RNS Number:3725T
Skyepharma PLC
17 December 2003


For Immediate Release                                          17 December 2003


                         SkyePharma PLC ("the Company")
                    Notification of Major Interest in Shares


In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 16 December 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders ("Fidelity"), had
increased their total holding to 76,531,117 ordinary shares of 10p each,
representing 12.37% of the issued share capital of the Company. In addition
Fidelity have informed the Company that they also hold 5,000,000 SkyePharma PLC
6% Convertible Bonds due 2005.

                                    - ends -


                      This information is provided by RNS
            The company news service from the London Stock Exchange
END

HOLLDLFFXLBLFBX