RNS Number:6701S
Skyepharma PLC
01 December 2003

1 December 2003


Immediate Release


                         SkyePharma PLC ("the Company")


As a result of transactions on 28 November 2003 by the SkyePharma PLC Share
Purchase Plan (an Inland Revenue approved all employee share purchase plan),
Michael Ashton and Donald Nicholson, directors of the Company, as trustees of
the Plan, became the beneficial owners of an additional 4,183 Ordinary Shares of
the Company, bringing the total held by the Plan to 90,981 Ordinary Shares of
the Company.


As a result the executive directors of the Company have the following additional
interests as a result of their personal participation in the Plan:-


                                           Partnership              Matching             Total number of
                                      Shares purchased        Shares awarded             Partnership and
                                  on 28 November 2003         on 28 November        Matching Shares held
                                         at #0.775 per        2003 at #0.775        on 28 November 2003.
                                                share.            per share.

Ian Gowrie-Smith                                   161                   161                       4,272
Michael Ashton                                     161                   161                       9,702
Donald Nicholson                                   161                   161                       9,702



In accordance with the rules of the Plan these directors have been awarded the
Matching Shares on the basis of one Matching Share for each Partnership Share.


The beneficial ownership of the Matching Shares will pass to the directors in
three years time subject to continued employment and the retention of the
underlying Partnership Shares.



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