D ON) IC50 = 6 nM (KRAS G12D OFF) Potency Inhibition of KRAS G12D signaling with sub-nanomolar potency Yes pERK IC50 = 0.2 – 0.9 nM KRAS G12D Selectivity Selectivity for KRAS G12D may enable avoidance of rash for dosing to maximal target inhibition and better combinability with other agents Yes Inhibits proliferation of KRAS G12D cell lines more potently than other KRAS mutations or KRAS wild-type Oral Bioavailability Oral bioavailability to enable convenient round-the-clock target coverage Yes Across preclinical species Anti-Tumor Efficacy Deep tumor regressions in preclinical KRAS G12D models at low oral doses Yes Tumor regressions @ 10-30 mg/kg PO BID Blood Brain Barrier Activity in intracranial tumor models may indicate potential to treat brain metastases (e.g. in NSCLC) Yes Efficacy @ 10 mg/kg PO BID in intracranial model *Zhou et al., AACR 2024; Best-in-class target profile based on the Company’s internal analysis and framework.

52 VS-7375: Initial Data Demonstrate Oral Bioavailability and Clinical Activity • 26 patients have been treated with VS-7375 in a Phase 1 dose escalation study being conducted in China1 • Both confirmed and unconfirmed partial responses have been observed, including patients with metastatic pancreatic cancer and advanced non-small cell lung cancer2 • Six dose cohorts have been cleared with no dose-limiting toxicities (DLTs) observed2 • Oral dosing of VS-7375 has achieved plasma levels in patients that correlate with efficacious exposures that induced deep tumor regressions across all preclinical KRAS G12D tumor models (preclinical data presented in collaboration with GenFleet at the AACR 2024 annual meeting) 2 • Companies expect to share updated preclinical and clinical data at upcoming medical meetings in mid-2025 1. GenFleet Stock Exchanged of Hong Kong Limited Application in Dec. 2024: https://www1.hkexnews.hk/app/sehk/2024/107026/documents/sehk24122701307.pdf; 2. VSTM DOF.

53 VS-7375 Shows Potential Best-in-Class Preclinical Properties Relative to Other Known G12D Inhibitors Criteria VSTM/ GenFleet VS-7375 Mirati/BMS MRTX1133 RevMed RMC-9805 Lilly LY3962673 AZ AZD0022 Incyte INCB161734 Quanta QTX3046 Tyligand TSN1611 Betta BPI-501836 Hengrui HRS-4642 ON/OFF selectivity ratio 3x 0.2x NR 0.016x NR 1.2x 0.0003x 1.2x NR NR Oral availability in preclinical models Y N Y Y Y Y Y Y N N AsPC-1 pERK IC50 0.5 nM NR 23 nM NR NR 7 nM 30 nM NR 0.8 nM NR Panc 04.03 pERK IC50 0.9 nM NR NR NR NR 19 nM NR NR 2.7 nM NR GP2D Oral dose for tumor regression 10 mg/kg PO BID 30 mg/kg IP BID 100 mg/kg PO QD 30 mg/kg PO BID NR No regression @ 30 mg/kg PO QD 100 mg/kg PO BID 10 mg/kg PO BID NR Slight regression @ 15 mg/kg IV QW Panc 04.03 Oral dose for tumor regression 10 mg/kg PO BID 30 mg/kg IP BID NR NR Tumor stasis @ 150 mg/kg PO BID Slight regression @ 30 mg/kg PO QD NR NR Regressio n @ 6 mg/kg IV BIW NR Efficacy demonstrated in intracranial model Y NR Y NR NR NR NR NR NR NR NR: not reported ; PO = oral administration; IP = intraperitoneal admiration; BID = twice per day; QD = once per day; QW = once per week; BIW = twice per weekReferences: GenFleet/Verastem AACR 2024; Hallin et al (Mirati) 2022; RevMed AACR 2023; RevMed AACR 2024; Lilly ENA 2023; Lilly AACR 2024; AstraZeneca (AZ) AACR 2024; Incyte AACR 2024; Quanta AACR 2023; Tyligand AACR 2024; Betta AACR 2024; Zhou et al (Hengrui) 2024. The safety and efficacy of VS-7375 and the other G12D inhibitors has not been established. No conclusions on the clinical safety or efficacy of VS-7375 or any of the other G12D inhibitors can be drawn at this time. Tumor regression On/Off Potency Oral BBB

54 Next Steps for VS-7375 & GenFleet Collaboration GenFleet plans to continue to enroll patients into Phase 1/2 trial for VS-7375/ GFH375 in China in patients with KRAS G12D-mutated advanced solid tumors Anticipate filing U.S. IND for VS-7375 during Q1 2025 and initiate a Phase 1/2a study in mid-2025 Ongoing discovery/lead optimization in 2nd and 3rd programs GenFleet/Verastem expect to share updated preclinical and clinical data at medical meetings in mid-2025

Achievements, Anticipated Milestones & Financials

56 Planned Near-Term LGSOC Commercial Launch, Followed by Meaningful Catalysts to Expand Into Larger, Underserved Patient Populations Program Anticipated Milestones & Activities Avutometinib + Defactinib in Recurrent Low-grade Serous Ovarian Cancer (LGSOC) ❑ Plan for June 30, 2025 PDUFA action date; U.S. commercial launch in recurrent KRAS mutant LGSOC in mid-2025 ❑ Publish RAMP 201 primary analysis and submit to NCCN in H1 2025 ❑ Present additional analyses from the RAMP 201 trial at a medical meeting in Q1 2025 • Continue site activations and patient enrollment in international Phase 3 confirmatory study • Share initial data from RAMP 201J Phase 2 clinical trial being conducted in Japan in H2 2025 Avutometinib + Defactinib + SOC in First-Line Metastatic Pancreatic Cancer ❑ Plan to report updated data from the ongoing RAMP 205 in Q1 2025 ❑ Determine RP2D for expansion cohort in H1 2025 ❑ Report updated data from the ongoing RAMP 205 trial at a medical meeting in mid-year 2025 Avutometinib ± Defactinib + Sotorasib: mKRAS G12C Non-small Cell Lung Cancer (NSCLC) ❑ Complete enrollment in the KRAS G12C inhibitor prior treated Stage 1 Part B doublet cohort in Q1 2025 ❑ Complete enrollment and evaluate the safety and efficacy of the triplet combination in H1 2025 ❑ Present an interim update at a medical meeting in H2 2025 VS-7375, KRAS G12D (ON/OFF) Inhibitor • GenFleet plans to continue to enroll patients into Phase 1/2 trial for VS-7375/GFH375 in China in patients with KRAS G12D-mutated advanced solid tumors ❑ Anticipate filing U.S. IND for VS-7375/GFH375 during Q1 2025 ❑ Expect to initiate Phase 1/2a trial in U.S. mid-2025 ❑ The Companies expect to share updated preclinical and clinical data at medical meetings in mid-2025 • Ongoing discovery/lead optimization in second and third programs

57 Key Financial Statistics Cash, cash equivalents & short-term investments $113.2M GAAP Operating Expenses $37.0M Non-GAAP Operating Expenses $35.1M* Shares Outstanding 40.3M** As of and for the quarter ended September 30, 2024 • Oberland Finance Credit Facility • Up to $150M available in a series of notes • $75M principal of notes outstanding • Remaining $75M available at Company’s option upon achievement of pre-defined milestones • $25M tranche upon FDA approval of avutometinib and defactinib for treatment of LGSOC • $50M tranche upon trailing six months revenue of at least $55M • Floating interest rate, subject to a floor and a cap • Interest only payments through January 2031 • No financial covenants Sources of Non-Dilutive Capital * Q3 2024 GAAP operating expenses of $37.03M less Q3 2024 stock-based compensation expense of $1.94M = $35.09M Q3 2024 non-GAAP operating expenses; **Excludes Series A Preferred (0.8M Shares on as-converted basis), Series B Preferred (4.2M Shares on as-converted basis), unexercised Warrants (18.3M shares upon exercise) and unexercised Pre-Funded Warrants (5.0M shares upon exercise) Cash, cash equivalents & short-term investments $88.8M Cash, cash equivalents & short-term investments – pro-forma $128.6M*** Select financials as of December 31, 2024 ***Cash, cash equivalents, & short-term investments of $88.8M as of December 31, 2024, plus proceeds of $32.3M in January 2025 from Oberland Finance credit facility after repayment of Oxford facility, and equity purchase from Oberland Finance of $7.5M in January 2025. Both the actual and pro forma December 31, 2024 balances stated herein are preliminary, unaudited estimates and subject to revision upon completion of the Company's closing and audit processes and do not present all information necessary for an understanding of the Company's financial condition as of, and its results of operations for the fiscal year ended December 31, 2024.

Thank You

Addendum

60 Avutometinib Patent Exclusivity Composition of Matter Method of Making Sept 2032 Dosing Protocol May 2038 Combination w/ Defactinib Dec 2042 Feb 2027 + 5 yrs (PTE) = 2032 Sept 2040 Solid Form PTE 2041 - 2042 if issued Methods or Treating; Combinations

61 Experienced Senior Management Team Previous experience: • CEO, The DNA Repair Co. (now On-Q-ity) • PharMetrics (now IMS) • Axion Daniel Paterson President and CEO Dan Calkins Chief Financial Officer Previous experience: • Technical Accounting Consultant- CFGI • PwC LLP Cathy Carew Chief Organizational Effectiveness Officer Previous experience: • Principal – HR Collaborative • Ironwood, ActiveBiotics, Dynogen, Tufts Health Plan Previous experience: • Chief Development Officer & SVP of Regulatory, OncXerna • Head of Global Regulatory, Lilly Oncology Colleen Mockbee Global Head of Regulatory Affairs and Development Mike Crowther Chief Commercial & Strategy Officer Previous experience: • CBO, Minerva Biotechnologies • Interim US lead and VP of US Marketing, Kite Pharma • Celgene John Hayslip, M.D. Chief Medical Officer Previous experience: • CMO, I-MAB • Nektar Therapeutics, AbbVie • University of Kentucky’s Markey Cancer Center Matt Ros Chief Operating Officer Previous experience: • CEO, FORE Biotherapeutics • EVP & CSBO, Epizyme • COO, Sanofi-Genzyme • BMS Nate Sanburn Chief Business Officer Previous experience: • Associate VP, Head of Collaborations & Late Phase BD, Lilly Oncology • National Gene Vector Lab, Indiana University Jonathan Pachter, Ph.D. Chief Scientific Officer Previous experience: • Head of Cancer Biology – OSI (now Astellas) • Schering-Plough

62 Avutometinib Monotherapy Provided Lower Rate of Response • Patients enrolled had comparable baseline characteristics as patients randomized to avutometinib plus defactinib regimen • Median of 3 prior lines of therapy, 49% had prior bevacizumab, 26% had prior MEKi • ORR: 17% in all patients, 23% KRAS mt and 13% KRAS wt • TEAEs leading to D/C: comparable between monotherapy (16%) and combination (10%) Source for all data: RAMP 201 data cut off as of June 30, 2024 Avutometinib Monotherapy 4.0 mg BIW 3 weeks on / 1 week off All patients N=69 KRAS mt N=30 KRAS wt N=39 Confirmed* ORR, n (%) 12 (17) 7 (23) 5 (13) CR 1 (1) 1 (3) 0 PR 11 (16) 6 (20) 5 (13) SD† , n (%) 43 (62) 17 (57) 26 (67) PD, n (%) 7 (10) 3 (10) 4 (10) Not Evaluable, n (%) 7 (10) 3 (10) 4 (10) RAMP 201

63 Low-Dose Regimen (Part D) Determined to be Suboptimal Based on Pre-Defined Analysis Source for all data: RAMP 201 data cut off as of June 30, 2024; D/C discontinuation IRC Assessment Avutometinib 3.2 mg + 200 mg Defactinib Regimen 3 weeks on / 1 week off N=109 Avutometinib 1.6 mg + 200 mg Defactinib 3 weeks on / 1 week off N=23 % Difference RECIST v1.1 Progressive Disease within 4 months 13 (12%) 5 (22%) +83% Low-dose regimen will not be pursued as a starting dose in the treatment of recurrent LGSOC • Patients enrolled in Part D had comparable baseline characteristics as patients randomized to the avutometinib plus defactinib regimen • Median of 3 prior lines of therapy, 40% had prior bevacizumab, 37% had prior MEKi • Suboptimal threshold: disease progression by 2nd scheduled assessment (Cycle 5 Day 1) >50% higher than that observed with avutometinib 3.2 mg BIW + defactinib • TEAEs leading to D/C: comparable between 3.2 mg dose (10%) and 1.6 mg dose (15%) RAMP 201

64 Optimized Dosing Schedule Defined: Favorable Tolerability Profile with Novel Intermittent Dosing Regimen Avutometinib monotherapy Daily at MTD N=6 28-day cycle RP2D Avutometinib monotherapy 4mg twice weekly N=26 28-day cycle RP2D (Avutometinib 3.2mg twice weekly + defactinib 200mg twice daily) N=38 21 days of 28-day cycle Treatment Related Adverse Event Grade ≥3 Grade ≥3 Grade ≥3 Rash 3 (50%) 5 (19%) 2 (5%) CK elevation (Creatine phosphokinase) 1 (17%) 2 (8%) 2 (5%) 1 Chenard-Poirier, et al. ASCO 2017; References: Banerji, Q4 2020 report; Data on file; RP2D: recommended phase 2 dosing Summary of Adverse Events Grade ≥ 3 Occurring in ≥ 5% of patients

65 FDA Breakthrough Designation Based on FRAME Data Breakthrough Through Therapy Designation for combination of avutometinib and defactinib for treatment of recurrent LGSOC after one or more prior lines of therapy including platinum-based chemotherapy *Denis, 5th Annual RAS-Targeted Drug Development Sept 2023; (Data cut off July 2023: Data on file); BICR: Blinded independent central review F R A10 4 0 0 4 F R A10 4 0 0 3 F R A1010 0 7 F R A101014 F R A1010 4 2 F R A101012 F R A1010 3 2 F R A10 3 0 0 2 F R A1010 3 8 F R A101015 F R A10 2 018 F R A10 2 010 F R A10 3 0 0 3 F R A101019 F R A1010 2 8 F R A1010 3 9 F R A1010 2 4 F R A1010 2 5 F R A1010 3 7 F R A1010 3 3 F R A1010 3 5 F R A1010 0 9 F R A1010 01 F R A1010 0 2 F R A10 3 0 01 F R A10 4 0 01 -100 -80 -60 -40 -20 0 20 B e st R e s p o n s e (% c h a n g e f r o m b a s elin e) U n d o c u m e nte d K RA S wt K RA S wt K RA S G12 D K RA S D 3 3 E, I2 4 N Prior MEK inhibitor * K RA S G12 A K RA S G12 V K RA S G12 D K RA S wt K RA S G12 D Confirmed partial response Unconfirmed partial response K RA S wt K RA S wt * Best response by RECIST K RA S wt K RA S G12 D K RA S wt K RA S wt K RA S G12 D K RA S D 5 7-T 5 8in s * * * Still on treatment * K RA S G12 D U n d o c u m e nte d * Stable disease K RA S wt K RA S wt K RA S wt K RA S G12 D K RA S wt K RA S G12 V ORR Overall Population (Confirmed ORR by BICR) 42% (11 confirmed PRs/26) 95% CI (19%, 36%) KRAS mt 58% (7 confirmed PRs/12) KRAS wt 33% (4 confirmed PRs/12) Median Duration of Response (DoR) (95% CI 8.5-47.3) across all LGSOC patients 26.9 months Median Progression Free Survival (PFS) (95% CI 11.1 – 31.2) across all LGSOC per RECIST 1.1 20.0 months Median number of prior lines of therapy 3.5 lines Responses observed in patients previously treated with MEK inhibitor No new safety findings with continued follow-up One (1) patient discontinued for adverse events as of July 2023 (skin AE) FRAME*

66 • Confirmed LGSOC diagnosis • Recurrent disease after prior platinum therapy • Documented KRAS mutation status • Measurable disease per RECIST v1.1 • Prior MEKi allowed • Prior Bevacizumab allowed Inclusion Criteria 1:1 Randomization n = 270 Stratification Factors: KRAS mutation status (wt vs. mt) Avutometinib 3.2 mg PO BIW Defactinib 200 mg BID 3 weeks on, 1 week off Avutometinib + Defactinib n = 135 Pegylated Liposomal Doxorubicin Paclitaxel Topotecan Letrozole Anastrozole Investigator’s Choice n = 135 Primary Endpoint: PFS (BICR by RECIST v1.1) Hierarchical Evaluation of PFS: KRAS mutant LGSOC only All recurrent LGSOC Secondary Endpointsa OS PFS by RECIST v1.1 per INV assessment ORR DoR DCR Safety Pharmacokinetics PROs a Unless otherwise specified, all tumor response-based endpoints will be analyzed using both BICR and INV assessments BICR: blinded independent central review; BID: twice a day; BIW: twice a week; DCR: disease control rate; DoR: duration of response; INV: investigator; KRAS: kirsten rat sarcoma virus; MEKi: MEK inhibitor; mt: mutant; PO: per oral; pts, patients; ORR: objective response rate; OS: overall survival; PD: progressive disease; PFS: progression-free survival; PROs: patient-reported outcomes; RECIST: response evaluation criteria in solid tumors; wt: wild type. May crossover upon BICR-confirmed PD RAMP 301: International Phase 3 Confirmatory Trial Evaluating Avutometinib + Defactinib in Recurrent LGSOC RAMP 301 (GOG-3907/ENGOT-ov81/NCRI): Ongoing Randomized Controlled Trial (RCT) NCT06072781

67 Gynecologic 25%-96% biomarker Colorectal 45%-50% biomarker Melanoma 100% biomarker Thyroid 35% biomarker Breast 22.5% biomarke r • LGSOC: MSKCC Phase 1/2 with Avutometinib + Defactinib + Letrozole; 70% biomarker; Prevalence 6k1 • Gynecologic Basket: University of Oklahoma Phase 2 with Avutometinib + Defactinib; 25% biomarker; Incidence4-8 : 85K • Mesonephric: MSKCC Phase 2 with Avutometinib + Defactinib; 96% biomarker; Incidence9 :~680 • KRAS mt: University of Chicago Phase 1/2 with Avutometinib + Cetuximab; 45% biomarker; Incidence2 : 148K • RAS/RAF wt: MDACC Phase 1/2 with Avutometinib + Defactinib + Cetuximab; 50% biomarker; Incidence2 : 148K • ER+/Her2-: Dana-Farber Cancer Institute Phase 1/2 with Avutometinib + Abemaciclib + Fulvestrant; 22.5% biomarker; Incidence2 : 279K • MAPK Alterations or wt: University of Utah Phase 1/2 with Avutometinib + Defactinib + Encorafenib; 100% biomarker; Incidence2 : 100K • MAPK Alterations: MSKCC Phase 2 with Avutometinib + Defactinib; 35% biomarker; Incidence3 : 44K Robust Investigator-Sponsored Trials Evaluates Multiple Potential Indications 1 Monk, Randall, Grisham, The Evolving Landscape of Chemotherapy in Newly Diagnosed Advanced Epithelial Ovarian Cancer, Am Soc Clin Oncol Educ Book; 2019; Slomovitz, Gourley, Carey, Malpica, Shih, Huntsman, Fader., Grisham et al, Low-Grade serous ovarian cancer: State of the Science; Gynecol Oncol; 2020. Grisham, Iyer, Low-Grade Serous Ovarian Cancer: Current Treatment Paradigms and Future Directions; Curr Treat Options Oncology; 2018; Globocan 2020; 2Cancer Statistics 2020, Siegel et. al. CA Cancer J Clin 2020;70:7-30; 3Cancer Statistics 2020, Siegel et. al. CA Cancer J Clin 2020;70:7-30 4Uterine cancer is one of the leading gynecologic neoplastic disorders in the US, of which over 80% are endometrioid adenocarcinomas (EA); 5Endometrioid OC (EnOC) accounts for approximately 10% of all OC, with the majority of cases diagnosed as low grade, early stage disease with excellent clinical; 6ucinous ovarian cancer: 3-11% of ovarian cancer (Hada et al., 2021); 790% of Ovarian Cancer is Epithelial Ovarian Cancer (https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2018/cancer-facts-and-figures-2018.pdf); 8HGSOC the most common type of ovarian cancer, accounting for approximately 75% of epithelial ovarian cancers. (https://ocrahope.org/news/high-grade-serous-carcinoma/) 9 Ji Son (David Hong) ASCO 2023