SNTI Senti Biosciences Inc

Senti Biosciences, Inc. (Nasdaq: SNTI) (“Senti Bio”), a biotechnology company developing a new generation of cell and gene therapies for patients living with incurable diseases using its proprietary Gene Circuit platform, today announced four poster presentations at the Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, being held November 1-5, 2023, in San Diego, CA.

Information about the poster sessions is as follows:

NOT gate gene circuits expand the range of tumor-associated antigens addressable by CAR-NK and -T cell therapies In collaboration with GeneFab LLCAbstract number: 257 Location: Poster Halls A and B1Date and time: November 3, 2023, 9:00 am - 7:00 pm PT

Small-molecule regulated safety switch for improved safety of CAR cell therapies in the brain In collaboration with BlueRock Therapeutics and GeneFab LLCAbstract number: 24 Location: Poster Halls A and B1Date and time: November 4, 2023, 9:00 am - 8:30 pm PT

Smart sensor promoters drive state-specific gene circuits to convert immunosuppressive macrophages into an anti-tumor phenotype In collaboration with BlueRock Therapeutics and GeneFab LLCAbstract number: 430Location: Poster Halls A and B1Date and time: November 4, 2023, 9:00 am - 8:30 pm PT

High-throughput discovery of constitutive promoters to drive strong expression of next-generation gene circuits in CAR-NK and -T cells Abstract number: 270 Location: Poster Halls A and B1Date and time: November 4, 2023, 9:00 am - 8:30 pm PT

Following the presentations, copies of the poster presentations will be available on the Scientific Presentations & Publications section of the Senti Bio website.

About Senti BioSenti Biosciences is a biotechnology company developing a new generation of cell and gene therapies for patients living with incurable diseases. To achieve this, Senti Bio is leveraging a synthetic biology platform called Gene Circuits to create therapies with enhanced precision and control. These Gene Circuits are designed to precisely kill cancer cells, spare healthy cells, increase specificity to target cells and control the expression of drugs even after administration. Senti Bio’s wholly-owned pipeline utilizes off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cells, outfitted with Gene Circuits, to target challenging liquid and solid tumor indications. Senti Bio has also preclinically demonstrated the potential breadth Gene Circuits in other modalities, diseases outside of oncology, and continues to advance these capabilities through partnerships with Spark Therapeutics and BlueRock Therapeutics.

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