As
filed with the Securities and Exchange Commission on November 14, 2024
Registration
No. 333-
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM
F-3
REGISTRATION
STATEMENT
UNDER
THE
SECURITIES ACT OF 1933
GALMED
PHARMACEUTICALS LTD.
(Exact
name of Registrant as specified in its charter)
State
of Israel |
|
Not
Applicable |
(State
or other jurisdiction of
incorporation or organization) |
|
(I.R.S.
Employer
Identification
No.) |
c/o
Meitar Law Offices
16
Abba Hillel Silver Rd.
Ramat
Gan 5250608 Israel
Tel:
(+972) (3) 693-8448
(Address
and telephone number of Registrant’s principal executive offices)
Puglisi
& Associates
850
Library Avenue
Newark,
Delaware 19711
(302)
738-6680
(Name,
address, and telephone number for agent for service)
Copies
of all communications, including communications sent to agent for service, should be sent to:
Gary
Emmanuel, Esq.
Greenberg
Traurig, P.A.
One
Azrieli Center
Round
Tower, 30th floor
132
Menachem Begin Rd
Tel
Aviv 6701101
Tel:
+972 (0) 3.636.6000 |
|
Mike
Rimon, Adv.
Elad
Ziv, Adv.
Meitar
| Law Offices
16
Abba Hillel Silver Rd.
Ramat
Gan 52506, Israel
Tel:
+972-3-610-3100 |
Approximate
date of commencement of proposed sale to the public: From time to time after this registration statement becomes effective.
If
only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the
following box. ☐
If
any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933, check the following box. ☒
If
this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following
box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.
☐
If
this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐
If
this Form is a registration statement pursuant to General Instruction I.C. or a post-effective amendment thereto that shall become effective
upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐
If
this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.C. filed to register additional
securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐
Indicate
by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933.
Emerging
growth company ☐
If
an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards† provided
pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
The
registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the
registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective
in accordance with Section 8(a) of the Securities Act, or until this Registration Statement shall become effective on such date as the
Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.
EXPLANATORY
NOTE
This
registration statement contains two prospectuses:
| ● | a
base prospectus which covers the offering, issuance and sale of such indeterminate number
of ordinary shares, debt securities, subscription rights, warrants and units, which together
shall have an aggregate initial offering price not to exceed $200,000,000; and |
| ● | a
sales agreement prospectus supplement covering the offering, issuance and sale of the registrant’s
ordinary shares that, may be issued and sold under a sales agreement, or the Sales Agreement,
between the registrant, with JonesTrading Institutional Services LLC in an aggregate amount
of up to $8,100,000 |
The
base prospectus immediately follows this explanatory note. The specific terms of any securities to be offered pursuant to the base prospectus
will be specified in a prospectus supplement to the base prospectus. The sales agreement prospectus supplement immediately follows the
base prospectus. The ordinary shares that may be offered, issued and sold under the Sales Agreement prospectus supplement is included
in the $200,000,000 of securities that may be offered, issued and sold by the registrant under the base prospectus. Upon termination
of the Sales Agreement, any portion of the $8,100,000 included in the Sales Agreement prospectus supplement that is not sold pursuant
to the Sales Agreement will be available for sale in other offerings pursuant to the base prospectus.
The
information in this prospectus is not complete and may be changed or supplemented. No securities described in this prospectus can be
sold until the registration statement that we filed to cover the securities has become effective under the rules of the Securities and
Exchange Commission. This prospectus is not an offer to sell the securities and it is not soliciting an offer to buy these securities
in any state where the offer or sale is not permitted.
SUBJECT
TO COMPLETION, DATED NOVEMBER 14, 2024
PROSPECTUS
GALMED
PHARMACEUTICALS LTD.
$200,000,000
Ordinary
Shares
Warrants
Subscription
Rights
Debt
Securities
Units
We
may offer, issue and sell from time to time up to US $200,000,000 of our ordinary shares, including in the form of warrants to
purchase ordinary shares, including in the form of subscription rights, debt securities and a combination of such securities, separately
or as units, in one or more offerings. This prospectus provides a general description of offerings of these securities that we may undertake.
We
refer to our ordinary shares, warrants, subscription rights, debt securities, and units collectively as “securities” in this
prospectus.
Each
time we sell securities pursuant to this prospectus, we will provide in a supplement to this prospectus the price and any other material
terms of any such offering. Any prospectus supplement may also add, update or change information contained in this prospectus. You should
read this prospectus and any applicable prospectus supplement, as well as the documents incorporated by reference or deemed incorporated
by reference into this prospectus, carefully before you invest in any securities. This prospectus may not be used to offer or sell
securities unless accompanied by a prospectus supplement.
We
may, from time to time, offer to sell the securities, through public or private transactions, directly or through underwriters, agents
or dealers, on or off the Nasdaq Capital Market, at prevailing market prices or at privately negotiated prices. If any underwriters,
agents or dealers are involved in the sale of any of these securities, the applicable prospectus supplement will set forth the names
of the underwriter, agent or dealer and any applicable fees, commissions or discounts.
The
highest aggregate market value of our outstanding ordinary shares held by non-affiliates within the 60 days prior to the filing date
of this prospectus was approximately $24.3 million, based on 1,656,992 ordinary shares outstanding, of which 1,609,819 are held by
non-affiliates, and the closing sale price of our ordinary shares on Nasdaq of $15.10 on September 17, 2024. Pursuant to General
Instruction I.B.5 of Form F-3, in no event will we sell, pursuant to the registration statement of which this prospectus forms
a part, securities with a value exceeding one-third of the aggregate market value of our outstanding ordinary shares held by non-affiliates
in any 12 calendar month period, so long as the aggregate market value of our ordinary shares held by non-affiliates is less than $75.0
million.
Our
ordinary shares are traded on the Nasdaq Capital Market under the symbol “GLMD.” The closing price of our ordinary shares,
as reported on the Nasdaq Capital Market on November 8, 2024, was $2.97.
Investing
in these securities involves a high degree of risk. Please carefully consider the risks discussed in this prospectus under “Risk
Factors” beginning on page 4 and the “Risk Factors” in “Item 3: Key Information- Risk Factors” of our
most recent Annual Report on Form 20-F incorporated by reference in this prospectus and in any applicable prospectus supplement for a
discussion of the factors you should consider carefully before deciding to purchase these securities.
Neither
the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined
whether this prospectus is truthful or complete. Any representation to the contrary is a criminal offense under the laws of the United
States.
The
date of this prospectus is , 2024
TABLE
OF CONTENTS
ABOUT
THIS PROSPECTUS
This
prospectus is part of a Registration Statement on Form F-3 that we filed with the Securities and Exchange Commission, or the SEC, utilizing
a “shelf” registration process. Under this shelf registration process, we may sell our securities described in this prospectus
in one or more offerings up to a total dollar amount of $200,000,000. This prospectus does not contain all of the information
set forth in the registration statement, certain parts of which are omitted in accordance with the rules and regulations of the SEC.
Accordingly, you should refer to the registration statement and its exhibits for further information about us and our securities. Copies
of the registration statement and its exhibits are on file with the SEC. Statements contained in this prospectus concerning the documents
we have filed with the SEC are not intended to be comprehensive, and in each instance we refer you to a copy of the actual document filed
as an exhibit to the registration statement or otherwise filed with the SEC.
Each
time we offer our securities, we will provide you with a prospectus supplement that will describe the specific amounts, prices and terms
of the securities we offer. The prospectus supplement may also add, update or change information contained in this prospectus. This prospectus,
together with applicable prospectus supplements and the documents incorporated by reference in this prospectus and any prospectus supplements,
includes all material information relating to this offering. Please read carefully both this prospectus and any prospectus supplement
together with additional information described below under “Where You Can Find More Information” and “Incorporation
by Reference.”
This
prospectus does not contain all of the information provided in the registration statement that we filed with the Commission. For further
information about us or our ordinary shares, you should refer to that registration statement, which you can obtain from the Commission
as described below under “Where You Can Find More Information” and “Incorporation by Reference.”
You
should rely only on the information incorporated by reference or provided in this prospectus or any prospectus supplement. “Incorporated
by reference” means that we can disclose important information to you by referring you to another document filed separately with
the SEC. We have not authorized anyone to provide you with different information. We are offering to sell, and seeking offers to buy,
our ordinary shares only in jurisdictions where offers and sales are permitted. We are not making, nor will we make, an offer to sell
securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information appearing in this prospectus
and any supplement to this prospectus is current only as of the dates on their respective covers. Our business, financial condition,
results of operations and prospects may have changed since that date.
We
prepare our financial statements in United States dollars and in accordance with accounting principles generally accepted in the United
States, or U.S. GAAP.
Certain
figures included in this prospectus have been subject to rounding adjustments. Accordingly, figures shown as totals in certain tables
may not be an arithmetic aggregation of the figures that precede them.
This
prospectus contains and incorporates by reference market data and industry statistics and forecasts that are based on independent industry
publications and other publicly-available information. Although we believe these sources are reliable, we do not guarantee the accuracy
or completeness of this information and we have not independently verified this information. Although we are not aware of any misstatements
regarding the market and industry data presented in this prospectus or the documents incorporated herein by reference, these estimates
involve risks and uncertainties and are subject to change based on various factors, including those discussed under the headings “Risk
Factors” in this prospectus, and under similar headings in the other documents that are incorporated herein by reference. Accordingly,
investors should not place undue reliance on this information.
In
this prospectus, “we,” “us,” “our,” the “Company” and “Galmed” refer to Galmed
Pharmaceuticals Ltd. and its subsidiaries, unless the context otherwise requires. All references to Aramchol mean Aramchol acid or Aramchol
meglumine (salt), unless the context otherwise requires. All references to “shares” or “ordinary shares” are
to our ordinary shares, NIS 1.80 nominal par value per share. All references to “Israel” are to the State of Israel. “U.S.
GAAP” means the generally accepted accounting principles of the United States.
Unless
otherwise stated, all of our financial information presented in this prospectus, or incorporated by reference into this prospectus, has
been prepared in accordance with U.S. GAAP. Any discrepancies in any table between totals and sums of the amounts listed are due to rounding.
Unless otherwise indicated, or the context otherwise requires, references in this prospectus, or incorporated by reference into this
prospectus, to financial and operational data for a particular year refer to the fiscal year of our company ended December 31 of that
year. Our reporting currency and financial currency is the U.S. dollar. In this prospectus, “NIS” means New Israeli Shekel,
and “$,” “US$” and “U.S. dollars” mean United States dollars.
All
trademarks or trade names referred to in this prospectus are the property of their respective owners. Solely for convenience, the trademarks
and trade names in this prospectus are referred to without the ® and ™ symbols, but such references should not be construed
as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. We do
not intend the use or display of other companies’ trademarks and trade names to imply a relationship with, or endorsement or sponsorship
of us by, any other companies.
This
prospectus includes statistical, market and industry data and forecasts which we obtained from publicly available information and independent
industry publications and reports that we believe to be reliable sources. These publicly available industry publications and reports
generally state that they obtain their information from sources that they believe to be reliable, but they do not guarantee the accuracy
or completeness of the information.
Effective
August 29, 2024, we effected a 1-for-12 reverse share split, or the Reverse Split, of our authorized ordinary shares, including our issued
and outstanding ordinary shares, and the par value of each share was accordingly increased from NIS 0.15 per share to NIS 1.80 per share.
Unless specifically provided otherwise herein, the share and per share information that follows in this prospectus, other than in the
historical financial statements and related notes included elsewhere in this prospectus, assumes the effect of the Reverse Split.
OUR
BUSINESS
This
summary highlights selected information contained elsewhere in this prospectus that we consider important. This summary does not contain
all of the information you should consider before investing in our securities. You should read this summary together with the entire
prospectus, including the risks related to our business, our industry, investing in our ordinary shares and our location in Israel, that
we describe under “Risk Factors” and our consolidated financial statements and the related notes included at the end of this
prospectus before making an investment in our securities.
Company
Overview
We
are a biopharmaceutical company focused on the development of Aramchol. We have focused almost exclusively on developing Aramchol
for the treatment of liver disease and have been developing Aramchol for PSC and exploring the feasibility of developing Aramchol
for other fibro-inflammatory and oncological indications outside of liver disease. We are also collaborating with the Hebrew
University in the development of Amilo-5MER, a 5 amino acid synthetic peptide.
We
believe that our lead product candidate, Aramchol, has the potential to be a disease modifying treatment for fatty liver disorders, including
NASH, which is a chronic disease that constitutes a large unmet medical need.
Aramchol
is a synthetic conjugate of 3-amino cholic acid, or a type of modified bile acid, and arachidic acid, or a type of saturated fatty acid,
which in its non-synthetic forms, is naturally occurring. The conjugated molecule acts upon important metabolic pathways, reducing fat
accumulation in the liver, improving fatty acid oxidation and regulating the transport of cholesterol. The ability of Aramchol to decrease
liver fat content may also reduce the inflammation and fibrosis in the liver and the risk of cardiovascular complications associated
with NASH. Pre-clinical studies suggest Aramchol’s effect on fibrosis is also direct via collagen production from human hepatic
stellate cells. We believe that Aramchol’s ability to reduce liver fat and liver fibrosis and the safety profile observed to date
will enable it to be a treatment for all stages of NASH in patients who are overweight or obese and have pre diabetes or type II diabetes
mellitus and prevent the hepatic complications associated therewith.
In
September 2019, we initiated our Phase 3 ARMOR Study to evaluate the efficacy and safety of Aramchol in subjects with NASH and fibrosis.
The ARMOR Study was originally comprised of two parts, a randomized, double-blind, placebo-controlled histology-based registrational
part and a clinically based part where subjects will continue with the same treatment for approximately five years. In December 2020,
we announced the addition of a 150-patient open label part to the ARMOR Study and suspended randomization of new patients into the double-blind,
placebo-controlled histology-based registrational part of ARMOR as all enrolled patients were transitioned to the open label part.
In
May 2022, we announced our plan to expand into new anti-fibrotic indications to maximize the potential of Aramchol while at the same
time discontinuing the open label part of its ARMOR Study having reached its objectives. Simultaneously, we initiated a cost reduction
plan and initiated a process to evaluate our strategic alternatives. Following the discontinuation of our open label part of the ARMOR
Study, we do not currently expect to initiate the second part of the ARMOR Study in the near term.
In
May 2023, we announced the initiation of a new clinical program to evaluate Aramchol meglumine for the treatment of PSC, a rare disease
for which there is no approved treatment. The randomized, double-blind, proof-of-concept clinical study (NCT06095986) will evaluate the
effects of 48 weeks of treatment with Aramchol meglumine vs. placebo in approximately 24 patients with PSC. The study’s endpoints
will include the conventional relevant laboratory parameters (alkaline phosphatase and bilirubin), sophisticated imaging including liver
stiffness using MR Elastography (MRE), imaging of the biliary tract using MR cholangiopancreatography, or MRCP, and hepatocyte-specific
contrast agents, histological fibrosis and molecular assessment as well as a range of biomarkers of disease activity and fibrosis. These
endpoints are expected to provide a robust assessment of the underlying disease and the effects of Aramchol.
While
PSC is more common in men, especially in Northern European heritage, and is often diagnosed between ages 30-40, we currently estimate
that the number of patients to be around 60,000, or 1 per 10,000, consisting of around 33,5000 patients in the United States and 32,500
patients collectively in France, Germany, Italy, Spain and the United Kingdom. In the preclinical stage, PSC likely involves ulcerative
colitis (UC) leading to biliary inflammation. As biliary fibrosis progresses to cirrhosis, it is coupled with complications and competing
risks, while about 50% of patients with PSC report clinical symptoms. While there are currently no approved drugs for the treatment of
PSC, there is a potential to gain orphan drug status.
We
initially planned to initiate a Phase 2 study in the last quarter of 2023 to evaluate Aramchol meglumine for the treatment of PSC. This
study was to be followed by a Phase 2b or a phase 2/3 confirmatory adaptive design trial. As a result of the outbreak of the Hamas-Israel
war, in November 2023, we determined that there would be a delay of seven to nine months in the initiation of the Phase 2 PSC study.
Currently, as we explore the feasibility of developing Aramchol for other indications, we do not currently have a timeline for the commencement
of the PSC trial we had been planning and can give no assurances that we will commence this trial.
As
PSC is a fibro-obliterative cholangiopathy where the disease progression is predominantly determined by biliary fibrosis, Aramchol meglumine
has been shown to downregulate Stearoyl-CoA desaturase 1 (SCD1), a key liver enzyme involved in lipid metabolism, attenuate fibrogenesis
by hepatic stellate cells (HSCs). Aramchol meglumine may have direct effects on cholangiocytes to reduce the production of fibrogenic
and inflammatory signals that activate HSCs suggesting that Aramchol meglumine may be beneficial in treating PSC.
In
addition, in May 2023, we entered into a definitive agreement, or the OnKai Agreement, for a $1.5 million equity investment in OnKai,
a US-based technology company developing an AI-based platform to advance healthcare for underserved populations across the United States
by facilitating alignment between healthcare stakeholders. The signing of the definitive agreement followed an announcement that we made
in January 2023 that we had entered into a non-binding termsheet for an equity investment in OnKai. The OnKai Agreement provided that
we will invest $1.5 million in exchange for series seed preferred shares of OnKai (which is in addition to a $1.5 million investment
that was made by us in OnKai through a Simple Agreement for Future Equity, or SAFE, and which converted at a 15% discount into series
seed preferred shares upon consummation of the Investment Round (as defined below)). Our investment in OnKai was part of an approximately
$6 million investment round, or the Investment Round, with other investors that was led by us of which SAFE notes of approximately $3.8
million were converted into preferred shares. On June 19, 2023, the Investment Round closed. Following the Investment Round, we hold
approximately 23.9% of the outstanding share capital of OnKai on an as-converted and fully diluted basis and our Chief Executive Officer
and director, Allen Baharaff serves as a board member of OnKai. In connection with the OnKai Agreement, our wholly-owned subsidiary,
Galmed Research and Development Ltd., or GRD, entered into a services agreement, or the OnKai Services Agreement, with OnKai. The OnKai
Services Agreement provides that GRD shall on a non-exclusive basis (i) provide support services to OnKai relating to finance, business
development, strategic planning, execution and others; and (ii) lend its experience to OnKai in building a strategy and for the development
of treatments for the underserved and that OnKai shall on a non-exclusive basis (i) take part in plan preparation to serve GDR’s
vision of developing drugs for the underserved population and (ii) when relevant, design a process on the clinical trial dashboard that
could potentially serve GDR’s future trial. See “Item 4. Information on the Company— Strategic Collaborations, Research
Arrangements and other Agreements—Onkai” in our Annual Report on Form 20-F for the fiscal year ended December 31, 2023, for
additional information. In July 2023, we announced that OnKai will apply its artificial intelligence models for enrollment and execution
of clinical trials in underserved communities, starting with our PSC clinical program.
In
September 2024, we announced that, based on the recently published results from the Phase 3 ARMOR Study, we planned to broaden our drug
development activities. The planned expansion consists of two additional programs over the next two years. One program aims to identify
novel Aramchol-based drug combinations to overcome resistance to standard-of-care oncological treatments for patients with advanced colorectal
and hepatic cancers. Another program aims to unravel new mechanisms of action that will allow the development of a novel Aramchol-based
drug combination targeting cardiac fibrosis, or scarring of the heart, which occurs in many cardiovascular diseases that can lead to
heart dysfunction and failure. We plan on releasing new data from in-vitro and ex-vivo studies in these programs during the fourth quarter
of 2024.
Corporate
Information
Our
principal executive offices and registered office in Israel are located at c/o Meitar Law Offices, 16 Abba Hillel Silver Rd., Ramat Gan
5250608 Israel and our telephone number is +972-3-693-8448. Our website address is http://www.galmedpharma.com. The information contained
on, or that can be accessed through, our website is neither a part of nor incorporated into this prospectus. We have included our website
address in this prospectus solely as an inactive textual reference. Puglisi & Associates, or Puglisi, serves as our authorized representative
in the United States for certain limited matters. Puglisi’s address is 850 Library Avenue, Newark, Delaware 19711.
RISK
FACTORS
Investing
in our securities involves significant risks. Before making an investment decision, you should carefully consider the risks described
under “Risk Factors” in the applicable prospectus supplement and under Item 3.D. – “Risk Factors” in our
most recent Annual Report on Form 20-F, or any updates in our Reports on Form 6-K, together with all of the other information appearing
in this prospectus or incorporated by reference into this prospectus and any applicable prospectus supplement, in light of your particular
investment objectives and financial circumstances. The risks so described are not the only risks facing us. Additional risks not presently
known to us or that we currently deem immaterial may also impair our business operations. Our business, financial condition and results
of operations could be materially adversely affected by any of these risks. The trading price of our securities could decline due to
any of these risks, and you may lose all or part of your investment. The discussion of risks includes or refers to forward-looking statements;
you should read the explanation of the qualifications and limitations on such forward-looking statements discussed elsewhere in this
prospectus.
CAUTIONARY
NOTE REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus and documents incorporated by reference into this prospectus and the other documents we have filed with the SEC that are incorporated
herein by reference may contain “forward-looking statements” within the meaning of the safe harbor provisions of Section
27A of the Securities Act, Section 21E of the Exchange Act, and the Private Securities Litigation Reform Act of 1995. Forward-looking
statements can be identified by the use of forward-looking words such as “believe,” “expect,” “intend,”
“plan,” “may,” “should,” “anticipate,” “could,” “might,” “seek,”
“target,” “will,” “project,” “forecast,” “continue” or their negatives or
variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters.
These forward-looking statements may be included in, among other things, various filings made by us with the SEC, press releases or oral
statements made by or with the approval of one of our authorized executive officers. Forward-looking statements relate to anticipated
or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters
that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause our actual results to
differ materially from any future results expressed or implied by the forward-looking statements. Many factors could cause our actual
activities or results to differ materially from the activities and results anticipated in forward-looking statements, including, but
not limited to, the factors summarized below:
|
● |
the
timing and cost of our pivotal Phase 3 ARMOR trial, or the ARMOR Study, if re-initiated, or any other pre-clinical or clinical
trials for our product candidates, Aramchol and Amilo-5MERr; |
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● |
completion and receiving favorable results of our ARMOR Study (if re-initiated)
for Aramchol or any other pre-clinical or clinical trial; |
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regulatory
action with respect to Aramchol or any other product candidate by the U.S. Food and Drug Administration, or FDA, the European Medicines
Authority, or EMA, or the Medicines and Healthcare Products Regulatory Agency, or the MHRA, including but not limited to acceptance
of an application for marketing authorization, review and approval of such application, and, if approved, the scope of the approved
indication and labeling; |
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● |
the
commercial launch and future sales of Aramchol and any future product candidates; |
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our
ability to achieve favorable pricing for Aramchol or any other product candidate; |
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our
expectations regarding the commercial market for PSC, non-alcoholic steato-hepatitis, or NASH (also known as MASH), in patients or
any other targeted indication; |
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third-party
payor reimbursement for Aramchol, Amilo-5MER or any other product candidate; |
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our
estimates regarding anticipated capital requirements and our needs for additional financing; |
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market
adoption of Aramchol or any other product candidate by physicians and patients; |
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the
timing, cost or other aspects of the commercial launch of Aramchol or any other product candidate; |
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our
ability to obtain and maintain adequate protection of our intellectual property; |
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the
possibility that we may face third-party claims of intellectual property infringement; |
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our
ability to manufacture our product candidates in commercial quantities, at an adequate quality or at an acceptable cost; |
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our
ability to establish adequate sales, marketing and distribution channels; |
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intense
competition in our industry, with competitors having substantially greater financial, technological, research and development, regulatory
and clinical, manufacturing, marketing and sales, distribution and personnel resources than we do; |
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the
development and approval of the use of Aramchol or any other product candidate for additional indications or in combination therapy; |
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our
expectations regarding licensing, acquisitions and strategic operations; |
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current
or future unfavorable economic and market conditions and adverse developments with respect to financial institutions and associated
liquidity risk; |
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security,
political and economic instability in the Middle East that could harm our business, including due to the recent attacks by Hamas
and other terrorist organizations from the Gaza Strip and elsewhere in the region and Israel’s war against them and military
hostilities with Hezbollah on the northern border of Israel; and |
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those
factors referred to in our most recent annual report on Form 20-F incorporated by reference herein in “Item 3. Key Information
- D. Risk Factors,” “Item 4. Information on the Company,” and “Item 5. Operating and Financial Review and
Prospects,” as well as in our most recent annual report on Form 20-F generally, which is incorporated by reference into this
prospectus. |
We
believe these forward-looking statements are reasonable; however, these statements are only current predictions and are subject to known
and unknown risks, uncertainties and other factors that may cause our or our industry’s actual results, levels of activity, performance
or achievements to be materially different from those anticipated by the forward-looking statements. We discuss many of these risks in
Item 3.D. – “Risk Factors” in our most recent Annual Report on Form 20-F, or any updates in our Reports on Form 6-K.
Given these uncertainties, you should not rely upon forward-looking statements as predictions of future events.
All
forward-looking statements attributable to us or to any person acting on our behalf speak only as of the date hereof and are expressly
qualified in their entirety by the cautionary statements included in this report. We undertake no obligations to update or revise forward-looking
statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipated events. In
evaluating forward-looking statements, you should consider these risks and uncertainties.
OFFER
STATISTICS AND EXPECTED TIMETABLE
We
may sell from time to time pursuant to this prospectus (as may be detailed in prospectus supplements) an indeterminate number of securities
as shall have a maximum aggregate offering price of $200,000,000. The actual per share price of the securities that we will offer
pursuant hereto will depend on a number of factors that may be relevant as of the time of offer (see “Plan of Distribution”
below).
CAPITALIZATION
AND INDEBTEDNESS
The
following table sets forth, on the basis of generally accepted accounting principles in the United States, our consolidated capitalization
and indebtedness as of September 30, 2024. The information in this table should be read in conjunction with and is qualified by reference
to the financial information thereto and other financial information incorporated by reference into this prospectus.
| |
As
of
September 30, 2024
(unaudited) | |
(U.S.
dollars in thousands) | |
Actual | |
Cash and cash equivalents | |
$ | 9,724 | |
| |
| | |
Shareholders’ equity: | |
| | |
Ordinary shares par value NIS 1.80 per share; authorized 1,666,667; issued and outstanding 529,896 ordinary shares (actual) | |
| 664 | |
Additional paid in capital | |
| 215,375 | |
Accumulated other comprehensive loss | |
| (342 | ) |
Accumulated deficit | |
| (197,260 | ) |
| |
| | |
Total shareholders’ equity | |
| 18,437 | |
The
above discussion and table are based on 1,506,992 ordinary shares outstanding as of September 30, 2024, and excludes as of such date:
| ● | 92,427
ordinary shares issuable upon exercise of outstanding stock options under our equity incentive
plan, at a weighted average exercise price of $168.02; |
| | |
| ● | 73,055
ordinary shares issuable upon the exercise of RSUs under our equity incentive plan; |
| | |
| ● | 22,686
ordinary shares reserved for future awards under our equity incentive plan; |
| | |
| ● | 173,333
ordinary shares issuable upon the exercise of outstanding warrants, with exercise price of
$15.0 per ordinary share; and |
| | |
| ● | 183,674
ordinary shares issued and issuable to YA II PN, LTD., or YA, pursuant to that certain Standby
Equity Purchase Agreement dated August 30, 2024 that we entered into with YA, or the SEPA,
consisting of (i) 150,000 ordinary shares that have been issued to YA, as advance shares
pursuant to the SEPA, and (ii) 23,674 ordinary shares that will be issued to YA as subsequent
commitment shares pursuant to the SEPA. |
Unless
otherwise indicated, all information in this prospectus assumes or gives effect to:
| ● | no
exercise of the options, RSU’s warrants and pre-funded warrants described above; and |
| | |
| ● | the
1-for-12 Reverse Split effected on August 29, 2024. |
USE
OF PROCEEDS
Except
as otherwise provided in the applicable prospectus supplement, we intend to use the net proceeds from the sale of the securities offered
by this prospectus for continued development of our pipeline products, as well as the advancement of new programs, business development
activities, and general corporate purposes. Although we have identified some potential uses of the net proceeds to be received upon completion
of this offering, we cannot specify these uses with certainty. Our management will have broad discretion in the application of the net
proceeds and could use them for purposes other than those contemplated as of the date of this prospectus. Our shareholders may not agree
with the manner in which our management chooses to allocate and spend the net proceeds. Moreover, our management may use the net proceeds
for corporate purposes that may not result in our being profitable or increase our market value.
TAXATION
The
material Israeli and U.S. federal income tax consequences relating to the purchase, ownership and disposition of any of the securities
offered by this prospectus will be set forth in the prospectus supplement offering those securities or incorporated by reference from
our Annual Report on Form 20-F or other public filings we make with the SEC.
DESCRIPTION
OF ORDINARY SHARES
The
following description of our share capital is a summary of the material terms of our Articles and Israeli corporate law regarding our
ordinary shares and the holders thereof. This description contains all material information concerning our ordinary shares but does not
purport to be complete.
General
Effective
August 29, 2024, we effected a 1-for-12 reverse share split of our authorized ordinary shares, including our issued and outstanding ordinary
shares, and the par value of each share was accordingly increased from NIS 0.15 per share to NIS 1.80 per share.
On
October 21, 2024, our shareholders approved an increase in our authorized share capital from NIS 3,000,000 divided into 1,666,667 ordinary
shares, NIS 1.80 par value per share to NIS 90,000,000 divided into 50,000,000 ordinary shares, NIS 1.80 par value per share.
Accordingly,
the registered share capital of the Company is NIS 90,000,000 divided into 50,000,000 ordinary shares, NIS 1.80 par value per share.
The
Nasdaq Capital Market
Our
ordinary shares are listed on the Nasdaq Capital Market under the symbol “GLMD”.
Memorandum
and Articles of Association
Our
registration number is 51-495351-2. Under Section 2 of our Articles, the purpose of the Company is to engage in any lawful activity.
Election
of Directors
Our
Board of Directors, or the Board, consists of three classes of directors, with one class being elected each year by shareholders at the
Company’s annual general meeting for a term of approximately three years. In accordance with our Articles, directors so elected
cannot be removed from office by the shareholders until the expiration of their term of office or until their office is vacated in accordance
with our Articles or the Companies Law. Ordinary shares do not have cumulative voting rights. As a result, the holders of ordinary shares
that represent a simple majority of the voting power represented at a shareholders’ meeting and voting at the meeting have the
power to elect all of the directors put forward for election.
Under
our Articles, a director shall vacate his or her office if that director dies; is declared bankrupt; is declared to be legally incompetent;
resigns such office by notice in writing given to the Company; is not re-elected by the shareholders upon expiration of his or her term
at the relevant annual general meeting of shareholders; or otherwise as provided in the Companies Law.
Our
Articles provide that a director may, by written notice to the Company, appoint another person to serve as an alternate director provided
that such appointment is approved by a majority of the directors then in office, and that such appointing director may remove such alternate
director. Any alternate director shall be entitled to notice of meetings of the Board and of relevant committees and to attend and vote
accordingly, except that the alternate has no standing at any meeting at which the appointing director is present or at which the appointing
director is not entitled to participate as provided in the Companies Law. A person who is not qualified to be appointed as a director,
or a person who already serves as a director or an alternate director, may not be appointed as an alternate director.
Unless
the appointing director limits the time or scope of the appointment, the appointment is effective for all purposes until the earlier
of (i) the appointing director ceasing to be a director; (ii) the appointing director terminating the appointment; or (iii) the occurrence,
with respect to the alternate, of any of the circumstances under which a director shall vacate his or her office. The appointment of
an alternate director does not in itself diminish the responsibility of the appointing director as a director. An alternate director
is solely responsible for his or her actions and omissions and is not deemed an agent of the appointing director. At present, there are
no effective appointments of alternate directors for our Board.
Borrowing
Powers
Our
Board may from time to time, and at its reasonable discretion, borrow or secure the payment of any sum or sums of money for reasonable
Company purposes. The directors may raise or secure the repayment of such sum or sums in such manner, at such times and upon such terms
and conditions in all respects as they see fit and, in particular, by issuing bonds, perpetual or redeemable debentures, debenture stock
or any mortgages, charges or other securities on the undertaking of the whole or any part of the property of the Company, both present
and future, including current uncalled capital and called but unpaid capital.
Fiduciary
Duties of Directors and Executive Officers
The
Companies Law codifies the fiduciary duties that Office Holders (as defined in the Companies Law) owe to a company.
An
Office Holder’s fiduciary duties consist of a duty of care and a duty of loyalty. The duty of care requires an Office Holder to
act with the level of care with which a reasonable Office Holder in the same position would have acted under the same circumstances.
The duty of loyalty requires that an Office Holder act in good faith and in the best interests of a company. The duty of care includes
a duty to use reasonable means to obtain:
| ● | information
on the advisability of a given action brought for his or her approval or performed by virtue
of his or her position; and |
| | |
| ● | all
other important information pertaining to these actions. |
The
duty of loyalty requires an Office Holder to act in good faith and for the benefit of a company, and includes a duty to:
| ● | refrain
from any conflict of interest between the performance of his or her duties to the company
and his or her other duties or personal affairs |
| | |
| ● | refrain
from any activity that is competitive with the company; |
| | |
| ● | refrain
from exploiting any business opportunity of the company to receive a personal gain for himself
or herself or others; and |
| | |
| ● | disclose
to the company any information or documents relating to the company’s affairs which
the Office Holder received as a result of his or her position as an Office Holder. |
Disclosure
of Personal Interests of an Office Holder
The
Companies Law requires that an Office Holder promptly disclose to Company, and in any event no later than the board of directors meeting
at which the transaction is first discussed, any personal interest that he or she may have concerning any existing or proposed transaction
with a company, as well as any substantial information or document with respect thereof. An interested Office Holder’s disclosure
must be made promptly and, in any event, no later than the first meeting of the board of directors at which the transaction is considered.
Under
the Companies Law, a “personal interest” includes an interest of any person in an action or transaction of a company, including
a personal interest of one’s relative or of a corporate body in which such person or a relative of such person is a 5% or greater
shareholder, director or general manager or in which he or she has the right to appoint at least one director or the general manager,
but excluding a personal interest stemming from one’s ownership of shares in a company. A personal interest furthermore includes
the personal interest of a person for whom the Office Holder holds a voting proxy or the interest of the Office Holder with respect to
his or her vote on behalf of the shareholder for whom he or she holds a proxy, even if such shareholder itself has no personal interest
in the approval of the matter. An Office Holder is not, however, obliged to disclose a personal interest if it derives solely from the
personal interest of a relative of such Office Holder in a transaction that is not considered an extraordinary transaction.
Under
the Companies Law, an extraordinary transaction is defined as any of the following:
| ● | a
transaction other than in the ordinary course of business; |
| | |
| ● | a
transaction that is not on market terms; or |
| | |
| ● | a
transaction that may have a material impact on a company’s profitability, assets or
liabilities. |
Approval
Procedure
If
an Office Holder has a personal interest in a transaction, approval by the board of directors is required for the transaction, unless
the articles of association of a company provide for a different method of approval. Our Articles do not provide for any such different
method of approval. Further, so long as an Office Holder has disclosed his or her personal interest in a transaction, the board of directors
may approve an action by the Office Holder that would otherwise be deemed a breach of the duty of loyalty. However, a company may not
approve a transaction or action that is adverse to such company’s interest or that is not performed by the Office Holder in good
faith. Approval first by a company’s audit committee and subsequently by the board of directors is required for an extraordinary
transaction in which an Office Holder has a personal interest. Arrangements regarding the Office Holders’ terms of office and employment
(which includes compensation, indemnification or insurance) generally require the approval of the remuneration committee, board of directors
and, in certain circumstances, the shareholders, in that order, and must generally be consistent with the Company’s Amended Compensation
Policy.
Generally,
a person who has a personal interest in a matter which is considered at a meeting of the board of directors or the audit committee may
not be present at such a meeting or vote on that matter unless a majority of the directors or members of the audit committee have a personal
interest in the matter, or unless the chairman of the audit committee or board of directors (as applicable) determines that he or she
should be present in order to present the transaction that is subject to approval. Generally, if a majority of the members of the audit
committee and the board of directors (as applicable) has a personal interest in the approval of a transaction, then all directors may
participate in discussions of the audit committee and/or the board of directors on such transaction. In case a majority of the members
of the board of directors have personal interest in the matter discussed, the approval of such transaction will also require shareholder
approval.
Transactions
with Controlling Shareholders
Pursuant
to Israeli law, the disclosure requirements regarding personal interests that apply to directors and executive officers also apply to
a controlling shareholder of a public company. In the context of a transaction involving a controlling shareholder or an officer who
is a controlling shareholder of a company, a controlling shareholder also includes any shareholder who holds 25% or more of the voting
rights if no other shareholder holds more than 50% of the voting rights. Two or more shareholders with a personal interest in the approval
of the same transaction are deemed to be a single shareholder and may be deemed a controlling shareholder for the purpose of approving
such transaction.
Extraordinary
transactions, including private placement transactions, with a controlling shareholder or in which a controlling shareholder has a personal
interest, and engagements with a controlling shareholder or his or her relative, directly or indirectly, including through a corporation
under his or her control, regarding the company’s receipt of services from the controlling shareholder, and if such controlling
shareholder is also an office holder or an employee of the company, regarding his or her terms of service or employment, require the
approval of the audit committee or remuneration committee, the board of directors and the shareholders of a company by a Special Majority,
in that order.
Arrangements
regarding the terms of office and employment of a controlling shareholder who is an Office Holder, and the terms of employment of a controlling
shareholder who is an employee of a company, require the approval of the remuneration committee, board of directors and the shareholders
by a Special Majority, in that order, with respect to Office Holders’ compensation.
To
the extent that any such transaction with a controlling shareholder is for a period extending beyond three years, approval is required
once every three years, unless, with respect to extraordinary transactions with a controlling shareholder or in which a controlling shareholder
has a personal interest, the audit committee determines that the duration of the transaction is reasonable given the circumstances related
thereto.
Dividends
and Dividend Policy
Dividends
may be distributed only out of profits available for dividends as determined by the Companies Law, provided the board of directors determines
that that there is no reasonable concern that the distribution will prevent the Company from being able to meet its existing and anticipated
obligations when they become due. Under the Companies Law, the distribution amount is further limited to the greater of retained earnings
or earnings generated over the two most recent years legally available for distribution according to the Company’s last reviewed
or audited financial statements, provided that the end of the period to which the financial statements relate is not more than six months
prior to the date of distribution. In the event that we do not meet such criteria, we may seek the approval of the court in order to
distribute a dividend. The court may approve our request if it is convinced that there is no reasonable concern that the payment of a
dividend will prevent us from satisfying our existing and foreseeable obligations as they become due.
Generally,
under the Companies Law, the decision to distribute dividends and the amount to be distributed is made by a company’s board of
directors. The Articles provide that the Board may from time to time declare, and cause the Company to pay, such dividends as may appear
to it to be justified by the profits of the Company and that the Board has the authority to determine the time for payment of such dividends
and the record date for determining the shareholders entitled to receive such dividends, provided the date is not before the date of
the resolution to distribute the dividend. Declaration of dividends does not require shareholder approval.
Pursuant
to our Articles, subject to the rights of holders of shares with limited or preferred rights, ordinary shares shall confer upon the holders
thereof equal rights to receive dividends and to participate in the distribution of the assets of the Company upon its winding-up, in
proportion to the amount paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in
respect of which such dividends are being paid or such distribution is being made, without regard to any premium paid in excess of the
nominal value, if any.
We
have never declared or paid any cash dividends on our ordinary shares and do not anticipate paying any cash dividends in the foreseeable
future. Payment of cash dividends, if any, in the future will be at the discretion of our Board and will depend on then-existing conditions,
including our financial condition, operating results, contractual restrictions, capital requirements, business prospects and other factors
our Board may deem relevant.
Payment
of dividends may also be subject to Israeli withholding taxes.
Transfer
of Shares
Ordinary
shares which have been fully paid-up are transferable by submission of a proper instrument of transfer to the Company or its transfer
agent together with the certificate of the shares to be transferred and such other evidence, if any, as the directors may require to
prove the rights of the intending transferor in the transferred shares.
Our
ordinary shares that are fully paid for are issued in registered form and may be freely transferred under our Articles, unless the transfer
is restricted or prohibited by applicable law or the rules of a stock exchange on which the shares are traded. The ownership or voting
of our ordinary shares by non-residents of Israel is not restricted in any way by our Articles or the laws of the State of Israel, except
for ownership by nationals of some countries that are, or have been, declared as enemies of Israel.
Shareholder
Meetings
Our
Articles provide that an annual general meeting must be held at least once in every calendar year, not later than 15 months after the
last preceding annual general meeting, at such time and place as may be determined by the Board. The Board may, in its discretion, convene
additional shareholder meetings and, pursuant to the Companies Law, must convene a meeting upon the demand of two directors or one quarter
of the directors then in office or upon the demand of the holder or holders of 5% of the Company’s issued share capital and 1%
of its voting rights or upon the demand of the holder or holders of 5% of its voting rights. All demands for shareholder meetings must
set forth the items to be considered at that meeting. Pursuant to the Companies Law and the regulations promulgated thereunder, the holder
or holders of 1% of the Company’s voting rights may request the inclusion of an item on the agenda of a future shareholder meeting,
provided the item is appropriate for discussion at a shareholder meeting, however, a matter relating to the appointment or removal of
a director may only be requested by one or more shareholders holding at least 5% of the voting rights as of the record date for the shareholder
meeting.
The
agenda for a shareholder meeting is determined by the Board and must include matters in respect of which the convening of a shareholder
meeting was demanded and any matter requested to be included by holder(s) of 1% of the Company’s voting rights, except in regards
to matters relating to the appointment or removal of a director, which have a threshold of 5% of the Company’s voting rights. According
to regulations promulgated pursuant to the Companies Law and governing the terms of notice and publication of shareholder meetings of
public companies, or the General Meeting Regulations, holder(s) of one percent or more of the Company’s voting rights may propose
any matter appropriate for deliberation at a shareholder meeting to be included on the agenda of a shareholder meeting, generally by
submitting a proposal within seven days of publicizing the convening of a shareholder meeting, or, if the Company publishes a preliminary
notice at least 21 days prior to publicizing the convening of a meeting (stating its intention to convene such meeting and the agenda
thereof), within 14 days of such preliminary notice. Any such proposal must further comply with the information requirements under applicable
law and the Articles.
Pursuant
to the Companies Law and regulations promulgated thereunder with respect to the convening of general meetings in a public company, shareholder
meetings generally require prior notice of not less than 21 days, and for certain matters specified in the Companies Law, not less than
35 days. The function of the annual general meeting is to elect directors in accordance with the Articles, receive and consider the profit
and loss account, the balance sheet and the ordinary reports and accounts of the directors and auditors, appoint auditors and fix their
remuneration and transact any other business which under the Articles or applicable law may be transacted by the shareholders of a company
in general meeting. Under the Companies Law and our Articles, shareholders are not permitted to take action by way of written consent
in lieu of a meeting.
Our
Articles determine that the quorum required for either an annual (regular) or an extraordinary (special) general meeting of shareholders
consists of at least two shareholders present in person or by proxy holding shares comprising in the aggregate more than 33.33% of the
voting rights of the Company. If a meeting is convened by the Board upon the demand of shareholders or upon the demand of less than 50%
of the directors then in office or directly by such shareholders or directors and no quorum is present within half an hour from the time
appointed, it shall be cancelled. If a meeting is otherwise called and no quorum is present within such time, the meeting is adjourned
to the same day one week later at the same time and place or at such other time and place as the Board may determine and specify in the
notice of the general meeting and it shall not be necessary to give notice of such adjournment. If a quorum is not present within half
an hour from the time stated for such adjourned meeting, any two shareholders present in person or by proxy at such meeting shall constitute
a quorum even if, between them, they represent shares conferring 33.33% or less of the voting rights of the Company.
Generally,
under the Companies Law and the Articles, shareholder resolutions are deemed adopted if approved by the holders of a simple majority
of the voting rights represented at a meeting and voting unless a different majority is required by law or pursuant to the Articles.
The Companies Law provides that resolutions on certain matters, such as amending a company’s articles of association, assuming
the authority of the board of directors in certain circumstances, appointing auditors, appointing external directors (if applicable),
approving certain transactions, increasing or decreasing the registered share capital and approving most mergers must be made by the
shareholders at a general meeting. A company may determine in its articles of association certain additional matters in respect of which
resolutions by the shareholders in a general meeting will be required.
Access
to Corporate Records
Under
the Companies Law, all shareholders generally have the right to review minutes of our general meetings, our shareholder register and
register of significant shareholders (as defined in the Companies Law), our Articles, our financial statements, other documents as provided
in the Companies Law, and any document we are required by law to file publicly with the Israeli Companies Registrar. Any shareholder
who specifies the purpose of its request may request to review any document in our possession that relates to: (i) any action or transaction
with a related party which requires shareholder approval under the Companies Law; or (ii) the approval, by the board of directors, of
an action in which an office holder has a personal interest. We may deny a request to review a document if we determine that the request
was not made in good faith, or if such denial is necessary to protect our interest or protect a trade secret or patent.
Shareholder
Duties
Pursuant
to the Companies Law, a shareholder has a duty to act in good faith and in a customary manner toward a company and other shareholders
and to refrain from abusing his or her power in the company, including, among other things, in voting at the general meeting of shareholders
and at class shareholder meetings with respect to the following matters:
| ● | an
amendment to the company’s articles of association; |
| | |
| ● | an
increase of the company’s authorized share capital; |
| | |
| ● | a
merger; or |
| | |
| ● | approval
of interested party transactions and acts of Office Holders that require shareholder approval. |
In
addition, a shareholder also has a general duty to refrain from discriminating against other shareholders.
Certain
shareholders have a further duty of fairness toward a company. These shareholders include any controlling shareholder, any shareholder
who knows that it has the power to determine the outcome of a shareholder vote or a shareholder class vote and any shareholder who has
the power to appoint or to prevent the appointment of an Office Holder of the company or other power towards the company. The Companies
Law does not define the substance of this duty of fairness, except to state that the remedies generally available upon a breach of contract
will also apply in the event of a breach of the duty to act with fairness, taking the shareholder’s position in the company into
account.
Mergers
and Acquisitions under Israeli Law
(i)
Merger
The
Companies Law permits merger transactions if approved by each party’s board of directors, and, unless certain requirements described
under the Companies Law are met, a majority of each party’s shareholders, by a majority of each party’s shares that are voted
on the proposed merger at a shareholders’ meeting.
The
board of directors of a merging company is required pursuant to the Companies Law to discuss and determine whether in its opinion there
exists a reasonable concern that as a result of a proposed merger, the surviving company will not be able to satisfy its obligations
towards its creditors, taking into account the financial condition of the merging companies. If the board of directors has determined
that such a concern exists, it may not approve a proposed merger. Following the approval of the board of directors of each of the merging
companies, the boards of directors must jointly prepare a merger proposal for submission to the Israeli Registrar of Companies.
For
purposes of the shareholder vote, unless a court rules otherwise, the merger will not be deemed approved if a majority of the shares
voting at the shareholders meeting (excluding abstentions) that are held by parties other than the other party to the merger, any person
who holds 25% or more of the means of control of the other party to the merger or any one on their behalf including their relatives or
corporations controlled by any of them, vote against the merger. In addition, if the non-surviving entity of the merger has more than
one class of shares, the merger must be approved by each class of shareholders.
If
the transaction would have been approved but for the separate approval of each class of shares or the exclusion of the votes of certain
shareholders as provided above, a court may still rule that the company has approved the merger upon the request of holders of at least
25% of the voting rights of a company, if the court holds that the merger is fair and reasonable, taking into account the appraisal of
the merging companies’ value and the consideration offered to the shareholders.
Under
the Companies Law, each merging company must send a copy of the proposed merger plan to its secured creditors. Certain unsecured creditors
who meet materiality thresholds are entitled to receive notice of the merger, as provided by the regulations promulgated under the Companies
Law. Upon the request of a creditor of either party to the proposed merger, the court may delay or prevent the merger if it concludes
that there exists a reasonable concern that, as a result of the merger, the surviving company will be unable to satisfy the obligations
of the target company. The court may also give instructions in order to secure the rights of creditors.
In
addition, a merger may not be completed unless at least 50 days have passed from the date that a proposal for approval of the merger
was filed with the Israeli Registrar of Companies and 30 days from the date that shareholder approval of both merging companies was obtained.
(ii)
Special Tender Offer
The
Companies Law provides that an acquisition of shares of an Israeli public company must be made by means of a special tender offer if
as a result of the acquisition the purchaser would become a holder of 25% or more of the voting rights in the company. This rule does
not apply if there is already another holder of 25% or more of the voting rights in the company. Similarly, the Companies Law provides
that an acquisition of shares in a public company must be made by means of a special tender offer if as a result of the acquisition the
purchaser would become a holder of more than 45% of the voting rights in the company, if there is no other shareholder of the company
who holds more than 45% of the voting rights in the company.
These
requirements do not apply if the acquisition (i) occurs in the context of a private offering, on the condition that the shareholders’
meeting approved the acquisition as a private offering whose purpose is to give the acquirer at least 25% of the voting rights in the
company if there is no person who holds at least 25% of the voting rights in the company, or as a private offering whose purpose is to
give the acquirer 45% of the voting rights in the company, if there is no person who holds 45% of the voting rights in the company; (ii)
was from a shareholder holding at least 25% of the voting rights in the company and resulted in the acquirer becoming a holder of at
least 25% of the voting rights in the company; or (iii) was from a holder of more than 45% of the voting rights in the company and resulted
in the acquirer becoming a holder of more than 45% of the voting rights in the company.
The
special tender offer may be consummated only if (i) at least 5% of the voting power attached to the company’s outstanding shares
will be acquired by the offeror and (ii) the special tender offer is accepted by a majority of the votes of those offerees who gave notice
of their position in respect of the offer; in counting the votes of offerees, the votes of a holder of control in the offeror, a person
who has personal interest in acceptance of the special tender offer, a holder of at least 25% of the voting rights in the company, or
any person acting on their or on the offeror’s behalf, including their relatives or companies under their control, are not taken
into account.
In
the event that a special tender offer is made, a company’s board of directors is required to express its opinion on the advisability
of the offer or shall abstain from expressing any opinion if it is unable to do so, provided that it gives the reasons for its abstention.
In addition, the board of directors must disclose any personal interest each of member of the board of directors have in the offer or
stems therefrom.
An
office holder in a target company who, in his or her capacity as an office holder, performs an action the purpose of which is to cause
the failure of an existing or foreseeable special tender offer or is to impair the chances of its acceptance, is liable to the potential
purchaser and shareholders for damages resulting from his acts, unless such office holder acted in good faith and had reasonable grounds
to believe he or she was acting for the benefit of the company. However, office holders of the target company may negotiate with the
potential purchaser in order to improve the terms of the special tender offer, and may further negotiate with third parties in order
to obtain a competing offer.
If
a special tender offer was accepted by a majority of the shareholders who announced their stand on such offer, then shareholders who
did not respond to the special offer or had objected to the special tender offer may accept the offer within four days of the last day
set for the acceptance of the offer. In the event that a special tender offer is accepted, then the purchaser or any person or entity
controlling it and any corporation controlled by them shall refrain from making a subsequent tender offer for the purchase of shares
of the target company and may not execute a merger with the target company for a period of one year from the date of the offer, unless
the purchaser or such person or entity undertook to effect such an offer or merger in the initial special tender offer.
(iii)
Full Tender Offer
Under
the Companies Law, a person may not acquire shares in a public company if, after the acquisition, he will hold more than 90% of the shares
or more than 90% of any class of shares of that company, unless a tender offer is made to purchase all of the shares or all of the shares
of the particular class. The Companies Law also provides, subject to certain exceptions, that as long as a shareholder in a public company
holds more than 90% of the company’s shares or of a class of shares, that shareholder shall be precluded from purchasing any additional
shares unless tendering an offer to purchase all of the outstanding shares of the company or the applicable class of the shares. If the
shareholders who do not respond to or accept the offer hold less than 5% of the issued and outstanding share capital of the company or
of the applicable class of the shares, and more than half of the shareholders who do not have a personal interest in the offer accept
the offer, all of the shares that the acquirer offered to purchase will be transferred to the acquirer by operation of law. However,
a tender offer will be accepted if the shareholders who do not accept it hold less than 2% of the issued and outstanding share capital
of the company or of the applicable class of the shares.
Upon
a successful completion of such a full tender offer, any shareholder that was an offeree in such tender offer, whether such shareholder
accepted the tender offer or not, has the right, within six months from the date of acceptance of the tender offer, to petition the court
to determine that the tender offer was for less than fair value and that the fair value should be paid as determined by the court. However,
under certain conditions, the purchaser may provide in its offer that an offeree who accepted the tender offer will not be entitled to
such rights.
If
the conditions set forth above are not met, the purchaser may not acquire additional shares of the company from shareholders who accepted
the tender offer to the extent that following such acquisition, the purchaser would own more than 90% of the company’s issued and
outstanding share capital.
Anti-Takeover
Measures under Israeli Law
The
Companies Law allows us to create and issue shares having rights different from those attached to our ordinary shares, including shares
providing certain preferred rights, distributions or other matters and shares having preemptive rights. As of the date hereof, no preferred
shares are authorized under our Articles. In the future, if we do authorize, create and issue a specific class of preferred shares, such
class of shares, depending on the specific rights that may be attached to it, may have the ability to frustrate or prevent a takeover
or otherwise prevent our shareholders from realizing a potential premium over the market value of their ordinary shares. The authorization
and designation of a class of preferred shares will require an amendment to our Articles, which requires the affirmative vote of at least
75% of the voting rights of the Company represented personally or by proxy and voting thereon at a general meeting at which a quorum
is present. The convening of the general meeting, the shareholders entitled to participate and the majority vote required to be obtained
at such a meeting will be subject to the requirements set forth in the Articles and the Companies Law as described above in “—
Shareholder Meetings.”
In
addition, certain provisions of the Articles may have the effect of rendering more difficult or discouraging an acquisition of the Company
deemed undesirable by the Board. The classification of the Board into three classes with terms of approximately three years each, may
make it more difficult for shareholders who oppose the policies of the Board to remove a majority of the then current directors from
office quickly. It may also, in some circumstances, together with the other provisions of the Articles and Israeli law, deter or delay
potential future merger, acquisition, tender or takeover offers, proxy contests or changes in control or management of the Company.
Recent
Israeli case law has affirmed the use of shareholder rights plans (also known as “poison pills”) as a legitimate anti-takeover
mechanism under Israeli law. Though the Company has not adopted a shareholder rights plan as of the date hereof, the Company may consider
adopting a shareholder rights plan under specific circumstances.
Changes
in Capital
Our
Articles enable us to increase or reduce our share capital. Any such changes are subject to the provisions of the Companies Law and must
be approved by a resolution duly passed by our shareholders at a general meeting by voting on such change in the capital. In addition,
transactions that have the effect of reducing capital, such as the declaration and payment of dividends in the absence of sufficient
retained earnings or profits and an issuance of shares for less than their nominal value (under certain circumstances), require the approval
of both our Board and an Israeli court.
Changes
in Shareholder Rights
Pursuant
to our Articles, if at any time the share capital is divided into different classes of shares, the Company may by shareholder resolution,
unless otherwise provided by the terms of issue of the shares of that class, modify, convert, broaden, add or otherwise alter the rights,
privileges, advantages, restrictions and provisions related or unrelated at that time to the shares of any class with the sanction of
a resolution passed by a simple majority of those present, personally or by proxy, and voting thereon at a separate general meeting of
the holders of the shares of that class. Such majority approval is consistent with Israeli.
DESCRIPTION
OF WARRANTS
We
may issue and offer warrants under the material terms and conditions described in this prospectus and any accompanying prospectus supplement.
The accompanying prospectus supplement may add, update or change the terms and conditions of the warrants as described in this prospectus.
We
may issue warrants to purchase our ordinary shares, including debt securities. Warrants may be issued independently or together with
any securities and may be attached to or separate from those securities. The warrants may be issued under warrant or subscription agreements
to be entered into between us and a bank or trust company, as warrant agent, all of which will be described in the prospectus supplement
relating to the warrants we are offering. The warrant agent will act solely as our agent in connection with the warrants and will not
have any obligation or relationship of agency or trust for or with any holders or beneficial owners of warrants.
The
particular terms of the warrants, the warrant or subscription agreements relating to the warrants and the warrant certificates representing
the warrants will be described in the applicable prospectus supplement, including some or all of the following:
|
● |
the
title of such warrants; |
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● |
the
aggregate number of such warrants; |
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● |
the
price or prices at which such warrants will be issued and exercised; |
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● |
the
currency or currencies in which the price of such warrants will be payable; |
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● |
the
securities purchasable upon exercise of such warrants; |
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● |
the
date on which the right to exercise such warrants shall commence and the date on which such right shall expire; |
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● |
if
applicable, the minimum or maximum amount of such warrants which may be exercised at any one time; |
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● |
if
applicable, the designation and terms of the securities with which such warrants are issued and the number of such warrants issued
with each such security; |
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● |
if
applicable, the date on and after which such warrants and the related securities will be separately transferable; |
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● |
if
applicable, any provisions for cashless exercise of the warrants; |
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● |
if
applicable; any exercise limitations with respect to the ownership limitations by the holder
exercising the warrant;
|
|
●
|
information
with respect to book-entry procedures, if any; |
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● |
any
material Israeli tax consequences and United States federal income tax consequences; |
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● |
the
anti-dilution provisions of the warrants, if any; and |
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● |
any
other terms of such warrants, including terms, procedures and limitations relating to the exchange and exercise of such warrants. |
Holders
of warrants will not be entitled, solely by virtue of being holders, to vote, to consent, to receive dividends, to receive notice as
shareholders with respect to any meeting of shareholders for the election of directors or any other matters, or to exercise any rights
whatsoever as a holder of the equity securities purchasable upon exercise of the warrants.
The
description in the applicable prospectus supplement of any warrants we offer will not necessarily be complete and will be qualified
in its entirety by reference to the applicable warrant agreement and warrant certificate, which will be filed with the SEC if we
offer warrants. For more information on how you can obtain copies of the applicable warrant agreement if we offer warrants, see
“Where You Can Find More Information” beginning on page 34 and “Incorporation of Information by Reference”
beginning on page 35. We urge you to read any applicable prospectus supplement and the applicable warrant agreement and form of
warrant certificate in their entirety.
DESCRIPTION
OF SUBSCRIPTION RIGHTS
We
may issue subscription rights to purchase our ordinary shares. These subscription rights may be issued independently or together with
any other security offered hereby and may or may not be transferable by the shareholder receiving the subscription rights in such offering.
In connection with any offering of subscription rights, we may enter into a standby arrangement with one or more underwriters or other
purchasers pursuant to which the underwriters or other purchasers may be required to purchase any securities remaining unsubscribed for
after such offering.
The
prospectus supplement relating to any subscription rights we offer, if any, will, to the extent applicable, include specific terms relating
to the offering, including some or all of the following:
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● |
the
price, if any, for the subscription rights; |
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● |
the
exercise price payable for each ordinary share upon the exercise of the subscription rights; |
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● |
the
number of subscription rights to be issued to each shareholder; |
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● |
the
number and terms of the ordinary shares which may be purchased per each subscription right; |
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● |
the
extent to which the subscription rights are transferable; |
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● |
any
other terms of the subscription rights, including the terms, procedures and limitations relating to the exchange and exercise of
the subscription rights; |
|
● |
the
date on which the right to exercise the subscription rights shall commence, and the date on which the subscription rights shall expire; |
|
|
|
|
● |
the
extent to which the subscription rights may include an over-subscription privilege with respect to unsubscribed securities; and |
|
|
|
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● |
if
applicable, the material terms of any standby underwriting or purchase arrangement which may be entered into by us in connection
with the offering of subscription rights. |
The
description in the applicable prospectus supplement of any subscription rights we offer will not necessarily be complete and will be
qualified in its entirety by reference to the applicable subscription right agreement, which will be filed with the SEC if we offer subscription
rights. For more information on how you can obtain copies of the applicable subscription right agreement if we offer subscription rights,
see “Where You Can Find More Information” beginning on page 34 and “Incorporation by Reference” beginning
on page 35. We urge you to read the applicable subscription right agreement and any applicable prospectus supplement in their entirety.
DESCRIPTION
OF DEBT SECURITIES
The
following description, together with the additional information we include in any applicable prospectus supplement, summarizes the material
terms and provisions of the debt securities that we may offer under this prospectus. The debt securities will be our direct general obligations
and may include debentures, notes, bonds or other evidences of indebtedness. The debt securities will be either senior debt securities
or subordinated debt securities. The debt securities will be issued under one or more separate indentures. Senior debt securities will
be issued under a senior debt indenture, and subordinated debt securities will be issued under a subordinated debt indenture. We use
the term “indentures” to refer to both the senior indenture and the subordinated indenture. A form of each of the senior
indenture and the subordinated indenture is filed as an exhibit to the registration statement of which this prospectus is a part. The
indentures will be qualified under the Trust Indenture Act. We use the term “indenture trustee” to refer to either the senior
trustee or the subordinated trustee, as applicable.
The
following summaries of material provisions of the debt securities and indentures are subject to, and qualified in their entirety by reference
to, all the provisions of the indenture applicable to a particular series of debt securities and the description thereof contained in
the prospectus supplement.
General
We
will describe in each prospectus supplement the following terms relating to a series of debt securities:
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● |
the
title or designation; |
|
● |
any
limit on the principal amount that may be issued; |
|
● |
whether
or not we will issue the series of debt securities in global form, the terms and the depositary; |
|
● |
the
annual interest rate, which may be fixed or variable, or the method for determining the rate and the date interest will begin to
accrue, the dates interest will be payable and the regular record dates for interest payment dates or the method for determining
such dates; |
|
● |
whether
or not the debt securities will be secured or unsecured, and the terms of any secured debt; |
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● |
the
terms of the subordination of any series of subordinated debt; |
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● |
the
place where payments will be payable; |
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● |
our
right, if any, to defer payment of interest and the maximum length of any such deferral period; |
|
|
|
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● |
the
date, if any, after which, and the price at which, we may, at our option, redeem the series of debt securities pursuant to any optional
redemption provisions; |
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● |
the
date, if any, on which, and the price at which we are obligated, pursuant to any mandatory sinking fund provisions or otherwise,
to redeem, or at the holder’s option to purchase, the series of debt securities; |
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● |
whether
the indenture will restrict our ability to pay dividends, or will require us to maintain any asset ratios or reserves; |
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● |
whether
we will be restricted from incurring any additional indebtedness; |
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● |
a
discussion on any material or special U.S. federal income tax considerations applicable to the debt securities; |
|
|
|
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● |
the
denominations in which we will issue the series of debt securities, if other than denominations of $1,000 and any integral multiple
thereof; and |
|
|
|
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● |
any
other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities. |
Conversion
or Exchange Rights
We
will set forth in the prospectus supplement the terms on which a series of debt securities may be convertible into or exchangeable for
ordinary shares or other securities. We will include provisions as to whether conversion or exchange is mandatory, at the option of the
holder or at our option. We may include provisions pursuant to which the number of ordinary shares or other securities that the holders
of the series of debt securities receive would be subject to adjustment.
Consolidation,
Merger or Sale
The
indentures will not contain any covenant which restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise
dispose of all or substantially all of our assets so long as (i) we are the surviving entity or (ii) the successor is a U.S. entity who
assumes all of our obligations under the indentures or the debt securities, as appropriate.
Events
of Default Under the Indenture
The
following may be events of default under the indentures with respect to any series of debt securities that we may issue:
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● |
if
we fail to pay interest when due and our failure continues for a number of days to be stated in the indenture and the time for payment
has not been extended or deferred; |
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● |
if
we fail to pay the principal, or premium, if any, when due and the time for payment has not been extended or delayed; |
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● |
if
we fail to observe or perform any other covenant contained in the debt securities or the indentures, other than a covenant specifically
relating to another series of debt securities, and our failure continues for a number of days to be stated in the indenture after
we receive notice from the indenture trustee or holders of at least 25% in aggregate principal amount of the outstanding debt securities
of the applicable series; and |
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● |
if
specified events of bankruptcy, insolvency or reorganization occur as to us. |
If
an event of default with respect to debt securities of any series occurs and is continuing, the indenture trustee or the holders of at
least 25% in aggregate principal amount of the outstanding debt securities of that series, by notice to us in writing, and to the indenture
trustee if notice is given by such holders, may declare the unpaid principal, premium, if any, and accrued interest, if any, due and
payable immediately; provided that if an event of bankruptcy, insolvency or reorganization occurs, such amounts shall automatically become
due and payable without any declaration or other action on the part of the trustee or any holder.
The
holders of a majority in principal amount of the outstanding debt securities of an affected series may waive any default or event of
default with respect to the series and its consequences, except defaults or events of default regarding payment of principal, premium,
if any, or interest, unless we have cured the default or event of default in accordance with the indenture. Any waiver will cure the
default or event of default.
Subject
to the terms of the indentures, if an event of default under an indenture occurs and is continuing, the indenture trustee will be under
no obligation to exercise any of its rights or powers under such indenture at the request or direction of any of the holders of the applicable
series of debt securities, unless such holders have offered the indenture trustee reasonable indemnity. The holders of a majority in
principal amount of the outstanding debt securities of any series will have the right to direct the time, method and place of conducting
any proceeding for any remedy available to the indenture trustee, or exercising any trust or power conferred on the indenture trustee,
with respect to the debt securities of that series, provided that:
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● |
the
direction given by the holder is not in conflict with any law or the applicable indenture; and |
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● |
subject
to its duties under the Trust Indenture Act, the indenture trustee need not take any action that might involve it in personal liability
or might be unduly prejudicial to the holders not involved in the proceeding. |
A
holder of the debt securities of any series will only have the right to institute a proceeding under the indentures or to appoint a receiver
or trustee, or to seek other remedies if:
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● |
the
holder has given written notice to the indenture trustee of a continuing event of default with respect to that series; |
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● |
the
holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series have made a written request,
and such holders have offered reasonable indemnity to the indenture trustee to institute the proceeding as trustee; and |
|
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|
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● |
the
indenture trustee does not institute the proceeding, and does not receive from the holders of a majority in aggregate principal amount
of the outstanding debt securities of that series other conflicting directions within 60 days after the notice, request and offer. |
These
limitations do not apply to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium,
if any, or interest on, the debt securities.
We
will periodically file statements with the indenture trustee regarding our compliance with specified covenants in the indentures.
Modification
of Indenture; Waiver
We
and the indenture trustee may change an indenture without the consent of any holders with respect to specific matters, including:
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● |
to
fix any ambiguity, defect or inconsistency in the indenture; and |
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● |
to
change anything that does not materially adversely affect the interests of any holder of debt securities of any series. |
In
addition, under the indentures, the rights of holders of a series of debt securities may be changed by us and the indenture trustee with
the written consent of the holders of at least a majority in aggregate principal amount of the outstanding debt securities of each series
that is affected. However, we and the indenture trustee may only make the following changes with the consent of each holder of any outstanding
debt securities affected:
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● |
changing
the fixed maturity of the series of debt securities or any installment of principal of or interest on any series of debt securities; |
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● |
reducing
the principal amount, reducing the rate of or extending the time of payment of interest, or any premium payable upon the redemption
of any debt securities; or |
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● |
reducing
the percentage of debt securities, the holders of which are required to consent to any amendment. |
Discharge
Each
indenture provides that we can elect to be discharged from our obligations with respect to one or more series of debt securities, except
for obligations to:
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● |
register
the transfer or exchange of debt securities of the series; |
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● |
replace
stolen, lost or mutilated debt securities of the series; |
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● |
maintain
paying agencies; |
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● |
hold
monies for payment in trust; |
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● |
compensate
and indemnify the indenture trustee; and |
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● |
appoint
any successor indenture trustee. |
In
order to exercise our rights to be discharged, we must deposit with the indenture trustee money or government obligations sufficient
to pay all the principal of, any premium, if any, and interest on, the debt securities of the series on the dates payments are due.
Form,
Exchange and Transfer
We
will issue the debt securities of each series only in fully registered form without coupons and, unless we otherwise specify in the applicable
prospectus supplement, in denominations of $1,000 and any integral multiple thereof. The indentures provide that we may issue debt securities
of a series in temporary or permanent global form and as book-entry securities that will be deposited with, or on behalf of, a depositary
named by us and identified in a prospectus supplement with respect to that series. See “Book-Entry Issuance” for a further
description of the terms relating to any book-entry securities.
Subject
to the terms of the indentures and the limitations applicable to global securities described in the applicable prospectus supplement,
the holder of the debt securities of any series, at its option, can exchange the debt securities for other debt securities of the same
series, in any authorized denomination and of like tenor and aggregate principal amount.
Subject
to the terms of the indentures and the limitations applicable to global securities set forth in the applicable prospectus supplement,
holders of the debt securities may present the debt securities for exchange or for registration of transfer, duly endorsed or with the
form of transfer endorsed thereon duly executed if so required by us or the security registrar, at the office of the security registrar
or at the office of any transfer agent designated by us for this purpose. Unless otherwise provided in the debt securities that the holder
presents for transfer or exchange, no service charge will be required for any registration of transfer or exchange, but we may require
payment of any taxes or other governmental charges.
We
will name in the applicable prospectus supplement the security registrar, and any transfer agent in addition to the security registrar,
that we initially designate for any debt securities. We may at any time designate additional transfer agents or rescind the designation
of any transfer agent or approve a change in the office through which any transfer agent acts, except that we will be required to maintain
a transfer agent in each place of payment for the debt securities of each series.
If
we elect to redeem the debt securities of any series, we will not be required to:
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● |
issue,
register the transfer of, or exchange any debt securities of that series during a period beginning at the opening of business 15
days before the day of mailing of a notice of redemption of any debt securities that may be selected for redemption and ending at
the close of business on the day of the mailing; or |
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● |
register
the transfer of or exchange any debt securities so selected for redemption, in whole or in part, except the unredeemed portion of
any debt securities we are redeeming in part. |
Payment
and Paying Agents
Unless
we otherwise indicate in the applicable prospectus supplement, we will make payment of the interest on any debt securities on any interest
payment date to the person in whose name the debt securities, or one or more predecessor securities, are registered at the close of business
on the regular record date for the interest.
We
will pay principal of and any premium and interest on the debt securities of a particular series at the office of the paying agents designated
by us, except that unless we otherwise indicate in the applicable prospectus supplement, we will make interest payments by check which
we will mail to the holder. Unless we otherwise indicate in a prospectus supplement, we will designate the corporate trust office of
the indenture trustee in the City of New York as our sole paying agent for payments with respect to debt securities of each series. We
will name in the applicable prospectus supplement any other paying agents that we initially designate for the debt securities of a particular
series. We will maintain a paying agent in each place of payment for the debt securities of a particular series.
All
money we pay to a paying agent or the indenture trustee for the payment of the principal of or any premium or interest on any debt securities
which remains unclaimed at the end of two years after such principal, premium or interest has become due and payable will be repaid to
us, and the holder of the security thereafter may look only to us for payment thereof.
Governing
Law
The
indentures and the debt securities will be governed by and construed in accordance with the laws of the State of New York, except to
the extent that the Trust Indenture Act is applicable.
Subordination
of Subordinated Notes
The
subordinated notes will be unsecured and will be subordinate and junior in priority of payment to certain of our other indebtedness to
the extent described in a prospectus supplement. The subordinated indenture does not limit the amount of subordinated notes which we
may issue. It also does not limit us from issuing any other secured or unsecured debt.
Regarding
the Indenture Trustee
We
will name the indenture trustee for debt securities issued under the applicable indenture in the applicable supplement to this prospectus
and, unless otherwise indicated in a prospectus supplement, the indenture trustee will also act as Transfer Agent and Paying Agent with
respect to the debt securities. The indenture trustee may be removed at any time with respect to the debt securities of any series by
act of the holders of a majority in principal amount of the outstanding debt securities of such series delivered to the indenture trustee
and to us.
Global
Securities
The
debt securities of a series may be issued in whole or in part in the form of one or more global securities that will be deposited with,
or on behalf of, a depository identified in an applicable subsequent filing and registered in the name of the depository or a nominee
for the depository. In such a case, one or more global securities will be issued in a denomination or aggregate denominations equal to
the portion of the aggregate principal amount of outstanding debt securities of the series to be represented by the global security or
securities. Unless and until it is exchanged in whole or in part for debt securities in definitive certificated form, a global security
may not be transferred except as a whole by the depository for the global security to a nominee of the depository or by a nominee of
the depository to the depository or another nominee of the depository or by the depository or any nominee to a successor depository for
that series or a nominee of the successor depository and except in the circumstances described in an applicable subsequent filing.
We
expect that the following provisions will apply to depository arrangements for any portion of a series of debt securities to be represented
by a global security. Any additional or different terms of the depository arrangement will be described in an applicable subsequent filing.
Upon
the issuance of any global security, and the deposit of that global security with or on behalf of the depository for the global security,
the depository will credit, on its book-entry registration and transfer system, the principal amounts of the debt securities represented
by that global security to the accounts of institutions that have accounts with the depository or its nominee. The accounts to be credited
will be designated by the underwriters or agents engaging in the distribution of the debt securities or by us, if the debt securities
are offered and sold directly by us. Ownership of beneficial interests in a global security will be limited to participating institutions
or persons that may hold interest through such participating institutions. Ownership of beneficial interests by participating institutions
in the global security will be shown on, and the transfer of the beneficial interests will be effected only through, records maintained
by the depository for the global security or by its nominee. Ownership of beneficial interests in the global security by persons that
hold through participating institutions will be shown on, and the transfer of the beneficial interests within the participating institutions
will be effected only through, records maintained by those participating institutions. The laws of some jurisdictions may require that
purchasers of securities take physical delivery of the securities in certificated form. The foregoing limitations and such laws may impair
the ability to transfer beneficial interests in the global securities.
So
long as the depository for a global security, or its nominee, is the registered owner of that global security, the depository or its
nominee, as the case may be, will be considered the sole owner or holder of the debt securities represented by the global security for
all purposes under the applicable Indenture. Unless otherwise specified in an applicable subsequent filing and except as specified below,
owners of beneficial interests in the global security will not be entitled to have debt securities of the series represented by the global
security registered in their names, will not receive or be entitled to receive physical delivery of debt securities of the series in
certificated form and will not be considered the holders thereof for any purposes under the Indenture. Accordingly, each person owning
a beneficial interest in the global security must rely on the procedures of the depository and, if such person is not a participating
institution, on the procedures of the participating institution through which the person owns its interest, to exercise any rights of
a holder under the Indenture.
The
depository may grant proxies and otherwise authorize participating institutions to give or take any request, demand, authorization, direction,
notice, consent, waiver or other action which a holder is entitled to give or take under the applicable Indenture. We understand that,
under existing industry practices, if we request any action of holders or any owner of a beneficial interest in the global security desires
to give any notice or take any action a holder is entitled to give or take under the applicable Indenture, the depository would authorize
the participating institutions to give the notice or take the action, and participating institutions would authorize beneficial owners
owning through such participating institutions to give the notice or take the action or would otherwise act upon the instructions of
beneficial owners owning through them.
Unless
otherwise specified in applicable subsequent filings, payments of principal, premium and interest on debt securities represented by a
global security registered in the name of a depository or its nominee will be made by us to the depository or its nominee, as the case
may be, as the registered owner of the global security.
We
expect that the depository for any debt securities represented by a global security, upon receipt of any payment of principal, premium
or interest, will credit participating institutions’ accounts with payments in amounts proportionate to their respective beneficial
interests in the principal amount of the global security as shown on the records of the depository. We also expect that payments by participating
institutions to owners of beneficial interests in the global security held through those participating institutions will be governed
by standing instructions and customary practices, as is now the case with the securities held for the accounts of customers registered
in street names, and will be the responsibility of those participating institutions. None of us, the trustees or any agent of ours or
the trustees will have any responsibility or liability for any aspect of the records relating to or payments made on account of beneficial
interests in a global security, or for maintaining, supervising or reviewing any records relating to those beneficial interests.
Unless
otherwise specified in the applicable subsequent filings, a global security of any series will be exchangeable for certificated debt
securities of the same series only if:
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● |
the
depository for such global securities notifies us that it is unwilling or unable to continue as depository or such depository ceases
to be a clearing agency registered under the Exchange Act and, in either case, a successor depository is not appointed by us within
90 days after we receive the notice or become aware of the ineligibility; |
|
● |
we
in our sole discretion determine that the global securities shall be exchangeable for certificated debt securities; or |
|
● |
there
shall have occurred and be continuing an event of default under the applicable Indenture with respect to the debt securities of that
series. |
Upon
any exchange, owners of beneficial interests in the global security or securities will be entitled to physical delivery of individual
debt securities in certificated form of like tenor and terms equal in principal amount to their beneficial interests, and to have the
debt securities in certificated form registered in the names of the beneficial owners, which names are expected to be provided by the
depository’s relevant participating institutions to the applicable trustee.
In
the event that the Depository Trust Company, or “DTC,” acts as depository for the global securities of any series, the global
securities will be issued as fully registered securities registered in the name of Cede & Co., DTC’s partnership nominee.
DTC
is a member of the U.S. Federal Reserve System, a limited-purpose trust company under New York State banking law and a registered clearing
agency with the Commission. Established in 1973, DTC was created to reduce costs and provide clearing and settlement efficiencies by
immobilizing securities and making “book-entry” changes to ownership of the securities. DTC provides securities movements
for the net settlements of the National Securities Clearing Corporation, or “NSCC,” and settlement for institutional trades
(which typically involve money and securities transfers between custodian banks and broker/dealers), as well as money market instruments.
DTC
is a subsidiary of The Depository Trust & Clearing Company, or “DTCC.” DTCC is a holding company established in 1999
to combine DTC and NSCC. DTCC, through its subsidiaries, provides clearing, settlement and information services for equities, corporate
and municipal bonds, government and mortgage backed securities, money market instruments and over the-counter derivatives. In addition,
DTCC is a leading processor of mutual funds and insurance transactions, linking funds and carriers with their distribution networks.
DTCC’s customer base extends to thousands of companies within the global financial services industry. DTCC serves brokers, dealers,
institutional investors, banks, trust companies, mutual fund companies, insurance carriers, hedge funds and other financial intermediaries—either
directly or through correspondent relationships.
DTCC
is industry-owned by its customers who are members of the financial community, such as banks, broker/dealers, mutual funds and other
financial institutions. DTCC operates on an at-cost basis, returning excess revenue from transaction fees to its member firms. All services
provided by DTC are regulated by the Commission.
The
2017 DTCC Board of Directors is composed of 20 directors serving one-year terms. Twelve directors are representatives of clearing agency
participants, including broker/dealers, custodian and clearing banks, and investment institutions; two directors are designated by DTCC’s
preferred shareholders, which are NYSE Euronext and FINRA; four directors are from non-participants; and the remaining two are the non-executive
chairman and the chief executive officer and president of DTCC. All of the Board members except those designated by the preferred shareholders
are elected annually.
To
facilitate subsequent transfers, the debt securities may be registered in the name of DTC’s nominee, Cede & Co. The deposit
of the debt securities with DTC and their registration in the name of Cede & Co. will effect no change in beneficial ownership. DTC
has no knowledge of the actual beneficial owners of the debt securities. DTC’s records reflect only the identity of the direct
participating institutions to whose accounts debt securities are credited, which may or may not be the beneficial owners. The participating
institutions remain responsible for keeping account of their holdings on behalf of their customers.
Delivery
of notices and other communications by DTC to direct participating institutions, by direct participating institutions to indirect participating
institutions, and by direct participating institutions and indirect participating institutions to beneficial owners of debt securities
are governed by arrangements among them, subject to any statutory or regulatory requirements as may be in effect.
Neither
DTC nor Cede & Co. consents or votes with respect to the debt securities. Under its usual procedures, DTC mails a proxy to the issuer
as soon as possible after the record date. The proxy assigns Cede & Co.’s consenting or voting rights to those direct participating
institution to whose accounts the debt securities are credited on the record date.
If
applicable, redemption notices shall be sent to Cede & Co. If less than all of the debt securities of a series represented by global
securities are being redeemed, DTC’s practice is to determine by lot the amount of the interest of each direct participating institutions
in that issue to be redeemed.
To
the extent that any debt securities provide for repayment or repurchase at the option of the holders thereof, a beneficial owner shall
give notice of any option to elect to have its interest in the global security repaid by us, through its participating institution, to
the applicable trustee, and shall effect delivery of the interest in a global security by causing the direct participating institution
to transfer the direct participating institution’s interest in the global security or securities representing the interest, on
DTC’s records, to the applicable trustee. The requirement for physical delivery of debt securities in connection with a demand
for repayment or repurchase will be deemed satisfied when the ownership rights in the global security or securities representing the
debt securities are transferred by direct participating institutions on DTC’s records.
DTC
may discontinue providing its services as securities depository for the debt securities at any time. Under such circumstances, in the
event that a successor securities depository is not appointed, debt security certificates are required to be printed and delivered as
described above.
We
may decide to discontinue use of the system of book-entry transfers through the securities depository. In that event, debt security certificates
will be printed and delivered as described above.
DESCRIPTION
OF UNITS
We
may issue units comprised of one or more of the other securities described in this prospectus in any combination. Each unit will be issued
so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights
and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities
included in the unit may not be held or transferred separately, at any time or at any time before a specified date.
The
applicable prospectus supplement will describe:
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the
designation and terms of the units and of the securities comprising the units, including whether and under what circumstances those
securities may be held or transferred separately; |
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the
material terms of a unit agreement under which the units will be issued; |
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any
provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities comprising the units; and |
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whether
the units will be issued in fully registered or global form. |
The
applicable prospectus supplement will describe the terms of any units. The preceding description and any description of units in the
applicable prospectus supplement does not purport to be complete and is subject to and is qualified in its entirety by reference to the
unit agreement and, if applicable, collateral arrangements and depositary arrangements relating to such units. For more information on
how you can obtain copies of the applicable unit agreement if we offer units, see “Where You Can Find More Information” beginning
on page 34 and “Incorporation by Reference” beginning on page 35. We urge you to read the applicable unit agreement
and any applicable prospectus supplement in their entirety.
PLAN
OF DISTRIBUTION
The
securities being offered by this prospectus may be sold:
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to
or through one or more underwriters on a firm commitment or agency basis; |
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through
put or call option transactions relating to the securities; |
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to
or through dealers, who may act as agents or principals, including a block trade (which may involve crosses) in which a broker or
dealer so engaged will attempt to sell as agent but may position and resell a portion of the block as principal to facilitate the
transaction; |
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through
privately negotiated transactions; |
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purchases
by a broker or dealer as principal and resale by such broker or dealer for its own account pursuant to this prospectus; |
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directly
to purchasers, including our affiliates, through a specific bidding or auction process, on a negotiated basis or otherwise; to or
through one or more underwriters on a firm commitment or best efforts basis; |
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exchange
distributions and/or secondary distributions; |
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ordinary
brokerage transactions and transactions in which the broker solicits purchasers; |
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in
an “at the market offering”, within the meaning of Rule 415(a)(4) of the Securities into an existing trading market,
on an exchange or otherwise; |
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transactions
not involving market makers or established trading markets, including direct sales or privately negotiated transactions; |
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transactions
in options, swaps or other derivatives that may or may not be listed on an exchange; |
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through
any other method permitted pursuant to applicable law; or |
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through
a combination of any such methods of sale. |
At
any time a particular offer of the securities covered by this prospectus is made, a revised prospectus or prospectus supplement, if required,
will be distributed which will set forth the aggregate amount of securities covered by this prospectus being offered and the terms of
the offering, including the name or names of any underwriters, dealers, brokers or agents, any discounts, commissions, concessions and
other items constituting compensation from us and any discounts, commissions or concessions allowed or re-allowed or paid to dealers.
Such prospectus supplement, and, if necessary, a post-effective amendment to the registration statement of which this prospectus is a
part, will be filed with the SEC to reflect the disclosure of additional information with respect to the distribution of the securities
covered by this prospectus. In order to comply with the securities laws of certain states, if applicable, the securities sold under this
prospectus may only be sold through registered or licensed broker-dealers. In addition, in some states the securities may not be sold
unless they have been registered or qualified for sale in the applicable state or an exemption from registration or qualification requirements
is available and is complied with.
The
distribution of securities may be effected from time to time in one or more transactions, including block transactions and transactions
on the Nasdaq Capital Market or any other organized market where the securities may be traded. The securities may be sold at a fixed
price or prices, which may be changed, or at market prices prevailing at the time of sale, at prices relating to the prevailing market
prices or at negotiated prices. The consideration may be cash or another form negotiated by the parties. Agents, underwriters or broker-dealers
may be paid compensation for offering and selling the securities. That compensation may be in the form of discounts, concessions or commissions
to be received from us or from the purchasers of the securities. Any dealers and agents participating in the distribution of the securities
may be deemed to be underwriters, and compensation received by them on resale of the securities may be deemed to be underwriting discounts.
If any such dealers or agents were deemed to be underwriters, they may be subject to statutory liabilities under the Securities Act.
Agents
may from time to time solicit offers to purchase the securities. If required, we will name in the applicable prospectus supplement any
agent involved in the offer or sale of the securities and set forth any compensation payable to the agent. Unless otherwise indicated
in the prospectus supplement, any agent will be acting on a best efforts basis for the period of its appointment. Any agent selling the
securities covered by this prospectus may be deemed to be an underwriter, as that term is defined in the Securities Act, of the securities.
To
the extent that we make sales to or through one or more underwriters or agents in at-the-market offerings, we will do so pursuant to
the terms of a distribution agreement between us and the underwriters or agents. If we engage in at-the-market sales pursuant to a distribution
agreement, we will sell any of our listed securities to or through one or more underwriters or agents, which may act on an agency basis
or on a principal basis. During the term of any such agreement, we may sell any of our listed securities on a daily basis in exchange
transactions or otherwise as we agree with the underwriters or agents. The distribution agreement will provide that any of our listed
securities which are sold will be sold at prices related to the then prevailing market prices for our listed securities. Therefore, exact
figures regarding proceeds that will be raised or commissions to be paid cannot be determined at this time and will be described in a
prospectus supplement. Pursuant to the terms of the distribution agreement, we also may agree to sell, and the relevant underwriters
or agents may agree to solicit offers to purchase, blocks of our listed securities. The terms of each such distribution agreement will
be set forth in more detail in a prospectus supplement to this prospectus.
If
underwriters are used in a sale, securities will be acquired by the underwriters for their own account and may be resold from time to
time in one or more transactions, including negotiated transactions, at a fixed public offering price or at varying prices determined
at the time of sale, or under delayed delivery contracts or other contractual commitments. Securities may be offered to the public either
through underwriting syndicates represented by one or more managing underwriters or directly by one or more firms acting as underwriters.
If an underwriter or underwriters are used in the sale of securities, an underwriting agreement will be executed with the underwriter
or underwriters, as well as any other underwriter or underwriters, with respect to a particular underwritten offering of securities,
and will set forth the terms of the transactions, including compensation of the underwriters and dealers and the public offering price,
if applicable. The prospectus and prospectus supplement will be used by the underwriters to resell the securities.
If
a dealer is used in the sale of the securities, we or an underwriter will sell the securities to the dealer, as principal. The dealer
may then resell the securities to the public at varying prices to be determined by the dealer at the time of resale. To the extent required,
we will set forth in the prospectus supplement the name of the dealer and the terms of the transactions.
We
may directly solicit offers to purchase the securities and may make sales of securities directly to institutional investors or others.
These persons may be deemed to be underwriters within the meaning of the Securities Act with respect to any resale of the securities.
To the extent required, the prospectus supplement will describe the terms of any such sales, including the terms of any bidding or auction
process, if used.
Agents,
underwriters and dealers may be entitled under agreements which may be entered into with us to indemnification by us against specified
liabilities, including liabilities incurred under the Securities Act, or to contribution by us to payments they may be required to make
in respect of such liabilities. If required, the prospectus supplement will describe the terms and conditions of the indemnification
or contribution. Some of the agents, underwriters or dealers, or their affiliates may be customers of, engage in transactions with or
perform services for us or our subsidiaries.
Any
person participating in the distribution of securities registered under the registration statement that includes this prospectus will
be subject to applicable provisions of the Securities Exchange Act of 1934, as amended, or the Exchange Act, and the applicable SEC rules
and regulations, including, among others, Regulation M, which may limit the timing of purchases and sales of any of our securities by
that person. Furthermore, Regulation M may restrict the ability of any person engaged in the distribution of our securities to engage
in market-making activities with respect to our securities. These restrictions may affect the marketability of our securities and the
ability of any person or entity to engage in market-making activities with respect to our securities.
Certain
persons participating in an offering may engage in over-allotment, stabilizing transactions, short-covering transactions, penalty bids
and other transactions that stabilize, maintain or otherwise affect the price of the offered securities. These activities may maintain
the price of the offered securities at levels above those that might otherwise prevail in the open market, including by entering stabilizing
bids, effecting syndicate covering transactions or imposing penalty bids, each of which is described below:
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a
stabilizing bid means the placing of any bid, or the effecting of any purchase, for the purpose of pegging, fixing or maintaining
the price of a security. |
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a
syndicate covering transaction means the placing of any bid on behalf of the underwriting syndicate or the effecting of any purchase
to reduce a short position created in connection with the offering. |
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a
penalty bid means an arrangement that permits the managing underwriter to reclaim a selling concession from a syndicate member in
connection with the offering when offered securities originally sold by the syndicate member are purchased in syndicate covering
transactions. |
These
transactions may be effected on an exchange or automated quotation system, if the securities are listed on that exchange or admitted
for trading on that automated quotation system, or in the over-the-counter market or otherwise.
If
so indicated in the applicable prospectus supplement, we will authorize agents, underwriters or dealers to solicit offers from certain
types of institutions to purchase offered securities from us at the public offering price set forth in such prospectus supplement pursuant
to delayed delivery contracts providing for payment and delivery on a specified date in the future. Such contracts will be subject only
to those conditions set forth in the prospectus supplement and the prospectus supplement will set forth the commission payable for solicitation
of such contracts.
In
addition, ordinary shares or warrants may be issued upon conversion of or in exchange for debt securities or other securities.
Any
underwriters to whom offered securities are sold for public offering and sale may make a market in such offered securities, but such
underwriters will not be obligated to do so and may discontinue any market making at any time without notice. The offered securities
may or may not be listed on a national securities exchange. No assurance can be given that there will be a market for the offered securities.
Any
securities that qualify for sale pursuant to Rule 144 or Regulation S under the Securities Act may be sold under Rule 144 or Regulation
S rather than pursuant to this prospectus.
In
connection with offerings made through underwriters or agents, we may enter into agreements with such underwriters or agents pursuant
to which we receive our outstanding securities in consideration for the securities being offered to the public for cash. In connection
with these arrangements, the underwriters or agents may also sell securities covered by this prospectus to hedge their positions in these
outstanding securities, including in short sale transactions. If so, the underwriters or agents may use the securities received from
us under these arrangements to close out any related open borrowings of securities.
We
may enter into derivative transactions with third parties or sell securities not covered by this prospectus to third parties in privately
negotiated transactions. If the applicable prospectus supplement indicates, in connection with those derivatives, such third parties
(or affiliates of such third parties) may sell securities covered by this prospectus and the applicable prospectus supplement, including
in short sale transactions. If so, such third parties (or affiliates of such third parties) may use securities pledged by us or borrowed
from us or others to settle those sales or to close out any related open borrowings of shares, and may use securities received from us
in settlement of those derivatives to close out any related open borrowings of shares. The third parties (or affiliates of such third
parties) in such sale transactions will be underwriters and will be identified in the applicable prospectus supplement (or a post-effective
amendment).
We
may loan or pledge securities to a financial institution or other third party that in turn may sell the securities using this prospectus.
Such financial institution or third party may transfer its short position to investors in our securities or in connection with a simultaneous
offering of other securities offered by this prospectus or in connection with a simultaneous offering of other securities offered by
this prospectus.
LEGAL
MATTERS
Meitar
| Law Offices, Ramat Gan, Israel, will pass upon certain legal matters regarding the securities
offered hereby under Israeli law and Greenberg Traurig, P.A., Tel Aviv, Israel, will pass upon certain legal matters regarding the securities
offered hereby under U.S. federal securities law. Additional legal matters may be passed upon for us or any underwriters, dealers or
agents, by counsel that we will name in the applicable prospectus supplement.
EXPERTS
The
consolidated financial statements of the Company for the years ended December 31, 2023 and 2022 incorporated in this prospectus by reference
have been audited by the accounting firm of Brightman Almagor Zohar & Co., a firm in the Deloitte Global Network, an independent
registered public accounting firm, as set forth in their report thereon, included therein, and incorporated herein by reference. Such
consolidated financial statements are incorporated herein by reference in reliance upon such report given on the authority of such firm
as experts in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
We
have filed with the SEC a registration statement on Form F-3, including amendments and relevant exhibits and schedules, under the Securities
Act covering the ordinary shares to be sold in this offering. This prospectus, which constitutes a part of the registration statement,
summarizes material provisions of contracts and other documents that we refer to in the prospectus. Since this prospectus does not contain
all of the information contained in the registration statement, you should read the registration statement and its exhibits and schedules
for further information with respect to us and our ordinary shares. Our SEC filings, including the registration statement, are also available
to you on the SEC’s Web site at www.sec.gov.
We
are subject to the information reporting requirements of the Exchange Act that are applicable to foreign private issuers, and under those
requirements we file reports with the SEC. Those other reports or other information may be inspected without charge at the locations
described above. As a foreign private issuer, we are exempt from the rules under the Exchange Act related to the furnishing and content
of proxy statements, and our officers, directors and principal shareholder are exempt from the reporting and short-swing profit recovery
provisions contained in Section 16 of the Exchange Act. In addition, we are not required under the Exchange Act to file annual, quarterly
and current reports and financial statements with the SEC as frequently or as promptly as United States companies whose securities are
registered under the Exchange Act. However, we file with the SEC, within four months after the end of each fiscal year, or such applicable
time as required by the SEC, an annual report on Form 20-F containing financial statements audited by an independent registered public
accounting firm.
INCORPORATION
OF CERTAIN DOCUMENTS BY REFERENCE
We
file annual and special reports and other information with the SEC (File Number 001-36345). These filings contain important information
that does not appear in this prospectus. The SEC allows us to “incorporate by reference” information into this prospectus,
which means that we can disclose important information to you by referring you to other documents which we have filed or will file with
the SEC. We are incorporating by reference in this prospectus the documents listed below and all amendments or supplements we may file
to such documents, as well as any future filings we may make with the SEC on Form 20-F under the Exchange Act before the time that all
of the securities offered by this prospectus have been sold or de-registered:
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our
Annual Report on Form 20-F for the year ended December 31, 2023, filed with the SEC on April 4, 2024; |
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the
Company’s Reports on Form 6-K filed with the SEC on May
30, 2024, June
5, 2024, July
11, 2024, July
18, 2024, August
27, 2024, August
28, 2024, August
30, 2024, September
16, 2024, September
19, 2024, September
20, 2024, September
25, 2024, October
15, 2024, October
21, 2024, and November 14, 2024 (to the extent expressly incorporated by reference into our effective registration statements
filed by us under the Securities Act); and |
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The
description of our ordinary shares, which is contained in our registration statement on Form 8-A filed with the SEC pursuant
to the Exchange Act on March 11, 2014 (File No. 001-36345), as amended by Exhibit 2.1 to the Company’s Annual Report on Form 20-F for the fiscal year ended December 31, 2023, filed with the SEC on April 4, 2024. |
In
addition, any reports on Form 6-K submitted to the SEC by us pursuant to the Exchange Act after the date of the initial registration
statement and prior to effectiveness of the registration statement that we specifically identify in such forms as being incorporated
by reference into the registration statement of which this prospectus forms a part and all subsequent annual reports on Form 20-F filed
after the effective date of this registration statement and prior to the termination of this offering and any reports on Form 6-K subsequently
submitted to the SEC or portions thereof that we specifically identify in such forms as being incorporated by reference into the registration
statement of which this prospectus forms a part, shall be considered to be incorporated into this prospectus by reference and shall be
considered a part of this prospectus from the date of filing or submission of such documents.
As
you read the above documents, you may find inconsistencies in information from one document to another. If you find inconsistencies between
the documents and this prospectus, you should rely on the statements made in the most recent document. All information appearing in this
prospectus is qualified in its entirety by the information and financial statements, including the notes thereto, contained in the documents
incorporated by reference herein.
We
will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this
prospectus, other than exhibits to such documents which are not specifically incorporated by reference into such documents. Please direct
your written or telephone requests to us at Galmed Pharmaceuticals Ltd., c/o Meitar Law Offices, 16 Abba Hillel Silver Rd., Ramat Gan
5250608 Israel, Attention: Yohai Stenzler, Chief Accounting Officer, telephone number: +972-3-693-8448.
ENFORCEABILITY
OF CIVIL LIABILITIES
We
are incorporated under the laws of the State of Israel. Service
of process upon us and upon our directors and officers and the experts named in this prospectus, most of whom reside outside the United
States, may be difficult to obtain within the United States. Furthermore, because a major portion of our assets and most of our directors
and officers are located outside the United States, any judgment obtained in the United States against us or any of our directors and
officers may not be collectible within the United States.
We
have been informed by our legal counsel in Israel, Meitar | Law Offices, that it may be difficult to initiate an action with respect
to U.S. securities law in original actions instituted in Israel or obtain a judgement based
on the civil liability provisions of the U.S. federal securities laws. Israeli courts may refuse to hear a claim based on an alleged
violation of U.S. securities laws reasoning that Israel is not the most appropriate forum to hear such a claim. In addition, even if
an Israeli court agrees to hear a claim, it may determine that Israeli law and not U.S. law is applicable to the claim. If U.S. law is
found to be applicable, the content of applicable U.S. law must be proved as a fact by expert witnesses which can be a time-consuming
and costly process. Certain matters of procedure may also be governed by Israeli law.
Subject
to specified time limitations and legal procedures, an Israeli court may enforce a foreign judgment in a civil matter which, subject
to certain exceptions, is non-appealable, including judgments based upon the civil liability provisions of the Securities Act and the
Exchange Act and including a monetary or compensatory judgment in a non-civil matter, provided, among other things, it finds that:
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the
judgment was rendered by a court which was, according to the laws of the state of the court, competent to render the judgment, |
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the
obligation imposed by the judgment is enforceable according to the rules relating to the enforceability of judgments in Israel and
the substance of the judgment is not contrary to public policy, and |
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the
judgment is executory in the state in which it was given. |
Even
if the above conditions are satisfied, an Israeli court will not enforce a foreign judgment if:
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the
judgement was given in a state whose laws do not provide for the enforcement of judgments of Israeli courts (subject to exceptional
cases), |
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the
enforcement of the judgement is likely to prejudice the sovereignty or security of the State of Israel, |
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the
judgment was obtained by fraud, |
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the
opportunity given to the defendant to bring its arguments and evidence before the court was not reasonable in the opinion of the
Israeli court, |
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the
judgment was rendered by a court not competent to render it according to the laws of private international law in Israel, |
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the
judgment is at variance with another judgment that was given in the same matter between the same parties and which is still valid,
or |
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at
the time the action was brought in the foreign court a suit in the same matter and between the same parties was pending before a
court or tribunal in Israel. |
If
a foreign judgment is enforced by an Israel court, it generally will be payable in Israeli currency, which can then be converted into
non-Israeli currency and transferred out of Israel. The usual practice in an action before an Israeli court to recover an amount in a
non-Israeli currency is for the Israeli court to issue a judgment for the equivalent amount in Israeli currency at the rate of exchange
in force on the date of the judgment, but the judgment debtor may make payment in foreign currency. Pending collection, the amount of
the judgment of an Israeli court stated in Israeli currency ordinarily will be linked to the Israeli consumer price index plus interest
at the annual statutory rate set by Israeli regulations prevailing at the time. Judgment creditors must bear the risk of unfavorable
exchange rates.
Puglisi
& Associates is the U.S. agent authorized to receive service of process in any action against us arising out of this offering. The
address of Puglisi & Associates is 850 Library Avenue, Newark, Delaware 19711.
EXPENSES
We
are paying all of the expenses of the registration of our securities under the Securities Act, including, to the extent applicable, registration
and filing fees, printing and duplication expenses, administrative expenses, accounting fees and the legal fees of our counsel. The following
is a statement of estimated expenses at the present time in connection with the distribution of the securities registered hereby. All
amounts shown are estimates except the SEC registration fee and the FINRA filing fee. The estimates do not include expenses related to
offerings of particular securities. Each prospectus supplement describing an offering of securities will reflect the estimated expenses
related to the offering of securities under that prospectus supplement.
SEC registration fees | |
$ | 30,620 | |
FINRA filing fee | |
$ | 30,500 | |
Legal fees and expenses | |
$ | * | |
Accountants fees and expenses | |
$ | * | |
Printing Fees | |
$ | * | |
Miscellaneous | |
$ | * | |
Total | |
$ | * | |
* |
These
fees and expenses depend on the securities offered and the number of issuances and accordingly cannot be estimated at this time. |
$200,000,000
Prospectus
,
2024
The
information in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement
filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and is not soliciting
an offer to buy these securities in any state where the offer or sale is not permitted.
SUBJECT
TO COMPLETION, DATED NOVEMBER 14, 2024
PROSPECTUS
SUPPLEMENT
Up
to $8,100,000
Ordinary Shares
We
have entered into a Capital on Demand™ Sales Agreement with JonesTrading Institutional Services LLC, or Jones, dated November 14,
2024 or the Sales Agreement, relating to the sale of our ordinary shares, par value NIS 1.80 per share, offered by this prospectus
supplement and the accompanying prospectus. In accordance with the terms of the Sales Agreement, we may offer and sell our ordinary shares,
having an aggregate offering price of up to $8,100,000 from time to time through or to Jones as sales agent or principal.
Sales
of our ordinary shares, if any, under this prospectus supplement may be made in sales deemed to be “at the market offerings”
as defined in Rule 415 promulgated under the Securities Act of 1933, as amended, or the Securities Act. Jones is not required to sell
any specific number or dollar amount of securities but will act as a sales agent and will use commercially reasonable efforts consistent
with its normal trading and sales practices, on mutually agreed terms between Jones and us. There is no arrangement for funds to be received
in any escrow, trust or similar arrangement.
Jones
will be entitled to compensation at a commission rate of 3% of the aggregate gross sales price per share sold pursuant to the terms of
the Sales Agreement. See “Plan of Distribution” beginning on page S-12 for additional information regarding the compensation
to be paid to Jones, in connection with the sale of the ordinary shares on our behalf, Jones will be deemed to be an “underwriter”
within the meaning of the Securities Act, and the compensation of Jones will be deemed to be underwriting commissions or discounts. We
also have agreed to provide indemnification and contribution to Jones with respect to certain liabilities, including liabilities under
the Securities Act or the Exchange Act of 1934, as amended, or the Exchange Act.
Our
ordinary shares are traded on the Nasdaq Capital Market, or Nasdaq, under the symbols “GLMD”. The last reported sale price
for our ordinary shares on November 8, 2024 as quoted on Nasdaq was $2.97 per share.
The
highest aggregate market value of our outstanding ordinary shares held by non-affiliates within the 60 days prior to the filing date
of this prospectus supplement was approximately $24.3 million, based on 1,656,992 ordinary shares outstanding, of which 1,609,819
are held by non-affiliates, and the closing sale price of our ordinary shares on Nasdaq of $15.10 on September 17, 2024. Pursuant
to General Instruction I.B.5 of Form F-3, in no event will we sell, pursuant to the registration statement of which this prospectus supplement
forms a part, securities with a value exceeding one-third of the aggregate market value of our outstanding ordinary shares held by non-affiliates
in any 12 calendar month period, so long as the aggregate market value of our ordinary shares held by non-affiliates is less than $75.0
million. During the 12 calendar-month period that ends on, and includes, the date hereof, we have not sold any securities pursuant
to General Instruction I.B.5 of Form F-3.
Investing
in the ordinary shares involves a high degree of risk. Please carefully consider the risks discussed in this prospectus supplement under
“Risk Factors” beginning on page S-6 and the “Risk Factors” in “Item 3. Key Information—D. Risk Factors”
of our most recent Annual Report on Form 20-F incorporated by reference in this prospectus supplement and in any applicable prospectus
supplement for a discussion of the factors you should consider carefully before deciding to purchase the ordinary shares.
Neither
the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the ordinary shares being offered
by this prospectus supplement, or determined if this prospectus supplement is truthful or complete. Any representation to the contrary
is a criminal offense.
The
date of this prospectus is , 2024
TABLE
OF CONTENTS
Prospectus
Supplement
Prospectus
ABOUT
THIS PROSPECTUS SUPPLEMENT
This
prospectus supplement is part of a registration statement that we have filed with the Securities and Exchange Commission, or the SEC,
utilizing a shelf registration process. This prospectus supplement is not complete without, and may not be utilized except in
connection with, the accompanying prospectus. This prospectus supplement provides supplemental information regarding us and updates certain
information contained in the accompanying prospectus and describes the specific terms of this offering. The accompanying prospectus gives
more general information, some of which may not apply to this offering. We incorporate important information into this prospectus supplement
and the accompanying prospectus by reference.
This
prospectus relates to the offering of our ordinary shares. Before buying any of the ordinary shares offered hereby, we urge you to read
carefully this prospectus, together with the information incorporated herein by reference as described below under the heading “Incorporation
of Certain Documents by Reference.”.
You
should rely only on the information contained in, or incorporated by reference into, this prospectus. We have not, and Jones has not,
authorized anyone to provide you with different or additional information.
We
are not making offers to sell or solicitations to buy our ordinary shares in any jurisdiction in which an offer or solicitation is not
authorized or in which the person making that offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to
make an offer or solicitation.
This
prospectus supplement and the accompanying prospectus contain summaries of certain provisions contained in some of the documents described
herein, but reference is made to the actual documents for complete information. All of the summaries are qualified in their entirety
by the actual documents. Copies of some of the documents referred to herein have been filed, will be filed or will be incorporated herein
by reference as exhibits to the registration statement, and you may obtain copies of those documents as described below under the section
entitled “Where You Can Find More Information.”
We
further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document
that is incorporated by reference herein were made solely for the benefit of the parties to such agreement, including, in some cases,
for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation, warranty or
covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly, such
representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs.
This
prospectus contains and incorporates by reference market data and industry statistics and forecasts that are based on independent industry
publications and other publicly-available information. Although we believe these sources are reliable, we do not guarantee the accuracy
or completeness of this information and we have not independently verified this information. Although we are not aware of any misstatements
regarding the market and industry data presented in this prospectus or the documents incorporated herein by reference, these estimates
involve risks and uncertainties and are subject to change based on various factors, including those discussed under the headings “Risk
Factors” in this prospectus, and under similar headings in the other documents that are incorporated herein by reference. Accordingly,
investors should not place undue reliance on this information.
The
name of our product candidate, Aramchol™, is a registered trademark or trademark of Galmed Pharmaceuticals Ltd. in Israel, the
United States and/or other countries. All other trademarks, service marks or other tradenames appearing in this prospectus are the property
of their respective owners. Unless otherwise mentioned or unless the context requires otherwise, all references in this prospectus to
the “Company,” “Galmed,” “we,” “us,” “our” or similar references mean Galmed
Pharmaceuticals Ltd., a corporation formed under the laws of the State of Israel, and its subsidiaries.
Effective
August 29, 2024, we effected a 1-for-12 reverse share split, or the Reverse Split, of our authorized ordinary shares, including our issued
and outstanding ordinary shares, and the par value of each share was accordingly increased from NIS 0.15 per share to NIS 1.80 per share.
Unless specifically provided otherwise herein, the share and per share information that follows in this prospectus supplement, other
than in the historical financial statements and related notes included elsewhere in this prospectus, assumes the effect of the Reverse
Split.
PROSPECTUS
SUPPLEMENT SUMMARY
This
summary highlights certain information about us, this offering and selected information contained elsewhere in or incorporated by reference
into this prospectus. This summary is not complete and does not contain all of the information that you should consider before deciding
whether to invest in our ordinary shares. For a more complete understanding of our company and this offering, we encourage you to read
and consider carefully the more detailed information in this prospectus, including the information incorporated by reference in this
prospectus, and the information included in any free writing prospectus that we have authorized for use in connection with this offering,
including the information under the heading “Risk Factors” in this prospectus on page S-6.
Company
Overview
We
are a biopharmaceutical company focused on the development of Aramchol. We have focused almost exclusively on developing Aramchol for
the treatment of liver disease and have been developing Aramchol for PSC and exploring the feasibility of developing Aramchol for other
fibro-inflammatory and oncological indications outside of liver disease. We are also collaborating with the Hebrew University in the
development of Amilo-5MER, a 5 amino acid synthetic peptide.
We
believe that our lead product candidate, Aramchol, has the potential to be a disease modifying treatment for fatty liver disorders, including
NASH, which is a chronic disease that constitutes a large unmet medical need.
Aramchol
is a synthetic conjugate of 3-amino cholic acid, or a type of modified bile acid, and arachidic acid, or a type of saturated fatty acid,
which in its non-synthetic forms, is naturally occurring. The conjugated molecule acts upon important metabolic pathways, reducing fat
accumulation in the liver, improving fatty acid oxidation and regulating the transport of cholesterol. The ability of Aramchol to decrease
liver fat content may also reduce the inflammation and fibrosis in the liver and the risk of cardiovascular complications associated
with NASH. Pre-clinical studies suggest Aramchol’s effect on fibrosis is also direct via collagen production from human hepatic
stellate cells. We believe that Aramchol’s ability to reduce liver fat and liver fibrosis and the safety profile observed to date
will enable it to be a treatment for all stages of NASH in patients who are overweight or obese and have pre diabetes or type II diabetes
mellitus and prevent the hepatic complications associated therewith.
In
September 2019, we initiated our Phase 3 ARMOR Study to evaluate the efficacy and safety of Aramchol in subjects with NASH and fibrosis.
The ARMOR Study was originally comprised of two parts, a randomized, double-blind, placebo-controlled histology-based registrational
part and a clinically based part where subjects will continue with the same treatment for approximately five years. In December 2020,
we announced the addition of a 150-patient open label part to the ARMOR Study and suspended randomization of new patients into the double-blind,
placebo-controlled histology-based registrational part of ARMOR as all enrolled patients were transitioned to the open label part.
In
May 2022, we announced our plan to expand into new anti-fibrotic indications to maximize the potential of Aramchol while at the same
time discontinuing the open label part of its ARMOR Study having reached its objectives. Simultaneously, we initiated a cost reduction
plan and initiated a process to evaluate our strategic alternatives. Following the discontinuation of our open label part of the ARMOR
Study, we do not currently expect to initiate the second part of the ARMOR Study in the near term.
In
May 2023, we announced the initiation of a new clinical program to evaluate Aramchol meglumine for the treatment of PSC, a rare disease
for which there is no approved treatment. The randomized, double-blind, proof-of-concept clinical study (NCT06095986) will evaluate the
effects of 48 weeks of treatment with Aramchol meglumine vs. placebo in approximately 24 patients with PSC. The study’s endpoints
will include the conventional relevant laboratory parameters (alkaline phosphatase and bilirubin), sophisticated imaging including liver
stiffness using MR Elastography (MRE), imaging of the biliary tract using MR cholangiopancreatography, or MRCP, and hepatocyte-specific
contrast agents, histological fibrosis and molecular assessment as well as a range of biomarkers of disease activity and fibrosis. These
endpoints are expected to provide a robust assessment of the underlying disease and the effects of Aramchol.
While
PSC is more common in men, especially in Northern European heritage, and is often diagnosed between ages 30-40, we currently estimate
that the number of patients to be around 60,000, or 1 per 10,000, consisting of around 33,5000 patients in the United States and 32,500
patients collectively in France, Germany, Italy, Spain and the United Kingdom. In the preclinical stage, PSC likely involves ulcerative
colitis (UC) leading to biliary inflammation. As biliary fibrosis progresses to cirrhosis, it is coupled with complications and competing
risks, while about 50% of patients with PSC report clinical symptoms. While there are currently no approved drugs for the treatment of
PSC, there is a potential to gain orphan drug status.
We
initially planned to initiate a Phase 2 study in the last quarter of 2023 to evaluate Aramchol meglumine for the treatment of PSC. This
study was to be followed by a Phase 2b or a phase 2/3 confirmatory adaptive design trial. As a result of the outbreak of the Hamas-Israel
war, in November 2023, we determined that there would be a delay of seven to nine months in the initiation of the Phase 2 PSC study.
Currently, as we explore the feasibility of developing Aramchol for other indications, we do not currently have a timeline for the commencement
of the PSC trial we had been planning and can give no assurances that we will commence this trial.
As
PSC is a fibro-obliterative cholangiopathy where the disease progression is predominantly determined by biliary fibrosis, Aramchol meglumine
has been shown to downregulate Stearoyl-CoA desaturase 1 (SCD1), a key liver enzyme involved in lipid metabolism, attenuate fibrogenesis
by hepatic stellate cells (HSCs). Aramchol meglumine may have direct effects on cholangiocytes to reduce the production of fibrogenic
and inflammatory signals that activate HSCs suggesting that Aramchol meglumine may be beneficial in treating PSC.
In
addition, in May 2023, we entered into a definitive agreement, or the OnKai Agreement, for a $1.5 million equity investment in OnKai,
a US-based technology company developing an AI-based platform to advance healthcare for underserved populations across the United States
by facilitating alignment between healthcare stakeholders. The signing of the definitive agreement followed an announcement that we made
in January 2023 that we had entered into a non-binding termsheet for an equity investment in OnKai. The OnKai Agreement provided that
we will invest $1.5 million in exchange for series seed preferred shares of OnKai (which is in addition to a $1.5 million investment
that was made by us in OnKai through a Simple Agreement for Future Equity, or SAFE, and which converted at a 15% discount into series
seed preferred shares upon consummation of the Investment Round (as defined below)). Our investment in OnKai was part of an approximately
$6 million investment round, or the Investment Round, with other investors that was led by us of which SAFE notes of approximately $3.8
million were converted into preferred shares. On June 19, 2023, the Investment Round closed. Following the Investment Round, we hold
approximately 23.9% of the outstanding share capital of OnKai on an as-converted and fully diluted basis and our Chief Executive Officer
and director, Allen Baharaff serves as a board member of OnKai. In connection with the OnKai Agreement, our wholly-owned subsidiary,
Galmed Research and Development Ltd., or GRD, entered into a services agreement, or the OnKai Services Agreement, with OnKai. The OnKai
Services Agreement provides that GRD shall on a non-exclusive basis (i) provide support services to OnKai relating to finance, business
development, strategic planning, execution and others; and (ii) lend its experience to OnKai in building a strategy and for the development
of treatments for the underserved and that OnKai shall on a non-exclusive basis (i) take part in plan preparation to serve GDR’s
vision of developing drugs for the underserved population and (ii) when relevant, design a process on the clinical trial dashboard that
could potentially serve GDR’s future trial. See “Item 4. Information on the Company— Strategic Collaborations, Research
Arrangements and other Agreements—Onkai” in our Annual Report on Form 20-F for the fiscal year ended December 31, 2023, or
the 2023 Annual Report, for additional information. In July 2023, we announced that OnKai will apply its artificial intelligence models
for enrollment and execution of clinical trials in underserved communities, starting with our PSC clinical program.
In
September 2024, we announced that, based on the recently published results from the Phase 3 ARMOR Study, we planned to broaden our drug
development activities. The planned expansion consists of two additional programs over the next two years. One program aims to identify
novel Aramchol-based drug combinations to overcome resistance to standard-of-care oncological treatments for patients with advanced colorectal
and hepatic cancers. Another program aims to unravel new mechanisms of action that will allow the development of a novel Aramchol-based
drug combination targeting cardiac fibrosis, or scarring of the heart, which occurs in many cardiovascular diseases that can lead to
heart dysfunction and failure. We plan on releasing new data from in-vitro and ex-vivo studies in these programs during the fourth quarter
of 2024.
Recent
Developments
Exercise
of Warrants
As
of October 18, 2024, investors from our public offering in July 2023 exercised warrants to purchase 293,333 ordinary shares for aggregate
net proceeds of $4.4 million.
Standby
Equity Purchase Agreement with Yorkville
On
August 30, 2024, we entered into a Standby Equity Purchase Agreement, or the SEPA, with YA II PN, LTD., a Cayman Islands exempt limited
partnership, or YA.
Pursuant
to the SEPA, we have the right, but not the obligation, to sell to YA from time to time, each such occurrence also an Advance, up to
$10.0 million, or the Initial Commitment Amount, of our Ordinary Shares, during the 36 months following the execution of the SEPA, subject
to the restrictions and satisfaction of the conditions in the SEPA. On October 21, 2024, we and YA entered into an amendment to the SEPA
to increase the Initial Commitment Amount to $20.0 million of our Ordinary Shares. At our option, the Ordinary Shares would be purchased
by YA from time to time at a price equal to 97% of the lowest of the three daily VWAPs (as hereinafter defined) during a three consecutive
trading day period commencing on the date that we, subject to certain limitations, deliver a notice to YA that we are committing YA to
purchase such Ordinary Shares, or the Advance Shares. We may also specify a certain minimum acceptable price per share in each Advance.
“VWAP” means, for any trading day, the daily volume weighted average price of our Ordinary Shares for such trading day on
the Nasdaq Stock Market during regular trading hours as reported by Bloomberg L.P. As consideration for YA irrevocable commitment to
purchase our Ordinary Shares up to the Initial Commitment Amount, we agreed to issue 31,566 Ordinary Shares, or the Commitment Shares,
to YA and also paid a $15,000 structuring fee to an affiliate of YA. The Commitment Shares shall be issued in four equal installments,
of which 7,892 Commitment Shares were issued on the date of execution of the SEPA and the remaining 23,674 Commitment Shares will be
issued in three equal installments 90 calendar days following the due date of the immediately preceding installment until all four installments
have been issued. As of the date of this prospectus supplement, we have issued an aggregate of 150,000 ordinary shares to YA as
Advance Shares under the SEPA for aggregate gross proceeds of approximately $0.5 million.
Corporate
Information
Our
principal executive offices and registered office in Israel are located at c/o Meitar Law Offices, 16 Abba Hillel Silver Rd., Ramat Gan
5250608 Israel and our telephone number is +972-3-693-8448. Our website address is http://www.galmedpharma.com. The information contained
on, or that can be accessed through, our website is neither a part of nor incorporated into this prospectus. We have included our website
address in this prospectus solely as an inactive textual reference. Puglisi & Associates, or Puglisi, serves as our authorized representative
in the United States for certain limited matters. Puglisi’s address is 850 Library Avenue, Newark, Delaware 19711.
THE
OFFERING
Ordinary
shares offered by us |
|
Our
ordinary shares having an aggregate offering price of up to $8.1 million. |
|
|
|
Ordinary
shares to be outstanding after this offering |
|
Up
to 4,337,092 ordinary shares (as more fully described in the notes following this table), assuming sales of 2,727,273 ordinary shares
in this offering at an offering price of $2.97 per share, which was the last reported sale price of our ordinary shares on the Nasdaq
Capital Market on November 8, 2024. The actual number of ordinary shares issued will vary depending on the sales price under this
offering. |
|
|
|
Plan
of Distribution |
|
“At
the market offering” that may be made from time to time through or to Jones, as sales agent or principal. See “Plan of
Distribution” on page S-12. |
|
|
|
Use
of Proceeds |
|
We
currently intend to use the net proceeds from this offering for (i) further clinical and pre-clinical development of existing and
new programs, (ii) business development related activities and (iii) general corporate purposes. See “Use of Proceeds”
on page S-11. |
|
|
|
Risk
Factors |
|
Investing
in our ordinary shares involves significant risks. See “Risk Factors” on page S-6, and under similar headings in other
documents incorporated by reference into this prospectus. |
|
|
|
Nasdaq
Capital Market symbol |
|
GLMD |
The
number of the ordinary shares to be issued and outstanding immediately after this offering as shown above assumes that all of the ordinary
shares offered hereby are sold and is based on 1,656,992 ordinary shares issued and outstanding as of November 8, 2024. This number excludes:
|
● |
92,427
ordinary shares issuable upon exercise of outstanding stock options under our equity incentive plan, at a weighted average exercise
price of $168.02; |
|
|
|
|
● |
42,394 ordinary shares issuable upon the exercise of
RSUs under our equity incentive plan; |
|
|
|
|
● |
22,686
ordinary shares reserved for future awards under our equity incentive plan; |
|
|
|
|
● |
173,333
ordinary shares issuable upon the exercise of outstanding warrants, with exercise price
of $15.00 per ordinary share; and |
|
|
|
|
● |
23,674
ordinary shares that will be issued to YA as subsequent commitment shares pursuant to the SEPA. |
Unless
otherwise indicated, all information in this prospectus assumes or gives effect to:
|
● |
no
exercise of the options, RSU’s, warrants and pre-funded warrants described above; and |
|
|
|
|
● |
the
1-for-12 Reverse Split effected on August 29, 2024. |
RISK
FACTORS
Investing
in our securities involves significant risks. Before making an investment decision, you should carefully consider the risks described
below and under the section titled “Item 3. Key Information—D. Risk Factors” in our Annual Report on Form 20-F for
the year ended December 31, 2023, as well as the information included or incorporated by reference in this prospectus supplement and
the accompanying prospectus, together with all of the other information appearing in this prospectus supplement or the accompanying prospectus
or incorporated by reference herein or therein, including in light of your particular investment objectives and financial circumstances.
The risks so described are not the only risks we face. Additional risks not presently known to us or that we currently deem immaterial
may also impair our business operations and become material. Our business, financial condition and results of operations could be materially
adversely affected by any of these risks. The trading price of our securities could decline due to any of these risks, and you may lose
all or part of your investment. The discussion of risks includes or refers to forward-looking statements; you should read the explanation
of the qualifications and limitations on such forward-looking statements discussed elsewhere in this prospectus supplement under the
caption “Cautionary Statement Regarding Forward-Looking Statements” below.
Risks
Related to this Offering
Since
we have broad discretion in how we use the proceeds from this offering, we may use the proceeds in ways with which you disagree.
Our
management will have broad discretion in the allocation of the net proceeds and could use them for purposes other than those contemplated
at the time of this offering. Accordingly, you will be relying on the judgment of our management with regard to the use of those net
proceeds, and you will not have the opportunity, as part of your investment decision, to assess whether the proceeds are being used appropriately.
It is possible that, pending their use, we may invest those net proceeds in a way that does not yield a favorable, or any, return for
us. The failure of our management to use such funds effectively could have a material adverse effect on our business, financial condition,
operating results and cash flows.
The
actual number of ordinary shares we will sell under the Sales Agreement with Jones, as well as the price at which we may sell such ordinary
shares, at any one time or in total, is uncertain.
Subject
to certain limitations in the Sales Agreement with Jones and compliance with applicable law, we have the discretion to deliver placement
notices to Jones at any time throughout the term of the Sales Agreement. The number of ordinary shares that are sold by Jones after delivering
a placement notice will fluctuate based on the market price of the ordinary shares during the sales period and limits we set with Jones
In addition, the price at which ordinary shares are sold by Jones, from time to time, will be dependent on the market price of our ordinary
shares and, as a result, purchasers of our ordinary shares that are sold under the Sales Agreement may purchase such ordinary shares
at different prices. Because the price per share of each ordinary share sold will fluctuate during this offering, it is not currently
possible to predict the number of shares that will be sold or the gross proceeds to be raised in connection with those sales.
A
substantial number of our ordinary shares will be sold in this offering, and we may sell or issue additional ordinary shares in the future,
which could cause the price of the ordinary shares to decline.
Assuming
we will sell an aggregate of 2,727,273 ordinary shares during the term of the Sales Agreement with Jones, the underlying ordinary
shares represented thereby will equal approximately 165% of our outstanding ordinary shares as of the date of this prospectus
supplement. This sale and any future issuances or sales of a substantial number of ordinary shares or ordinary shares in the public market
or otherwise, including during this offering, or the perception that such issuances or sales may occur, could adversely affect the price
of the ordinary shares. We may issue a substantial number of ordinary shares in connection with the exercise of warrants and options
to purchase our ordinary shares, which are eligible for, or may become eligible for, unrestricted resale. Any sales or registration of
such shares in the public market or otherwise could reduce the prevailing market price for the ordinary shares, as well as make future
sales of equity securities by us less attractive or not feasible, thus limiting our capital resources.
You
may experience future dilution as a result of future equity offerings.
In
order to raise additional capital, we may in the future offer additional ordinary shares or other securities convertible into or exchangeable
for our ordinary shares, including during this offering. We cannot assure you that we will be able to sell ordinary shares or other securities
in any other offering at a price per share that is equal to or greater than the price per share paid by investors in this offering, and
investors purchasing ordinary shares or other securities in the future could have rights superior to existing shareholders. The price
per ordinary share at which we sell additional ordinary shares or other securities convertible into or exchangeable for our ordinary
shares in future transactions may be higher or lower than the price per ordinary share in this offering.
The
price of the ordinary shares may be volatile.
The
market price of the ordinary shares has fluctuated in the past. Consequently, the current market price of the ordinary shares may not
be indicative of future market prices, and we may be unable to sustain or increase the value of your investment in the ordinary shares.
The
ordinary shares offered hereby will be sold in “at the market offerings,” and investors who buy shares at different times
will likely pay different prices.
Investors
who purchase ordinary shares in this offering at different times will likely pay different prices, and so they may experience different
levels of dilution and different outcomes in their investment results. We will have discretion, subject to market demand, to vary the
timing, prices, and numbers of ordinary shares sold in this offering. In addition, subject to the final determination by our board of
directors, there is no minimum or maximum sales price for ordinary shares to be sold in this offering. Investors may experience a decline
in the value of the ordinary shares they purchase in this offering as a result of sales made at prices lower than the prices they paid.
Our
headquarters and other significant operations are located in Israel and, therefore, our results may be adversely affected by political,
economic and military instability in Israel.
Our
executive office is located in Ramat Gan, Israel. In addition, certain of our key employees, officers and directors are residents of
Israel. Accordingly, political, economic and military conditions in the Middle East may affect our business directly. Since the establishment
of the State of Israel in 1948, a number of armed conflicts have occurred between Israel and its neighboring countries and terrorist
organizations active in the region, including Hamas (an Islamist militia and political group in the Gaza Strip) and Hezbollah (an Islamist
militia and political group in Lebanon).
In
October 2023, Hamas terrorists infiltrated Israel’s southern border from the Gaza Strip and conducted a series of attacks on civilian
and military targets. Hamas also launched extensive rocket attacks on Israeli population and industrial centers located along Israel’s
border with the Gaza Strip and in other areas within the State of Israel. These attacks resulted in extensive deaths, injuries and kidnapping
of civilians and soldiers. Following the attack, Israel’s security cabinet declared war against Hamas and a military campaign against
these terrorist organizations commenced in parallel to their continued rocket and terror attacks. In addition, since the commencement
of these events, there have been continued hostilities along Israel’s northern border with Lebanon (with the Hezbollah terror organization)
and on other fronts from various extremist groups in the region, such as the Houthis in Yemen and various rebel militia groups in Syria
and Iraq. Israel has carried out a number of targeted strikes on sites belonging to these terror organizations and in October 2024, Israel
began limited ground operations against Hezbollah in Lebanon. In addition, Iran recently launched direct attacks on Israel involving
hundreds of drones and missiles and has threatened to continue to attack Israel. These situations may potentially escalate in the future
to more violent events which may affect Israel and us. Such clashes may escalate in the future into a greater regional conflict.
In
connection with the Israeli security cabinet’s declaration of war against Hamas and possible hostilities with other organizations,
several hundred thousand Israeli military reservists were drafted to perform immediate military service. Although many of such military
reservists have since been released, they may be called up for additional reserve duty, depending on developments in the war in Gaza
and along Israel’s other borders. While none of our employees in Israel have been called to active military duty, we rely on service
providers located in Israel and have entered into certain agreements with Israeli counterparties. Employees of such service providers
or contractual counterparties may be called for service in the current or future wars or other armed conflicts with Hamas as well as
the other pending or future armed conflicts in which Israel is or may become engaged, and such persons may be absent for an extended
period of time. As a result, our operations may be disrupted by such absences, which disruption may materially and adversely affect our
business and results of operations.
While
our executive offices are located in Ramat Gan, Israel, which is not near Israel’s borders where the main hostilities are currently
taking place and none of our employees have been called into military reserve duty, to help mitigate the effects of Israel’s war
with Hamas, we have taken several measures, including work-from-home measures and have a business continuity plan.
Disruptions
that could severely impact our business, clinical trials, and supply chains, include:
limitations
on employee resources that would otherwise be focused on the conduct of our business including because of military reserve duty call-ups
in the future that impact our employees and the affect the current war between Israel and Hamas on the productivity of our employees
and external partners; delays in necessary interactions with vendors, local regulators, and other important agencies and contractors
due to limitations in employee resources; and impacts from prolonged remote work arrangements, such as increased cybersecurity risks
and strains on our business continuity plans.
The
intensity and duration of Israel’s current war against Hamas and Hezbollah is difficult to predict, as are such war’s economic
implications on the Company’s business and operations, on Israel’s economy in general, on the trading price of shares of
our ordinary shares and could impact our ability to raise additional capital on a timely basis or at all. These events may be intertwined
with wider macroeconomic indications of a deterioration of Israel’s economic standing that may involve further downgrade in Israel’s
credit rating by rating agencies, which may have a material adverse effect on the Company and its ability to effectively conduct its
operations. The impact of the current war between Israel and Hamas may also have the effect of heightening many of the other risks described
in the “Risk Factors” section of our 2023 Annual Report.
In
addition, some countries around the world restrict doing business with Israel and Israeli companies, and additional countries may impose
restrictions on doing business with Israel and Israeli companies if hostilities in Israel or political instability in the region continue
or increase. In addition, there have been increased efforts by countries, activists and organizations to cause companies and consumers
to boycott Israeli goods and services. In addition, in January 2024 the International Court of Justice, or ICJ, issued an interim ruling
in a case filed by South Africa against Israel in December 2023, making allegations of genocide amid and in connection with the war in
Gaza, and ordered Israel, among other things, to take measures to prevent genocidal acts, prevent and punish incitement to genocide,
and take steps to provide basic services and humanitarian aid to civilians in Gaza. There are concerns that companies and businesses
will terminate, and may have already terminated, certain commercial relationships with Israeli companies following the ICJ decision.
The foregoing efforts by countries, activists and organizations, particularly if they become more widespread, as well as the ICJ rulings
and future rulings and orders of other tribunals against Israel (if handed), may materially and adversely impact our business, clinical
trials, and supply chains.
Furthermore,
following Hamas’ attack on Israel and Israel’s security cabinet declaration of war against Hamas, the Houthi movement, which
controls parts of Yemen has launched attacks on Israeli-controlled or owned ships in the Red Sea, resulting in shipping companies rerouting
their cargo ships or ceasing shipments to Israel in the case of the latter. The hostilities with Hamas, Hezbollah, the Houthi movement
and other terrorist organizations, include and may include terror, missile and drone attacks. In the event that our facilities are damaged
as a result of hostile actions, or hostilities otherwise disrupt our ongoing operations, our ability to deliver or provide products and
services in a timely manner to meet our contractual obligations towards customers and vendors could be materially and adversely affected.
Any hostilities involving Israel or the interruption or curtailment of trade between Israel and its present trading partners could have
a material adverse effect on our business and could make it more difficult for us to raise capital. Our insurance policies do not cover
losses that may occur as a result of events associated with war and terrorism. Although the Israeli government currently covers the reinstatement
value of direct damages that are caused by terrorist attacks or acts of war, we cannot assure you that this government coverage will
be maintained or that it will sufficiently cover our potential damages. Any losses or damages incurred by us could have a material adverse
effect on our business. Any armed conflicts or political instability in the region would likely negatively affect business conditions
and could harm our results of operations.
Finally,
political conditions within Israel may affect our operations. Israel has held five general elections between 2019 and 2022, and prior
to October 2023, the Israeli government pursued extensive changes to Israel’s judicial system, which sparked extensive political
debate and unrest. In response to such initiative, many individuals, organizations and institutions, both within and outside of Israel,
voiced concerns that the proposed changes may negatively impact the business environment in Israel including due to reluctance of foreign
investors to invest or transact business in Israel, as well as to increased currency fluctuations, downgrades in credit rating, increased
interest rates, increased volatility in security markets and other changes in macroeconomic conditions. To date, these initiatives have
been substantially put on hold. If such changes to Israel’s judicial system are again pursued by the government and approved by
the parliament, this may have an adverse effect on our business, our results of operations and our ability to raise additional funds,
if deemed necessary by our management and board of directors.
CAUTIONARY
NOTE REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus and documents incorporated by reference into this prospectus and the other documents we have filed with the SEC that are incorporated
herein by reference may contain “forward-looking statements” within the meaning of the safe harbor provisions of Section
27A of the Securities Act, Section 21E of the Exchange Act, and the Private Securities Litigation Reform Act of 1995. Forward-looking
statements can be identified by the use of forward-looking words such as “believe,” “expect,” “intend,”
“plan,” “may,” “should,” “anticipate,” “could,” “might,” “seek,”
“target,” “will,” “project,” “forecast,” “continue” or their negatives or
variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters.
These forward-looking statements may be included in, among other things, various filings made by us with the SEC, press releases or oral
statements made by or with the approval of one of our authorized executive officers. Forward-looking statements relate to anticipated
or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters
that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause our actual results to
differ materially from any future results expressed or implied by the forward-looking statements. Many factors could cause our actual
activities or results to differ materially from the activities and results anticipated in forward-looking statements, including, but
not limited to, the factors summarized below:
|
● |
the
timing and cost of our pivotal Phase 3 ARMOR trial, or the ARMOR Study, if re-initiated, or any other pre-clinical or clinical
trials for our product candidates, Aramchol and Amilo-5MER; |
|
● |
completion
and receiving favorable results of the ARMOR Study (if re-initiated) for Aramchol or any other
pre-clinical or clinical trial; |
|
|
|
|
● |
regulatory
action with respect to Aramchol or any other product candidate by the U.S. Food and Drug Administration, or FDA, the European Medicines
Authority, or EMA, or the Medicines and Healthcare Products Regulatory Agency, or the MHRA, including but not limited to acceptance
of an application for marketing authorization, review and approval of such application, and, if approved, the scope of the approved
indication and labeling; |
|
● |
the
commercial launch and future sales of Aramchol and any future product candidates; |
|
● |
our
ability to achieve favorable pricing for Aramchol or any other product candidate; |
|
● |
our
expectations regarding the commercial market for PSC, non-alcoholic steato-hepatitis, or NASH (also known as MASH), in patients or
any other targeted indication; |
|
● |
third-party
payor reimbursement for Aramchol, Amilo-5MER or any other product candidate; |
|
● |
our
estimates regarding anticipated capital requirements and our needs for additional financing; |
|
● |
market
adoption of Aramchol or any other product candidate by physicians and patients; |
|
● |
the
timing, cost or other aspects of the commercial launch of Aramchol or any other product candidate; |
|
● |
our
ability to obtain and maintain adequate protection of our intellectual property; |
|
|
|
|
● |
the
possibility that we may face third-party claims of intellectual property infringement; |
|
|
|
|
● |
our
ability to manufacture our product candidates in commercial quantities, at an adequate quality or at an acceptable cost; |
|
|
|
|
● |
our
ability to establish adequate sales, marketing and distribution channels;
|
|
● |
intense
competition in our industry, with competitors having substantially greater financial, technological, research and development, regulatory
and clinical, manufacturing, marketing and sales, distribution and personnel resources than we do; |
|
|
|
|
● |
the
development and approval of the use of Aramchol or any other product candidate for additional indications or in combination therapy; |
|
|
|
|
● |
our
expectations regarding licensing, acquisitions and strategic operations; |
|
|
|
|
● |
current
or future unfavorable economic and market conditions and adverse developments with respect to financial institutions and associated
liquidity risk; |
|
|
|
|
● |
security,
political and economic instability in the Middle East that could harm our business, including due to the recent attacks by Hamas
and other terrorist organizations from the Gaza Strip and elsewhere in the region and Israel’s war against them and military
hostilities with Hezbollah on the northern border of Israel; and |
|
|
|
|
● |
those
factors referred to in our most recent annual report on Form 20-F incorporated by reference herein in “Item 3. Key Information
- D. Risk Factors,” “Item 4. Information on the Company,” and “Item 5. Operating and Financial Review and
Prospects,” as well as in our most recent annual report on Form 20-F generally, which is incorporated by reference into this
prospectus supplement. |
We
believe these forward-looking statements are reasonable; however, these statements are only current predictions and are subject to known
and unknown risks, uncertainties and other factors that may cause our or our industry’s actual results, levels of activity, performance
or achievements to be materially different from those anticipated by the forward-looking statements. We discuss many of these risks in
Item 3.D. – “Risk Factors” in our most recent Annual Report on Form 20-F, or any updates in our Reports on Form 6-K.
Given these uncertainties, you should not rely upon forward-looking statements as predictions of future events.
All
forward-looking statements attributable to us or to any person acting on our behalf speak only as of the date hereof and are expressly
qualified in their entirety by the cautionary statements included in this prospectus supplement. We undertake no obligations to update
or revise forward-looking statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of
unanticipated events. In evaluating forward-looking statements, you should consider these risks and uncertainties. You should read this
prospectus supplement, the accompanying prospectus and the documents we have filed with the SEC that are incorporated by reference and
any free writing prospectus that we have authorized for use in connection with this offering completely and with the understanding that
our actual future results may be materially different from what we expect. We qualify all of the forward-looking statements in the foregoing
documents by these cautionary statements.
USE
OF PROCEEDS
The
amount of proceeds from this offering will depend upon the number of ordinary shares sold and the market price at which they are sold.
There can be no assurance that we will be able to sell any shares under or fully utilize the Sales Agreement with Jones.
We
estimate that the net proceeds to us from the sale of our ordinary shares offered hereby will be approximately $7.7 million, after
deducting sales agent’s fees and the estimated offering expenses payable by us and assuming that we sell all of the shares offered
hereunder.
We
intend to use the net proceeds from this offering for continued development of our pipeline products, as well as the advancement of
new programs, business development activities, and general corporate purposes. Although we have identified some potential uses of
the net proceeds to be received upon completion of this offering, we cannot specify these uses with certainty. Our management will
have broad discretion in the application of the net proceeds and could use them for purposes other than those contemplated as of the
date of this prospectus. Our shareholders may not agree with the manner in which our management chooses to allocate and spend the
net proceeds. Moreover, our management may use the net proceeds for corporate purposes that may not result in our being profitable
or increase our market value. Our expected use of net proceeds under the SEPA represents our current intentions based on our present
plans and business condition, which could change in the future as our plans and business conditions evolve. As of the date of this
prospectus, we cannot predict with certainty any or all of the particular uses for the net proceeds to be received under the SEPA,
or the amounts, if any, that we will actually spend on the uses set forth above. The amounts and timing of our actual use of the net
proceeds may vary depending on numerous factors, including our ability to obtain additional financing and changes we may make to our
development plan. As a result, our management will have broad discretion in the application of the net proceeds, which may include
uses not set forth above, and investors will be relying on our judgment regarding the application of the net proceeds from this
offering.
Pending
the use of the net proceeds from this offering as described above, we intend to invest the net proceeds in a variety of capital preservation
investments, short and intermediate term, interest-bearing, investment-grade instruments, U.S. government securities and highly rated
corporate debt securities, although our investment policy may change following the date of this prospectus supplement. It is possible
that, pending their use, we may invest the net proceeds in a way that does not yield a favorable, or any, return for us.
CAPITALIZATION
The
table below sets forth our capitalization and indebtedness as of September 30, 2024:
|
● |
on
an actual basis; |
|
|
|
|
● |
on
a pro forma basis, after giving effect to the issuance and sale of 150,000 ordinary shares as Advance Shares under the SEPA for gross
proceeds of approximately $0.5 million, as if such issuance and sale had occurred on September 30, 2024; and |
|
|
|
|
● |
on
a pro forma as adjusted basis, giving further effect to the sale of an aggregate of 2,727,273 ordinary shares at an assumed price
of $2.97 per ordinary share, the last reported sale price of our ordinary shares on November 8, 2024, for aggregate net proceeds
of approximately $7.9 million, after deducting sales agent fees and estimated aggregate offering expenses payable by us. |
The
pro forma and pro forma as adjusted amounts shown below are unaudited, represent management’s estimate, and their accounting treatment
has not completed. The information in this table should be read in conjunction with and is qualified by reference to the financial statements
and notes thereto and other financial information incorporated by reference into this prospectus supplement.
| |
As
of September 30, 2024 (unaudited) | |
(U.S.
dollars in thousands) | |
Actual | | |
Pro
Forma | | |
Pro
Forma
As Adjusted | |
Cash and cash equivalents | |
$ | 9,724 | | |
$ | 10,147 | | |
$ | 17,804 | |
| |
| | | |
| | | |
| | |
Shareholders’ equity: | |
| | | |
| | | |
| | |
Ordinary shares par value NIS 1.80 per share;
authorized 1,666,667; issued and outstanding 1,506,992 ordinary shares (actual) and 1,656,992 ordinary shares (as adjusted) | |
| 664 | | |
| 737 | | |
| 2,064 | |
Additional paid in capital | |
| 215,375 | | |
| 215,752 | | |
| 222,055 | |
Accumulated other comprehensive loss | |
| (342 | ) | |
| (342 | ) | |
| (342 | ) |
Accumulated deficit | |
| (197,260 | ) | |
| (197,260 | ) | |
| (197,260 | ) |
| |
| | | |
| | | |
| | |
Total shareholders’ equity | |
| 18,437 | | |
| 18,860 | | |
| 26,517 | |
The
number of the ordinary shares to be issued and outstanding immediately after this offering as shown above assumes that all of the ordinary
shares offered hereby are sold and is based on 1,506,992 ordinary shares issued and outstanding as of September 30, 2024. This number
excludes:
| ● | 92,427
ordinary shares issuable upon exercise of outstanding stock options under our equity incentive
plan, at a weighted average exercise price of $168.02; |
| | |
| ● | 73,055 ordinary shares issuable upon the exercise of RSUs under our equity
incentive plan; |
| | |
| ● | 22,686
ordinary shares reserved for future awards under our equity incentive plan; |
| | |
|
● |
173,333 ordinary shares issuable
upon the exercise of outstanding warrants, with exercise price of $15.0 per ordinary share; and |
|
|
|
|
● |
150,000
ordinary shares issued and issuable to YA pursuant to the SEPA, and (ii) 23,674 ordinary shares that will be issued to YA as subsequent
commitment shares pursuant to the SEPA. |
Unless
otherwise indicated, all information in this prospectus assumes or gives effect to:
| ● | no
exercise of the options, RSU’s, warrants and pre-funded warrants described above; and |
| | |
| ● | the
1-for-12 Reverse Split effected on August 29, 2024. |
PLAN
OF DISTRIBUTION
We
have entered into the Sales Agreement with Jones under which we may issue and sell up to $8.1 million of our ordinary shares from time
to time through or to Jones, acting as sales agent or principal. Sales of our ordinary shares, if any, under this prospectus supplement
will be made at market prices by any method deemed to be an “at the market offering” as defined in Rule 415(a)(4) under the
Securities Act.
Each
time that we wish to issue and sell our ordinary shares under the Sales Agreement, we will provide Jones with a placement notice describing
the amount of ordinary shares to be sold, the time period during which sales are requested to be made, any limitation on the amount of
ordinary shares that may be sold in any single day, any minimum price below which sales may not be made or any minimum price requested
for sales in a given time period and any other instructions relevant to such requested sales. Upon receipt of a placement notice, Jones,
acting as our sales agent, will use commercially reasonable efforts, consistent with its normal trading and sales practices and applicable
state and federal laws, rules and regulations and the rules of the Nasdaq Stock Market LLC, to sell our ordinary shares under the terms
and subject to the conditions of the placement notice and the Sales Agreement. We or Jones may suspend the offering of ordinary shares
pursuant to a placement notice upon notice and subject to other conditions.
Unless
the parties agree otherwise, settlement for sales of ordinary shares will occur on the first trading day following the date on
which any sales are made in return for payment of the net proceeds to us. There are no arrangements to place any of the proceeds of this
offering in an escrow, trust or similar account. Sales of our ordinary shares as contemplated in this prospectus supplement will be settled
through the facilities of The Depository Trust Company or by such other means as we and Jones may agree upon.
We
will pay Jones commissions for its services in acting as our sales agent in the sale of our ordinary shares pursuant to the Sales Agreement.
Jones will be entitled to compensation at a fixed commission rate of 3% of the gross proceeds from the sale of our ordinary shares on
our behalf pursuant to the Sales Agreement. We have also agreed to reimburse Jones for the fees and expenses of its legal counsel in
an amount not to exceed (a) $50,000 in connection with the Sales Agreement, (b) in an amount not to exceed $2,500 per calendar quarter
thereafter payable in connection with each Representation Date (as defined in the Sales Agreement) with respect to which we are obligated
to deliver a bringdown certificate (for which no waiver is applicable), and (c) in an amount not to exceed $10,000 for each program “refresh”
executed pursuant to the Sales Agreement.
We
estimate that the total expenses for this offering, excluding compensation payable to Jones and certain expenses reimbursable to Jones
under the terms of the Sales Agreement, will be approximately $150,000. The remaining sales proceeds, after deducting any expenses
payable by us and any transaction fees imposed by any governmental, regulatory, or self-regulatory organization in connection with the
sales, will equal our net proceeds for the sale of such ordinary shares.
Because
there are no minimum sale requirements as a condition to this offering, the actual total public offering price, commissions and net proceeds
to us, if any, are not determinable at this time. The actual dollar amount and number of ordinary shares we sell through this prospectus
supplement will be dependent, among other things, on market conditions and our capital raising requirements.
Jones
will provide written confirmation to us before the open on Nasdaq Stock Market LLC on the day following each day on which our ordinary
shares are sold under the Sales Agreement. Each confirmation will include the number of shares sold on that day, the aggregate gross
proceeds of such sales and the proceeds to us. In connection with the sale of the ordinary shares on our behalf, Jones will be deemed
to be an “underwriter” within the meaning of the Securities Act, and the compensation of Jones will be deemed to be underwriting
commissions or discounts. We have agreed to provide indemnification and contribution to Jones against certain civil liabilities, including
liabilities under the Securities Act.
Jones
will not engage in any market making activities involving our ordinary shares while the offering is ongoing under this prospectus supplement
if such activity would be prohibited under Regulation M or other anti-manipulation rules under the Securities Act. As our sales agent,
Jones will not engage in any transactions that stabilizes our ordinary shares.
The
offering of our ordinary shares pursuant to the Sales Agreement will terminate upon the earlier of (i) the sale of all ordinary shares
subject to the Sales Agreement and (ii) the termination of the sales agreement as permitted therein. We and Jones may each terminate
the sales agreement at any time upon three days’ prior notice.
This
summary of the material provisions of the Sales Agreement does not purport to be a complete statement of its terms and conditions.
Jones
and its affiliates may in the future provide various investment banking, commercial banking, financial advisory and other financial services
for us and our affiliates, for which services they may in the future receive customary fees. In the course of its business, Jones may
actively trade our securities for its own account or for the accounts of customers, and, accordingly, Jones may at any time hold long
or short positions in such securities.
This
prospectus supplement and the accompanying prospectus in electronic format may be made available on a website maintained by Jones, and
Jones may distribute the prospectus supplement and the accompanying prospectus electronically.
LEGAL
MATTERS
Certain
legal matters with respect to U.S. law will be passed upon for us by Greenberg Traurig, P.A., Tel Aviv, Israel and certain legal matters
with respect to Israeli law will be passed upon for us by Meitar | Law Offices, Ramat Gan, Israel. JonesTrading Institutional Services
LLC are being represented in connection with this offering by Ellenoff Grossman Scholle LLP, New York, New York.
EXPERTS
The
consolidated financial statements of the Company for the year ended December 31, 2023 incorporated in this prospectus by reference have
been audited by the accounting firm of Brightman Almagor Zohar & Co. (a member of Deloitte Touche Tohmatsu Limited), an independent
registered public accounting firm, as set forth in their report thereon, included therein, and incorporated herein by reference. Such
consolidated financial statements are incorporated herein by reference in reliance upon such report given on the authority of such firm
as experts in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
We
have filed with the SEC a registration statement on Form F-3, of which this prospectus supplement and the accompanying prospectus is
a part, for the ordinary shares offered by this prospectus. This prospectus supplement and the accompanying prospectus, including the
information incorporated by reference herein and therein, do not include all of the information contained in the registration statement.
You should refer to the registration statement and its exhibits for additional information.
We
file annual, quarterly and special reports, proxy statements and other information with the SEC. The SEC maintains an Internet site that
contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC. The
SEC’s Internet site can be found at www.sec.gov. In addition, we make available on or through our Internet site copies of these
reports as soon as reasonably practicable after we electronically file or furnish them to the SEC. Our Internet site can be found at
www.galmedpharma.investorroom.com/sec-filings. The information contained on, or that can be accessed through, our website is neither
a part of nor incorporated into this prospectus supplement.
INCORPORATION
OF CERTAIN INFORMATION BY REFERENCE
The
SEC allows us to incorporate by reference information into this document. This means that we can disclose important information to you
by referring you to another document filed separately with the SEC. The information incorporated by reference is considered to be a part
of this document, except for any information superseded by information that is included directly in this prospectus or incorporated by
reference subsequent to the date of this prospectus.
We
incorporate by reference the following documents or information that we have filed with the SEC:
|
● |
the
Company’s Annual Report on Form 20-F for the fiscal year ended December 31, 2023, filed with the SEC on April 4, 2024; |
|
|
|
|
● |
the
Company’s Reports on Form 6-K filed with the SEC on May
30, 2024, June
5, 2024, July
11, 2024, July
18, 2024, August
27, 2024, August
28, 2024, and August
30, 2024, September
16, 2024, September
19, 2024, September
20, 2024, September
25, 2024, October
15, 2024, October
21, 2024 and November 14, 2024 (to the extent expressly incorporated by reference into our effective registration statements
filed by us under the Securities Act); and |
|
|
|
|
● |
The
description of our ordinary shares, which is contained in our registration statement on Form 8-A filed with the SEC pursuant to the
Exchange Act on March 11, 2014 (File No. 001-36345), as amended by Exhibit 2.1 to the Company’s Annual Report on Form 20-F for
the fiscal year ended December 31, 2023, filed with the SEC on April 4, 2024. |
In
addition, any reports on Form 6-K submitted to the SEC by us pursuant to the Exchange Act after the date of the initial registration
statement and prior to effectiveness of the registration statement that we specifically identify in such forms as being incorporated
by reference into the registration statement of which this prospectus forms a part and all subsequent annual reports on Form 20-F filed
after the effective date of this registration statement and prior to the termination of this offering and any reports on Form 6-K subsequently
submitted to the SEC or portions thereof that we specifically identify in such forms as being incorporated by reference into the registration
statement of which this prospectus forms a part, shall be considered to be incorporated into this prospectus by reference and shall be
considered a part of this prospectus from the date of filing or submission of such documents.
As
you read the above documents, you may find inconsistencies in information from one document to another. If you find inconsistencies between
the documents and this prospectus, you should rely on the statements made in the most recent document. All information appearing in this
prospectus is qualified in its entirety by the information and financial statements, including the notes thereto, contained in the documents
incorporated by reference herein.
We
will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this
prospectus, other than exhibits to such documents which are not specifically incorporated by reference into such documents. Please direct
your written or telephone requests to us at Galmed Pharmaceuticals Ltd., c/o Meitar Law Offices, 16 Abba Hillel Silver Rd., Ramat Gan
5250608 Israel, Attention: Yohai Stenzler, Chief Accounting Officer, telephone number: +972-3-693-8448.
Up
to 8,100,000
Ordinary
Shares
PROSPECTUS
SUPPLEMENT
,
2024
PART
II
INFORMATION
NOT REQUIRED IN PROSPECTUS
Item
8. Indemnification of Directors and Officers
Under
the Israeli Companies Law, 5759-1999, or the Companies Law, a company may not exculpate an office holder from liability for a breach
of the duty of loyalty. An Israeli company may exculpate an office holder in advance from liability to the company, in whole or in part,
for damages caused to the company as a result of a breach of the duty of care but only if a provision authorizing such exculpation is
included in its articles of association. Our Articles include such a provision. The Company may not exculpate in advance a director from
liability arising out of a prohibited dividend or distribution to shareholders.
Under
the Companies Law and the Israeli Securities Law, 5728-1968, or the Securities Law, a company may indemnify, or undertake in advance
to indemnify, an office holder for the following liabilities and expenses, imposed on office holder or incurred by office holder due
to acts performed by him or her as an office holder, provided its articles of association include a provision authorizing such indemnification:
|
● |
monetary
liability incurred by or imposed on him or her in favor of another person pursuant to a judgment, including a settlement or arbitrator’s
award approved by a court. However, if an undertaking to indemnify an office holder with respect to such liability is provided in
advance, then such an undertaking must be limited to events which, in the opinion of the board of directors, can be foreseen based
on the company’s activities when the undertaking to indemnify is given, and to an amount or according to criteria determined
by the board of directors as reasonable under the circumstances, and such undertaking shall detail the abovementioned foreseen events
and amount or criteria; |
|
● |
reasonable
litigation expenses, including attorneys’ fees, incurred by the office holder as a result of an investigation or proceeding
instituted against him or her by an authority authorized to conduct such investigation or proceeding, provided that (i) no indictment
was filed against such office holder as a result of such investigation or proceeding; and (ii) no financial liability was imposed
upon him or her as a substitute for the criminal proceeding as a result of such investigation or proceeding or, if such financial
liability was imposed, it was imposed with respect to an offense that does not require proof of criminal intent or as a monetary
sanction; |
|
● |
a
monetary liability imposed on him or her in favor of an injured party at an Administrative Procedure (as defined below) pursuant
to Section 52(54)(a)(1)(a) of the Securities Law; |
|
● |
expenses
incurred by an office holder in connection with an Administrative Procedure under the Securities Law, including reasonable litigation
expenses and reasonable attorneys’ fees; and |
|
● |
reasonable
litigation expenses, including attorneys’ fees, incurred by the office holder or imposed by a court in proceedings instituted
against him or her by the company, on its behalf, or by a third-party, or in connection with criminal proceedings in which the office
holder was acquitted, or as a result of a conviction for an offense that does not require proof of criminal intent. |
|
● |
An
“Administrative Procedure” is defined as a procedure pursuant to chapters H3 (Monetary Sanction by the Israeli Securities
Authority), H4 (Administrative Enforcement Procedures of the Administrative Enforcement Committee) or I1 (Arrangement to prevent
Procedures or Interruption of procedures subject to conditions) to the Securities Law. |
Under
the Companies Law and the Securities Law, a company may insure an office holder against the following liabilities incurred for acts performed
by him or her as an office holder if and to the extent provided in the company’s articles of association:
|
● |
a
breach of the duty of loyalty to the company, provided that the office holder acted in good faith and had a reasonable basis to believe
that such act would not prejudice the company; |
|
● |
a
breach of the duty of care to the company or to a third-party; |
|
● |
a
monetary liability imposed on the office holder in favor of a third-party; |
|
● |
a
monetary liability imposed on the office holder in favor of an injured party at an Administrative Procedure pursuant to Section 52(54)(a)(1)(a)
of the Securities Law; and |
|
● |
expenses
incurred by an office holder in connection with an Administrative Procedure, including reasonable litigation expenses and reasonable
attorneys’ fees. |
Nevertheless,
under the Companies Law, a company may not indemnify, exculpate or insure an office holder against any of the following:
|
● |
a
breach of the duty of loyalty, except for indemnification and insurance for a breach of the duty of loyalty to the company in the
event office holder acted in good faith and had a reasonable basis to believe that the act would not prejudice the company; |
|
● |
a
breach of the duty of care committed intentionally or recklessly, excluding a breach arising out of the negligent conduct of the
office holder; |
|
● |
an
act or omission committed with intent to derive unlawful personal benefit; or |
|
● |
a
fine, monetary sanction, penalty or forfeit levied against the office holder. |
Under
the Companies Law, exculpation, indemnification and insurance of office holders require the approval of the remuneration committee, board
of directors and, in certain circumstances, the shareholders, as described under “Item 6 — Directors, Senior Management and
Employees—B. Compensation” in our Annual Report on Form 20-F for the fiscal year ended December 31, 2023, as filed with the
SEC on April 4, 2024.
Our
Articles permit us to exculpate, indemnify and insure our office holders to the fullest extent permitted by the Companies Law and Securities
Law. Each of our office holders have entered into an indemnification agreement exculpating them, to the fullest extent permitted by Israeli
law, from liability to us for damages caused to us as a result of a breach of the duty of care and undertaking to indemnify them to the
fullest extent permitted by Israeli law, including with respect to liabilities resulting from certain acts performed by such office holders
in their capacity as an office holder of the Company, our subsidiaries or our affiliates. The indemnification is limited both in terms
of amount and coverage.
In
the opinion of the SEC, indemnification of directors and office holders for liabilities arising under the Securities Act, however, is
against public policy and therefore unenforceable.
Item
9. Exhibits
|
* |
To
be filed by amendment or by a report filed under the Securities Exchange Act of 1934, as amended, and incorporated herein by reference,
if applicable |
|
|
|
|
** |
Filed
herewith. |
|
|
|
|
*** |
To
be filed separately under the electronic form type 305B2, if applicable. |
|
|
|
|
(1) |
Incorporated
herein by reference to Amendment No. 1 to the Registration Statement on Form F-1 filed with the SEC on February 28, 2014. |
Item
10. Undertakings
(a)
The undersigned registrant hereby undertakes:
|
(1) |
To
file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement: |
i.
To include any prospectus required by section 10(a)(3) of the Securities Act of 1933;
ii.
To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-
effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in
the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the “Calculation
of Registration Fee” table in the effective registration statement;
iii.
To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or
any material change to such information in the registration statement;
provided,
however, that paragraphs (a)(1)(i), (a)(1)(ii) and a(l)(iii) do not apply if the registration statement is on Form S-3 or Form F-3 and
the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished
to the SEC by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the registration
statement.
|
(2) |
That
for the purpose of determining any liability under the Securities Act of 1933, each post-effective amendment that contains a form
of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and this offering of
such securities at that time shall be deemed to be the initial bona fide offering thereof. |
|
(3) |
To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering. |
|
(4) |
To
file a post-effective amendment to the registration statement to include any financial statements required by Item 8.A. of Form 20-F
at the start of any delayed offering or throughout a continuous offering. Financial statements and information otherwise required
by Section 10(a)(3) of the Act need not be furnished, provided that the registrant includes in the prospectus, by means of a post-effective
amendment, financial statements required pursuant to this paragraph (a)(4) and other information necessary to ensure that all other
information in the prospectus is at least as current as the date of those financial statements. Notwithstanding the foregoing, with
respect to registration statements on Form F-3, a post-effective amendment need not be filed to include financial statements and
information required by Section 10(a)(3) of the Act or Rule 3-19 of this chapter if such financial statements and information are
contained in periodic reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the Form F-3. |
|
(5) |
That,
for the purpose of determining liability under the Securities Act to any purchaser: |
|
i |
If
the registrant is relying on Rule 430B: |
|
(A) |
Each
prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the
date the filed prospectus was deemed part of and included in the registration statement; and |
|
(B) |
Each
prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5) or (b)(7) as part of a registration statement in reliance on Rule
430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii) or (x) for the purpose of providing the information required
by section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier
of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in
the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at
that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities
in the registration statement to which the prospectus relates, and the offering of such securities at that time shall be deemed to
be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that
is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration
statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior
to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part
of the registration statement or made in any such document immediately prior to such effective date. |
|
ii. |
If
the registrant is subject to Rule 430C, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating
to an offering, other than registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A,
shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness. Provided,
however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a
document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration
statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that
was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately
prior to such date of first use. |
|
(6) |
That,
for the purpose of determining liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution
of the securities: |
The
undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration
statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold
to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will
be considered to offer or sell such securities to such purchaser:
|
i. |
Any
preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule
424; |
|
ii. |
Any
free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by
the undersigned registrant; |
|
iii. |
The
portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant
or its securities provided by or on behalf of the undersigned registrant; and |
|
iv. |
Any
other communication that is an offer in the offering made by the undersigned registrant to the purchaser. |
|
(b) |
The
undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing
of the registrant’s annual report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act of 1934 (and, where
applicable, each filing of an employee benefit plan’s annual report pursuant to section 15(d) of the Securities Exchange Act
of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof. |
|
(h) |
Insofar
as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the registrant pursuant to the provisions described in Item 10 hereof, or otherwise, the registrant has been advised that
in the opinion of the SEC such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will,
unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final
adjudication of such issue. |
|
(j) |
The
undersigned registrant hereby undertakes to file an application for the purpose of determining the eligibility of the trustee to
act under subsection (a) of section 310 of the Trust Indenture Act (“Act”) in accordance with the rules and regulations
prescribed by the Commission under section 305(b)(2) of the Act. |
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form F-3 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunder duly authorized, in the city of Ramat Gan, State of Israel, on November 14, 2024.
|
GALMED
PHARMACEUTICALS LTD. |
|
|
|
|
By: |
/s/
Allen Baharaff |
|
|
Allen
Baharaff |
|
|
President
and Chief Executive Officer |
POWER
OF ATTORNEY
Each
person whose signature appears below hereby constitutes and appoints each of Allen Baharaff and Yohai Stenzler, acting alone, his true
and lawful attorney-in-fact and agent, with full power of substitution and resubstitution for him and in his name, place and stead, in
any and all capacities, to sign any or all amendments or supplements to this registration statement, whether pre-effective or post-effective
and any and all additional registration statements pursuant to Rule 462(b) of the Securities Act of 1933, as amended, and to file the
same with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto
said attorney-in-fact and agent full power and authority to do and perform each and every act and thing necessary or appropriate to be
done with respect to this registration statement or any amendments or supplements hereto or any and all additional registration statements
pursuant to Rule 462(b) of the Securities Act of 1933, as amended, in the premises, as fully to all intents and purposes as he might
or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may
lawfully do or cause to be done by virtue thereof.
Pursuant
to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons in the
capacities and on the dates indicated.
Signature |
|
Title |
|
Date |
|
|
|
|
|
/s/
Allen Baharaff |
|
Chief
Executive Officer, President, Director |
|
November
14, 2024 |
Allen
Baharaff |
|
(Principal
Executive Officer) |
|
|
|
|
|
|
|
/s/
Doron Cohen |
|
Chief
Financial Officer |
|
November
14, 2024 |
Doron
Cohen |
|
(Principal
Financial Officer) |
|
|
|
|
|
|
|
/s/
Yohai Stenzler |
|
Chief
Accounting Officer |
|
November
14, 2024 |
Yohai
Stenzler |
|
(Principal
Accounting Officer) |
|
|
|
|
|
|
|
/s/
David Sidransky, M.D. |
|
Director |
|
November
14, 2024 |
David
Sidransky, M.D. |
|
|
|
|
|
|
|
|
|
/s/
Shmuel Nir |
|
Director |
|
November
14, 2024 |
Shmuel
Nir |
|
|
|
|
|
|
|
|
|
/s/
Amir Poshinski |
|
Director |
|
November
14, 2024 |
Amir
Poshinski |
|
|
|
|
|
|
|
|
|
/s/
Carol L. Brosgart, M.D. |
|
Director |
|
November
14, 2024 |
Carol
L. Brosgart, M.D |
|
|
|
|
AUTHORIZED
REPRESENTATIVE
Pursuant
to the Securities Act of 1933, the undersigned, the duly authorized representative in the United States of Galmed Pharmaceuticals Ltd.
has signed this registration statement in the city of Newark, the State of Delaware, on November 14, 2024.
|
Puglisi
& Associates |
|
|
|
|
By:
|
/s/
Donald J. Puglisi |
|
Name: |
Donald J. Puglisi |
|
Title: |
Authorized Representative |
Exhibit
1.2
Galmed
Pharmaceuticals Ltd.
Ordinary
Shares
(NIS
1.80 par value per share)
Capital
on Demand™ Sales Agreement
November
14, 2024
JonesTrading
Institutional Services LLC
325
Hudson Street., 6th Floor
New
York, NY 10013
Ladies
and Gentlemen:
Galmed
Pharmaceuticals Ltd., a company organized under the laws of the State of Israel (the “Company”), confirms its agreement
(this “Agreement”) with JonesTrading Institutional Services LLC (the “Agent”), as follows:
1.
Issuance and Sale of Shares. The Company agrees that, from time to time during the term of this Agreement, on the terms and subject
to the conditions set forth herein, it may issue and sell through or to the Agent, as agent or principal, ordinary shares (the “Placement
Shares”) of the Company, NIS 1.80 par value per share (the “Ordinary Shares”), provided, however,
that in no event shall the Company issue or sell, through or to the Agent, Placement Shares for an aggregate gross sales proceeds that
would exceed (a) the dollar amount of the Ordinary Shares registered on the Registration Statement (as defined below), (b) the number
of authorized but unissued Ordinary Shares, or (c) the dollar amount of the Ordinary Shares permitted to be sold under Form F-3, including
General Instruction I.B.5 of Form F-3, or (iv) the dollar amount of the Ordinary Shares for which the Company has filed a Prospectus
or Prospectus Supplement (each as defined below) (the least of (i), (ii), (iii) and (iv), the “Maximum Amount”). Notwithstanding
anything to the contrary contained herein, the parties hereto agree that compliance with the limitations set forth in this Section 1
on the amount of Placement Shares issued and sold under this Agreement shall be the sole responsibility of the Company and that Agent
shall have no obligation in connection with such compliance. The issuance and sale of Placement Shares hereunder will be effected pursuant
to the Registration Statement and at no earlier time than such time as the Registration Statement shall have been declared effective
by the Securities and Exchange Commission (the “Commission”), although nothing in this Agreement shall be construed
as requiring the Company to issue any Placement Shares.
As
of the date hereof, the Company has filed, or will file, in accordance with the provisions of the Securities Act of 1933, as amended,
and the rules and regulations thereunder (the “Securities Act”), with the Commission a registration statement on Form
F-3, including a base prospectus, relating to certain securities, including the Placement Shares to be issued from time to time by the
Company, and which incorporates by reference documents that the Company has filed or will file in accordance with the provisions of the
Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder (the “Exchange Act”). The Company
has prepared a prospectus or prospectus supplement to the base prospectus included as part of the registration statement specifically
relating to the Placement Shares (the “Prospectus Supplement”). The Company will furnish to the Agent, for use by
the Agent, copies of the base prospectus included as part of such registration statement, as supplemented by the Prospectus Supplement,
relating to the Placement Shares. Except where the context otherwise requires, such registration statement, and any post-effective amendment
thereto, including all documents filed as part thereof or incorporated by reference therein, and including any information contained
in a Prospectus (as defined below) subsequently filed with the Commission pursuant to Rule 424(b) under the Securities Act or deemed
to be a part of such registration statement pursuant to Rule 430B or 462(b) under the Securities Act or any subsequent registration statement
on Form F-3 filed pursuant to Rule 415(a)(6) under the Securities Act by the Company to cover any Placement Shares, as a result of the
end of the three-year period described in Rule 415(a)(5) of the Securities Act, is herein called the “Registration Statement.”
The base prospectus, including all documents incorporated therein by reference, to the extent such information has not been superseded
or modified in accordance with Rule 412 under the Securities Act (as qualified by Rule 430B(g) of the Securities Act), included in the
Registration Statement, as it may be supplemented by one or more prospectus supplements, in the form in which such Prospectus Supplement
has most recently been filed by the Company with the Commission pursuant to Rule 424(b) under the Securities Act, together with any then
issued Issuer Free Writing Prospectus (defined below), is herein called the “Prospectus.”
Any
reference herein to the Registration Statement, any Prospectus Supplement, the Prospectus or any Issuer Free Writing Prospectus shall
be deemed to refer to and include the documents, if any, incorporated by reference therein (the “Incorporated Documents”),
including, unless the context otherwise requires, the documents, if any, filed as exhibits to such Incorporated Documents. Any reference
herein to the terms “amend,” “amendment” or “supplement” with respect to the Registration Statement,
the Prospectus Supplement, the Prospectus or any Issuer Free Writing Prospectus shall be deemed to refer to and include the filing of
any document under the Exchange Act on or after the most-recent effective date of the Registration Statement, or the date of the Prospectus,
Prospectus Supplement or such Issuer Free Writing Prospectus, as the case may be, and incorporated therein by reference. For purposes
of this Agreement, all references to the Registration Statement, the Prospectus or to any amendment or supplement thereto shall be deemed
to include the most recent copy filed with the Commission pursuant to its Electronic Data Gathering Analysis and Retrieval system, or
if applicable, the Interactive Data Electronic Application system when used by the Commission (collectively, “EDGAR”).
2.
Placements. Each time that the Company wishes to issue and sell Placement Shares hereunder (each, a “Placement”),
it will notify the Agent by email notice (or other method mutually agreed to in writing by the parties) of the number or dollar value
of Placement Shares to be issued, the time period during which sales are requested to be made, any limitation on the number of Placement
Shares that may be sold in any one Trading Day and any minimum price below which sales may not be made (a “Placement Notice”),
the form of which is attached hereto as Schedule 1. The Placement Notice shall originate from any of the individuals from the
Company set forth on Schedule 3 (with a copy to each of the other individuals from the Company listed on such schedule), and shall
be addressed to each of the individuals from the Agent set forth on Schedule 3, as such Schedule 3 may be amended from
time to time. The Placement Notice shall be effective unless and until (i) the Agent notifies the Company that the Agent declines to
accept the terms contained therein for any reason, in its sole discretion, (ii) the entire amount of the Placement Shares thereunder
have been sold, (iii) the Company suspends or terminates the Placement Notice, (iv) the Company issues a subsequent Placement Notice
with parameters superseding those of the earlier-dated Placement Notice, or (iv) this Agreement has been terminated under the provisions
of Section 12. The amount of any discount, commission or other compensation to be paid by the Company to the Agent in connection
with the sale of the Placement Shares shall be calculated in accordance with the terms set forth in Schedule 2. It is expressly
acknowledged and agreed that neither the Company nor the Agent will have any obligation whatsoever with respect to a Placement or any
Placement Shares unless and until the Company delivers a Placement Notice to the Agent and the Agent does not decline (and the Company
does not suspend or terminate in accordance with the terms of this Agreement) such Placement Notice pursuant to the terms set forth above,
and then only upon the terms specified therein and herein. In the event of a conflict between the terms of this Agreement and the terms
of a Placement Notice, the terms of the Placement Notice will control with respect to the matters covered thereby.
3.
Sale of Placement Shares by the Agent. Subject to the provisions of Section 5(a), the Agent, for the period specified in
the Placement Notice, will use its commercially reasonable efforts consistent with its normal trading and sales practices and applicable
state and federal laws, rules and regulations and the rules of the Nasdaq Stock Market LLC (the “Exchange”), to sell
the Placement Shares up to the amount specified in, and otherwise in accordance with the terms of such Placement Notice. The Agent will
provide written confirmation to the Company no later than the opening of the Trading Day immediately following the Trading Day on which
it has made sales of Placement Shares hereunder setting forth the number of Placement Shares sold on such day, the compensation payable
by the Company to the Agent pursuant to Section 2 with respect to such sales, and the Net Proceeds (as defined below) payable
to the Company, with an itemization of the deductions made by the Agent (as set forth in Section 5(b)) from the gross proceeds
that it receives from such sales. Subject to the terms of the Placement Notice, the Agent may sell Placement Shares by any method permitted
by law deemed to be an “at the market offering” as defined in Rule 415(a)(4) under the Securities Act, including sales made
directly on or through the Exchange or any other existing trading market for the Ordinary Shares, in negotiated transactions at market
prices prevailing at the time of sale or at prices related to such prevailing market prices and/or any other method permitted by law.
4.
Suspension of Sales.
(a)
The Company or the Agent may, upon notice to the other party in writing (including by email correspondence to each of the individuals
of the other party set forth on Schedule 3, if receipt of such correspondence is actually acknowledged by any of the individuals
to whom the notice is sent, other than via auto-reply) or by telephone (confirmed immediately by verifiable facsimile transmission or
email correspondence to each of the individuals of the other party set forth on Schedule 3), suspend any sale of Placement Shares;
provided, however, that such suspension shall not affect or impair any party’s obligations with respect to any Placement
Shares sold hereunder prior to the receipt of such notice. Each party agrees that no such notice under this Section 4 shall be effective
against any other party unless it is made to one of the individuals named on Schedule 3 hereto as associated with such other party,
as such Schedule may be amended in writing from time to time. Notwithstanding any other provision of this Agreement, during any period
in which the Company is in possession of material non-public information, the Company and the Agent agree that (i) no sale of Placement
Shares will take place, (ii) the Company shall not request the sale of any Placement Shares and shall suspend or cancel any effective
Placement Notices instructing the Agent to make any sales, and (iii) the Agent shall not be obligated to sell or offer to sell any Placement
Shares.
5.
Sale and Delivery to the Agent; Settlement.
(a)
Sale of Placement Shares. On the basis of the representations and warranties herein contained and subject to the terms
and conditions herein set forth, upon the Agent’s acceptance of the terms of a Placement Notice, and unless the sale of the Placement
Shares described therein has been declined, suspended, or otherwise terminated in accordance with the terms of this Agreement, the Agent,
for the period specified in the Placement Notice, will use its commercially reasonable efforts consistent with its normal trading and
sales practices and applicable law and regulations and the rules of the Exchange to sell such Placement Shares up to the amount specified,
and otherwise in accordance with the terms of such Placement Notice. The Company acknowledges and agrees that (i) there can be no assurance
that the Agent will be successful in selling Placement Shares, (ii) the Agent will incur no liability or obligation to the Company or
any other person or entity if it does not sell Placement Shares for any reason other than a failure by the Agent to use its commercially
reasonable efforts consistent with its normal trading and sales practices and applicable law and regulations to sell such Placement Shares
as required under this Agreement and (iii) the Agent shall be under no obligation to purchase Placement Shares on a principal basis pursuant
to this Agreement, except as otherwise agreed by the Agent and the Company.
(b)
Settlement of Placement Shares. Unless otherwise specified in the applicable Placement Notice, settlement for sales of
Placement Shares will occur on the first (1st) Trading Day (or such earlier day as is industry practice for regular-way trading)
following the date on which such sales are made (each, a “Settlement Date”). The amount of proceeds to be delivered
to the Company on a Settlement Date against receipt of the Placement Shares sold (the “Net Proceeds”) will be equal
to the aggregate sales price received by the Agent, after deduction for (i) the Agent’s commission, discount or other compensation
for such sales payable by the Company pursuant to Section 2 hereof, and (ii) any transaction fees imposed by any governmental or self-regulatory
organization in respect of such sales.
(c)
Delivery of Placement Shares. On or before each Settlement Date, the Company will, or will cause its transfer agent to, electronically
transfer the Placement Shares being sold by crediting the Agent’s or its designee’s account (provided the Agent shall have
given the Company written notice of such designee at least one Trading Day prior to the Settlement Date) at The Depository Trust Company
through its Deposit and Withdrawal at Custodian System or by such other means of delivery as may be mutually agreed upon by the parties
hereto which in all cases shall be freely tradable, transferable, registered shares in good deliverable form. On each Settlement Date,
the Agent will deliver the related Net Proceeds in same day funds to an account designated by the Company on, or prior to, the Settlement
Date. The Company agrees that if the Company, or its transfer agent (if applicable), defaults in its obligation to deliver Placement
Shares on a Settlement Date through no fault of the Agent, the Company agrees that in addition to and in no way limiting the rights and
obligations set forth in Section 10(a) hereto, it will (i) hold the Agent harmless against any loss, claim, damage, or expense (including
reasonable and documented legal fees and expenses), as incurred, arising out of or in connection with such default by the Company or
its transfer agent (if applicable) and (ii) pay to the Agent (without duplication) any commission, discount, or other compensation to
which it would otherwise have been entitled absent such default.
(d)
Limitations on Offering Size. Under no circumstances shall the Company cause or request the offer or sale of any Placement
Shares if, after giving effect to the sale of such Placement Shares, the aggregate gross sales proceeds of Placement Shares sold pursuant
to this Agreement would exceed the lesser of (A) together with all sales of Placement Shares under this Agreement, the Maximum Amount
and (B) the amount authorized from time to time to be issued and sold under this Agreement by the Company’s board of directors,
a duly authorized committee thereof or a duly authorized executive committee, and notified to the Agent in writing. Under no circumstances
shall the Company cause or request the offer or sale of any Placement Shares pursuant to this Agreement at a price lower than the minimum
price authorized from time to time by the Company’s board of directors, a duly authorized committee thereof or a duly authorized
executive committee and notified to the Agent in writing. Further, under no circumstances shall the Company cause or permit the aggregate
offering amount of Placement Shares sold pursuant to this Agreement to exceed the Maximum Amount. Notwithstanding anything to the contrary
contained herein, the parties hereto agree that compliance with the limitations set forth in this Section 5 on the amount of Placement
Shares issued and sold under this Agreement shall be the sole responsibility of the Company and that the Agent shall have no obligation
in connection with such compliance.
6.
Representations and Warranties of the Company. Except as disclosed in the Registration Statement or Prospectus (including the
Incorporated Documents), the Company represents and warrants to, and agrees with the Agent that as of the date of this Agreement and
as of each Applicable Time (as defined below), unless such representation, warranty or agreement specifies otherwise:
(a)
Registration Statement and Prospectus. As of the date of this Agreement and at each Applicable Time, the Company and the transactions
contemplated by this Agreement meet the requirements for and comply with the applicable conditions set forth in Form F-3 (including General
Instructions I.A and I.B) under the Securities Act. The Registration Statement has been, or will be, filed with the Commission and has
been declared effective by the Commission under the Securities Act prior to the issuance of any Placement Notices by the Company. As
of each Applicable Time, the Registration Statement is effective. The Prospectus Supplement will name the Agent as the agent in the section
entitled “Plan of Distribution.” The Company has not received, and has no notice of, any order of the Commission preventing
or suspending the use of the Registration Statement, or threatening or instituting proceedings for that purpose. The Registration Statement
and the offer and sale of Placement Shares as contemplated hereby meet the requirements of Rule 415 under the Securities Act and comply
in all material respects with said Rule. Any statutes, regulations, contracts or other documents that are required to be described in
the Registration Statement or the Prospectus or to be filed as exhibits to the Registration Statement have been so described or filed.
Copies of the Registration Statement, the Prospectus, and any amendments or supplements thereto and all documents incorporated by reference
therein that were filed with the Commission on or prior to the date of this Agreement have been delivered, or are available through EDGAR,
to the Agent and its counsel. The Company has not distributed and, prior to the later to occur of each Settlement Date and completion
of the distribution of the Placement Shares, will not distribute any offering material in connection with the offering or sale of the
Placement Shares other than the Registration Statement and the Prospectus and any Issuer Free Writing Prospectus (as defined below) to
which the Agent has consented. The Ordinary Shares are registered pursuant to Section 12(b) of the Exchange Act and are currently listed
on the Exchange under the trading symbol “GLMD.” The Company has taken no action designed to, or likely to have the effect
of, terminating the registration of the Ordinary Shares under the Exchange Act, delisting the Ordinary Shares from the Exchange. The
Company has not received any notification that the Commission or the Exchange is contemplating terminating such registration or listing.
Except as set forth in the Registration Statement and in the Prospectus, to the Company’s knowledge (following due inquiry), it
is in compliance with all applicable listing requirements of the Exchange. The Company has no reason to believe that it will not in the
foreseeable future continue to be in compliance with all such listing and maintenance requirements.
(b)
No Misstatement or Omission. The Registration Statement, when it became or becomes effective, and the Prospectus, and any amendment
or supplement thereto, on the date of such Prospectus or amendment or supplement, conformed and will conform in all material respects
with the requirements of the Securities Act. At each Settlement Date, the Registration Statement and the Prospectus, as of such date,
will conform in all material respects with the requirements of the Securities Act. The Registration Statement, when it became or becomes
effective, did not, or will not, at each Applicable Time contain an untrue statement of a material fact or omit to state a material fact
required to be stated therein or necessary to make the statements therein not misleading. The Prospectus and any amendment or supplement
thereto, on the date thereof and at each Applicable Time (defined below), did not and will not include an untrue statement of a material
fact or omit to state a material fact necessary to make the statements therein, in light of the circumstances under which they were made,
not misleading. The documents incorporated by reference in the Prospectus or any Prospectus Supplement did not, and any further documents
filed and incorporated by reference therein will not, when filed with the Commission, contain an untrue statement of a material fact
or omit to state a material fact required to be stated in such document or necessary to make the statements in such document, in light
of the circumstances under which they were made, not misleading. The foregoing shall not apply to statements in, or omissions from, any
such document made in reliance upon, and in conformity with, information furnished to the Company by Agent specifically for use in the
preparation thereof.
(c)
Conformity with Securities Act and Exchange Act. The Registration Statement, the Prospectus, any Issuer Free Writing Prospectus
or any amendment or supplement thereto, and the documents incorporated by reference in the Registration Statement, the Prospectus or
any amendment or supplement thereto, when such documents were or are filed with the Commission under the Securities Act or the Exchange
Act or became or become effective under the Securities Act, as the case may be, conformed or will conform in all material respects with
the requirements of the Securities Act and the Exchange Act, as applicable.
(d)
Financial Information. The financial statements (including the related notes thereto) of the Company and its consolidated subsidiaries
included or incorporated by reference in the Registration Statement and the Prospectus comply in all material respects with the applicable
requirements of the Securities Act and the Exchange Act, as applicable, and present fairly in all material respects the financial position
of the Company and its consolidated subsidiaries as of the dates indicated and the results of their operations and the changes in their
cash flows for the periods specified (subject, in the case of unaudited interim financial statements, to normal year-end audit adjustments);
such financial statements have been prepared in conformity with generally accepted accounting principles in the United States (“GAAP”)
applied on a consistent basis throughout the periods covered thereby, except for (i) such adjustments to accounting standards and practices
as are noted therein, (ii) in the case of unaudited interim financial statements, to the extent such financial statements may not include
footnotes required by GAAP or may be condensed or summary statements, and (iii) such adjustments which will not be material, either individually
or in the aggregate); and the other financial information included or incorporated by reference in the Registration Statement and the
Prospectus has been derived from the accounting records of the Company and its consolidated subsidiaries and presents fairly in all material
respects the information shown thereby; all disclosures included or incorporated by reference in the Registration Statement and the Prospectus
regarding “non-GAAP financial measures” (as such term is defined by the rules and regulations of the Commission) comply in
all material respects with Regulation G of the Exchange Act and Item 10 of Regulation S-K of the Securities Act, to the extent applicable;
and the pro forma financial information and the related notes thereto included or incorporated by reference in the Registration Statement
and the Prospectus have been prepared in accordance with the applicable requirements of the Securities Act and the Exchange Act, as applicable,
and the assumptions underlying such pro forma financial information are reasonable and are set forth in the Registration Statement and
the Prospectus.
(e)
Conformity with EDGAR Filing. The Prospectus delivered to the Agent for use in connection with the sale of the Placement Shares
pursuant to this Agreement will be identical to the versions of the Prospectus created to be transmitted to the Commission for filing
via EDGAR, except to the extent permitted by Regulation S-T.
(f)
Organization. The Company and each of its subsidiaries have been duly organized and are validly existing and in good standing
under the laws of their respective jurisdictions of organization (to the extent such concept is applicable in such jurisdiction), are
duly qualified to do business and are in good standing in each jurisdiction (to the extent such concept is applicable in such jurisdiction)
in which their respective ownership or lease of property or the conduct of their respective businesses as currently conducted requires
such qualification, and have all power and authority necessary to own or hold their respective properties and to conduct the businesses
in which they are engaged, except where the failure to be so qualified or in good standing or have such power or authority would not
reasonably be expected, individually or in the aggregate, to have a material adverse effect on the business, properties, management,
financial position, shareholders’ equity, results of operations or prospects of the Company and its subsidiaries taken as a whole
or would materially and adversely affect the ability of the Company to perform its obligations under this Agreement (a “Material
Adverse Effect”). The Company does not own or control, directly or indirectly, any corporation, association or other entity
other than the subsidiaries listed in Exhibit 8.1 to the Company’s most recent Annual Report on Form 20-F. The Company has not
been designated as a “breaching company” (within the meaning of the Israeli Companies Law, 5759-1999, as amended (including
the rules and regulations promulgated thereunder, the “Companies Law”)) by the Registrar of Companies of the State
of Israel, nor has a proceeding been instituted in Israel by the Registrar of Companies of the State of Israel for the dissolution of
the Company. The amended and restated articles of association and any other organizational documents of the Company comply with the requirements
of applicable Israeli law and are in full force and effect.
(g)
Subsidiaries. The subsidiaries set forth on Exhibit 8.1 to the Company’s most recent Annual Report on Form 20-F (collectively,
the “Subsidiaries”), are the Company’s only significant subsidiaries (as such term is defined in Rule 1-02 of
Regulation S-X promulgated by the Commission). Except as set forth in the Registration Statement and in the Prospectus, the Company owns,
directly or indirectly, all of the equity interests of the Subsidiaries free and clear of any lien, charge, security interest, encumbrance,
right of first refusal or other restriction, and all the equity interests of the Subsidiaries are validly issued and are fully paid,
nonassessable and free of preemptive and similar rights. No Subsidiary is currently prohibited, directly or indirectly, from paying any
dividends to the Company, from making any other distribution on such Subsidiary’s capital stock, from repaying to the Company any
loans or advances to such Subsidiary from the Company or from transferring any of such Subsidiary’s property or assets to the Company
or any other Subsidiary of the Company.
(h)
No Violation or Default. Neither the Company nor any Subsidiary is (i) in violation of its charter or by-laws or similar organizational
documents; (ii) in default, and no event has occurred that, with notice or lapse of time or both, would constitute such a default, in
the due performance or observance of any term, covenant or condition contained in any indenture, mortgage, deed of trust, loan agreement
or other agreement or instrument to which the Company or any Subsidiary is a party or by which the Company or any Subsidiary is bound
or to which any of the property or assets of the Company or any Subsidiary is subject; or (iii) in violation of any law or statute or
any judgment, order, rule or regulation of any court or arbitrator or governmental or regulatory authority, except, in the case of each
of clauses (ii) and (iii) above, for any such violation or default that would not, individually or in the aggregate, have a Material
Adverse Effect. To the Company’s knowledge, no other party under any material contract or other agreement to which it or any Subsidiary
is a party is in default in any respect thereunder where such default would have a Material Adverse Effect.
(i)
No Material Adverse Effect. Subsequent to the respective dates as of which information is given in the Registration Statement,
the Prospectus and the Free Writing Prospectuses, if any (including any document deemed incorporated by reference therein), there has
not been (i) any Material Adverse Effect or the occurrence of any development that the Company reasonably expects will result in a Material
Adverse Effect, (ii) any transaction which is material to the Company and the Subsidiaries taken as a whole, (iii) any obligation or
liability, direct or contingent (including any off-balance sheet obligations), incurred by the Company or any Subsidiary, which is material
to the Company and the Subsidiaries taken as a whole, (iv) any material change in the capital stock or outstanding long-term indebtedness
of the Company or any of its Subsidiaries (other than (A) the grant of awards under equity incentive plans, (B) changes in the number
of shares of outstanding ordinary shares due to exercise or conversion of securities exercisable for or convertible into ordinary shares
outstanding from time to time, (C) any repurchase of capital stock of the Company, (D) as a result of the sale of Placement Shares or
(E) other than as publicly reported or announced) or (v) any dividend or distribution of any kind declared, paid or made on the capital
stock of the Company or any Subsidiary, other than in each case above in the ordinary course of business or as otherwise disclosed in
the Registration Statement or Prospectus (including any document deemed incorporated by reference therein).
(j)
Capitalization. The issued and outstanding shares of the Company (i) have been validly issued, are fully paid and nonassessable
and, (ii) other than as disclosed in the Registration Statement or the Prospectus, are not subject to any preemptive rights, rights of
first refusal or similar rights and (iii) were issued in compliance with the Companies Law and the Israeli Securities Law 5728-1968 (the
“Israeli Securities Law”). The Company has an authorized, issued and outstanding and fully diluted capitalization
as set forth in the Registration Statement and the Prospectus as of the dates referred to therein (other than the grant of securities
under the Company’s equity incentive plans, or changes in the number of outstanding ordinary shares of the Company due to the issuance
of shares upon the exercise or conversion of securities exercisable for, or convertible into, ordinary shares outstanding from time to
time) and such authorized capital stock conforms in all material respects to the description thereof set forth in the Registration Statement
and the Prospectus. The description of the securities of the Company in the Registration Statement and the Prospectus is complete and
accurate in all material respects. Except as disclosed in or contemplated by the Registration Statement or the Prospectus, as of the
date referred to therein, the Company does not have any outstanding options to purchase, or any rights or warrants to subscribe for,
or any securities or obligations convertible into, or exchangeable for, or any contracts or commitments to issue or sell, any shares
of capital stock or other securities.
(k)
Authorization; Enforceability. The Company has full legal right, power and authority to enter into this Agreement and perform
the transactions contemplated hereby. This Agreement has been duly authorized, executed and delivered by the Company and is a legal,
valid and binding agreement of the Company enforceable in accordance with its terms, except to the extent that (i) enforceability may
be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ rights generally and by general
equitable principles; and (ii) the indemnification and contribution provisions of Section 10 hereof may be limited by federal or state
securities laws and public policy considerations in respect thereof.
(l)
Authorization of Placement Shares. The Placement Shares to be issued and sold by the Company hereunder have been duly authorized
by the Company and, when issued and delivered and paid for as provided herein, will be duly and validly issued, fully paid and nonassessable
and will conform in all material respects to the descriptions thereof in the Registration Statement and the Prospectus; and the issuance
of the Placement Shares is not subject to any preemptive or similar rights.
(m)
No Consents Required. No consent, approval, authorization, order, registration or qualification of or with any court or arbitrator
or governmental or regulatory authority having jurisdiction over the Company is required for the execution, delivery and performance
by the Company this Agreement, the issuance and sale by the Company of the Placement Shares, except for such consents, approvals, authorizations,
orders and registrations or qualifications as may be required under applicable state securities laws or by the by-laws and rules of the
Financial Industry Regulatory Authority (“FINRA”) or the Exchange in connection with the sale of the Placement Shares
by the Agent.
(n)
No Preferential Rights. (i) No person, as such term is defined in Rule 1-02 of Regulation S-X promulgated under the Securities
Act (each, a “Person”), has the right, contractual or otherwise, to cause the Company or any of its Subsidiaries to
issue or sell to such Person any Ordinary Shares or shares of any other capital stock or other securities of the Company or any of its
Subsidiaries (other than upon the exercise of options or warrants or the vesting of restricted stock units into ordinary shares), (ii)
no Person has any preemptive rights, resale rights, rights of first refusal, rights of co-sale, or any other rights (whether pursuant
to a “poison pill” provision or otherwise) to purchase any Ordinary Shares or shares of any other capital stock or other
securities of the Company or any of its Subsidiaries, (iii) no Person has the right to act as an underwriter or as a financial advisor
to the Company or any of its Subsidiaries in connection with the offer and sale of Ordinary Shares, and (iv) no Person has the right,
contractual or otherwise, to require the Company or any of its Subsidiaries to register under the Securities Act any Ordinary Shares
or shares of any other capital stock or other securities of the Company or any of its Subsidiaries, or to include any such shares or
other securities in the Registration Statement or the offering contemplated thereby, whether as a result of the filing or effectiveness
of the Registration Statement or the sale of the Placement Shares as contemplated thereby or otherwise , except for such rights as have
been or will be duly waived on or prior to the date hereof.
(o)
Independent Public Accountant. The Company’s accountants, whose report on the financial statements of the Company is filed
with the Commission as part of the Company’s most recent Annual Report on Form 20-F filed with the Commission and incorporated
by reference into the Registration Statement and the Prospectus, are and, during the periods covered by their report, were an independent
registered public accounting firm with respect to the Company within the meaning of the Securities Act and the Public Company Accounting
Oversight Board (United States). To the Company’s knowledge, the Company’s accountants are not in violation of the auditor
independence requirements of the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”) with respect to the Company.
(p)
Enforceability of Agreements. All agreements between the Company and third parties expressly referenced in the Prospectus, other
than such agreements that have expired by their terms or the termination of which is disclosed in documents filed by the Company on EDGAR,
are legal, valid and binding obligations of the Company enforceable against the Company in accordance with their respective terms, except
to the extent that (i) enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors’ rights generally and by general equitable principles and (ii) the indemnification provisions of certain agreements may
be limited by federal or state securities laws or public policy considerations in respect thereof; except for any unenforceability that,
individually or in the aggregate, would not reasonably be expected to have a Material Adverse Effect.
(q)
No Litigation. There are no legal, governmental or regulatory actions, suits or proceedings pending, nor, to the Company’s
knowledge, any legal, governmental or regulatory investigations, to which the Company or any Subsidiary is a party or to which any property
of the Company or any Subsidiary is the subject that, individually or in the aggregate, if determined adversely to the Company or any
Subsidiary, would have a Material Adverse Effect or materially and adversely affect the ability of the Company to perform its obligations
under this Agreement; to the Company’s knowledge, no such actions, suits or proceedings are threatened or contemplated by any governmental
or regulatory authority or threatened by others that, individually or in the aggregate, if determined adversely to the Company or any
Subsidiary, would reasonably be expected to have a Material Adverse Effect; and (i) there are no current or pending legal, governmental
or regulatory audits or investigations, actions, suits or proceedings that are required under the Securities Act to be described in the
Prospectus that are not so described; and (ii) there are no contracts or other documents that are required under the Securities Act to
be filed as exhibits to the Registration Statement that are not so filed.
(r)
Consents and Permits. The Company and its Subsidiaries have made all filings, applications and submissions required by, possesses
and is operating in compliance with, all approvals, licenses, certificates, certifications, clearances, consents, grants, exemptions,
marks, notifications, orders, permits and other authorizations issued by, the appropriate federal, state or foreign Governmental Authority
(including, without limitation, the United States Food and Drug Administration (the “FDA”), the United States Drug
Enforcement Administration or any other foreign, federal, state, provincial, court or local government or regulatory authorities including
self-regulatory organizations engaged in the regulation of clinical trials, pharmaceuticals, biologics or biohazardous substances or
materials) necessary for the ownership or lease of their respective properties or to conduct its businesses as described in the Registration
Statement and the Prospectus (collectively, “Permits”), except for such Permits the failure of which to possess, obtain
or make the same would not have a Material Adverse Effect; the Company and its Subsidiaries are in compliance with the terms and conditions
of all such Permits, except where the failure to be in compliance would not have a Material Adverse Effect; all of the Permits are valid
and in full force and effect, except where any invalidity, individually or in the aggregate, would not be reasonably expected to have
a Material Adverse Effect; and neither the Company nor any of its Subsidiaries has received any written notice relating to the limitation,
revocation, cancellation, suspension, modification or non-renewal of any such Permit which, singly or in the aggregate, if the subject
of an unfavorable decision, ruling or finding, would have a Material Adverse Effect, or has any reason to believe that any such license,
certificate, permit or authorization will not be renewed in the ordinary course. To the extent required by applicable laws and regulations
of the FDA, the Company or the applicable Subsidiary has submitted to the FDA an Investigational New Drug Application or amendment or
supplement thereto for each clinical trial it has conducted or sponsored or is conducting or sponsoring; all such submissions were in
material compliance with applicable laws and rules and regulations when submitted and no material deficiencies have been asserted by
the FDA with respect to any such submissions.
(s)
Regulatory Filings; Clinical Studies. Except as disclosed in the Registration Statement and the Prospectus, neither the Company
nor any of its Subsidiaries has failed to file with the applicable governmental authorities (including, without limitation, the FDA,
or any foreign, federal, state, provincial or local governmental authority performing functions similar to those performed by the FDA)
any required filing, declaration, listing, registration, report or submission, except for such failures that, individually or in the
aggregate, would not have a Material Adverse Effect; except as disclosed in the Registration Statement and the Prospectus, all such filings,
declarations, listings, registrations, reports or submissions were in compliance with applicable laws when filed and no deficiencies
have been asserted by any applicable regulatory authority with respect to any such filings, declarations, listings, registrations, reports
or submissions, except for any deficiencies that, individually or in the aggregate, would not have a Material Adverse Effect. The Company
and its Subsidiaries have operated and currently is, in all material respects, in compliance with the United States Federal Food, Drug,
and Cosmetic Act, all applicable rules and regulations of the FDA and other federal, state, local and foreign governmental authority
exercising comparable authority. The Company has no knowledge of any studies, tests or trials not described in the Prospectus the results
of which reasonably call into question in any material respect the results of the studies, tests and trials described in the Prospectus.
To the Company’s knowledge, after due inquiry of its third party contract resource organizations, the preclinical studies and tests
and clinical trials described in the Prospectus were, and, if still pending, are being conducted in all material respects in accordance
with the experimental protocols, procedures and controls pursuant to, where applicable, accepted professional and scientific standards
for products or product candidates comparable to those being developed by the Company; the descriptions of such studies, tests and trials,
and the results thereof, contained in the Prospectus are accurate and complete in all material respects; the Company is not aware of
any tests, studies or trials not described in the Prospectus, the results of which reasonably call into question the results of the tests,
studies and trials described in the Prospectus; and the Company has not received any written notice or correspondence from the FDA or
any foreign, state or local Governmental Authority exercising comparable authority or any institutional review board or comparable authority
requiring the termination, suspension, clinical hold or material modification of any tests, studies or trials.
(t)
Market Capitalization. At the time the Registration Statement was, or will be, originally declared effective, and at the time
the Company’s most recent Annual Report on Form 20-F was filed with the Commission, the Company met or will meet the then applicable
requirements for the use of Form F-3 under the Securities Act, including, but not limited to, General Instruction I.B.5 of Form F-3.
As of the close of trading on the Exchange on July 3, 2024, the aggregate market value of the outstanding voting and non-voting common
equity (as defined in Securities Act Rule 405) of the Company held by persons other than affiliates of the Company (pursuant to Securities
Act Rule 144, those that directly, or indirectly through one or more intermediaries, control, or are controlled by, or are under common
control with, the Company) (the “Non-Affiliate Shares”), was approximately $20.2 million (calculated by multiplying
(x) the highest price at which the common equity of the Company closed on the Exchange during the 60 days prior to the date of this Agreement
times (y) the number of Non-Affiliate Shares). The Company is not a shell company (as defined in Rule 405 under the Securities Act) and
has not been a shell company for at least 12 calendar months previously and if it has been a shell company at any time previously, has
filed current Form 10 information (as defined in Instruction I.B.5 of Form F-3) with the Commission at least 12 calendar months previously
reflecting its status as an entity that is not a shell company.
(u)
No Material Defaults. Neither the Company nor any Subsidiary has defaulted on any installment on indebtedness for borrowed money
or on any rental on one or more long-term leases, which defaults, individually or in the aggregate, would reasonably be expected to have
a Material Adverse Effect. The Company has not filed a report pursuant to Section 13(a) or 15(d) of the Exchange Act since the filing
of its last Annual Report on Form 20-F, indicating that it (i) has failed to pay any dividend or sinking fund installment on preferred
stock or (ii) has defaulted on any installment on indebtedness for borrowed money or on any rental on one or more long-term leases, which
defaults, individually or in the aggregate, would reasonably be expected to have a Material Adverse Effect.
(v)
Certain Market Activities. Neither the Company, nor any of the Subsidiaries, nor any of their respective directors, officers or,
to the Company’s knowledge, controlling persons has taken, directly or indirectly, any action designed, or that has constituted
or might reasonably be expected to cause or result in, under the Exchange Act or otherwise, the stabilization or manipulation of the
price of any security of the Company to facilitate the sale or resale of the Placement Shares. The Company has not engaged and will not
engage in any form of solicitation, advertising or other action constituting an offer or a sale under the Israeli Securities Law and
the regulations promulgated thereunder in connection with the transactions contemplated hereby which would require the publication of
a prospectus in the State of Israel under the laws of the State of Israel.
(w)
Broker/Dealer Relationships. Neither the Company, any of its Subsidiaries, nor any of the Company’s affiliates (i) is required
to register as a “broker” or “dealer” in accordance with the provisions of the Exchange Act or (ii) directly
or indirectly through one or more intermediaries, controls or is a “person associated with a member” or “associated
person of a member” (within the meaning set forth in the FINRA Manual).
(x)
No Reliance. The Company has not relied upon the Agent or legal counsel for the Agent for any legal, tax or accounting advice
in connection with the offering and sale of the Placement Shares.
(y)
Taxes. The Company and the Subsidiaries have filed all federal, state, local and foreign tax returns which have been required
to be filed and paid all taxes shown thereon through the date hereof, to the extent that such taxes have become due and are not being
contested in good faith, except where the failure to file or pay would not have a Material Adverse Effect. Except as otherwise disclosed
in or contemplated by the Registration Statement or the Prospectus, no tax deficiency has been determined adversely to the Company or
any Subsidiary which has had, individually or in the aggregate, a Material Adverse Effect. The Company has no knowledge of any federal,
state or other governmental tax deficiency, penalty or assessment which has been asserted or threatened against it which would reasonably
be expected to have a Material Adverse Effect.
(z)
Title to Real and Personal Property. The Company and its Subsidiaries have good and marketable title (and where applicable, in
fee simple) to all items of real property owned by them, good and valid title to all personal property described in the Registration
Statement or Prospectus as being owned by them, in each case free and clear of all liens, encumbrances and claims, except those matters
that (i) do not materially interfere with the use made and proposed to be made of such property by the Company and any of its Subsidiaries
or (ii) would not, individually or in the aggregate, have a Material Adverse Effect. Any real or personal property described in the Registration
Statement or Prospectus as being leased by the Company and any of its Subsidiaries is held by them under valid, existing and enforceable
leases, except those that (A) do not materially interfere with the use made or proposed to be made of such property by the Company or
any of its Subsidiaries or (B) would not be reasonably expected, individually or in the aggregate, to have a Material Adverse Effect.
Each of the properties of the Company and its Subsidiaries complies with all applicable codes, laws and regulations (including, without
limitation, building and zoning codes, laws and regulations and laws relating to access to such properties), except if and to the extent
disclosed in the Registration Statement or Prospectus or except for such failures to comply that would not, individually or in the aggregate,
reasonably be expected to interfere in any material respect with the use made and proposed to be made of such property by the Company
and its Subsidiaries or otherwise have a Material Adverse Effect. None of the Company or its subsidiaries has received from any governmental
authorities any notice of any condemnation of, or zoning change affecting, the properties of the Company and its Subsidiaries, and the
Company knows of no such condemnation or zoning change which is threatened, except for such that would not reasonably be expected to
interfere in any material respect with the use made and proposed to be made of such property by the Company and its Subsidiaries or otherwise
have a Material Adverse Effect, individually or in the aggregate.
(aa)
Intellectual Property. Except as disclosed in the Registration Statement and the Prospectus, the Company and its Subsidiaries
own, possess, license or have other rights to use all foreign and domestic patents, patent applications, trade and service marks, trade
and service mark registrations, trade names, copyrights, licenses, inventions, trade secrets, technology, Internet domain names, know-how
and other intellectual property (collectively, the “Intellectual Property”), necessary for the conduct of their respective
businesses as now conducted and planned to be conducted except to the extent that the failure to own, possess, license or otherwise hold
adequate rights to use such Intellectual Property would not, individually or in the aggregate, have a Material Adverse Effect. Except
as disclosed in the Registration Statement and the Prospectus (i) there are no rights of third parties to any such Intellectual Property
owned by the Company and its Subsidiaries; (ii) to the Company’s knowledge, there is no infringement by third parties of any such
Intellectual Property; (iii) there is no pending or, to the Company’s knowledge, threatened action, suit, proceeding or claim by
others challenging the Company’s and its Subsidiaries’ rights in or to any such Intellectual Property, and the Company is
unaware of any facts which could form a reasonable basis for any such action, suit, proceeding or claim; (iv) there is no pending or,
to the Company’s knowledge, threatened action, suit, proceeding or claim by others challenging the validity or scope of any such
Intellectual Property; (v) there is no pending or, to the Company’s knowledge, threatened action, suit, proceeding or claim by
others that the Company and its Subsidiaries infringe or otherwise violate any patent, trademark, copyright, trade secret or other proprietary
rights of others; (vi) to the Company’s knowledge (after due inquiry), there is no third-party U.S. patent or published U.S. patent
application which contains claims for which an Interference Proceeding (as defined in 35 U.S.C. § 135) has been commenced against
any patent or patent application described in the Prospectus as being owned by or licensed to the Company; and (vii) the Company and
its Subsidiaries have complied with the terms of each agreement pursuant to which Intellectual Property has been licensed to the Company
or such Subsidiary, and all such agreements are in full force and effect, except, in the case of any of clauses (i)-(vii) above, for
any such infringement by third parties or any such pending or threatened suit, action, proceeding or claim as would not, individually
or in the aggregate, result in a Material Adverse Effect.
(bb)
Environmental Laws. Except as set forth in the Registration Statement or the Prospectus, the Company and its Subsidiaries (i)
are in compliance with any and all applicable federal, state, local and foreign laws, rules, regulations, decisions and orders relating
to the protection of human health and safety, the environment or hazardous or toxic substances or wastes, pollutants or contaminants
(collectively, “Environmental Laws”); (ii) have received and are in compliance with all permits, licenses or other
approvals required of them under applicable Environmental Laws to conduct their respective businesses as described in the Registration
Statement and the Prospectus; and (iii) have not received notice of any actual or potential liability for the investigation or remediation
of any disposal or release of hazardous or toxic substances or wastes, pollutants or contaminants, except, in the case of any of clauses
(i), (ii) or (iii) above, for any such failure to comply or failure to receive required permits, licenses, other approvals or liability
as would not, individually or in the aggregate, have a Material Adverse Effect.
(cc)
Disclosure Controls. The Company maintains systems of internal accounting controls compliant in all material respects with all
applicable Laws (including the Israeli Securities Law and the Exchange Act) and sufficient to provide reasonable assurance that (i) transactions
are executed in accordance with management’s general or specific authorizations; (ii) transactions are recorded as necessary to
permit preparation of financial statements in conformity with generally accepted accounting principles and to maintain asset accountability;
(iii) access to assets is permitted only in accordance with management’s general or specific authorization; and (iv) the recorded
accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to
any differences. The Company’s internal control over financial reporting is effective and the Company is not aware of any material
weaknesses in its and its Subsidiaries internal control over financial reporting (other than as set forth in the Prospectus). Since the
date of the latest audited financial statements of the Company included in the Prospectus, there has been no change in the Company’s
nor in its Subsidiaries internal control over financial reporting that has materially affected, or is reasonably likely to materially
affect, the Company’s or such Subsidiary internal control over financial reporting (other than as set forth in the Prospectus).
The Company has established disclosure controls and procedures (as defined in Exchange Act Rules 13a-15 and 15d-15) for the Company (and
any applicable Subsidiary) and designed such disclosure controls and procedures to ensure that material information relating to the Company
and each of its Subsidiaries is made known to the certifying officers by others within those entities, particularly during the period
in which the Company’s Annual Report on Form 20-F or Current Report on Form 6-K containing unaudited quarterly financial statements,
as the case may be, is being prepared. The Company’s certifying officers have evaluated the effectiveness of the Company’s
disclosure controls and procedures as of a date within 90 days prior to the filing date of the Annual Report on Form 20-F for the fiscal
year most recently ended (such date, the “Evaluation Date”). The Company presented in its Annual Report on
Form 20-F for the fiscal year most recently ended the conclusions of the certifying officers about the effectiveness of the disclosure
controls and procedures based on their evaluations as of the Evaluation Date and the disclosure controls and procedures are effective.
Since the Evaluation Date, there have been no significant changes in the Company’s internal controls (as such term is defined in
Item 307(b) of Regulation S-K under the Securities Act) or, to the Company’s knowledge, in other factors that could significantly
affect the Company’s internal controls.
(dd)
Sarbanes-Oxley. There is and has been no failure on the part of the Company or, any of the Company’s directors or officers,
in their capacities as such, to comply with any applicable provisions of the Sarbanes-Oxley Act and the applicable rules and regulations
promulgated thereunder in all material respects. Each of the principal executive officer and the principal financial officer of the Company
(or each former principal executive officer of the Company and each former principal financial officer of the Company as applicable)
has made all certifications required by Sections 302 and 906 of the Sarbanes-Oxley Act with respect to all reports, schedules, forms,
statements and other documents required to be filed by it or furnished by it to the Commission during the 12 months prior to the date
of this Agreement. For purposes of the preceding sentence, “principal executive officer” and “principal financial officer”
shall have the meanings given to such terms in the Sarbanes-Oxley Act.
(ee)
Finder’s Fees. Neither the Company nor any Subsidiary has incurred any liability for any finder’s fees, brokerage
commissions or similar payments in connection with the transactions herein contemplated, except as may otherwise exist with respect to
Agent pursuant to this Agreement.
(ff)
Labor Disputes. No labor disturbance by or dispute with employees of the Company or any Subsidiary exists or, to the knowledge
of the Company, is threatened which would have a Material Adverse Effect
(gg)
Investment Company Act. Neither the Company or any Subsidiary is or, after giving effect to the offering and sale of the Placement
Shares, will it be an “investment company” or an entity “controlled” by an “investment company,”
as such terms are defined in the Investment Company Act of 1940, as amended (the “Investment Company Act”).
(hh)
Operations. The operations of the Company and the Subsidiaries are and have been conducted at all times in compliance with applicable
financial record keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money
laundering statutes of all jurisdictions to which the Company or the Subsidiaries are subject, the rules and regulations thereunder and
any related or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the
“Money Laundering Laws”), except as would not have a Material Adverse Effect; and no action, suit or proceeding by
or before any court or governmental agency, authority or body or any arbitrator involving the Company or any Subsidiary with respect
to the Money Laundering Laws is pending or, to the knowledge of the Company, threatened.
(ii)
Off-Balance Sheet Arrangements. There are no transactions, arrangements and other relationships between and/or among the Company,
and/or any of its affiliates and any unconsolidated entity, including, but not limited to, any structural finance, special purpose or
limited purpose entity (each, an “Off-Balance Sheet Transaction”) that could reasonably be expected to affect materially
the Company’s liquidity or the availability of or requirements for its capital resources, including those Off-Balance Sheet Transactions
described in the Commission’s Statement about Management’s Discussion and Analysis of Financial Conditions and Results of
Operations (Release Nos. 33-8056; 34-45321; FR-61), required to be described in the Prospectus which have not been described as required.
(jj)
Other Agreements. The Company is not a party to any agreement with an agent or underwriter for any other “at the market”
or continuous equity transaction.
(kk)
ERISA. To the knowledge of the Company, each material employee benefit plan, within the meaning of Section 3(3) of the Employee
Retirement Income Security Act of 1974, as amended (“ERISA”) or Section 102 of the Israeli Income Tax Ordinance (the
“Israeli Code”), that is maintained, administered or contributed to by the Company or any of its affiliates for employees
or former employees of the Company and any of its Subsidiaries has been maintained in material compliance with its terms and the requirements
of any applicable statutes, orders, rules and regulations, including but not limited to ERISA and the Internal Revenue Code of 1986,
as amended (the “Code”) as well as the Israeli Code; no prohibited transaction, within the meaning of Section 406
of ERISA or Section 4975 of the Code, and no breach of Section 102 of the Israeli Code has occurred which would result in a material
liability to the Company with respect to any such plan excluding transactions effected pursuant to a statutory or administrative exemption;
and for each such plan that is subject to the funding rules of Section 412 of the Code or Section 302 of ERISA, no “accumulated
funding deficiency” as defined in Section 412 of the Code has been incurred, whether or not waived, and the fair market value of
the assets of each such plan (excluding for these purposes accrued but unpaid contributions) exceeds the present value of all benefits
accrued under such plan determined using reasonable actuarial assumptions.
(ll)
Forward Looking Statements. No forward-looking statement (within the meaning of Section 27A of the Securities Act and Section
21E of the Exchange Act) (a “Forward Looking Statement”) contained in the Registration Statement and the Prospectus
has been made or reaffirmed without a reasonable basis or has been disclosed other than in good faith and been prepared in accordance
with Item 10 of Regulation S-K under the Securities Act.
(mm)
Agent Purchases. The Company acknowledges and agrees that Agent has informed the Company that the Agent may, to the extent permitted
under the Securities Act and the Exchange Act, purchase and sell Ordinary Shares for its own account while this Agreement is in effect,
provided, that (i) no such purchase or sales shall take place while a Placement Notice is in effect (except to the extent the Agent may
engage in sales of Placement Shares purchased or deemed purchased from the Company as a “riskless principal” or in a similar
capacity) and (ii) the Company shall not be deemed to have authorized or consented to any
such purchases or sales by the Agent.
(nn)
Margin Rules. Neither the issuance, sale and delivery of the Placement Shares nor the application of the proceeds thereof by the
Company as described in the Registration Statement and the Prospectus will violate Regulation T, U or X of the Board of Governors of
the Federal Reserve System or any other regulation of such Board of Governors.
(oo)
Insurance. The Company and the Subsidiaries carry, or are covered by, insurance in such amounts and covering such risks as the
Company and the Subsidiaries reasonably believe is adequate for the conduct of their business and as is customary for companies of similar
size engaged in similar businesses in similar industries.
(pp)
No Improper Practices. (i) Neither the Company nor the Subsidiaries, nor any director, officer, or employee of the Company or
any Subsidiary nor, to the Company’s knowledge, any agent, affiliate or other person acting on behalf of the Company or any Subsidiary
has, in the past five years, made any unlawful contributions to any candidate for any political office (or failed fully to disclose any
contribution in violation of applicable law) or made any contribution or other payment to any official of, or candidate for, any federal,
state, municipal, or foreign office or other person charged with similar public or quasi-public duty in violation of any applicable law
or of the character required to be disclosed in the Prospectus; (ii) no relationship, direct or indirect, exists between or among the
Company or any Subsidiary or any affiliate of any of them, on the one hand, and the directors, officers and stockholders of the Company
or any Subsidiary, on the other hand, that is required by the Securities Act to be described in the Registration Statement and the Prospectus
that is not so described; (iii) no relationship, direct or indirect, exists between or among the Company or any Subsidiary or any affiliate
of them, on the one hand, and the directors, officers, or stockholders of the Company or any Subsidiary, on the other hand, that is required
by the rules of FINRA or the Israeli Securities Law to be described in the Registration Statement and the Prospectus that is not so described;
(iv) except as described in the Registration Statement and the Prospectus, there are no material outstanding loans or advances or material
guarantees of indebtedness by the Company or any Subsidiary to or for the benefit of any of their respective officers or directors or
any of the members of the families of any of them; and (v) the Company has not offered, or caused any placement agent to offer, Ordinary
Shares to any person with the intent to influence unlawfully (A) a customer or supplier of the Company or any Subsidiary to alter the
customer’s or supplier’s level or type of business with the Company or any Subsidiary or (B) a trade journalist or publication
to write or publish favorable information about the Company or any Subsidiary or any of their respective products or services, and, (vi)
neither the Company nor any Subsidiary nor any director, officer or employee of the Company or any Subsidiary nor, to the Company’s
knowledge, any agent, affiliate or other person acting on behalf of the Company or any Subsidiary has (A) violated or is in violation
of any applicable provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended, or any other applicable anti-bribery or anti-corruption
law (collectively, “Anti-Corruption Laws”), (B) promised, offered, provided, attempted to provide or authorized the provision
of anything of value, directly or indirectly, to any person for the purpose of obtaining or retaining business, influencing any act or
decision of the recipient, or securing any improper advantage; or (C) made any payment of funds of the Company or any Subsidiary or received
or retained any funds in violation of any Anti-Corruption Laws.
(qq)
Status Under the Securities Act. The Company was not and is not an ineligible issuer as defined in Rule 405 under the Securities
Act at the times specified in Rules 164 and 433 under the Securities Act in connection with the offering of the Placement Shares.
(rr)
No Misstatement or Omission in an Issuer Free Writing Prospectus. Each Issuer Free Writing Prospectus, as of its issue date and
as of each Applicable Time (as defined below), through the consummation of the Placement for which such Issuer Free Writing Prospectus
is used or deemed used, did not, does not and will not include any information that conflicted, conflicts or will conflict with the information
contained in the Registration Statement or the Prospectus, including any incorporated document deemed to be a part thereof that has not
been superseded or modified. The foregoing sentence does not apply to statements in or omissions from any Issuer Free Writing Prospectus
based upon and in conformity with written information furnished to the Company by the Agent specifically for use therein.
(ss)
No Conflicts. Neither the execution of this Agreement by the Company, nor the issuance, offering or sale of the Placement Shares,
nor the consummation of any of the transactions contemplated herein and therein, nor the compliance by the Company with the terms and
provisions hereof and thereof will conflict with, or will result in a breach of, any of the terms and provisions of, or has constituted
or will constitute a default under, or has resulted in or will result in the creation or imposition of any lien, charge or encumbrance
upon any property or assets of the Company or any of its Subsidiaries pursuant to the terms of any contract or other agreement to which
the Company or any of its Subsidiaries may be bound or to which any of the property or assets of the Company or any of its Subsidiaries
is subject, except (i) such conflicts, breaches or defaults as may have been waived and (ii) such conflicts, breaches and defaults that
would not have a Material Adverse Effect; nor will such action result (x) in any violation of the provisions of the organizational or
governing documents of the Company or any of its Subsidiaries, or (y) in any material violation of the provisions of any statute or any
order, rule or regulation applicable to the Company or any of its Subsidiaries or of any Governmental Authority having jurisdiction over
the Company or any of its Subsidiaries.
(tt)
Sanctions. (i) The Company represents that, neither it nor any Subsidiary (collectively, the “Entity”) nor,
any director, officer, employee, nor to the Entity’s knowledge, any agent, affiliate or representative of the Entity, is a government,
individual, or entity (in this paragraph (tt), “Covered Person”) that is, or is owned or controlled by a Covered Person
that is:
(A)
the subject of any sanctions administered or enforced by the U.S. Department of Treasury’s Office of Foreign Assets Control (“OFAC”),
the United Nations Security Council, the European Union, Her Majesty’s Treasury, or other relevant sanctions authority (collectively,
“Sanctions”), nor
(B)
located, organized or resident in a country or territory that is the subject of Sanctions administered by OFAC.
(ii)
The Entity represents and covenants that it will not, directly or indirectly, use the proceeds of the offering, or lend, contribute or
otherwise make available such proceeds to any subsidiary, joint venture partner or other Covered Person:
(A)
to fund or facilitate any activities or business of or with any Covered Person or in any country or territory that, at the time of such
funding or facilitation, is the subject of Sanctions; or
(B)
in any other manner that will result in a violation of Sanctions by any Covered Person (including any Covered Person participating in
the offering, whether as underwriter, advisor, investor or otherwise).
(iii)
The Entity represents and covenants that, except as detailed in the Prospectus, for the past 5 years, it has not knowingly engaged in,
is not now knowingly engaged in, and will not knowingly engage in, any dealings or transactions with any Covered Person, or in any country
or territory, that at the time of the dealing or transaction is or was the subject of Sanctions.
(uu)
Stock Transfer Taxes. On each Settlement Date, all stock transfer or other taxes (other than income taxes) which are required
to be paid in connection with the sale and transfer of the Placement Shares to be sold hereunder will be, or will have been, fully paid
or provided for by the Company and all laws imposing such taxes will be or will have been fully complied with in all material respects.
(vv)
Stamp Tax. No Israeli stamp or other Israeli issuance or transfer taxes or similar Israeli issuance or transfer duties and assuming
that the Agent is not otherwise subject to taxation in Israel due to Israeli tax residence, the existence of a permanent establishment
in Israel, a fixed place of business in Israel or any business activity of the Agent in Israel, no capital gains, income, withholding
or other taxes are payable in Israel by or on behalf of the Agent in connection with the sale and delivery by the Company of the Placement
Shares to or for the account of the Agent or the sale and delivery by the Agent of the Placement Shares to the purchasers thereof.
(ww)
Compliance with Laws. Each of the Company and its Subsidiaries: (A) is and at all times has been in compliance with all statutes,
rules, or regulations applicable to the ownership, testing, development, manufacture, packaging, processing, use, distribution, marketing,
labeling, promotion, sale, offer for sale, storage, import, export or disposal of any product manufactured or distributed by the Company
or its Subsidiaries (“Applicable Laws”), except as could not, individually or in the aggregate, reasonably be expected
to result in a Material Adverse Effect; (B) has not received any FDA Form 483, notice of adverse finding, warning letter, untitled letter
or other correspondence or notice from the FDA or any other governmental authority alleging or asserting noncompliance with any Applicable
Laws or any licenses, certificates, approvals, clearances, authorizations, permits and supplements or amendments thereto required by
any such Applicable Laws (“Authorizations”); (C) possesses all material Authorizations and such Authorizations are
valid and in full force and effect and are not in material violation of any term of any such Authorizations; (D) has not received notice
of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any governmental authority
or third party alleging that any product operation or activity is in violation of any Applicable Laws or Authorizations and has no knowledge
that any such governmental authority or third party is considering any such claim, litigation, arbitration, action, suit, investigation
or proceeding; (E) has not received notice that any governmental authority has taken, is taking or intends to take action to limit, suspend,
modify or revoke any Authorizations and has no knowledge that any such governmental authority is considering such action; (F) has filed,
obtained, maintained or submitted all material reports, documents, forms, notices, applications, records, claims, submissions and supplements
or amendments as required by any Applicable Laws or Authorizations and that all such reports, documents, forms, notices, applications,
records, claims, submissions and supplements or amendments were complete and correct on the date filed (or were corrected or supplemented
by a subsequent submission); and (G) has not, either voluntarily or involuntarily, initiated, conducted, or issued or caused to be initiated,
conducted or issued, any recall, market withdrawal or replacement, safety alert, post sale warning, “dear healthcare provider”
letter, or other notice or action relating to the alleged lack of safety or efficacy of any product or any alleged product defect or
violation and, to the Company’s knowledge, no third party has initiated, conducted or intends to initiate any such notice or action.
(xx)
Statistical and Market-Related Data. The statistical, demographic and market-related data included in the Registration Statement
and Prospectus are based on or derived from sources that the Company believes to be reliable and accurate or represent the Company’s
good faith estimates that are made on the basis of data derived from such sources.
(yy)
Cybersecurity & Protection of Personal Data. The Company and its Subsidiaries’ information technology assets and equipment,
computers, systems, networks, hardware, software, websites, applications, and databases (collectively, “IT Systems”)
are adequate for, and operate and perform in all material respects as required in connection with the operation of the business of the
Company as currently conducted, free and clear of all material bugs, errors, defects, Trojan horses, time bombs, malware and other corruptants.
The Company and its Subsidiaries have implemented and maintained commercially reasonable physical, technical and administrative controls,
policies, procedures, and safeguards to maintain and protect their material confidential information and the integrity, continuous operation,
redundancy and security of all IT Systems and data, including all “Personal Data” (defined below) and all sensitive, confidential
or regulated data (“Confidential Data”) used in connection with their businesses except as would not, individually
or in the aggregate for all such matters have a Material Adverse Effect. “Personal Data” includes (i) a natural person’s
name, street address, telephone number, e-mail address, photograph, social security number or tax identification number, driver’s
license number, passport number, credit card number, bank information, or customer or account number; (ii) any information which would
qualify as “personally identifying information” under the Federal Trade Commission Act, as amended; (iii) “personal
data” as defined by GDPR or applicable Israeli laws; (iv) any information which would qualify as “protected health information”
under the Health Insurance Portability and Accountability Act of 1996, as amended by the Health Information Technology for Economic and
Clinical Health Act (collectively, “HIPAA”); (v) any “personal information” as defined by the California
Consumer Privacy Act (“CCPA”); and (vi) any other piece of information that allows the identification of such natural
person, or his or her family, or permits the collection or analysis of any data related to an identified person’s health or sexual
orientation. There have been no breaches, violations, outages or unauthorized uses of or accesses to same, except for those that have
been remedied without material cost or liability or the duty to notify any other person, nor any incidents under internal review or investigations
relating to the same. The Company and its Subsidiaries are presently in material compliance with all applicable laws or statutes and
all judgments, orders, rules and regulations of any court or arbitrator or governmental or regulatory authority, internal policies and
contractual obligations relating to the privacy and security of IT Systems, Confidential Data (including confidential data of third parties),
and Personal Data and to the protection of such IT Systems, Confidential Data, and Personal Data from unauthorized use, access, misappropriation
or modification.
(zz)
Compliance with Data Privacy Laws. The Company and its Subsidiaries are, and at all prior times were, in compliance in all material
respects with all applicable state and federal data privacy and security laws and regulations, including without limitation HIPAA, CCPA,
and the European Union General Data Protection Regulation (“GDPR”) (EU 2016/679) (collectively, the “Privacy
Laws”). To ensure compliance with the Privacy Laws, the Company has in place, complies with, and takes appropriate steps to
ensure compliance in all material respects with their policies and procedures relating to data privacy and security and the collection,
storage, use, processing, disclosure, handling, and analysis of Personal Data and Confidential Data (the “Policies”).
The Company has at all times made all disclosures to users or customers required by applicable laws and regulatory rules or requirements,
and none of such disclosures made or contained in any Policy have been inaccurate or in violation of any applicable laws and regulatory
rules or requirements in any material respect. The Company further certifies that neither it nor any subsidiary: (i) has received notice
of any actual or potential liability under or relating to, or actual or potential violation of, any of the Privacy Laws, and has no knowledge
of any event or condition that would reasonably be expected to result in any such notice; (ii) is currently conducting or paying for,
in whole or in part, any investigation, remediation, or other corrective action pursuant to any Privacy Law; or (iii) is a party to any
order, decree, or agreement that imposes any obligation or liability under any Privacy Law, except in the case of the foregoing (i),
(ii) and (iii) as would not, individually or in the aggregate, have a Material Adverse Effect.
(aaa)
Reserved.
(bbb)
Stabilization. The Company has not taken, nor will it take, directly or indirectly, any action designed to, or which might reasonably
be expected to cause or result in, or which has constituted or which might reasonably be expected to constitute, the stabilization or
manipulation of the price of the Ordinary Shares or any security of the Company to facilitate the sale or resale of any of the Placement
Shares.
(ccc)
Governmental Grants. Except as set forth in the Registration Statement and the Prospectus, neither the Company nor its Subsidiary
has received any grant from the Israel Innovation Authority of the Ministry of Economy and Industry of the State of Israel (formerly
known as the Office of the Chief Scientist) (the “IIA”) or any other Israeli governmental or regulatory authority,
including the Investment Center of the Ministry of Economy and Industry of the State of Israel. Neither the Company nor its Subsidiary
has received any notice denying, revoking or modifying any “Approved Enterprise,” “Benefited Enterprise,” “Preferred
Enterprise,” “Preferred Technology Enterprise” or “Special Preferred Technology Enterprise” status or benefits
with respect to any of the Company’s facilities or operations (collectively and together with the grants approved or received by
the IIA, the “Governmental Grant”). No event has occurred, and no circumstance or condition exists, that would reasonably
be expected to give rise to or serve as the basis for (i) the annulment, revocation, withdrawal, suspension, cancellation, recapture
or modification of the Governmental Grant, (ii) the imposition of any material limitation on the Governmental Grant or (iii) a requirement
that the Company return or refund any benefits provided under the Governmental Grant. All information supplied by the Company with respect
to the applications or notifications relating to Governmental Grant was true, correct and complete in all material respects when supplied
to the appropriate authorities.
(ddd)
Choice of Law. The choice of laws of the State of New York as the governing law of this Agreement is a valid choice of law under
the laws of the State of Israel. The Company has the power to submit and, pursuant to Section 18 of this Agreement, has validly and irrevocably
submitted to the personal jurisdiction of each State and Federal Court Sitting In The City of New York, Borough of Manhattan. Subject
to the conditions and qualifications set forth in the Registration Statement and the Prospectus, a final and conclusive judgment against
the Company for a definitive sum of money entered by any court in the United States may be enforced by an Israeli court. Neither the
Company nor its properties or assets has immunity under the State of Israel, U.S. federal or New York state law from any legal action,
suit or proceeding, from the giving of any relief in any such legal action, suit or proceeding, from set-off or counterclaim, from the
jurisdiction of the State of Israel, U.S. federal or New York state court, from service of process, attachment upon or prior to judgment,
or attachment in aid of execution of judgment, or from execution of a judgment, or other legal process or proceeding for the giving of
any relief or for the enforcement of a judgment, in any such court with respect to their respective obligations, liabilities or any other
matter under or arising out of or in connection herewith; and, to the extent that the Company or any of its properties, assets or revenues
may have or may hereafter become entitled to any such right of immunity in any such court in which proceedings arising out of, or relating
to the transactions contemplated by this Agreement, may at any time be commenced, the Company has, pursuant to this Agreement, waived,
and it will waive such right to the extent permitted by law.
Any
certificate signed by an officer of the Company and delivered to the Agent or to counsel for the Agent pursuant to or in connection with
this Agreement shall be deemed to be a representation and warranty by the Company, as applicable, to the Agent as to the matters set
forth therein.
7.
Covenants of the Company. The Company covenants and agrees with Agent that:
(a)
Registration Statement Amendments. After the date of this Agreement and during any period in which a Prospectus relating to any
Placement Shares is required to be delivered by the Agent under the Securities Act (including in circumstances where such requirement
may be satisfied pursuant to Rule 172 under the Securities Act or similar rule), (i) the Company will notify the Agent promptly of the
time when any subsequent amendment to the Registration Statement, other than documents incorporated by reference, has been filed with
the Commission and/or has become effective or any subsequent supplement to the Prospectus has been filed and of any request by the Commission
for any amendment or supplement to the Registration Statement or Prospectus or for additional information related to the transactions
contemplated by this Agreement, (ii) the Company will prepare and file with the Commission, promptly upon the Agent’s request,
any amendments or supplements to the Registration Statement or Prospectus that, in the Agent’s reasonable opinion, may be necessary
or advisable in connection with the distribution of the Placement Shares by the Agent (provided, however, that the failure
of the Agent to make such request shall not relieve the Company of any obligation or liability hereunder, or affect the Agent’s
right to rely on the representations and warranties made by the Company in this Agreement and provided, further, that the
only remedy the Agent shall have with respect to the failure to make such filing shall be to cease making sales under this Agreement
until such amendment or supplement is filed); (iii) the Company will not file any amendment or supplement to the Registration Statement
or Prospectus, other than documents incorporated by reference, relating to the Placement Shares or a security convertible into the Placement
Shares unless a copy thereof has been submitted to the Agent within a reasonable period of time before the filing and the Agent has not
objected thereto (provided, however, that (A) the failure of the Agent to make such objection shall not relieve the Company
of any obligation or liability hereunder, or affect the Agent’s right to rely on the representations and warranties made by the
Company in this Agreement; (B) the Company has no obligation to provide the Agent any advance copy of such filing or to provide Agent
an opportunity to object to such filing if the filing does not name the Agent or does not relate to or otherwise affect the transactions
contemplated by this Agreement; and (C) provided, further, that the only remedy the Agent shall have with respect to the
failure by the Company to obtain such consent shall be to cease making sales under this Agreement) and the Company will furnish to the
Agent at the time of filing thereof a copy of any document that upon filing is deemed to be incorporated by reference into the Registration
Statement or Prospectus, except for those documents available via EDGAR; and (iv) the Company will cause each amendment or supplement
to the Prospectus to be filed with the Commission as required pursuant to the applicable paragraph of Rule 424(b) of the Securities Act
or, in the case of any document to be incorporated by reference therein, to be filed with the Commission as required pursuant to the
Exchange Act, within the time period prescribed (the determination to file or not file any amendment or supplement with the Commission
under this Section 7(a), based on the Company’s reasonable opinion or reasonable objections, shall be made exclusively by the Company).
(b)
Notice of Commission Stop Orders. The Company will advise the Agent, promptly after it receives notice or obtains knowledge thereof,
of the issuance or threatened issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement,
of the suspension of the qualification of the Placement Shares for offering or sale in any jurisdiction, or of the initiation or threatening
of any proceeding for any such purpose; and it will promptly use its commercially reasonable efforts to prevent the issuance of any stop
order or to obtain its withdrawal if such a stop order should be issued. The Company will advise the Agent promptly after it receives
any request by the Commission for any amendments to the Registration Statement or any amendment or supplements to the Prospectus or any
Issuer Free Writing Prospectus or for additional information related to the offering of the Placement Shares or for additional information
related to the Registration Statement, the Prospectus or any Issuer Free Writing Prospectus.
(c)
Delivery of Prospectus; Subsequent Changes. During any period in which a Prospectus relating to the Placement Shares is required
to be delivered by the Agent under the Securities Act with respect to the offer and sale of the Placement Shares, (including in circumstances
where such requirement may be satisfied pursuant to Rule 172 under the Securities Act or similar rule), the Company will use its commercially
reasonable efforts to comply with all requirements imposed upon it by the Securities Act, as from time to time in force, and file on
or before their respective due dates all reports and any definitive proxy or information statements required to be filed by the Company
with the Commission pursuant to Sections 13(a), 13(c), 14, 15(d) or any other provision of or under the Exchange Act. If the Company
has omitted any information from the Registration Statement pursuant to Rule 430B under the Securities Act, it will use its commercially
reasonable efforts to comply with the provisions of and make all requisite filings with the Commission pursuant to said Rule 430B and
to notify the Agent promptly of all such filings. If during such period any event occurs as a result of which the Prospectus as then
amended or supplemented would include an untrue statement of a material fact or omit to state a material fact necessary to make the statements
therein, in the light of the circumstances then existing, not misleading, or if during such period it is necessary to amend or supplement
the Registration Statement or Prospectus to comply with the Securities Act, the Company will promptly notify the Agent to suspend the
offering of Placement Shares during such period and the Company will promptly amend or supplement the Registration Statement or Prospectus
(at the expense of the Company) so as to correct such statement or omission or effect such compliance; provided, however, that the Company
may delay the filing of any amendment or supplement, if in the judgment of the Company, it is in the best interests of the Company.
(d)
Listing of Placement Shares. Prior to the date of the first Placement Notice, the Company will use its commercially reasonable
efforts to cause the Placement Shares to be listed on the Exchange.
(e)
Delivery of Registration Statement and Prospectus. The Company will furnish to the Agent and its counsel (at the reasonable expense
of the Company) copies of the Registration Statement, the Prospectus (including all documents incorporated by reference therein) and
all amendments and supplements to the Registration Statement or Prospectus that are filed with the Commission during any period in which
a Prospectus relating to the Placement Shares is required to be delivered under the Securities Act (including all documents filed with
the Commission during such period that are deemed to be incorporated by reference therein), in each case as soon as reasonably practicable
and in such quantities as the Agent may from time to time reasonably request and, at Agent’s reasonable request, will also furnish
copies of the Prospectus to each exchange or market on which sales of the Placement Shares may be made; provided, however, that the Company
shall not be required to furnish any document (other than the Prospectus) to the Agent or their counsel to the extent such document is
available on EDGAR.
(f)
Earnings Statement. The Company will make generally available to its security holders as soon as practicable, but in any event
not later than 15 months after the end of the Company’s current fiscal quarter, an earning statement covering a 12-month period
that satisfies the provisions of Section 11(a) and Rule 158 of the Securities Act, provided that the Company will be deemed to have furnished
such statements to its security holders to the extent they are filed with the Commission on EDGAR.
(g)
Use of Proceeds. The Company will use the Net Proceeds as described in the Prospectus in the section entitled “Use of Proceeds.”
(h)
Notice of Other Sales. Without the prior written consent of the Agent, the Company will not, (A) directly or indirectly, offer
to sell, sell, contract to sell, grant any option to sell or otherwise dispose of any Ordinary Shares (other than the Placement Shares
offered pursuant to this Agreement) or securities convertible into or exchangeable for Ordinary Shares, warrants or any rights to purchase
or acquire Ordinary Shares during the period beginning on the date on which any Placement Notice is delivered to the Agent hereunder
and ending on the final Settlement Date with respect to Placement Shares sold pursuant to such Placement Notice (or, if the Placement
Notice has been terminated or suspended prior to the sale of all Placement Shares covered by a Placement Notice, the date of such suspension
or termination); and (B) directly or indirectly in any other “at the market” or continuous equity transaction offer to sell,
sell, contract to sell, grant any option to sell or otherwise dispose of any Ordinary Shares (other than the Placement Shares offered
or sold pursuant to this Agreement or Ordinary Shares offered or sold pursuant to an equity line transaction) or securities convertible
into or exchangeable for Ordinary Shares, warrants or any rights to purchase or acquire, Ordinary Shares prior to the termination of
this Agreement; provided, however, that such restrictions will not be required in connection with the Company’s issuance
or sale of (i) Ordinary Shares, restricted stock units, options to purchase Ordinary Shares, warrants to purchase Ordinary Shares or
Ordinary Shares issuable upon the exercise of options or warrants or the vesting of any of the foregoing, pursuant to any option, warrant
or benefits plan, stock ownership plan or dividend reinvestment plan (but not Ordinary Shares subject to a waiver to exceed plan limits
in its dividend reinvestment plan) of the Company whether now in effect or hereafter implemented, (ii) Ordinary Shares issuable upon
conversion of securities or the exercise of warrants, options or other rights in effect or outstanding, and disclosed in filings by the
Company available on EDGAR from time to time or otherwise in writing to the Agent, and (iii) Ordinary Shares or securities convertible
into or exchangeable for Ordinary Shares issued in privately negotiated transactions to vendors, customers or other commercial or strategic
partners or potential commercial or strategic partners, as consideration for mergers, acquisitions, or other business combinations or
strategic alliances occurring after the date of this Agreement which are not issued for capital raising purposes.
(i)
Change of Circumstances. The Company will, at any time during the pendency of a Placement Notice advise the Agent promptly after
it shall have received notice or obtained knowledge thereof, of any information or fact that would alter or affect in any material respect
any opinion, certificate, letter or other document required to be provided to the Agent pursuant to this Agreement.
(j)
Due Diligence Cooperation. The Company will cooperate with any reasonable due diligence review conducted by the Agent or its representatives
in connection with the transactions contemplated hereby, including, without limitation, providing information and making available documents
and senior corporate officers, during regular business hours and at the Company’s principal offices, as the Agent may reasonably
request.
(k)
Required Filings Relating to Placement of Placement Shares. The Company shall disclose in (x) its Annual Report on Form 20-F and
(y) any Periodic Report on Form 6-K under which the Company furnishes its quarterly results of operations for the prior quarter, in each
case to be filed by the Company with, or furnished by the Company to, the Commission from time to time, the number of the Placement Shares
sold through the Agent under this Agreement, and the net proceeds to the Company from the sale of the Placement Shares pursuant to this
Agreement during the relevant fiscal year and the fourth quarter of such fiscal year (in the case of an Annual Report on Form 20-F) or
the relevant quarter (in the case of a Periodic Report on Form 6-K in which the Company furnishes its quarterly results of operations
for the relevant quarter). The Company agrees that on such dates as the Securities Act shall require with respect to the Placement Shares,
the Company will (i) file a prospectus supplement with the Commission under the applicable paragraph of Rule 424(b) under the Securities
Act, which prospectus supplement will set forth, within the relevant period, the amount of Placement Shares sold through the Agent, the
Proceeds to the Company and the compensation payable by the Company to the Agent with respect to such Placement Shares, and (ii) deliver
such number of copies of each such prospectus supplement to each exchange or market on which such sales were effected as may be required
by the rules or regulations of such exchange or market; provided, however, that no such filing shall be required if the Company shall
have disclosed such information in its most recent periodic report filed pursuant to the Exchange Act, and such disclosure is sufficient
pursuant to the Exchange Act.
(l)
Representation Dates; Certificate. (1) Prior to the date of the first Placement Notice and (2) each time the Company:
(i)
files the Prospectus relating to the Placement Shares or amends or supplements (other than a prospectus supplement relating solely to
an offering of securities other than the Placement Shares) the Registration Statement or the Prospectus relating to the Placement Shares
by means of a post-effective amendment, sticker, or supplement but not by means of incorporation of documents by reference into the Registration
Statement or the Prospectus relating to the Placement Shares;
(ii)
files an Annual Report on Form 20-F under the Exchange Act (including any Form 20-F/A containing amended financial information or a material
amendment to the previously filed Form 20-F);
(iii)
files its quarterly results of operations on Form 6-K under the Exchange Act; or
(iv)
furnishes or files a current report on Form 6-K containing amended financial information under the Exchange Act that is incorporated
by reference into the Registration Statement;
(each
date of filing of one or more of the documents referred to in clauses (i) through (iv) shall be a “Representation Date.”)
the
Company shall furnish the Agent (but in the case of clause (iv) above only if the Agent reasonably determines that the information contained
in such Form 6-K is material) with a certificate within five (5) Trading Days of each Representation Date, in the form attached hereto
as Exhibit 7(l), modified, as necessary, to relate to the Registration Statement and the Prospectus as amended or supplemented. The requirement
to provide a certificate under this Section 7(1) shall be waived for any Representation Date occurring at a time a Placement Notice is
not pending or a suspension is in effect, which waiver shall continue until the earlier to occur of the date the Company delivers instructions
for the sale of Placement Shares hereunder (which for such calendar quarter shall be considered a Representation Date) and the next occurring
Representation Date. Notwithstanding the foregoing, if the Company subsequently decides to sell Placement Shares following a Representation
Date when a Placement Notice was not pending or a suspension was in effect and did not provide the Agent with a certificate under this
Section 7(l), then before the Company delivers the instructions for the sale of Placement Shares or the Agent sells any Placement Shares
pursuant to such instructions, the Company shall provide the Agent with a certificate in conformity with this Section 7(l) dated as of
the date that the instructions for the sale of Placement Shares are issued.
(m)
Opinions and Negative Assurance Letter. (1) Prior to the date of the first Placement Notice and (2) within five (5) Trading Days
of each Representation Date with respect to which the Company is obligated to deliver a certificate pursuant to Section 7(l) for
which no waiver is applicable and excluding the date of this Agreement, the Company shall cause to be furnished to the Agent a written
opinion of each of Greenberg Traurig, P.A. (“Company U.S. Counsel”), and Meitar | Law Offices (“Company Israeli
Counsel”) and (ii) a negative assurance letter of Company U.S. Counsel, each in form and substance reasonably satisfactory
to the Agent and its counsel, modified, as necessary, to relate to the Registration Statement and the Prospectus as then amended or supplemented;
provided, that in lieu of such opinions for subsequent periodic filings under the Exchange Act, counsel may furnish the Agent
with a letter (a “Reliance Letter”) to the effect that the Agent may rely on a prior opinion delivered under this
Section 7(m) to the same extent as if it were dated the date of such letter (except that statements in such prior opinion shall be deemed
to relate to the Registration Statement and the Prospectus as amended or supplemented as of the date of the Reliance Letter).
(n)
Comfort Letter; Officers’ Certificate. (1) Prior to the date of the first Placement Notice and (2) within five (5) Trading
Days of each Representation Date with respect to which the Company is obligated to deliver a certificate pursuant to Section 7(l)
for which no waiver is applicable and excluding the date of this Agreement, the Company shall cause its independent registered public
accounting firm to furnish the Agent letters (the “Comfort Letters”), dated the date the Comfort Letter is delivered,
which shall meet the requirements set forth in this Section 7(o); provided, that if requested by the Agent, the Company shall
cause a Comfort Letter to be furnished to the Agent within ten (10) Trading Days of the date of occurrence of any material transaction
or event, including the restatement of the Company’s financial statements. The Comfort Letter from the Company’s independent
registered public accounting firm shall be in a form and substance reasonably satisfactory to the Agent, (i) confirming that they are
an independent registered public accounting firm within the meaning of the Securities Act and the PCAOB, (ii) stating, as of such date,
the conclusions and findings of such firm with respect to the financial information and other matters ordinarily covered by accountants’
“comfort letters” to underwriters in connection with registered public offerings (the first such letter, the “Initial
Comfort Letter”) and (iii) updating the Initial Comfort Letter with any information that would have been included in the Initial
Comfort Letter had it been given on such date and modified as necessary to relate to the Registration Statement and the Prospectus, as
amended and supplemented to the date of such letter. Additionally, at the time any Comfort Letter is delivered, the Chief Financial Officer,
Chief Executive Officer or Principal Financial Officer of the Company shall deliver to the Agent a certificate, in form and substance
reasonably satisfactory to the Agent, relating to any financial information included or incorporated by reference in the Registration
Statement and Prospectus for which comfort is not provided in the Comfort Letter.
(o)
Market Activities. The Company will not, directly or indirectly, (i) take any action designed to cause or result in, or that constitutes
or would reasonably be expected to constitute, the stabilization or manipulation of the price of any security of the Company to facilitate
the sale or resale of Ordinary Shares or (ii) sell, bid for, or purchase Ordinary Shares in violation of Regulation M, or pay anyone
any compensation for soliciting purchases of the Placement Shares other than the Agent; provided, however, that the Company may bid for
and purchase Ordinary Shares in accordance with Rule 10b-18 under the Exchange Act.
(p)
Investment Company Act. The Company will conduct its affairs in such a manner so as to reasonably ensure that neither it nor any
Subsidiary will be or become, at any time prior to the termination of this Agreement, an “investment company,” as such term
is defined in the Investment Company Act, assuming no change in the Commission’s current
interpretation as to entities that are not considered an investment company.
(q)
No Offer to Sell. Other than the Prospectus and the Issuer Free Writing Prospectus approved in advance by the Company and the
Agent in its capacity as agent hereunder, neither the Agent nor the Company (including its agents and representatives, other than the
Agent in its capacity as such) will make, use, prepare, authorize, approve or refer to any written communication (as defined in Rule
405 under the Securities Act), required to be filed with the Commission, that constitutes an offer to sell or solicitation of an offer
to buy Placement Shares hereunder.
(r)
Blue Sky and Other Qualifications. The Company will use its commercially reasonable efforts, in cooperation with the Agent,
to qualify the Placement Shares for offering and sale, or to obtain an exemption for the Placement Shares to be offered and sold, under
the applicable securities laws of such states and other jurisdictions (domestic or foreign) as the Agent may designate and to maintain
such qualifications and exemptions in effect for so long as required for the distribution of the Placement Shares (but in no event for
less than one year from the date of this Agreement); provided, however, that the Company shall not be obligated to file
any general consent to service of process or to qualify as a foreign corporation or as a dealer in securities in any jurisdiction in
which it is not so qualified or to subject itself to taxation in respect of doing business in any jurisdiction in which it is not otherwise
so subject. In each jurisdiction in which the Placement Shares have been so qualified or exempt, the Company will file such statements
and reports as may be required by the laws of such jurisdiction to continue such qualification or exemption, as the case may be, in effect
for so long as required for the distribution of the Placement Shares (but in no event for less than one year from the date of this Agreement).
(s)
Sarbanes-Oxley Act. The Company and the Subsidiaries will maintain and keep accurate books and records reflecting their assets
and maintain internal accounting controls in a manner designed to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles
and including those policies and procedures that (i) pertain to the maintenance of records that in reasonable detail accurately and fairly
reflect the transactions and dispositions of the assets of the Company, (ii) provide reasonable assurance that transactions are recorded
as necessary to permit the preparation of the Company’s consolidated financial statements in accordance with generally accepted
accounting principles, (iii) that receipts and expenditures of the Company are being made only in accordance with management’s
and the Company’s directors’ authorization, and (iv) provide reasonable assurance regarding prevention or timely detection
of unauthorized acquisition, use or disposition of the Company’s assets that could have a material effect on its financial statements.
The Company and the Subsidiaries will maintain such controls and other procedures, including, without limitation, those required by Sections
302 and 906 of the Sarbanes-Oxley Act, and the applicable regulations thereunder that are designed to ensure that information required
to be disclosed by the Company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and
reported, within the time periods specified in the Commission’s rules and forms, including, without limitation, controls and procedures
designed to ensure that information required to be disclosed by the Company in the reports that it files or submits under the Exchange
Act is accumulated and communicated to the Company’s management, including its principal executive officer and principal financial
officer, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure and to ensure
that material information relating to the Company or the Subsidiaries is made known to them by others within those entities, particularly
during the period in which such periodic reports are being prepared.
(t)
Secretary’s Certificate; Further Documentation. Prior to the date of the first Placement Notice, the Company shall deliver
to the Agent a certificate of the Secretary of the Company and attested to by an executive officer of the Company, dated as of such date,
certifying as to (i) the articles of association of the Company, (ii) any other organizational documents of the Company, (iii) the resolutions
of the Board of Directors of the Company authorizing the execution, delivery and performance of this Agreement and the issuance of the
Placement Shares and (iv) the incumbency of the officers duly authorized to execute this Agreement and the other documents contemplated
by this Agreement. Within five (5) Trading Days of each Representation Date, the Company shall have furnished to the Agent such further
information, certificates and documents as the Agent may reasonably request.
(u)
Intellectual Property Certificate. (1) Prior to the date of the first Placement Notice and (2) within five (5) Trading Days of
each Representation Date with respect to which the Company is obligated to deliver a certificate pursuant to Section 7(l) for
which no waiver is applicable and excluding the date of this Agreement, the Company shall cause to be furnished to the Agent a certificate
certifying to certain intellectual property matters of the Company, in form and substance satisfactory to counsel for the Agent, and
attested to by an executive officer of the Company, dated as of such date. The requirement to provide a certificate under this Section
7(1) shall be waived for any Representation Date occurring at a time a Placement Notice is not pending or a suspension is in effect,
which waiver shall continue until the earlier to occur of the date the Company delivers instructions for the sale of Placement Shares
hereunder (which for such calendar quarter shall be considered a Representation Date) and the next occurring Representation Date. Notwithstanding
the foregoing, if the Company subsequently decides to sell Placement Shares following a Representation Date when a Placement Notice was
not pending or a suspension was in effect and did not provide the Agent with a certificate under this Section 7(l), then before the Company
delivers the instructions for the sale of Placement Shares or the Agent sells any Placement Shares pursuant to such instructions, the
Company shall provide the Agent with a certificate in conformity with this Section 7(l) dated as of the date that the instructions for
the sale of Placement Shares are issued.
8.
Payment of Expenses. The Company will pay all expenses incident to the performance of its obligations under this Agreement, including
(i) the preparation and filing of the Registration Statement and the Prospectus, including any fees required by the Commission, and the
printing or electronic delivery of the Prospectus as originally filed and of each amendment and supplement thereto, in such number as
the Agent shall deem necessary, (ii) the printing and delivery to the Agent of this Agreement and such other documents as may be required
in connection with the offering, purchase, sale, issuance or delivery of the Placement Shares, (iii) the preparation, issuance and delivery
of the certificates, if any, for the Placement Shares to the Agent, including any stock or other transfer taxes and any capital duties,
stamp duties or other duties or taxes payable upon the sale, issuance or delivery of the Placement Shares to the Agent, (iv) the fees
and disbursements of the counsel, accountants and other advisors to the Company, (v) the reasonable fees and expenses of the Agent including
but not limited to the reasonable fees and expenses of the counsel to the Agent, payable upon the execution of this Agreement, in an
amount not to exceed (a) $50,000 in connection with the execution of this Agreement, (b) in an amount not to exceed $2,500 per calendar
quarter thereafter payable in connection with each Representation Date with respect to which the Company is obligated to deliver a certificate
pursuant to Section 7(l) for which no waiver is applicable excluding the date of this Agreement, and (c) $15,000 for each program “refresh”
(i.e. filing of a new registration statement, prospectus or prospectus supplement relating to the Placement Shares and/or an amendment
of this Agreement) executed pursuant to this Agreement, (vi) the printing and delivery to the Agent of copies of any Permitted Free Writing
Prospectus (as defined below) and the Prospectus and any amendments or supplements thereto in such number as the Agent shall deem necessary,
(vii) the fees and expenses of the transfer agent and registrar for the Ordinary Shares, (viii) the filing and other fees incident to
any review by FINRA of the terms of the sale of the Placement Shares including the fees of the Agent’s counsel (subject to the
cap, set forth in clause (v) above), and (xi) the fees and expenses incurred in connection with the listing of the Placement Shares on
the Exchange. If requested by the Agent, the Company agrees to pay the fees and expenses of counsel to the Agent set forth in clause
(v) above by wire transfer of immediately available funds directly to such counsel upon presentation of an invoice containing the requisite
payment information prepared by such counsel.
9.
Conditions to the Agent’s Obligations. The obligations of the Agent hereunder with respect to a Placement will be subject
to the continuing accuracy and completeness of the representations and warranties made by the Company herein, to the due performance
by the Company of its obligations hereunder, to the completion by the Agent of a due diligence review satisfactory to it in its reasonable
judgment, and to the continuing satisfaction (or waiver by the Agent in its sole discretion) of the following additional conditions:
(a)
Registration Statement Effective. The Registration Statement shall have become effective and shall be available for the sale of
all Placement Shares contemplated to be issued by any Placement Notice.
(b)
No Material Notices. None of the following events shall have occurred and be continuing: (i) receipt by the Company of any request
for additional information from the Commission or any other federal or state governmental authority during the period of effectiveness
of the Registration Statement, the response to which would require any post-effective amendments or supplements to the Registration Statement
or the Prospectus; (ii) the issuance by the Commission or any other federal or state governmental authority of any stop order suspending
the effectiveness of the Registration Statement or the initiation of any proceedings for that purpose; (iii) receipt by the Company of
any notification with respect to the suspension of the qualification or exemption from qualification of any of the Placement Shares for
sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose; or (iv) the occurrence of any event that
makes any statement of material fact made in the Registration Statement or the Prospectus or any material document incorporated or deemed
to be incorporated therein by reference untrue in any material respect or that requires the making of any changes in the Registration
Statement, the Prospectus or Incorporated Documents so that, in the case of the Registration Statement, it will not contain any materially
untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements
therein not misleading and, that in the case of the Prospectus, it will not contain any materially untrue statement of a material fact
or omit to state any material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances
under which they were made, not misleading.
(c)
No Misstatement or Material Omission. The Agent shall not have advised the Company that the Registration Statement or Prospectus,
or any amendment or supplement thereto, contains an untrue statement of fact that in the Agent’s reasonable opinion is material,
or omits to state a fact that in the Agent’s reasonable opinion is material and is required to be stated therein or is necessary
to make the statements therein not misleading.
(d)
Material Changes. Except as contemplated in the Prospectus, or disclosed in the Company’s reports filed with the Commission,
there shall not have been any material adverse change in the authorized share capital of the Company or any Material Adverse Effect or
any development that would cause a Material Adverse Effect, or a downgrading in or withdrawal of the rating assigned to any of the Company’s
securities (other than asset backed securities) by any rating organization or a public announcement by any rating organization that it
has under surveillance or review its rating of any of the Company’s securities (other than asset backed securities), the effect
of which, in the case of any such action by a rating organization described above, in the reasonable judgment of the Agent (without relieving
the Company of any obligation or liability it may otherwise have), is so material as to make it impracticable or inadvisable to proceed
with the offering of the Placement Shares on the terms and in the manner contemplated in the Prospectus.
(e)
Legal Opinions. The Agent shall have received the opinions and the negative assurance letter required to be delivered pursuant
to Section 7(m) on or before the date on which such delivery of such opinion and letter, as applicable, is required pursuant to Section
7(n).
(f)
Comfort Letter. The Agent shall have received the Comfort Letter required to be delivered pursuant to Section 7(o) on or before
the date on which such delivery of such Comfort Letter is required pursuant to Section 7(o).
(g)
Representation Certificate. The Agent shall have received the certificate required to be delivered pursuant to Section 7(l) on
or before the date on which delivery of such certificate is required pursuant to Section 7(l).
(h)
Secretary’s Certificate. On the date of this Agreement, the Agent shall have received a certificate, signed on behalf of
the Company by its corporate Secretary, in form and substance reasonably satisfactory to the Agent and its counsel.
(i)
No Suspension. Trading in the Ordinary Shares shall not have been suspended on the Exchange, and the Ordinary Shares shall not
have been delisted from the Exchange.
(j)
Other Materials. On each date on which the Company is required to deliver a certificate pursuant to Section 7(l), the Company
shall have furnished to the Agent such appropriate further information, opinions, certificates, letters and other documents as the Agent
may reasonably request. All such opinions, certificates, letters and other documents will be in compliance with the provisions hereof.
(k)
Securities Act Filings Made. All filings with the Commission required by Rule 424 under the Securities Act to have been filed
prior to the issuance of any Placement Notice hereunder shall have been made within the applicable time period prescribed for such filing
by Rule 424.
(l)
Approval for Listing. The Placement Shares shall either have been (i) approved for listing on the Exchange, subject only to notice
of issuance, or (ii) the Company shall have filed an application for listing of the Placement Shares on the Exchange at, or prior to,
the issuance of any Placement Notice and the Exchange shall have reviewed such application and not provided any objections thereto.
(m)
FINRA. If applicable, FINRA shall have raised no objection to the terms of this offering and the amount of compensation allowable
or payable to the Agent as described in the Prospectus.
(n)
No Termination Event. There shall not have occurred any event that would permit the Agent to terminate this Agreement pursuant
to Section 12(a).
10.
Indemnification and Contribution.
(a)
Company Indemnification. The Company agrees to indemnify and hold harmless the Agent, its affiliates and its partners, members,
directors, officers, employees and agents and each person, if any, who controls the Agent or any affiliate within the meaning of Section
15 of the Securities Act or Section 20 of the Exchange Act as follows:
(i)
against any and all loss, liability, claim, damage and expense whatsoever, as incurred, joint or several, arising out of or based upon
any untrue statement or alleged untrue statement of a material fact contained in the Registration Statement (or any amendment thereto),
or the omission or alleged omission therefrom of a material fact required to be stated therein or necessary to make the statements therein
not misleading, or arising out of any untrue statement or alleged untrue statement of a material fact included in any related Issuer
Free Writing Prospectus or the Prospectus (or any amendment or supplement thereto), or the omission or alleged omission therefrom of
a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not
misleading;
(ii)
against any and all loss, liability, claim, damage and expense whatsoever, as incurred, joint or several, to the extent of the aggregate
amount paid in settlement of any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened,
or of any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission; provided
that (subject to Section 10(d) below) any such settlement is effected with the written consent of the Company, which consent shall not
unreasonably be delayed or withheld; and
(iii)
against any and all expense whatsoever, as incurred (including the fees and disbursements of counsel), reasonably incurred in investigating,
preparing or defending against any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened,
or any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission (whether or
not a party), of the Company to the extent that any such expense is not paid under (i) or (ii) above,
provided,
however, that this indemnity agreement shall not apply to any loss, liability, claim, damage or expense to the extent arising
out of any untrue statement or omission or alleged untrue statement or omission made solely in reliance upon and in conformity with the
Agent’s Information (as defined below).
(b)
Agent Indemnification. The Agent agrees to indemnify and hold harmless the Company and its directors and each officer of the Company
who signed the Registration Statement, and each person, if any, who controls the Company within the meaning of Section 15 of the Securities
Act or Section 20 of the Exchange Act against any and all loss, liability, claim, damage and expense described in the indemnity contained
in Section 10(a), as incurred, but only with respect to untrue statements or omissions, or alleged untrue statements or omissions,
made in the Registration Statement (or any amendments thereto), the Prospectus (or any amendment or supplement thereto) or any Issuer
Free Writing Prospectus (or any amendment or supplement thereto) in reliance upon and in conformity with information relating to the
Agent and furnished to the Company in writing by the Agent expressly for use therein. The Company hereby acknowledges that the only information
that the Agent has furnished to the Company expressly for use in the Registration Statement, the Prospectus, any Prospectus Supplement
or any Issuer Free Writing Prospectus (or any amendment or supplement thereto) are the statements set forth in the 8th paragraph
under the caption “Plan of Distribution” in the Prospectus (the “Agent’s Information”).
(c)
Procedure. Any party that proposes to assert the right to be indemnified under this Section 10 will, promptly after receipt of
notice of commencement of any action against such party in respect of which a claim is to be made against an indemnifying party or parties
under this Section 10, notify each such indemnifying party of the commencement of such action, enclosing a copy of all papers served,
but the omission so to notify such indemnifying party will not relieve the indemnifying party from (i) any liability that it might have
to any indemnified party otherwise than under this Section 10 and (ii) any liability that it may have to any indemnified party under
the foregoing provision of this Section 10 unless, and only to the extent that, such omission results in the forfeiture of substantive
rights or defenses by the indemnifying party. If any such action is brought against any indemnified party and it notifies the indemnifying
party of its commencement, the indemnifying party will be entitled to participate in and, to the extent that it elects by delivering
written notice to the indemnified party promptly after receiving notice of the commencement of the action from the indemnified party,
jointly with any other indemnifying party similarly notified, to assume the defense of the action, with counsel reasonably satisfactory
to the indemnified party, and after notice from the indemnifying party to the indemnified party of its election to assume the defense,
the indemnifying party will not be liable to the indemnified party for any other legal expenses except as provided below and except for
the reasonable and documented costs of investigation subsequently incurred by the indemnified party in connection with the defense. The
indemnified party will have the right to employ its own counsel in any such action, but the fees, expenses and other charges of such
counsel will be at the expense of such indemnified party unless (1) the employment of counsel by the indemnified party has been authorized
in writing by the indemnifying party, (2) the indemnified party has reasonably concluded (based on advice of counsel) that there may
be legal defenses available to it or other indemnified parties that are different from or in addition to those available to the indemnifying
party, (3) a conflict or potential conflict exists (based on advice of counsel to the indemnified party) between the indemnified party
and the indemnifying party (in which case the indemnifying party will not have the right to direct the defense of such action on behalf
of the indemnified party) or (4) the indemnifying party has not in fact employed counsel to assume the defense of such action or counsel
reasonably satisfactory to the indemnified party, in each case, within a reasonable time after receiving notice of the commencement of
the action; in each of which cases the reasonable and documented fees, disbursements and other charges of counsel will be at the expense
of the indemnifying party or parties. It is understood that the indemnifying party or parties shall not, in connection with any proceeding
or related proceedings in the same jurisdiction, be liable for the reasonable fees, disbursements and other charges of more than one
separate firm (plus local counsel) admitted to practice in such jurisdiction at any one time for all such indemnified party or parties.
All such fees, disbursements and other charges will be reimbursed by the indemnifying party promptly after the indemnifying party receives
a written invoice relating fees, disbursements and other reasonable charges in reasonable detail. An indemnifying party will not, in
any event, be liable for any settlement of any action or claim effected without its written consent (such consent not to be unreasonably
withheld or delayed). No indemnifying party shall, without the prior written consent of each indemnified party, settle or compromise
or consent to the entry of any judgment in any pending or threatened claim, action or proceeding relating to the matters contemplated
by this Section 10 (whether or not any indemnified party is a party thereto), unless such settlement, compromise or consent (1) includes
an express and unconditional release of each indemnified party, in form and substance reasonably satisfactory to such indemnified party,
from all liability arising out of such litigation, investigation, proceeding or claim and (2) does not include a statement as to or an
admission of fault, culpability or a failure to act by or on behalf of any indemnified party.
(d)
Contribution. In order to provide for just and equitable contribution in circumstances in which the indemnification provided for
in the foregoing paragraphs of this Section 10 is applicable in accordance with its terms but for any reason is held to be unavailable
or insufficient from the Company or the Agent, the Company and the Agent will contribute to the total losses, claims, liabilities, expenses
and damages (including any investigative, legal and other expenses reasonably incurred and documented in connection with, and any amount
paid in settlement of, any action, suit or proceeding or any claim asserted) to which the Company and the Agent may be subject in such
proportion as shall be appropriate to reflect the relative benefits received by the Company on the one hand and the Agent on the other
hand. The relative benefits received by the Company on the one hand and the Agent on the other hand shall be deemed to be in the same
proportion as the total net proceeds from the sale of the Placement Shares (before deducting expenses) received by the Company bear to
the total compensation received by the Agent from the sale of Placement Shares on behalf of the Company. If, but only if, the allocation
provided by the foregoing sentence is not permitted by applicable law, the allocation of contribution shall be made in such proportion
as is appropriate to reflect not only the relative benefits referred to in the foregoing sentence but also the relative fault, if any,
of the Company, on the one hand, and the Agent, on the other hand, with respect to the statements or omission that resulted in such loss,
claim, liability, expense or damage, or action in respect thereof, as well as any other relevant equitable considerations with respect
to such offering. Such relative fault shall be determined by reference to, among other things, whether the untrue or alleged untrue statement
of a material fact or omission or alleged omission to state a material fact relates to information supplied by the Company or the Agent,
the intent of the parties and their relative knowledge, access to information and opportunity to correct or prevent such statement or
omission. The Company and the Agent agree that it would not be just and equitable if contributions pursuant to this Section 10(e) were
to be determined by pro rata allocation or by any other method of allocation that does not take into account the equitable considerations
referred to herein. The amount paid or payable by an indemnified party as a result of the loss, claim, liability, expense, or damage,
or action in respect thereof, referred to above in this Section 10(e) shall be deemed to include, for the purpose of this Section 10(e),
any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action
or claim to the extent consistent with Section 10(c) hereof. Notwithstanding the foregoing provisions of this Section 10(e), the Agent
shall not be required to contribute any amount in excess of the commissions received by it under this Agreement and no person found guilty
of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any
person who was not guilty of such fraudulent misrepresentation. For purposes of this Section 10(e), any person who controls a party to
this Agreement within the meaning of the Securities Act, any affiliates of the Agent and any officers, directors, partners, employees
or agents of the Agent or any of its affiliates, will have the same rights to contribution as that party, and each director of the Company
and each officer of the Company who signed the Registration Statement will have the same rights to contribution as the Company, subject
in each case to the provisions hereof. Any party entitled to contribution, promptly after receipt of notice of commencement of any action
against such party in respect of which a claim for contribution may be made under this Section 10(e), will notify in writing any such
party or parties from whom contribution may be sought, but the omission to so notify will not relieve that party or parties from whom
contribution may be sought from any other obligation it or they may have under this Section 10(e) except to the extent that the failure
to so notify such other party materially prejudiced the substantive rights or defenses of the party from whom contribution is sought.
Except for a settlement entered into pursuant to the last sentence of Section 10(c) hereof, no party will be liable for contribution
with respect to any action or claim settled without its written consent if such consent is required pursuant to Section 10(c)
hereof.
11.
Representations and Agreements to Survive Delivery. The indemnity and contribution agreements contained in Section 10 of this
Agreement and all representations and warranties of the Company herein or in certificates delivered pursuant hereto shall survive, as
of their respective dates, regardless of (i) any investigation made by or on behalf of the Agent, any controlling persons, or the Company
(or any of their respective officers, directors or controlling persons), (ii) delivery and acceptance of the Placement Shares and payment
therefor or (iii) any termination of this Agreement.
12.
Termination.
(a)
The Agent may terminate this Agreement, by notice to the Company, as hereinafter specified at any time (1) if there has been, since the
time of execution of this Agreement or since the date as of which information is given in the Prospectus, any change, or any development
or event involving a prospective change, in the condition, financial or otherwise, or in the business, properties, earnings, results
of operations or prospects of the Company and its Subsidiaries considered as one enterprise, whether or not arising in the ordinary course
of business, which individually or in the aggregate, in the sole judgment of the Agent is material and adverse and makes it impractical
or inadvisable to market the Placement Shares or to enforce contracts for the sale of the Placement Shares, (2) if there has occurred
any material adverse change in the financial markets in the United States or the international financial markets, any outbreak of hostilities
or escalation thereof or other calamity or crisis or pandemic or any change or development involving a prospective change in national
or international political, financial or economic conditions, in each case the effect of which is such as to make it, in the judgment
of the Agent, impracticable or inadvisable to market the Placement Shares or to enforce contracts for the sale of the Placement Shares,
(3) if trading in the Ordinary Shares has been suspended or limited by the Commission or the Exchange, or if trading generally on the
Exchange has been suspended or limited, or minimum prices for trading have been fixed on the Exchange, (4) if any suspension of trading
of any securities of the Company on any exchange or in the over-the-counter market shall have occurred and be continuing, (5) if a major
disruption of securities settlements or clearance services in the United States shall have occurred and be continuing, or (6) if a banking
moratorium has been declared by either U.S. Federal or New York authorities. Any such termination shall be without liability of any party
to any other party except that the provisions of Section 8 (Payment of Expenses), Section 10 (Indemnification and Contribution), Section
11 (Representations and Agreements to Survive Delivery), Section 17 (Governing Law and Time; Waiver of Jury Trial) and Section 18 (Consent
to Jurisdiction) hereof shall remain in full force and effect notwithstanding such termination. If the Agent elects to terminate this
Agreement as provided in this Section 12(a), the Agent shall provide the required notice as specified in Section 13 (Notices).
(b)
The Company shall have the right, by giving three (3) days notice as hereinafter specified to terminate this Agreement in its sole discretion
at any time after the date of this Agreement. Any such termination shall be without liability of any party to any other party except
that the provisions of Section 8, Section 10, Section 11, Section 17 and Section 18 hereof shall remain in full force and effect notwithstanding
such termination.
(c)
The Agent shall have the right, by giving three (3) days written notice as hereinafter specified to terminate this Agreement in its sole
discretion at any time after the date of this Agreement. Any such termination shall be without liability of any party to any other party
except that the provisions of Section 8, Section 10, Section 11, Section 17 and Section 18 hereof shall remain in full force and effect
notwithstanding such termination.
(d)
This Agreement shall remain in full force and effect unless terminated pursuant to Sections 12(a), (b), or (c) above or otherwise by
mutual agreement of the parties; provided, however, that any such termination by mutual agreement shall in all cases be deemed to provide
that Section 8, Section 10, Section 11, Section 17 and Section 18 shall remain in full force and effect.
(e)
Any termination of this Agreement shall be effective on the date specified in such notice of termination; provided, however, that such
termination shall not be effective until the close of business on the date of receipt of such notice by the Agent or the Company, as
the case may be; provided, further, any termination of this Agreement in accordance with the terms of Section 12(b) or (c) shall not
be effective until the date that is three days after the date of such written notice. If such termination shall occur prior to the Settlement
Date for any sale of Placement Shares, such Placement Shares shall settle in accordance with the provisions of this Agreement.
13.
Notices. All notices or other communications required or permitted to be given by any party to any other party pursuant to the
terms of this Agreement shall be in writing, unless otherwise specified, and if sent to the Agent, shall be delivered to:
JonesTrading
Institutional Services LLC
900
Island Park Drive, Suite 200
Daniel
Island, SC 29492
Attn:
Burke Cook
Email:
burke@jonestrading.com
With
a copy to
Ellenoff
Grossman & Schole LLP
1345
Avenue of the Americas, 11th Floor
New
York, NY 10105
Attention:
Matthew Bernstein, Esq.
Email:
mbernstein@egsllp.com
Telephone:
(212) 370-1300
and
if to the Company, shall be delivered to:
Galmed
Pharmaceuticals Ltd.
16
Abba Hillel Silver Rd.
Ramat
Gan 52506, Israel
Attn:
Allen Baharaff
Email:
ab@galmedpharma.com
with
a copy to:
Greenberg
Traurig, P.A.
One
Azrieli Center
Round
Tower
132
Menachem Begin Rd
Tel
Aviv 6701101
Tel:
+1 212 801 9337
Attn:
Gary Emmanuel
Email:
gary.emmanuel@gtlaw.com
and
Meitar
| Law Offices
16
Abba Hillel Silver Rd.
Ramat
Gan 52506, Israel
Tel:
+972-3-610-3100
Attn:
Mike Rimon
Email:
mrimon@meitar.com
Each
party to this Agreement may change such address for notices by sending to the parties to this Agreement written notice of a new address
for such purpose. Each such notice or other communication shall be deemed given (i) when delivered personally or by verifiable facsimile
transmission (with an original to follow) on or before 4:30 p.m., New York City time, on a Business Day or, if such day is not a Business
Day, on the next succeeding Business Day, (ii) by Electronic Notice as set forth below, (iii) on the next Business Day after timely delivery
to a nationally-recognized overnight courier or (iv) on the Business Day actually received if deposited in the U.S. mail (certified or
registered mail, return receipt requested, postage prepaid). For purposes of this Agreement, “Business Day” shall
mean any day on which the Exchange and commercial banks in the City of New York are open for business.
An
electronic communication (“Electronic Notice”) shall be deemed written notice for purposes of this Section 13 if sent
to the electronic mail address specified by the receiving party under this Section 13. Electronic Notice shall be deemed received at
the time the party sending Electronic Notice receives verification of receipt by the receiving party. Any party receiving Electronic
Notice may request and shall be entitled to receive the notice on paper, in a nonelectronic form (“Nonelectronic Notice”)
which shall be sent to the requesting party within ten (10) days of receipt of the written request for Nonelectronic Notice.
14.
Successors and Assigns. This Agreement shall inure to the benefit of and be binding upon the Company and the Agent and the parties
referred to in Section 10 hereof. References to any of the parties contained in this Agreement shall be deemed to include the successors
and permitted assigns of such party. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the
parties hereto or their respective successors and permitted assigns any rights, remedies, obligations or liabilities under or by reason
of this Agreement, except as expressly provided in this Agreement. Neither party may assign its rights or obligations under this Agreement
without the prior written consent of the other party; provided, however, that the Agent may assign its rights and obligations hereunder
to an affiliate thereof without obtaining the Company’s consent.
15.
Adjustments for Share Splits. The parties acknowledge and agree that all share-related numbers contained in this Agreement shall
be adjusted to take into account any share split, share dividend or similar event effected with respect to the Ordinary Shares.
16.
Entire Agreement; Amendment; Severability. This Agreement (including all schedules and exhibits attached hereto and Placement
Notices issued pursuant hereto) constitutes the entire agreement and supersedes all other prior and contemporaneous agreements and undertakings,
both written and oral, among the parties hereto with regard to the subject matter hereof. Neither this Agreement nor any term hereof
may be amended except pursuant to a written instrument executed by the Company and the Agent. In the event that any one or more of the
provisions contained herein, or the application thereof in any circumstance, is held invalid, illegal or unenforceable as written by
a court of competent jurisdiction, then such provision shall be given full force and effect to the fullest possible extent that it is
valid, legal and enforceable, and the remainder of the terms and provisions herein shall be construed as if such invalid, illegal or
unenforceable term or provision was not contained herein, but only to the extent that giving effect to such provision and the remainder
of the terms and provisions hereof shall be in accordance with the intent of the parties as reflected in this Agreement. No implied waiver
by a party shall arise in the absence of a waiver in writing signed by such party. No failure or delay in exercising any right, power,
or privilege hereunder shall operate as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further
exercise thereof or the exercise of any right, power, or privilege hereunder.
17.
GOVERNING LAW AND TIME; WAIVER OF JURY TRIAL. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF
THE STATE OF NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAWS. SPECIFIED TIMES OF DAY REFER TO NEW YORK CITY TIME. EACH
PARTY HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING
ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.
18.
CONSENT TO JURISDICTION. EACH PARTY HEREBY IRREVOCABLY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS
SITTING IN THE CITY OF NEW YORK, BOROUGH OF MANHATTAN, FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION WITH ANY TRANSACTION
CONTEMPLATED HEREBY, AND HEREBY IRREVOCABLY WAIVES, AND AGREES NOT TO ASSERT IN ANY SUIT, ACTION OR PROCEEDING, ANY CLAIM THAT IT IS
NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT, THAT SUCH SUIT, ACTION OR PROCEEDING IS BROUGHT IN AN INCONVENIENT FORUM
OR THAT THE VENUE OF SUCH SUIT, ACTION OR PROCEEDING IS IMPROPER. EACH PARTY HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND
CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING BY MAILING A COPY THEREOF (CERTIFIED OR REGISTERED MAIL, RETURN
RECEIPT REQUESTED) TO SUCH PARTY AT THE ADDRESS IN EFFECT FOR NOTICES TO IT UNDER THIS AGREEMENT AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE
GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN ANY WAY ANY RIGHT TO
SERVE PROCESS IN ANY MANNER PERMITTED BY LAW.
19.
Waiver of Immunity. With respect to any suit or proceeding arising out of or relating to this Agreement or the transactions contemplated
hereby, the Company irrevocably waives, to the fullest extent permitted by applicable law, all immunity (whether on the basis of sovereignty
or otherwise) from jurisdiction, service of process, attachment (both before and after judgment) and execution to which it might otherwise
be entitled, and with respect to any such suit or proceeding, the Company waives any such immunity in any court of competent jurisdiction,
and will not raise or claim or cause to be pleaded any such immunity at or in respect of any such suit or proceeding, including, without
limitation, any immunity pursuant to the U.S. Foreign Sovereign Immunities Act of 1976, as amended.
20.
Currency Provisions. The obligations of the Company pursuant to this Agreement in respect of any sum due to the Agent, its partners,
members, directors, officers, employees and agents and each person, if any, who controls the Agent or any affiliate within the meaning
of Section 15 of the Securities Act or Section 20 of the Exchange Act, shall, notwithstanding any judgment in a currency other than United
States dollars, not be discharged until the first business day, following receipt by such person of any sum adjudged to be so due in
such other currency, on which such person may in accordance with normal banking procedures purchase United States dollars with such other
currency. If the United States dollars so purchased are less than the sum originally due to any such person in United States dollars
hereunder, the Company agrees as a separate obligation and notwithstanding any such judgment, to indemnify such person against such loss.
21.
Payments. All payments made or deemed to be made by the Company under this Agreement, if any, to the Agent and each of the Agent’s
affiliates and their respective partners, members, directors, officers, employees and agents, and each person, if any, who (i) controls
such Agent within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act or (ii) is controlled by or is under
common control with such Agent (each, a “Payee”), as the case may be, will be made without withholding or deduction
for or on account of any present or future taxes, duties, assessments or governmental charges of whatsoever nature imposed or levied
by or on behalf of the State of Israel or any political subdivision or any taxing authority thereof or therein or of any other jurisdiction
in which the Company is organized or incorporated, engaged in business for tax purposes or is otherwise resident for tax purposes or
has a permanent establishment, any jurisdiction from or through which a payment is made by or on behalf of the Company, or any political
subdivision, authority or agency in or of any of the foregoing having power to tax (each, a “Relevant Taxing Jurisdiction”),
unless the Company is or becomes required by law to withhold or deduct such taxes, duties, assessments or other governmental charges.
In such event, the Company will pay such additional amounts as will result, after such withholding or deduction, in the receipt by the
applicable Payee of the amounts that would otherwise have been received by such Payee had such deduction or withholding not been required.
All sums payable, paid or deemed payable under this Agreement shall be considered exclusive of value added tax, sales tax or other similar
taxes which shall be borne by, paid, collected and remitted by the Company, if applicable, in accordance with applicable law.
22.
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument. Delivery of an executed Agreement by one party to the other may be made
by facsimile, electronic mail (including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions
Act, the Electronic Signatures and Records Act or other applicable law, e.g., www.docusign.com) or other transmission method and any
counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
23.
Construction. The section and exhibit headings herein are for convenience only and shall not affect the construction hereof. References
herein to any law, statute, ordinance, code, regulation, rule or other requirement of any governmental authority shall be deemed to refer
to such law, statute, ordinance, code, regulation, rule or other requirement of any governmental authority as amended, reenacted, supplemented
or superseded in whole or in part and in effect from time to time and also to all rules and regulations promulgated thereunder.
24.
Permitted Free Writing Prospectuses.
The
Company represents, warrants and agrees that, unless it obtains the prior written consent of the Agent, and the Agent represents, warrants
and agrees that, unless it obtains the prior written consent of the Company, it has not made and will not make any offer relating to
the Placement Shares that would constitute an Issuer Free Writing Prospectus, or that would otherwise constitute a “free writing
prospectus,” as defined in Rule 405, required to be filed with the Commission. Any such free writing prospectus consented to by
the Agent or by the Company, as the case may be, is hereinafter referred to as a “Permitted Free Writing Prospectus.” The
Company represents and warrants that it has treated and agrees that it will treat each Permitted Free Writing Prospectus as an “issuer
free writing prospectus,” as defined in Rule 433, and has complied and will comply with the requirements of Rule 433 applicable
to any Permitted Free Writing Prospectus, including timely filing with the Commission where required, legending and record keeping. For
the purposes of clarity, the parties hereto agree that all free writing prospectuses, if any, listed in Exhibit 24 hereto are
Permitted Free Writing Prospectuses.
25.
Absence of Fiduciary Relationship.
The
Company acknowledges and agrees that:
(a)
the Agent is acting solely as agent in connection with the public offering of the Placement Shares and in connection with each transaction
contemplated by this Agreement and the process leading to such transactions, and no fiduciary or advisory relationship between the Company
or any of its respective affiliates, shareholders (or other equity holders), creditors or employees or any other party, on the one hand,
and the Agent, on the other hand, has been or will be created in respect of any of the transactions contemplated by this Agreement, irrespective
of whether or not the Agent has advised or is advising the Company on other matters, and the Agent has no obligation to the Company with
respect to the transactions contemplated by this Agreement except the obligations expressly set forth in this Agreement;
(b)
it is capable of evaluating and understanding, and understands and accepts, the terms, risks and conditions of the transactions contemplated
by this Agreement;
(c)
neither the Agent nor its affiliates have provided any legal, accounting, regulatory or tax advice with respect to the transactions contemplated
by this Agreement and the Company has consulted its own legal, accounting, regulatory and tax advisors to the extent it has deemed appropriate;
(d)
it is aware that the Agent and its affiliates are engaged in a broad range of transactions which may involve interests that differ from
those of the Company and the Agent and its affiliates have no obligation to disclose such interests and transactions to the Company by
virtue of any fiduciary, advisory or agency relationship or otherwise; and
(e)
it waives, to the fullest extent permitted by law, any claims it may have against the Agent or its affiliates for breach of fiduciary
duty or alleged breach of fiduciary duty in connection with the sale of Placement Shares under this Agreement and agrees that the Agent
and its affiliates shall not have any liability (whether direct or indirect, in contract, tort or otherwise) to it in respect of such
a fiduciary duty claim or to any person asserting a fiduciary duty claim on its behalf or in right of it or the Company, employees or
creditors of Company.
26.
Definitions.
As
used in this Agreement, the following terms have the respective meanings set forth below:
“Applicable
Time” means (i) each Representation Date, (ii) the time of each sale of any Placement Shares pursuant to this Agreement, and
(iii) each Settlement Date.
“Issuer
Free Writing Prospectus” means any “issuer free writing prospectus,” as defined in Rule 433, relating to the Placement
Shares that (1) is required to be filed with the Commission by the Company, (2) is a “road show” that is a “written
communication” within the meaning of Rule 433(d)(8)(i) whether or not required to be filed with the Commission, or (3) is exempt
from filing pursuant to Rule 433(d)(5)(i) because it contains a description of the Placement Shares or of the offering that does not
reflect the final terms, in each case in the form filed or required to be filed with the Commission or, if not required to be filed,
in the form retained in the Company’s records pursuant to Rule 433(g) under the Securities Act Regulations.
“Rule
172,” “Rule 405,” “Rule 415,” “Rule 424,” “Rule 424(b),”
“Rule 430B,” and “Rule 433” refer to such rules under the Securities Act.
“Trading
Day” means any day on which Ordinary Shares are purchased and sold on the Exchange.
All
references in this Agreement to financial statements and schedules and other information that is “contained,” “included”
or “stated” in the Registration Statement or the Prospectus (and all other references of like import) shall be deemed to
mean and include all such financial statements and schedules and other information that is incorporated by reference in the Registration
Statement or the Prospectus, as the case may be.
All
references in this Agreement to the Registration Statement, the Prospectus or any amendment or supplement to any of the foregoing shall
be deemed to include the copy filed with the Commission pursuant to EDGAR; all references in this Agreement to any Issuer Free Writing
Prospectus (other than any Issuer Free Writing Prospectuses that, pursuant to Rule 433, are not required to be filed with the Commission)
shall be deemed to include the copy thereof filed with the Commission pursuant to EDGAR; and all references in this Agreement to “supplements”
to the Prospectus shall include, without limitation, any supplements, “wrappers” or similar materials prepared in connection
with any offering, sale or private placement of any Placement Shares by the Agent outside of the United States.
If
the foregoing correctly sets forth the understanding between the Company and the Agent, please so indicate in the space provided below
for that purpose, whereupon this letter shall constitute a binding agreement between the Company and the Agent.
|
Very
truly yours, |
|
|
|
|
Galmed
Pharmaceuticals Ltd. |
|
|
|
|
By: |
|
|
Name: |
Allen
Baharaff |
|
Title: |
Chief
Executive Officer |
|
|
|
|
ACCEPTED
as of the date first-above written: |
|
|
|
|
JONESTRADING
INSTITUTIONAL SERVICES LLC |
|
|
|
|
By: |
|
|
Name: |
|
|
Title: |
|
SCHEDULE
1
FORM
OF PLACEMENT NOTICE
|
From: |
GALMED
PHARMACEUTICALS LTD. |
|
|
|
|
To: |
JONESTRADING
INSTITUTIONAL SERVICES LLC |
|
|
Attention:
_____________________ |
|
|
|
|
Subject: |
Placement
Notice |
|
|
|
|
Date: |
[●] |
Ladies
and Gentlemen:
Pursuant
to the terms and subject to the conditions contained in the Capital on Demand™ Sales Agreement between GALMED PHARMACEUTICALS
LTD. (the “Company”) and JONESTRADING INSTITUTIONAL SERVICES LLC (“Agent”), dated [●], 2024,
the Company hereby requests that the Agent sell up to ____________ of the Company’s Ordinary Shares, par value NIS 1.80 per share,
at a minimum market price of $_______ per share, during the time period beginning [month, day, time] and ending [month, day, time].
SCHEDULE
2
Compensation
The
Company shall pay to the Agent in cash, upon each sale of Placement Shares pursuant to this Agreement, an amount equal to 3.0% of the
aggregate gross proceeds from each sale of Placement Shares.
SCHEDULE
3
Notice
Parties
The
Company
Allen
Baharaff
Doron
Cohen
Yohai
Stenzler
Guy
Nehemya
The
Agent
Moe
Cohen
Bryan
Turley
James
O’Neill
Jack
Terranova
Burke
Cook
Ryan
Loforte
with
a copy to JTCM@jonestrading.com
EXHIBIT
7(l)
Form
of Representation Date Certificate
____________________,
20__
The
undersigned, the duly qualified and elected __________ of Galmed Pharmaceuticals Ltd., a company organized under the laws of the State
of Israel (the “Company”), does hereby certify in such capacity and on behalf of the Company, pursuant to Section
7(l) of the Sales Agreement, dated _____, 2024, by and between JonesTrading Institutional Services LLC , as agent (the “Agent”)
and the Company (the “Sales Agreement”), that to the best of the knowledge of the undersigned:
(i)
The representations and warranties of the Company in Section 6 of the Sales Agreement are true and correct on and as of the date
hereof with the same force and effect as if expressly made on and as of the date hereof, except for those representations and warranties
that speak solely as of a specific date and which were true and correct as of such date; provided, however, that such representations
and warranties also shall be qualified by the disclosure included or incorporated by reference in the Registration Statement and the
Prospectus; and
(ii)
The Company has complied with all agreements and satisfied all conditions on its part to be performed or satisfied pursuant to the Sales
Agreement at or prior to the date hereof.
Each
of Company U.S. Counsel, Company Israeli Counsel, and Ellenoff Grossman & Schole LLP, counsel to the Agent, is entitled to rely upon
this certificate in connection with the respective opinions and/or negative assurance letters given by such firms pursuant to the Sales
Agreement.
Capitalized
terms not defined herein but used herein shall have the same meaning ascribed to them in the Sales Agreement.
|
Galmed
Pharmaceuticals Ltd. |
|
|
|
By: |
|
|
Name:
|
|
|
Title: |
|
Exhibit 4.4
GALMED PHARMACEUTICALS LTD.
INDENTURE
Dated as of , 20
[ ]
Trustee
Senior Debt Securities
Table
of Contents
|
|
Page |
|
|
|
ARTICLE I |
DEFINITIONS AND INCORPORATION BY REFERENCE |
1 |
|
|
|
Section 1.1 |
Definitions |
1 |
Section 1.2 |
Other Definitions |
4 |
Section 1.3 |
Incorporation by Reference of Trust Indenture Act |
5 |
Section 1.4 |
Rules of Construction |
5 |
|
|
|
ARTICLE II |
THE SECURITIES |
6 |
|
|
|
Section 2.1 |
Issuable in Series |
6 |
Section 2.2 |
Establishment of Terms of Series of Securities |
6 |
Section 2.3 |
Denominations; Provision for Payment |
8 |
Section 2.4 |
Execution and Authentication |
8 |
Section 2.5 |
Registrar and Paying Agent |
9 |
Section 2.6 |
Paying Agent to Hold Money in Trust |
10 |
Section 2.7 |
Securityholder Lists |
10 |
Section 2.8 |
Transfer and Exchange |
10 |
Section 2.9 |
Mutilated, Destroyed, Lost and Stolen Securities |
11 |
Section 2.10 |
Outstanding Securities |
12 |
Section 2.11 |
Treasury Securities |
12 |
Section 2.12 |
Temporary Securities |
12 |
Section 2.13 |
Cancellation |
13 |
Section 2.14 |
Defaulted Interest |
13 |
Section 2.15 |
Global Securities |
13 |
Section 2.16 |
CUSIP Numbers |
14 |
|
|
|
ARTICLE III |
REDEMPTION |
15 |
|
|
|
Section 3.1 |
Notice to Trustee |
15 |
Section 3.2 |
Selection of Securities to be Redeemed |
15 |
Section 3.3 |
Notice of Redemption |
15 |
Section 3.4 |
Effect of Notice of Redemption |
16 |
Section 3.5 |
Deposit of Redemption Price |
17 |
Section 3.6 |
Securities Redeemed in Part |
17 |
|
|
|
ARTICLE IV |
COVENANTS |
17 |
|
|
|
Section 4.1 |
Payment of Principal and Interest |
17 |
Section 4.2 |
Reports by Company |
17 |
Section 4.3 |
Compliance Certificate |
18 |
Section 4.4 |
Stay, Extension and Usury Laws |
18 |
Section 4.5 |
Corporate Existence |
18 |
Table
of Contents
(continued)
|
|
Page |
|
|
|
ARTICLE V |
SUCCESSORS |
19 |
|
|
|
Section 5.1 |
Consolidation, Merger and Sale of Assets |
19 |
Section 5.2 |
Successor Person Substituted |
19 |
|
|
|
ARTICLE VI |
DEFAULTS AND REMEDIES |
19 |
|
|
|
Section 6.1 |
Events of Default |
19 |
Section 6.2 |
Acceleration of Maturity; Rescission and Annulment |
21 |
Section 6.3 |
Collection of Indebtedness and Suits for Enforcement by Trustee |
21 |
Section 6.4 |
Trustee May File Proofs of Claim |
22 |
Section 6.5 |
Trustee May Enforce Claims Without Possession of Securities |
23 |
Section 6.6 |
Application of Money Collected |
23 |
Section 6.7 |
Limitation on Suits |
23 |
Section 6.8 |
Unconditional Right of Holders to Receive Principal and Interest |
24 |
Section 6.9 |
Restoration of Rights and Remedies |
24 |
Section 6.10 |
Rights and Remedies Cumulative |
24 |
Section 6.11 |
Delay or Omission Not Waiver |
25 |
Section 6.12 |
Control by Holders |
25 |
Section 6.13 |
Waiver of Past Defaults |
25 |
Section 6.14 |
Undertaking for Costs |
26 |
|
|
|
ARTICLE VII |
TRUSTEE |
26 |
|
|
|
Section 7.1 |
Duties of Trustee |
26 |
Section 7.2 |
Rights of Trustee |
27 |
Section 7.3 |
Individual Rights of Trustee |
29 |
Section 7.4 |
Trustee’s Disclaimer |
29 |
Section 7.5 |
Notice of Defaults |
29 |
Section 7.6 |
Reports by Trustee to Holders |
29 |
Section 7.7 |
Compensation and Indemnity |
29 |
Section 7.8 |
Replacement of Trustee |
30 |
Section 7.9 |
Successor Trustee by Merger, Etc |
31 |
Section 7.10 |
Eligibility; Disqualification |
31 |
Section 7.11 |
Preferential Collection of Claims Against Company |
31 |
|
|
|
ARTICLE VIII |
SATISFACTION AND DISCHARGE; DEFEASANCE |
32 |
|
|
|
Section 8.1 |
Satisfaction and Discharge of Indenture |
32 |
Section 8.2 |
Application of Trust Funds; Indemnification |
33 |
Section 8.3 |
Legal Defeasance of Securities of any Series |
33 |
Section 8.4 |
Covenant Defeasance |
35 |
Table
of Contents
(continued)
|
|
Page |
Section 8.5 |
Repayment to Company |
36 |
Section 8.6 |
Reinstatement |
36 |
|
|
|
ARTICLE IX |
AMENDMENTS AND WAIVERS |
36 |
|
|
|
Section 9.1 |
Without Consent of Holders |
36 |
Section 9.2 |
With Consent of Holders |
37 |
Section 9.3 |
Limitations |
38 |
Section 9.4 |
Compliance with Trust Indenture Act |
38 |
Section 9.5 |
Revocation and Effect of Consents |
38 |
Section 9.6 |
Notation on or Exchange of Securities |
39 |
Section 9.7 |
Trustee Protected |
39 |
|
|
|
ARTICLE X |
MISCELLANEOUS |
39 |
|
|
|
Section 10.1 |
Trust Indenture Act Controls |
39 |
Section 10.2 |
Notices |
39 |
Section 10.3 |
Communication by Holders with Other Holders |
40 |
Section 10.4 |
Certificate and Opinion as to Conditions Precedent |
40 |
Section 10.5 |
Statements Required in Certificate or Opinion |
41 |
Section 10.6 |
Rules by Trustee and Agents |
41 |
Section 10.7 |
Legal Holidays |
41 |
Section 10.8 |
No Recourse Against Others |
41 |
Section 10.9 |
Counterparts |
42 |
Section 10.10 |
Governing Law; Jury Trial Waiver |
42 |
Section 10.11 |
No Adverse Interpretation of Other Agreements |
42 |
Section 10.12 |
Successors |
42 |
Section 10.13 |
Severability |
42 |
Section 10.14 |
Table of Contents, Headings, Etc |
42 |
Section 10.15 |
Securities in a Foreign Currency |
43 |
Section 10.16 |
Judgment Currency |
43 |
Section 10.17 |
Force Majeure |
44 |
|
|
|
ARTICLE XI |
SINKING FUNDS |
44 |
|
|
|
Section 11.1 |
Applicability of Article |
44 |
Section 11.2 |
Satisfaction of Sinking Fund Payments with Securities |
45 |
Section 11.3 |
Redemption of Securities for Sinking Fund |
45 |
GALMED PHARMACEUTICALS LTD.
Reconciliation and tie between Trust Indenture
Act of 1939 and Indenture
dated as of ____________, 20
§ 310(a)(1) |
7.10 |
(a)(2) |
7.10 |
(a)(3) |
Not Applicable |
(a)(4) |
Not Applicable |
(a)(5) |
7.10 |
(b) |
7.10 |
§ 311(a) |
7.11 |
(b) |
7.11 |
§ 312(a) |
2.7 |
(b) |
10.3 |
(c) |
10.3 |
§ 313(a) |
7.6 |
(b)(1) |
7.6 |
(b)(2) |
7.6 |
(c)(1) |
7.6 |
(d) |
7.6 |
§ 314(a) |
4.2, 10.5 |
(b) |
Not Applicable |
(c)(1) |
10.4 |
(c)(2) |
10.4 |
(c)(3) |
Not Applicable |
(d) |
Not Applicable |
(e) |
10.5 |
(f) |
Not Applicable |
§ 315(a) |
7.1 |
(b) |
7.5 |
(c) |
7.1 |
(d) |
7.1 |
(e) |
6.14 |
§ 316(a) |
2.11 |
(a)(1)(A) |
6.12 |
(a)(1)(B) |
6.13 |
(b) |
6.8 |
§ 317(a)(1) |
6.3 |
(a)(2) |
6.4 |
(b) |
2.6 |
§ 318(a) |
10.1 |
Note: This reconciliation and tie shall not,
for any purpose, be deemed to be part of the Indenture.
Indenture dated as of __________, 20__, between
GALMED PHARMACEUTICALS LTD., a company organized under the laws of the State of Israel (“Company”), and _______________,
as trustee (“Trustee”).
Each party agrees as follows for the benefit
of the other party and for the equal and ratable benefit of the Holders of the Securities issued under this Indenture.
ARTICLE I
DEFINITIONS AND INCORPORATION BY REFERENCE
Section 1.1 Definitions.
“Affiliate”
of any specified person means any other person directly or indirectly controlling or controlled by or under common control with
such specified person. For the purposes of this definition, “control” (including, with correlative meanings, the terms
“controlled by” and “under common control with”), as used with respect to any person, shall mean the possession,
directly or indirectly, of the power to direct or cause the direction of the management or policies of such person, whether through
the ownership of voting securities or by agreement or otherwise.
“Agent”
means any Registrar or Paying Agent.
“Board of Directors”
means the board of directors of the Company or any duly authorized committee thereof.
“Board Resolution”
means a copy of a resolution certified by the Secretary or an Assistant Secretary of the Company to have been adopted by the Board
of Directors or pursuant to authorization by the Board of Directors and to be in full force and effect on the date of the certification
and delivered to the Trustee.
“Business Day”
means, for a particular Series, any day except a Saturday, Sunday or any day, including a legal holiday, on which banking institutions
are authorized or required by law, regulation or executive order to close in The City of New York (or in connection with any payment,
the place of payment).
“Capital Stock”
of any person means any and all shares, interests, participations, rights or other equivalents (however designated) of the equity
of such person.
“Certificated
Securities” means definitive Securities in registered non-global certificated form.
“Company”
means the party named as such above until a successor, which duly assumes the obligations under this Indenture, replaces it and
thereafter means the successor.
“Company Order”
means a written order signed in the name of the Company by an Officer.
“Corporate Trust
Office” means the office of the Trustee at which at any particular time its corporate trust business related to this
Indenture shall be principally administered, which office at the date hereof is located at __________________,; Attention: _______________,
or such other address as the Trustee may designate from time to time by notice to the Holders and the Company, or the corporate
trust office of any successor Trustee at which this Indenture shall be administered (or such other address as a successor Trustee
may designate from time to time by notice to the Holders of the Company).
“Default”
means any event which is, or after notice or passage of time or both would be, an Event of Default.
“Depositary”
means, with respect to the Securities of any Series issuable or issued in whole or in part in the form of one or more Global Securities,
the person designated as Depositary for such Series by the Company, which Depositary shall be a clearing agency registered under
the Exchange Act; and if at any time there is more than one such person, “Depositary” as used with respect to the Securities
of any Series shall mean the Depositary with respect to the Securities of such Series.
“Discount Security”
means any Security that provides for an amount less than the stated principal amount thereof to be due and payable upon declaration
of acceleration of the maturity thereof pursuant to Section 6.2.
“Dollars”
and “$” means the currency of The United States of America.
“Exchange Act”
means the Securities Exchange Act of 1934, as amended.
“Foreign Currency”
means any currency or currency unit issued by a government other than the government of The United States of America.
“Foreign Government
Obligations” means, with respect to Securities of any Series that are denominated in a Foreign Currency, direct obligations
of, or obligations guaranteed by, the government that issued or caused to be issued such currency for the payment of which obligations
its full faith and credit is pledged and which are not callable or redeemable at the option of the issuer thereof.
“GAAP”
means accounting principles generally accepted in The United States of America set forth in the opinions and pronouncements of
the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of
the Financial Accounting Standards Board or in such other statements by such other entity as have been approved by a significant
segment of the accounting profession, which are in effect as of the date of determination.
“Global Security”
or “Global Securities” means a Security or Securities, as the case may be, in the form established pursuant
to Section 2.2 evidencing all or part of a Series of Securities, issued to the Depositary for such Series or its nominee, and registered
in the name of such Depositary or nominee.
“Holder”
or “Securityholder” means a person in whose name a Security is registered on the books of the Registrar.
“Indenture”
means this Indenture as amended or supplemented from time to time and shall include the form and terms of particular Series of
Securities established as contemplated hereunder.
“interest”
means, with respect to any Security, any interest on such Security, and with respect to any Discount Security which by its terms
bears interest only after Maturity, interest payable after Maturity.
“Maturity,”
when used with respect to any Security, means the date on which the principal of such Security becomes due and payable as therein
or herein provided, whether at the Stated Maturity or by declaration of acceleration, call for redemption or otherwise.
“Officer”
means the Chairman of the Board of Directors, the Chief Executive Officer, the Chief Financial Officer, the President, any Senior
Vice President or Vice President, the Treasurer, Assistant Treasurer, Secretary or Assistant Secretary of the Company.
“Officer’s
Certificate” means a certificate signed by any Officer (or any person designated in writing by an Officer of the Company
as authorized to execute and deliver Officer’s Certificates) and delivered to the Trustee.
“Opinion of Counsel”
means a written opinion of legal counsel. The counsel may be an employee of or counsel to the Company. Opinions of Counsel required
to be delivered under this Indenture may have qualifications customary for opinions of the type required.
“person”
means any individual, corporation, company, voluntary association, partnership, trust, joint venture, limited liability company,
unincorporated organization or government or any agency, instrumentality or political subdivision thereof.
“principal”
of a Security means the principal of the Security plus, when appropriate, the premium, if any, on the Security.
“Responsible Officer”
means any officer of the Trustee in its Corporate Trust Office having direct responsibility for administration of this Indenture
and also means, with respect to a particular corporate trust matter, any other officer to whom any corporate trust matter is referred
because of his or her knowledge of and familiarity with a particular subject and who shall have direct responsibility for the administration
of this Indenture.
“SEC”
means the Securities and Exchange Commission.
“Securities”
means the debentures, notes or other debt instruments of the Company of any Series authenticated and delivered under this Indenture.
“Series”
or “Series of Securities” means each series of debentures, notes or other debt instruments of the Company created
pursuant to Sections 2.1 and 2.2 hereof.
“Stated Maturity”
when used with respect to any Security, means the date specified in such Security as the fixed date on which the principal of such
Security is due and payable.
“Subsidiary”
means, with respect to any person, any corporation, partnership, joint venture, limited liability company or other business entity
of which a majority of the outstanding shares of Capital Stock or other interests having the power to vote in the election of directors,
managers or trustees thereof is at the time directly or indirectly owned or controlled by such person or one or more of the other
Subsidiaries of such person, or a combination thereof.
“TIA”
means the Trust Indenture Act of 1939 (15 U.S. Code §§ 77aaa-77bbbb) as in effect on the date of this Indenture; provided,
however, that in the event the Trust Indenture Act of 1939 is amended after such date, “TIA” means, to the extent required
by any such amendment, the Trust Indenture Act as so amended.
“Trustee”
means the person named as the “Trustee” in the first paragraph of this instrument until a successor Trustee shall have
become such pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall mean or include
each person who is then a Trustee hereunder, and if at any time there is more than one such person, “Trustee” as used
with respect to the Securities of any Series shall mean the Trustee with respect to Securities of that Series.
“United States”
or “U.S.” means The United States of America (including the states thereof and the District of Columbia), its
territories and possessions and other areas subject to its jurisdiction.
“U.S. Government
Obligations” means securities which are direct obligations of, or guaranteed by, The United States of America for the
payment of which its full faith and credit is pledged and which are not callable or redeemable at the option of the issuer thereof,
and shall also include a depository receipt issued by a bank or trust company as custodian with respect to any such U.S. Government
Obligation or a specific payment of interest on or principal of any such U.S. Government Obligation held by such custodian for
the account of the holder of a depository receipt, provided that (except as required by law) such custodian is not authorized to
make any deduction from the amount payable to the holder of such depository receipt from any amount received by the custodian in
respect of the U.S. Government Obligation evidenced by such depository receipt.
Section 1.2 Other
Definitions.
TERM |
DEFINED IN SECTION |
“Bankruptcy Law” |
6.1 |
“Custodian” |
6.1 |
“Event of Default” |
6.1 |
“Judgment Currency” |
10.16 |
“Legal Holiday” |
10.7 |
“mandatory sinking fund payment” |
11.1 |
“optional sinking fund payment” |
11.1 |
“Paying Agent” |
2.5 |
“Registrar” |
2.5 |
“Required Currency” |
10.16 |
“successor person” |
5.1 |
Section 1.3 Incorporation
by Reference of Trust Indenture Act.
Whenever this Indenture
refers to a provision of the TIA, the provision is incorporated by reference in and made a part of this Indenture. The following
TIA terms used in this Indenture have the following meanings:
“Commission”
means the SEC.
“indenture securities”
means the Securities.
“indenture security
holder” means a Securityholder.
“indenture to
be qualified” means this Indenture.
“indenture trustee”
or “institutional trustee” means the Trustee.
“obligor”
on the indenture securities means the Company and any successor obligor upon the Securities.
All other terms used in
this Indenture that are defined by the TIA, defined by TIA reference to another statute or defined by SEC rule under the TIA and
not otherwise defined herein are used herein as so defined.
Section 1.4 Rules
of Construction.
Unless the context otherwise
requires:
(a) a
term has the meaning assigned to it;
(b) an
accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP;
(c) “or”
is not exclusive;
(d) words
in the singular include the plural, and in the plural include the singular; and
(e) provisions
apply to successive events and transactions.
ARTICLE II
THE SECURITIES
Section 2.1 Issuable
in Series.
The aggregate principal
amount of Securities that may be authenticated and delivered under this Indenture is unlimited. The Securities may be issued in
one or more Series. All Securities of a Series shall be identical except as may be set forth or determined in the manner provided
in a Board Resolution, supplemental indenture hereto or Officer’s Certificate establishing the terms of such Series. In the
case of Securities of a Series to be issued from time to time, the Board Resolution, Officer’s Certificate or supplemental
indenture establishing the terms thereof may provide for the method by which specified terms (such as interest rate, maturity date,
record date or date from which interest shall accrue) are to be determined. Securities may differ between Series in respect of
any matters, provided that all Series of Securities shall be equally and ratably entitled to the benefits of this Indenture.
Section 2.2 Establishment
of Terms of Series of Securities.
At or prior to the issuance
of any Securities within a Series, the following shall be established (as to the Series generally, in the case of Subsection 2.2.1
and either as to such Securities within the Series or as to the Series generally in the case of Subsections 2.2.2 through 2.2.23)
by or pursuant to a Board Resolution, and set forth or determined in the manner provided in a Board Resolution, supplemental indenture
hereto or Officer’s Certificate:
2.2.1 the
title (which shall distinguish the Securities of that particular Series from the Securities of any other Series) of the Series;
2.2.2 the
price or prices (expressed as a percentage of the principal amount thereof) at which the Securities of the Series will be issued;
2.2.3 any
limit upon the aggregate principal amount of the Securities of the Series which may be authenticated and delivered under this Indenture
(except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities
of the Series pursuant to Section 2.8, 2.9, 2.12, 3.6 or 9.6);
2.2.4 the
date or dates on which the principal of the Securities of the Series is payable;
2.2.5 the
rate or rates (which may be fixed or variable) per annum or, if applicable, the method used to determine such rate or rates (including,
but not limited to, any commodity, commodity index, stock exchange index or financial index) at which the Securities of the Series
shall bear interest, if any, the date or dates from which such interest, if any, shall accrue, the date or dates on which such
interest, if any, shall commence and be payable and any regular record date for the interest payable on any interest payment date;
2.2.6 the
place or places where the principal of and interest, if any, on the Securities of the Series shall be payable, where the Securities
of such Series may be surrendered for registration of transfer or exchange and where notices and demands to or upon the Company
in respect of the Securities of such Series and this Indenture may be delivered, and the method of such payment, if by wire transfer,
mail or other means;
2.2.7 if
applicable, the period or periods within which, the price or prices at which and the terms and conditions upon which the Securities
of the Series must be redeemed or may be redeemed, in whole or in part, at the option of the Company;
2.2.8 the
obligation, if any, of the Company to redeem or purchase the Securities of the Series pursuant to any sinking fund or analogous
provisions or at the option of a Holder thereof and the period or periods within which, the price or prices at which and the terms
and conditions upon which Securities of the Series shall be redeemed or purchased, in whole or in part, pursuant to such obligation;
2.2.9 the
dates, if any, on which and the price or prices at which the Securities of the Series will be repurchased by the Company at the
option of the Holders thereof and other detailed terms and provisions of such repurchase obligations;
2.2.10 if
other than denominations of $1,000 and integral multiples of $1,000 in excess thereof, the denominations in which the Securities
of the Series shall be issuable;
2.2.11 the
forms of the Securities of the Series and whether the Securities will be issuable as Global Securities;
2.2.12 if
other than the principal amount thereof, the portion of the principal amount of the Securities of the Series that shall be payable
upon declaration of acceleration of the maturity thereof pursuant to Section 6.2;
2.2.13 the
currency of denomination of the Securities of the Series, which may be Dollars or any Foreign Currency, and if such currency of
denomination is a composite currency, the agency or organization, if any, responsible for overseeing such composite currency;
2.2.14 the
designation of the currency, currencies or currency units in which payment of the principal of and interest, if any, on the Securities
of the Series will be made;
2.2.15 if
payments of principal of or interest, if any, on the Securities of the Series are to be made in one or more currencies or currency
units other than that or those in which such Securities are denominated, the manner in which the exchange rate with respect to
such payments will be determined;
2.2.16 the
manner in which the amounts of payment of principal of or interest, if any, on the Securities of the Series will be determined,
if such amounts may be determined by reference to an index based on a currency or currencies or by reference to a commodity, commodity
index, stock exchange index or financial index;
2.2.17 the
provisions, if any, relating to any security provided for the Securities of the Series;
2.2.18 any
addition to, deletion of or change in the Events of Default which applies to any Securities of the Series and any change in the
right of the Trustee or the requisite Holders of such Securities to declare the principal amount thereof due and payable pursuant
to Section 6.2;
2.2.19 any
addition to, deletion of or change in the covenants set forth in Articles IV or V which applies to Securities of the Series;
2.2.20 any
Depositaries, trustees, interest rate calculation agents, exchange rate calculation agents or other agents with respect to Securities
of such Series if other than those appointed herein;
2.2.21 the
provisions, if any, relating to conversion or exchange of any Securities of such Series, including if applicable, the conversion
or exchange price, the conversion or exchange period, the securities or other property into which the Securities will be convertible,
provisions as to whether conversion or exchange will be mandatory, at the option of the Holders thereof or at the option of the
Company, the events requiring an adjustment of the conversion price or exchange price and provisions affecting conversion or exchange
if such Series of Securities are redeemed;
2.2.22 whether
any of the Company’s direct or indirect Subsidiaries will guarantee the Securities of that Series, including the terms of
subordination, if any, of such guarantees; and
2.2.23 any
other terms of the Series (which may supplement, modify or delete any provision of this Indenture insofar as it applies to such
Series), including any terms that may be required under applicable law or regulations or advisable in connection with the marketing
of Securities of that Series.
All Securities of any one
Series need not be issued at the same time and may be issued from time to time, consistent with the terms of this Indenture, if
so provided by or pursuant to the Board Resolution, supplemental indenture hereto or Officer’s Certificate referred to above.
Section 2.3 Denominations;
Provision for Payment.
The Securities of any Series
shall be issuable, except as otherwise provided with respect to Securities of any Series pursuant to Section 2.2, as registered
Securities in the denominations of one thousand Dollars ($1,000) or any integral multiples of $1,000 in excess thereof. Unless
otherwise provided with respect to Securities of any Series pursuant to Section 2.2, the principal of and the interest on the Securities
of any Series, if any, thereon, shall by payable in Dollars at the Corporate Trust Office of the Trustee. Unless otherwise specified
pursuant to Section 2.2 with respect to any Securities of any Series, interest on the Securities of any Series shall be computed
on the basis of a 360-day year consisting of twelve 30-day months.
Section 2.4 Execution
and Authentication.
Two Officers shall sign
the Securities for the Company by manual or facsimile signature.
If an Officer whose signature
is on a Security no longer holds that office at the time the Security is authenticated, the Security shall nevertheless be valid.
A Security shall not be
valid until authenticated by the manual signature of the Trustee or an authenticating agent. The signature shall be conclusive
evidence that the Security has been authenticated under this Indenture.
The Trustee shall at any
time, and from time to time, authenticate Securities for original issue in the principal amount provided in the Board Resolution,
supplemental indenture hereto or Officer’s Certificate, upon receipt by the Trustee of a Company Order. Each Security shall
be dated the date of its authentication.
The aggregate principal
amount of Securities of any Series outstanding at any time may not exceed any limit upon the maximum principal amount for such
Series set forth in the Board Resolution, supplemental indenture hereto or Officer’s Certificate delivered pursuant to Section
2.2, except as provided in Section 2.9.
Prior to the issuance of
Securities of any Series, the Trustee shall have received and (subject to Section 7.1) shall be fully protected in conclusively
relying on: (a) the Board Resolution, supplemental indenture hereto or Officer’s Certificate delivered pursuant to Section
2.2 establishing the form of the Securities of that Series or of Securities within that Series and the terms of the Securities
of that Series or of Securities within that Series, (b) an Officer’s Certificate complying with Section 9.7 (with respect
to the execution of supplemental indentures) and Section 10.4, and (c) an Opinion of Counsel complying with Section 9.7 (with respect
to the execution of supplemental indentures) and Section 10.4.
The Trustee shall have
the right, but not the obligation, to decline to authenticate and deliver any Securities of such Series: (a) if the Trustee, being
advised by counsel, determines that such action may not be taken lawfully; or (b) if the Trustee in good faith determines that
such action would expose the Trustee to personal liability.
The Trustee may appoint
an authenticating agent acceptable to the Company to authenticate Securities. An authenticating agent may authenticate Securities
whenever the Trustee may do so. Each reference in this Indenture to authentication by the Trustee includes authentication by such
agent. An authenticating agent has the same rights as an Agent to deal with the Company or an Affiliate of the Company.
Section 2.5 Registrar
and Paying Agent.
The Company shall maintain,
with respect to each Series of Securities, at the place or places specified with respect to such Series, an office or agency where
Securities of such Series may be presented or surrendered for payment (“Paying Agent”) and where Securities of such
Series may be surrendered for registration of transfer or exchange (“Registrar”). The Registrar shall keep a register
with respect to each Series of Securities and to their transfer and exchange. The Company will give prompt written notice to the
Trustee of the name and address, and any change in the name or address, of each Registrar or Paying Agent. If at any time the Company
shall fail to maintain any such required Registrar or Paying Agent or shall fail to furnish the Trustee with the name and address
thereof, such presentations and surrenders may be made or served at the Corporate Trust Office of the Trustee, and the Company
hereby appoints the Trustee as its agent to receive all such presentations and surrenders.
The Company may also from
time to time designate one or more co-registrars or additional paying agents and may from time to time rescind such designations;
provided, however, that no such designation or rescission shall in any manner relieve the Company of its obligations to maintain
a Registrar or Paying Agent in each place so specified for Securities of any Series for such purposes. The Company will give prompt
written notice to the Trustee of any such designation or rescission and of any change in the name or address of any such co-registrar
or additional paying agent. The term “Registrar” includes any co-registrar; and the term “Paying Agent”
includes any additional paying agent. The Company or any of its Affiliates may serve as Registrar or Paying Agent.
The Company hereby appoints
the Trustee as the initial Registrar and Paying Agent for each Series unless another Registrar or Paying Agent, as the case may
be, is appointed prior to the time Securities of that Series are first issued.
Section 2.6 Paying
Agent to Hold Money in Trust.
The Company shall require
each Paying Agent other than the Trustee to agree in writing that the Paying Agent will hold in trust, for the benefit of Securityholders
of any Series of Securities, or the Trustee, all money held by the Paying Agent for the payment of principal of or interest on
the Securities of that Series, and will notify the Trustee in writing of any default by the Company in making any such payment.
While any such default continues, the Trustee may require a Paying Agent to pay all money held by it to the Trustee. The Company
at any time may require a Paying Agent to pay all money held by it to the Trustee. Upon payment over to the Trustee, the Paying
Agent (if other than the Company or a Subsidiary of the Company) shall have no further liability for the money. If the Company
or a Subsidiary of the Company acts as Paying Agent, it shall segregate and hold in a separate trust fund for the benefit of Securityholders
of any Series of Securities all money held by it as Paying Agent. Upon any bankruptcy, reorganization or similar proceeding with
respect to the Company, the Trustee shall serve as Paying Agent for the Securities.
Section 2.7 Securityholder
Lists.
The Trustee shall preserve
in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of Securityholders
of each Series of Securities and shall otherwise comply with TIA § 312(a). If the Trustee is not the Registrar, the Company
shall furnish to the Trustee at least ten days before each interest payment date and at such other times as the Trustee may request
in writing a list, in such form and as of such date as the Trustee may reasonably require, of the names and addresses of Securityholders
of each Series of Securities.
Section 2.8 Transfer
and Exchange.
Where Securities of a Series
are presented to the Registrar or a co-registrar with a request to register a transfer or to exchange them for an equal principal
amount of Securities of the same Series, the Registrar shall register the transfer or make the exchange if its requirements for
such transactions are met. To permit registrations of transfers and exchanges, the Trustee shall authenticate Securities at the
Registrar’s request. No service charge shall be made for any registration of transfer or exchange (except as otherwise expressly
permitted herein), but the Company may require payment of a sum sufficient to cover any transfer tax or similar governmental charge
payable in connection therewith (other than any such transfer tax or similar governmental charge payable upon exchanges pursuant
to Sections 2.12, 3.6 or 9.6).
Neither the Company nor
the Registrar shall be required (a) to issue, register the transfer of, or exchange Securities of any Series for the period beginning
at the opening of business fifteen days immediately preceding the mailing of a notice of redemption of Securities of that Series
selected for redemption and ending at the close of business on the day of such mailing, or (b) to register the transfer of or exchange
Securities of any Series selected, called or being called for redemption as a whole or the portion being redeemed of any such Securities
selected, called or being called for redemption in part.
Section 2.9 Mutilated,
Destroyed, Lost and Stolen Securities.
If any mutilated Security
is surrendered to the Trustee, the Company shall execute and the Trustee shall authenticate and deliver in exchange therefor a
new Security of the same Series and of like tenor and principal amount and bearing a number not contemporaneously outstanding.
If there shall be delivered
to the Company and the Trustee (a) evidence to their satisfaction of the destruction, loss or theft of any Security and (b) such
security or indemnity bond as may be required by each of them to hold itself and any of its agents harmless, then, in the absence
of written notice to the Company or the Trustee that such Security has been acquired by a bona fide purchaser, the Company shall
execute and upon receipt of a Company Order the Trustee shall authenticate and make available for delivery, in lieu of any such
destroyed, lost or stolen Security, a new Security of the same Series and of like tenor and principal amount and bearing a number
not contemporaneously outstanding.
In case any such mutilated,
destroyed, lost or stolen Security has become or is about to become due and payable, the Company in its discretion may, instead
of issuing a new Security, pay such Security.
Upon the issuance of any
new Security under this Section 2.9, the Company may require the payment of a sum sufficient to cover any tax or other governmental
charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected
therewith.
Every new Security of any
Series issued pursuant to this Section 2.9 in lieu of any destroyed, lost or stolen Security shall constitute an original additional
contractual obligation of the Company, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by
anyone, and shall be entitled to all the benefits of this Indenture equally and proportionately with any and all other Securities
of that Series duly issued hereunder.
The provisions of this
Section 2.9 are exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement
or payment of mutilated, destroyed, lost or stolen Securities.
Section 2.10 Outstanding
Securities.
The Securities outstanding
at any time are all the Securities authenticated by the Trustee except for those canceled by the Registrar and those described
in this Section 2.10 as not outstanding.
If a Security is replaced
pursuant to Section 2.9, it ceases to be outstanding unless the Trustee receives proof satisfactory to it that the replaced Security
is held by a bona fide purchaser.
If the Paying Agent (other
than the Company, a Subsidiary of the Company or an Affiliate of the Company) holds on the Maturity of Securities of a Series money
sufficient to pay such Securities payable on that date, then on and after that date such Securities of the Series cease to be outstanding
and interest on them ceases to accrue.
The Company may purchase
or otherwise acquire the Securities, whether by open market purchases, negotiated transactions or otherwise. A Security does not
cease to be outstanding because the Company or an Affiliate of the Company holds the Security.
In determining whether
the Holders of the requisite principal amount of outstanding Securities have given any request, demand, authorization, direction,
notice, consent or waiver hereunder, the principal amount of a Discount Security that shall be deemed to be outstanding for such
purposes shall be the amount of the principal thereof that would be due and payable as of the date of such determination upon a
declaration of acceleration of the Maturity thereof pursuant to Section 6.2.
Section 2.11 Treasury
Securities.
In determining whether
the Holders of the required principal amount of Securities of a Series have concurred in any request, demand, authorization, direction,
notice, consent or waiver, Securities of a Series owned by the Company or any Affiliate of the Company shall be disregarded, except
that for the purposes of determining whether the Trustee shall be protected in conclusively relying on any such request, demand,
authorization, direction, notice, consent or waiver, only Securities of a Series that a Responsible Officer of the Trustee actually
knows are so owned shall be so disregarded. Securities so owned which have been pledged in good faith shall not be disregarded
if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right to deliver any such request, demand, authorization,
direction, notice, consent or waiver with respect to the Securities and that the pledgee is not the Company or any other obligor
upon the Securities or any Affiliate of the Company or of such other obligor.
Section 2.12 Temporary
Securities.
Until definitive Securities
are ready for delivery, the Company may prepare and the Trustee shall authenticate temporary Securities upon a Company Order. Temporary
Securities shall be substantially in the form of definitive Securities but may have variations that the Company considers appropriate
for temporary Securities. Without unreasonable delay, the Company shall prepare and the Trustee upon receipt of a Company Order
shall authenticate definitive Securities of the same Series and date of maturity in exchange for temporary Securities. Until so
exchanged, temporary Securities shall have the same rights under this Indenture as the definitive Securities.
Section 2.13 Cancellation.
The Company at any time
may deliver Securities to the Trustee for cancellation. The Registrar and the Paying Agent, if not the Trustee, shall forward to
the Trustee any Securities surrendered to them for registration of transfer, exchange or payment. The Trustee shall cancel all
Securities surrendered for transfer, exchange, payment, replacement, conversion or cancellation and shall dispose of such canceled
Securities (subject to the record retention requirement of the Exchange Act and the Trustee) in accordance with its customary procedures
and deliver a certificate of such cancellation to the Company upon written request of the Company. The Company may not issue new
Securities to replace Securities that it has paid or delivered to the Trustee for cancellation.
Section 2.14 Defaulted
Interest.
If the Company defaults
in a payment of interest on a Series of Securities, it may pay the defaulted interest, plus, to the extent permitted by law, any
interest payable on the defaulted interest, to the persons who are Securityholders of the Series on a subsequent special record
date. The Company shall fix the record date and payment date. At least 10 days before the special record date, the Company shall
mail to the Trustee and to each Securityholder of the Series a notice that states the special record date, the payment date and
the amount of interest to be paid. The Company may pay defaulted interest in any other lawful manner.
Section 2.15 Global
Securities.
2.15.1 Terms
of Securities. A Board Resolution, a supplemental indenture hereto or an Officer’s Certificate shall establish whether
the Securities of a Series shall be issued in whole or in part in the form of one or more Global Securities and the Depositary
for such Global Security or Securities.
2.15.2 Transfer
and Exchange. Notwithstanding any provisions to the contrary contained in Section 2.8 of this Indenture and in addition thereto,
any Global Security shall be exchangeable pursuant to Section 2.8 of this Indenture for Securities registered in the names of Holders
other than the Depositary for such Security or its nominee only if (a) such Depositary notifies the Company that it is unwilling
or unable to continue as Depositary for such Global Security or if at any time such Depositary ceases to be a clearing agency registered
under the Exchange Act, and, in either case, the Company fails to appoint a successor Depositary registered as a clearing agency
under the Exchange Act within 90 days of such event or (b) the Company determines in its sole discretion not to have such Securities
represented by one or more Global Securities and executes and delivers to the Trustee an Officer’s Certificate to the effect
that such Global Security shall be so exchangeable. Any Global Security that is exchangeable pursuant to the preceding sentence
shall be exchangeable for Securities registered in such names as the Depositary shall direct in writing in an aggregate principal
amount equal to the principal amount of the Global Security with like tenor and terms.
Except as provided in this
Section 2.15.2, a Global Security may not be transferred except as a whole by the Depositary with respect to such Global Security
to a nominee of such Depositary, by a nominee of such Depositary to such Depositary or another nominee of such Depositary or by
the Depositary or any such nominee to a successor Depositary or a nominee of such a successor Depositary.
2.15.3 Legend.
Any Global Security issued hereunder shall bear a legend in substantially the following form:
“THIS SECURITY IS
A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITARY OR
A NOMINEE OF THE DEPOSITARY. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY
OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE
DEPOSITARY TO A NOMINEE OF THE DEPOSITARY, BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY,
OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH A SUCCESSOR DEPOSITARY.”
2.15.4 Acts
of Holders. The Depositary, as a Holder, may appoint agents and otherwise authorize participants to give or take any request,
demand, authorization, direction, notice, consent, waiver or other action which a Holder is entitled to give or take under this
Indenture.
2.15.5 Payments.
Notwithstanding the other provisions of this Indenture, unless otherwise specified as contemplated by Section 2.2, payment of the
principal of and interest, if any, on any Global Security shall be made to the Holder thereof, which in the case of a Depositary
therefor will be made in accordance with its applicable procedures.
2.15.6 Consents,
Declaration and Directions. The Company, the Trustee and any Agent shall treat a person as the Holder of such principal amount
of outstanding Securities of such Series represented by a Global Security as shall be specified in a written statement of the Depositary
or by the applicable procedures of such Depositary with respect to such Global Security, for purposes of obtaining any consents,
declarations, waivers or directions required to be given by the Holders pursuant to this Indenture.
Section 2.16 CUSIP
Numbers.
The Company in issuing
the Securities may use “CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP”
numbers in notices of redemption as a convenience to Holders; provided that any such notice may state that no representation is
made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and
that reliance may be placed only on the other elements of identification printed on the Securities, and any such redemption shall
not be affected by any defect in or omission of such numbers. The Trustee shall have no liability for any defect in the “CUSIP”
numbers as they appear on any Security, notice or elsewhere. The Company will promptly notify the Trustee in writing of any change
in the “CUSIP” numbers.
ARTICLE III
REDEMPTION
Section 3.1 Notice
to Trustee.
The Company may, with respect
to any Series of Securities, reserve the right to redeem and pay the Series of Securities or may covenant to redeem and pay the
Series of Securities or any part thereof prior to the Stated Maturity thereof at such time and on such terms as provided for in
such Securities. If a Series of Securities is redeemable and the Company wants or is obligated to redeem prior to the Stated Maturity
thereof all or part of the Series of Securities pursuant to the terms of such Securities, it shall notify the Trustee in writing
of the redemption date and the principal amount of Series of Securities to be redeemed. The Company shall give the notice to the
Trustee at least 45 days before the redemption date, unless a shorter period is satisfactory to the Trustee.
Section 3.2 Selection
of Securities to be Redeemed.
Unless otherwise indicated
for a particular Series by a Board Resolution, a supplemental indenture hereto or an Officer’s Certificate, if less than
all the Securities of a Series are to be redeemed, the Trustee shall select the Securities of the Series to be redeemed in any
manner that the Trustee deems fair and appropriate, including selecting by lot or other method, unless otherwise required by law
or applicable stock exchange requirements, subject, in the case of Global Securities, to the applicable rules and procedures of
the Depositary; provided that the unredeemed portion of the principal amount of any Security shall be in an authorized denomination
(which shall not be less than the minimum authorized denomination) for such Security. The Trustee shall make the selection from
Securities of the Series outstanding not previously called for redemption. Provisions of this Indenture that apply to Securities
of a Series called for redemption also apply to portions of Securities of that Series called for redemption.
Section 3.3 Notice
of Redemption.
Unless otherwise indicated
for a particular Series by Board Resolution, a supplemental indenture hereto or an Officer’s Certificate, at least 30 days
but not more than 60 days before a redemption date, the Company shall mail a notice of redemption by first-class mail to each Holder
whose Securities are to be redeemed.
The notice shall identify
the Securities of the Series to be redeemed and shall state:
(a) the
redemption date;
(b) the
redemption price and the amount of accrued interest, if any, to be paid;
(c) the
name and address of the Paying Agent and, if applicable, the conversion Agent;
(d) for
convertible Securities, the conversion price;
(e) if
any Global Security is being redeemed in part, the portion of the principal amount of such Global Security to be redeemed and that,
after the redemption date upon surrender of such Global Security, the principal amount thereof will be decreased by the portion
thereof redeemed pursuant thereto;
(f) if
any Certificated Security is being redeemed in part, the portion of the principal amount of such Security to be redeemed, and that,
after the redemption date, upon surrender of such Security, a new Certificated Security in principal amount equal to the unredeemed
portion thereof will be issued in the name of the Holder thereof upon cancellation of the original Certificated Security;
(g) that
Securities of the Series (or portion thereof) called for redemption must be surrendered to the Paying Agent to collect the redemption
price;
(h) that
interest on Securities of the Series called for redemption ceases to accrue on and after the redemption date unless the Company
defaults in the deposit of the redemption price;
(i) the
CUSIP number, if any, and state that no representation is made as to the correctness or accuracy of the CUSIP number, if any, listed
in the SEC’s notice or printed on the Securities; and
(j) any
other information as may be required by the terms of the particular Series or the Securities of a Series being redeemed.
At the Company’s
request, the Trustee shall give the notice of redemption in the Company’s name and at its expense, provided, however, that
the Company has delivered to the Trustee, at least 15 days (unless a shorter time shall be acceptable to the Trustee) prior to
the notice date, an Officer’s Certificate requesting that the Trustee give such notice and setting forth the information
to be stated in such notice.
Section 3.4 Effect
of Notice of Redemption.
Once notice of redemption
is mailed as provided in Section 3.3, Securities of a Series called for redemption become due and payable on the redemption date
and at the redemption price. Except as otherwise provided in the supplemental indenture, Board Resolution or Officer’s Certificate
for a Series, a notice of redemption may not be conditional. Upon surrender to the Paying Agent, such Securities shall be paid
at the redemption price plus accrued interest to the redemption date other than Securities or portions of Securities called for
redemption which have been delivered by the Company to the Registrar for cancellation. The Paying Agent shall return to the Company
any money not required for that purpose.
Unless the Company shall
default in the payment of Securities (and accrued interest) called for redemption, interest on such Securities shall cease to accrue
after the redemption date. Convertible Securities called for redemption shall cease to be convertible after the close of business
on the Business Day immediately preceding the redemption date, unless the Company shall default in the payment of such Securities
on the redemption date, in which event the Securities shall remain convertible until paid (together with accrued interest).
Failure to give notice
of redemption, or any defect in such notice to the Holder of any Security of a Series designated for redemption, in whole or in
part, shall not affect the sufficiency of any notice of redemption with respect to the Holder of any other Security of such Series.
Section 3.5 Deposit
of Redemption Price.
On or before 10:00 a.m.,
New York City time, on the redemption date, the Company shall deposit with the Paying Agent money sufficient to pay the redemption
price of and accrued interest, if any, on all Securities to be redeemed on that date.
Section 3.6 Securities
Redeemed in Part.
Upon surrender of a Certificated
Security that is redeemed in part, the Trustee shall authenticate for the Holder a new Certificated Security of the same Series
and the same maturity equal in principal amount to the unredeemed portion of the Security surrendered and concurrently cancel the
surrendered Certificated Security.
ARTICLE IV
COVENANTS
Section 4.1 Payment
of Principal and Interest.
The Company covenants and
agrees for the benefit of the Holders of each Series of Securities that it will duly and punctually pay the principal of and interest,
if any, on the Securities of that Series in accordance with the terms of such Securities and this Indenture. On or before 10:00
a.m., New York City time, on the applicable payment date, the Company shall deposit with the Paying Agent money sufficient to pay
the principal of and interest, if any, on the Securities of each Series in accordance with the terms of such Securities and this
Indenture. Principal and interest shall be considered paid on the date due if the Paying Agent holds in accordance with this Indenture
on that date money sufficient to pay all principal and interest then due and the Paying Agent is not prohibited from paying such
money to the Holders on such date pursuant to the terms of this Indenture.
Section 4.2 Reports
by Company.
(a) As
long as any Securities are outstanding, the Company shall file with the Trustee, and transmit to the Holders, such information,
documents and other reports, and such summaries thereof, as may be required pursuant to TIA § 314(a). All reports, information
and documents referred to in this Section 4.2 will be deemed to be filed with the Trustee and transmitted to the Holders at the
time such reports, information or documents are publicly filed with the SEC via the SEC’s EDGAR filing system (or any successor
system), it being understood that the Trustee shall have no responsibility whatsoever to determine if such filings have been made.
(b) Delivery
of reports, information and documents to the Trustee under this Section 4.2 are for informational purposes only and shall not constitute
a representation or warranty as to the accuracy or completeness of the reports, information and documents. The Trustee’s
receipt of the foregoing shall not constitute constructive notice of any information contained therein or determinable from information
contained therein, including the Company’s compliance with any of its covenants hereunder (as to which the Trustee is entitled
to rely exclusively on Officer’s Certificates).
Section 4.3 Compliance
Certificate.
To the extent any Securities
of a Series are outstanding, the Company shall deliver to the Trustee, within 120 days after the end of each fiscal year of the
Company, an Officer’s Certificate (which need not contain the statements provided for in Section 10.4) from its principal
executive officer, principal financial officer or principal accounting officer stating that a review of the activities of the Company
and its Subsidiaries during the preceding fiscal year has been made under the supervision of the signing Officer with a view to
determining whether the Company has kept, observed, performed and fulfilled its obligations under this Indenture, and further stating,
as to such Officer signing such certificate, that to his or her knowledge the Company is not in default in the performance or observance
of any of the terms, provisions and conditions hereof (or, if a Default or Event of Default shall have occurred, describing all
such Defaults or Events of Default of which the Officer has knowledge). Such Officer’s Certificate need not include a reference
to any non-compliance that has been fully cured prior to the date as of which such certificate speaks.
Section 4.4 Stay,
Extension and Usury Laws.
The Company covenants (to
the extent that it may lawfully do so) that it will not at any time insist upon, plead, or in any manner whatsoever claim or take
the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, which may
affect the covenants or the performance of this Indenture or the Securities; and the Company (to the extent it may lawfully do
so) hereby expressly waives all benefit or advantage of any such law and covenants that it will not, by resort to any such law,
hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer and permit the execution of every
such power as though no such law has been enacted.
Section 4.5 Corporate
Existence.
Subject to Article V, the
Company will do or cause to be done all things necessary to preserve and keep in full force and effect its corporate existence
and rights (charter and statutory); provided, however, that the Company shall not be required to preserve any such right if the
Board of Directors shall determine that the preservation thereof is no longer desirable in the conduct of the business of the Company
and its Subsidiaries taken as a whole and that the loss thereof is not adverse in any material respect to the Holders.
ARTICLE V
SUCCESSORS
Section 5.1 Consolidation,
Merger and Sale of Assets.
The Company may not consolidate
with or merge with or into, sell, convey, transfer or dispose of all or substantially all of its assets to any other person (a
“successor person”), whether in one transaction or a series of related transactions, unless:
(a) (i)
the Company is the surviving corporation or (ii) the successor person (if other than the Company) (A) is a corporation, limited
liability corporation, partnership or trust organized under the laws of the United States; and (B) expressly assumes, by an indenture
supplemental hereto, the Company’s obligations on the Securities and under this Indenture; and
(b) immediately
after giving effect to the transaction, no Default or Event of Default shall have happened and be continuing.
The Company shall deliver
to the Trustee prior to the consummation of the proposed transaction an Officer’s Certificate to the foregoing effect and
an Opinion of Counsel stating that the proposed transaction and any supplemental indenture comply with Section 5.1 of this Indenture.
Notwithstanding the above,
any Subsidiary of the Company may consolidate with, merge into or transfer all or part of its properties to the Company. Neither
an Officer’s Certificate nor an Opinion of Counsel shall be required to be delivered in connection therewith.
Section 5.2 Successor
Person Substituted.
Upon any consolidation
or merger, or any sale, conveyance, transfer, or lease of all or substantially all of the assets of the Company and its Subsidiaries
in accordance with Section 5.1, the successor person formed by such consolidation or into or with which the Company is merged or
to which such sale, conveyance, transfer, or lease is made shall succeed to, and be substituted for, and may exercise every right
and power of, the Company under this Indenture and the Securities with the same effect as if such successor person has been named
as the Company herein; and, thereafter, the predecessor Company, in the case of a sale, conveyance or transfer (other than a lease),
shall be released from all obligations and covenants under this Indenture and the Securities.
ARTICLE VI
DEFAULTS AND REMEDIES
Section 6.1 Events
of Default.
“Event of Default,”
wherever used herein with respect to Securities of any Series, means any one of the following events, unless in the establishing
Board Resolution, supplemental indenture or Officer’s Certificate, it is provided that such Series shall not have the benefit
of said Event of Default:
(a) failure
to pay any interest on any Security of that Series when it becomes due and payable, and continuance of such default for a period
of 30 days (unless the entire amount of such payment is deposited by the Company with the Trustee or with a Paying Agent prior
to 10:00 a.m., New York City time, on the 30th day of such period);
(b) failure
to pay principal of any Security of that Series at its Maturity;
(c) default
in the performance or breach of any covenant of the Company in this Indenture (other than defaults pursuant to sub-clauses (a)
through (c) above or defaults related to a covenant that has been included in this Indenture solely for the benefit of a Series
of Securities other than that Series), which default continues uncured for a period of 90 days after there has been given, by registered
or certified mail, to the Company by the Trustee or to the Company and the Trustee by the Holders of at least 25% in principal
amount of the outstanding Securities of that Series a written notice specifying such default or breach and requiring it to be remedied
and stating that such notice is a “Notice of Default” hereunder;
(d) the
Company pursuant to or within the meaning of any Bankruptcy Law:
(i) commences
a voluntary case,
(ii) consents
to the entry of an order for relief against it in an involuntary case,
(iii) consents
to the appointment of a Custodian of it or for all or substantially all of its property, or
(iv) makes
a general assignment for the benefit of its creditors;
(e) a
court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:
(i) is
for relief against the Company in an involuntary case,
(ii) appoints
a Custodian of the Company or for all or substantially all of its property, or
(iii) orders
the liquidation of the Company, and the order or decree remains unstayed and in effect for 60 days; or
(f) any
other Event of Default provided with respect to Securities of that Series, which is specified in a Board Resolution, a supplemental
indenture hereto or an Officer’s Certificate, in accordance with Section 2.2.18.
The term “Bankruptcy
Law” means title 11, U.S. Code or any similar federal or state law for the relief of debtors. The term “Custodian”
means any receiver, trustee, assignee, liquidator or similar official under any Bankruptcy Law.
A Default under one Series
of Securities issued under this Indenture will not necessarily be a default under another Series of Securities under this Indenture.
The Company will, so long
as any of the Securities are outstanding, deliver to the Trustee, within 30 days of becoming aware of any Default or Event of Default,
an Officer’s Certificate specifying such Default or Event of Default and what action the Company is taking or proposes to
take with respect thereto.
Section 6.2 Acceleration
of Maturity; Rescission and Annulment.
If an Event of Default
with respect to Securities of any Series at the time outstanding occurs and is continuing (other than an Event of Default referred
to in Section 6.1(d) or (e)) then in every such case the Trustee or the Holders of not less than 25% in principal amount of the
outstanding Securities of that Series may declare the principal amount (or, if any Securities of that Series are Discount Securities,
such portion of the principal amount as may be specified in the terms of such Securities) of and accrued and unpaid interest, if
any, on all of the Securities of that Series to be due and payable immediately, by a notice in writing to the Company (and to the
Trustee if given by Holders), and upon any such declaration such principal amount (or specified amount) and accrued and unpaid
interest, if any, shall become immediately due and payable. If an Event of Default specified in Section 6.1(d) or (e) shall occur,
the principal amount (or specified amount) of and accrued and unpaid interest, if any, on all outstanding Securities shall ipso
facto become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Holder.
At any time after such
a declaration of acceleration with respect to any Series has been made and before a judgment or decree for payment of the money
due has been obtained by the Trustee as hereinafter in this Article provided, the Holders of a majority in principal amount of
the outstanding Securities of that Series, by written notice to the Company and the Trustee, may rescind and annul such declaration
and its consequences if all Events of Default with respect to Securities of that Series, other than the non-payment of the principal
and interest, if any, of Securities of that Series which have become due solely by such declaration of acceleration, have been
cured or waived as provided in Section 6.13.
No such rescission shall
affect any subsequent Default.
Section 6.3 Collection
of Indebtedness and Suits for Enforcement by Trustee.
The Company covenants that
if
(a) default
is made in the payment of any interest on any Security when such interest becomes due and payable and such default continues for
a period of 30 days, or
(b) default
is made in the payment of principal of any Security at the Maturity thereof, or
(c) default
is made in the deposit of any sinking fund payment, if any, when and as due by the terms of a Security,
then, the Company will, upon demand
of the Trustee, pay to it, for the benefit of the Holders of such Securities, the whole amount then due and payable on such Securities
for principal and interest and, to the extent that payment of such interest shall be legally enforceable, interest on any overdue
principal and any overdue interest at the rate or rates prescribed therefor in such Securities, and, in addition thereto, such
further amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses,
disbursements and advances of the Trustee, its agents and counsel.
If the Company fails to
pay such amounts forthwith upon such demand, the Trustee, in its own name and as trustee of an express trust, may institute a judicial
proceeding for the collection of the sums so due and unpaid, may prosecute such proceeding to judgment or final decree and may
enforce the same against the Company or any other obligor upon such Securities and collect the moneys adjudged or deemed to be
payable in the manner provided by law out of the property of the Company or any other obligor upon such Securities, wherever situated.
If an Event of Default
with respect to any Securities of any Series occurs and is continuing, the Trustee may in its discretion proceed to protect and
enforce its rights and the rights of the Holders of Securities of such Series by such appropriate judicial proceedings as the Trustee
shall deem most effectual to protect and enforce any such rights, whether for the specific enforcement of any covenant or agreement
in this Indenture or in aid of the exercise of any power granted herein, or to enforce any other proper remedy.
Section 6.4 Trustee
May File Proofs of Claim.
In case of the pendency
of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial
proceeding relating to the Company or any other obligor upon the Securities or the property of the Company or of such other obligor
or their creditors, the Trustee (irrespective of whether the principal of the Securities shall then be due and payable as therein
expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand on the Company for
the payment of overdue principal or interest) shall be entitled and empowered, by intervention in such proceeding or otherwise,
(a) to
file and prove a claim for the whole amount of principal and interest owing and unpaid in respect of the Securities and to file
such other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim
for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel) and of the Holders
allowed in such judicial proceeding, and
(b) to
collect and receive any moneys or other property payable or deliverable on any such claims and to distribute the same,
and any custodian, receiver, assignee, trustee,
liquidator, sequestrator or other similar official in any such judicial proceeding is hereby authorized by each Holder to make
such payments to the Trustee and, in the event that the Trustee shall consent to the making of such payments directly to the Holders,
to pay to the Trustee any amount due it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its
agents and counsel, and any other amounts due the Trustee under Section 7.7.
Nothing herein contained
shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan of reorganization,
arrangement, adjustment or composition affecting the Securities or the rights of any Holder thereof or to authorize the Trustee
to vote in respect of the claim of any Holder in any such proceeding.
Section 6.5 Trustee
May Enforce Claims Without Possession of Securities.
All rights of action and
claims under this Indenture or the Securities may be prosecuted and enforced by the Trustee without the possession of any of the
Securities or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the Trustee shall
be brought in its own name as trustee of an express trust, and any recovery of judgment shall, after provision for the payment
of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, be for the ratable
benefit of the Holders of the Securities in respect of which such judgment has been recovered.
Section 6.6 Application
of Money Collected.
Any money or property collected
by the Trustee pursuant to this Article shall be applied in the following order, at the date or dates fixed by the Trustee and,
in case of the distribution of such money or property on account of principal or interest, upon presentation of the Securities
and the notation thereon of the payment if only partially paid and upon surrender thereof if fully paid:
First: To the payment of
all amounts due to the Trustee under this Indenture; and
Second: To the payment
of the amounts then due and unpaid for principal of and interest on the Securities in respect of which or for the benefit of which
such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on
such Securities for principal and interest, respectively; and
Third: To the Company.
Section 6.7 Limitation
on Suits.
No Holder of any Security
of any Series shall have any right to institute any proceeding, judicial or otherwise, with respect to this Indenture, or for the
appointment of a receiver or trustee, or for any other remedy hereunder, unless:
(a) such
Holder has previously given written notice to the Trustee of a continuing Event of Default with respect to the Securities of that
Series;
(b) the
Holders of not less than 25% in principal amount of the outstanding Securities of that Series have made written request to the
Trustee to institute proceedings in respect of such Event of Default in its own name as Trustee hereunder;
(c) such
Holder or Holders have offered to the Trustee indemnity or security satisfactory to the Trustee against the costs, expenses and
liabilities which might be incurred by the Trustee in compliance with such request;
(d) the
Trustee has failed to institute any such proceeding for 60 days after its receipt of such notice, request and offer of indemnity;
and
(e) no
direction inconsistent with such written request has been given to the Trustee during such 60-day period by the Holders of a majority
in principal amount of the outstanding Securities of that Series;
it being understood, intended and expressly
covenanted by the Holder of every Security with every other Holder and the Trustee that no one or more of such Holders shall have
any right in any manner whatever by virtue of, or by availing of, any provision of this Indenture to affect, disturb or prejudice
the rights of any other of such Holders, or to obtain or to seek to obtain priority or preference over any other of such Holders
or to enforce any right under this Indenture, except in the manner herein provided and for the equal and ratable benefit of all
such Holders of the applicable Series; provided, however, that the Trustee does not have an affirmative duty to ascertain
whether or not such actions or forbearances are unduly prejudicial to such Holders.
Section 6.8 Unconditional
Right of Holders to Receive Principal and Interest.
Notwithstanding any other
provision in this Indenture, the Holder of any Security has the right, which is absolute and unconditional, to receive payment
of the principal of and interest, if any, on such Security on the Maturity of such Security, including the Stated Maturity expressed
in such Security (or, in the case of redemption, on the redemption date) and to institute suit for the enforcement of any such
payment, and such rights shall not be impaired without the consent of such Holder.
Section 6.9 Restoration
of Rights and Remedies.
If the Trustee or any Holder
has instituted any proceeding to enforce any right or remedy under this Indenture and such proceeding has been discontinued or
abandoned for any reason, or has been determined adversely to the Trustee or to such Holder, then and in every such case, subject
to any determination in such proceeding, the Company, the Trustee and the Holders shall be restored severally and respectively
to their former positions hereunder and thereafter all rights and remedies of the Trustee and the Holders shall continue as though
no such proceeding had been instituted.
Section 6.10 Rights
and Remedies Cumulative.
Except as otherwise provided
with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities in Section 2.9, no right or remedy
herein conferred upon or reserved to the Trustee or to the Holders is intended to be exclusive of any other right or remedy, and
every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right and remedy given
hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder,
or otherwise, shall not, to the extent permitted by law, prevent the concurrent assertion or employment of any other appropriate
right or remedy.
Section 6.11 Delay
or Omission Not Waiver.
No delay or omission of
the Trustee or of any Holder of any Securities to exercise any right or remedy accruing upon any Event of Default shall impair
any such right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy
given by this Article or by law to the Trustee or to the Holders may be exercised from time to time, and as often as may be deemed
expedient, by the Trustee or by the Holders, as the case may be.
Section 6.12 Control
by Holders.
The Holders of a majority
in principal amount of the outstanding Securities of any Series shall have the right to direct the time, method and place of conducting
any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee, with respect
to the Securities of such Series, provided that:
(a) such
direction shall not be in conflict with any rule of law or with this Indenture;
(b) the
Trustee may take any other action deemed proper by the Trustee which is not inconsistent with such direction;
(c) subject
to the provisions of Section 7.1, the Trustee shall have the right to decline to follow any such direction if the Trustee in good
faith shall, by a Responsible Officer of the Trustee, determine that the proceeding so directed would involve the Trustee in personal
liability; and
(d) prior
to taking any action as directed under this Section 6.12, the Trustee shall be entitled to indemnity satisfactory to it against
the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction.
Section 6.13 Waiver
of Past Defaults.
The Holders of not less
than a majority in principal amount of the outstanding Securities of any Series may on behalf of the Holders of all the Securities
of such Series waive any past Default hereunder with respect to such Series and its consequences, except a Default in the payment
of the principal of or interest on any Security of such Series (provided, however, that the Holders of a majority
in principal amount of the outstanding Securities of any Series may rescind an acceleration and its consequences, including any
related payment default that resulted from such acceleration). Upon any such waiver, such Default shall cease to exist, and any
Event of Default arising therefrom shall be deemed to have been cured, for every purpose of this Indenture; but no such waiver
shall extend to any subsequent or other Default.
Section 6.14 Undertaking
for Costs.
All parties to this Indenture
agree, and each Holder of any Security by his acceptance thereof shall be deemed to have agreed, that any court may in its discretion
require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any
action taken, suffered or omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the
costs of such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees
and expenses, against any party litigant in such suit, having due regard to the merits and good faith of the claims or defenses
made by such party litigant; but the provisions of this Section 6.14 shall not apply to any suit instituted by the Company, to
any suit instituted by the Trustee, to any suit instituted by any Holder, or group of Holders, holding in the aggregate more than
10% in principal amount of the outstanding Securities of any Series, or to any suit instituted by any Holder for the enforcement
of the payment of the principal of or interest on any Security on or after the Maturity of such Security, including the Stated
Maturity expressed in such Security (or, in the case of redemption, on the redemption date).
ARTICLE VII
TRUSTEE
Section 7.1 Duties
of Trustee.
(a) If
an Event of Default has occurred and is continuing, the Trustee shall exercise the rights and powers vested in it by this Indenture
and use the same degree of care and skill in their exercise as a prudent person would exercise or use under the circumstances in
the conduct of such person’s own affairs.
(b) Except
during the continuance of an Event of Default:
(i) The
Trustee need perform only those duties that are specifically set forth in this Indenture and no others.
(ii) In
the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness
of the opinions expressed therein, upon Officer’s Certificates or Opinions of Counsel furnished to the Trustee and conforming
to the requirements of this Indenture; however, in the case of any such Officer’s Certificates or Opinions of Counsel which
by any provisions hereof are specifically required to be furnished to the Trustee, the Trustee shall examine such Officer’s
Certificates and Opinions of Counsel to determine whether or not they conform to the requirements of this Indenture (but need not
confirm or investigate the accuracy of mathematical calculations or other facts stated therein).
(c) The
Trustee may not be relieved from liability for its own negligent action, its own negligent failure to act or its own willful misconduct,
except that:
(i) This
sub-clause (c) does not limit the effect of sub-clause (b) of this Section 7.1.
(ii) The
Trustee shall not be liable for any error of judgment made in good faith by a Responsible Officer, unless it is proved that the
Trustee was negligent in ascertaining the pertinent facts.
(iii) The
Trustee shall not be liable with respect to any action taken, suffered or omitted to be taken by it with respect to Securities
of any Series in good faith in accordance with the direction of the Holders of a majority in principal amount of the outstanding
Securities of such Series relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee,
or exercising any trust or power conferred upon the Trustee, under this Indenture with respect to the Securities of such Series
in accordance with Section 6.12.
(d) Every
provision of this Indenture that in any way relates to the Trustee is subject to sub-clauses (a), (b) and (c) of this Section 7.1.
(e) The
Trustee may refuse to perform any duty or exercise any right or power unless it receives indemnity satisfactory to it against the
costs, expenses and liabilities which might be incurred by it in performing such duty or exercising such right or power.
(f) The
Trustee shall not be liable for interest on any money received by it. Money held in trust by the Trustee need not be segregated
from other funds except to the extent required by law.
(g) No
provision of this Indenture shall require the Trustee to risk its own funds or otherwise incur any financial liability in the performance
of any of its duties, or in the exercise of any of its rights or powers, if adequate indemnity against such risk is not assured
to the Trustee in its satisfaction.
(h) The
Paying Agent, the Registrar and any authenticating agent shall be entitled to the protections and immunities as are set forth in
sub-clauses (e), (f) and (g) of this Section 7.1 and in Section 7.2, each with respect to the Trustee.
Section 7.2 Rights
of Trustee.
(a) The
Trustee may conclusively rely on and shall be protected in acting or refraining from acting upon any document (whether in its original
or facsimile form) believed by it to be genuine and to have been signed or presented by the proper person. The Trustee need not
investigate any fact or matter stated in the document.
(b) Before
the Trustee acts or refrains from acting, it shall be entitled to receive an Officer’s Certificate or an Opinion of Counsel
or both. The Trustee shall not be liable for any action it takes or omits to take in good faith in conclusive reliance on such
Officer’s Certificate or Opinion of Counsel.
(c) The
Trustee may act through agents and shall not be responsible for the misconduct or negligence of any agent appointed with due care.
No Depositary shall be deemed an agent of the Trustee and the Trustee shall not be responsible for any act or omission by any Depositary.
(d) The
Trustee shall not be liable for any action it takes or omits to take in good faith which it believes to be authorized or within
its rights or powers, provided that the Trustee’s conduct does not constitute willful misconduct or negligence.
(e) The
Trustee may consult with counsel of its selection and the advice of such counsel or any Opinion of Counsel shall be full and complete
authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in reliance
thereon.
(f)
The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture
at the request or direction of any of the Holders of Securities unless such Holders shall have offered to the Trustee
security or indemnity reasonably satisfactory to it against the costs, expenses and liabilities which might be incurred by it
in compliance with such request or direction.
(g) The
Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement,
instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness
or other paper or document, but the Trustee, in its discretion, may make such further inquiry or investigation into such facts
or matters as it may see fit and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation.
(h) The
Trustee shall not be deemed to have notice of any Default or Event of Default unless a Responsible Officer of the Trustee has actual
knowledge thereof or unless written notice of any event which is in fact such a default is received by a Responsible Officer of
the Trustee at the Corporate Trust Office of the Trustee, and such notice references the Securities generally or the Securities
of a particular Series and this Indenture.
(i)
In no event shall the Trustee be liable to any person for special, punitive, indirect, consequential or incidental loss
or damage of any kind whatsoever (including but not limited to lost profits), even if the Trustee has been advised of the
likelihood of such loss or damage.
(j)
The permissive right of the Trustee to take the actions permitted by this Indenture shall not be construed as an
obligation or duty to do so.
(k) The
rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be indemnified,
are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other
Person employed to act hereunder.
(l)
The Trustee shall not be required to give any bond or surety in respect of the performance of its powers and duties
hereunder.
(m) The
Trustee may request that the Company deliver a certificate setting forth the names of individuals and/or titles of officers authorized
at such time to take specified actions pursuant to this Indenture.
Section 7.3 Individual
Rights of Trustee.
The Trustee in its individual
or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or an Affiliate of
the Company with the same rights it would have if it were not Trustee. Any Agent may do the same with like rights. However, the
Trustee is also subject to Sections 7.10 and 7.11 hereof.
Section 7.4 Trustee’s
Disclaimer.
The Trustee makes no representation
as to the validity or adequacy of this Indenture or the Securities, it shall not be accountable for the Company’s use of
the proceeds from the Securities, and it shall not be responsible for any statement in the Securities other than its authentication.
Section 7.5 Notice
of Defaults.
If a Default or Event of
Default occurs and is continuing with respect to the Securities of any Series and if it is actually known to a Responsible Officer
of the Trustee, the Trustee shall mail to each Securityholder of the Securities of that Series notice of a Default or Event of
Default within 90 days after it occurs or, if later, after a Responsible Officer of the Trustee has knowledge of such Default or
Event of Default. Except in the case of a Default or Event of Default in payment of principal of or interest on any Security of
any Series, the Trustee may withhold the notice if and so long as it in good faith determines that withholding the notice is in
the interests of Securityholders of that Series.
Section 7.6 Reports
by Trustee to Holders.
Within 60 days after each
anniversary of the date of this Indenture, the Trustee shall transmit by mail to all Securityholders, as their names and addresses
appear on the register kept by the Registrar, a brief report dated as of such reporting date, in accordance with, and to the extent
required under, TIA § 313.
A copy of each report at
the time of its mailing to Securityholders of any Series shall be filed with the SEC and each national securities exchange on which
the Securities of that Series are listed. The Company shall promptly notify the Trustee in writing when Securities of any Series
are listed on any national securities exchange or of any delisting thereof.
Section 7.7 Compensation
and Indemnity.
The Company shall pay to
the Trustee from time to time compensation for its services as the Company and the Trustee shall from time to time agree upon in
writing. The Trustee’s compensation shall not be limited by any law on compensation of a trustee of an express trust. The
Company shall reimburse the Trustee upon request for all reasonable out of pocket expenses incurred by it. Such expenses shall
include the reasonable compensation and expenses of the Trustee’s agents and counsel.
The Company shall indemnify
each of the Trustee and any predecessor Trustee against any cost, expense, claim (whether asserted by the Company, a Holder or
any other person) or liability (including the cost of defending itself), including taxes (other than taxes based upon, measured
by or determined by the income of the Trustee), incurred by it except as set forth in the next paragraph in the performance of
its duties under this Indenture as Trustee or Agent. The Trustee shall notify the Company promptly of any claim for which it may
seek indemnity. Failure by the Trustee to so notify the Company shall not relieve the Company of its obligations hereunder, unless
and to the extent that the Company is materially prejudiced thereby. The Company shall defend the claim and the Trustee shall cooperate
in the defense. The Trustee may have one separate counsel and the Company shall pay the reasonable fees and expenses of such counsel.
The Company need not pay for any settlement made without its consent, which consent will not be unreasonably withheld. This indemnification
shall apply to officers, directors, employees, shareholders and agents of the Trustee.
The Company need not reimburse
any expense or indemnify against any loss or liability incurred by the Trustee or by any officer, director, employee or shareholder
of the Trustee through willful misconduct or negligence.
To secure the Company’s
payment obligations in this Section 7.7, the Trustee shall have a lien prior to the Securities of any Series on all money or property
held or collected by the Trustee, except that held in trust to pay principal of and interest on particular Securities of that Series.
When the Trustee incurs
expenses or renders services after an Event of Default specified in Section 6.1(f) or (g) occurs, the expenses and the compensation
for the services are intended to constitute expenses of administration under any Bankruptcy Law.
The provisions of this
Section 7.7 shall survive the termination of this Indenture or the resignation or removal of the Trustee.
Section 7.8 Replacement
of Trustee.
A resignation or removal
of the Trustee and appointment of a successor Trustee shall become effective only upon the successor Trustee’s acceptance
of appointment as provided in this Section 7.8.
The Trustee may resign
at any time with respect to the Securities of one or more Series by so notifying the Company at least 30 days prior to the date
of the proposed resignation. The Holders of a majority in principal amount of the Securities of any Series may remove the Trustee
with respect to that Series by so notifying the Trustee and the Company in writing. The Company may remove the Trustee with respect
to Securities of one or more Series if:
(a) the
Trustee fails to comply with Section 7.10;
(b) the
Trustee is adjudged a bankrupt or an insolvent or an order for relief is entered with respect to the Trustee under any Bankruptcy
Law;
(c) a
Custodian or public officer takes charge of the Trustee or its property; or
(d) the
Trustee becomes incapable of acting.
If the Trustee resigns
or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint a successor Trustee.
Within one year after the successor Trustee takes office, the Holders of a majority in principal amount of the then outstanding
Securities may appoint a successor Trustee to replace the successor Trustee appointed by the Company.
If a successor Trustee
with respect to the Securities of any one or more Series does not take office within 30 days after the retiring Trustee resigns
or is removed, the retiring Trustee, the Company or the Holders of at least a majority in principal amount of the Securities of
the applicable Series may petition any court of competent jurisdiction for the appointment of a successor Trustee at the expense
of the Company.
A successor Trustee shall
deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Immediately after that, the retiring
Trustee shall transfer all property held by it as Trustee to the successor Trustee subject to the lien provided for in Section
7.7, the resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all the rights,
powers and duties of the Trustee with respect to each Series of Securities for which it is acting as Trustee under this Indenture.
A successor Trustee shall mail a notice of its succession to each Securityholder of each such Series. Notwithstanding replacement
of the Trustee pursuant to this Section 7.8, the Company’s obligations under Section 7.7 hereof shall continue for the benefit
of the retiring Trustee with respect to expenses and liabilities incurred by it for actions taken or omitted to be taken in accordance
with its rights, powers and duties under this Indenture prior to such replacement.
Section 7.9 Successor
Trustee by Merger, Etc.
If the Trustee consolidates
with, merges or converts into, or transfers all or substantially all of its corporate trust business to, another corporation, the
successor corporation without any further act shall be the successor Trustee, if such successor corporation is eligible and qualified
under Section 7.10.
Section 7.10 Eligibility;
Disqualification.
This Indenture shall always
have a Trustee who satisfies the requirements of TIA § 310(a)(1), (2) and (5). The Trustee shall always have a combined
capital and surplus of at least $25,000,000 as set forth in its most recent published annual report of condition. The Trustee shall
comply with TIA § 310(b).
Section 7.11 Preferential
Collection of Claims Against Company.
The Trustee is subject
to TIA § 311(a), excluding any creditor relationship listed in TIA § 311(b). A Trustee who has resigned or been removed
shall be subject to TIA § 311(a) to the extent indicated.
ARTICLE VIII
SATISFACTION AND DISCHARGE; DEFEASANCE
Section 8.1 Satisfaction
and Discharge of Indenture.
This Indenture shall upon
Company Order cease to be of further effect (except as hereinafter provided in this Section 8.1), and the Trustee, at the expense
of the Company, shall execute instruments acknowledging satisfaction and discharge of this Indenture, when
(a) either
(i) all
Securities theretofore authenticated and delivered (other than Securities that have been destroyed, lost or stolen and that have
been replaced or paid as provided in Section 2.9) have been delivered to the Trustee for cancellation; or
(ii) all
such Securities not theretofore delivered to the Trustee for cancellation:
(1) have
become due and payable, or
(2) will
become due and payable at their Stated Maturity within one year, or
(3) have
been called for redemption or are to be called for redemption within one year under arrangements satisfactory to the Trustee for
the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company;
and the Company, in the case
of (1), (2) or (3) above, has irrevocably deposited or caused to be deposited with the Trustee as trust funds in trust an amount
of money or U.S. Government Obligations sufficient for the purpose of paying and discharging the entire indebtedness on such Securities
not theretofore delivered to the Trustee for cancellation, for principal and interest to the date of such deposit (in the case
of Securities which have become due and payable on or prior to the date of such deposit) or to the Stated Maturity or redemption
date, as the case may be;
(b) the
Company has paid or caused to be paid all other sums payable hereunder by the Company; and
(c) the
Company has delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that all conditions
precedent herein provided for relating to the satisfaction and discharge of this Indenture have been complied with.
Notwithstanding the satisfaction
and discharge of this Indenture, the obligations of the Company to the Trustee under Section 7.7, and, if money shall have been
deposited with the Trustee pursuant to sub-clause (a) of this Section 8.1, the provisions of Sections 2.5, 2.8, 2.9, 8.2 and 8.5
shall survive.
Section 8.2 Application
of Trust Funds; Indemnification.
(a) Subject
to the provisions of Section 8.5, all money or U.S. Government Obligations deposited with the Trustee pursuant to Section 8.1,
all money and U.S. Government Obligations or Foreign Government Obligations deposited with the Trustee pursuant to Section 8.3
or 8.4 and all money received by the Trustee in respect of U.S. Government Obligations or Foreign Government Obligations deposited
with the Trustee pursuant to Section 8.3 or 8.4, shall be held in trust and applied by it, in accordance with the provisions of
the Securities and this Indenture, to the payment, either directly or through any Paying Agent (including the Company acting as
its own Paying Agent) as the Trustee may determine, to the persons entitled thereto, of the principal and interest for whose payment
such money has been deposited with or received by the Trustee or to make mandatory sinking fund payments or analogous payments
as contemplated by Sections 8.3 or 8.4.
(b) The
Company shall pay and shall indemnify the Trustee against any tax, fee or other charge imposed on or assessed against U.S. Government
Obligations or Foreign Government Obligations deposited pursuant to Sections 8.3 or 8.4 or the interest and principal received
in respect of such obligations other than any payable by or on behalf of Holders.
(c) The
Trustee shall deliver or pay to the Company from time to time upon Company Order any U.S. Government Obligations or Foreign Government
Obligations or money held by it as provided in Sections 8.3 or 8.4 which, in the opinion of a nationally recognized firm of independent
certified public accountants or investment bank expressed in a written certification thereof delivered to the Trustee, are then
in excess of the amount thereof which then would have been required to be deposited for the purpose for which such U.S. Government
Obligations or Foreign Government Obligations or money were deposited or received. This provision shall not authorize the sale
by the Trustee of any U.S. Government Obligations or Foreign Government Obligations held under this Indenture.
Section 8.3 Legal
Defeasance of Securities of any Series.
Unless this Section 8.3
is otherwise specified, pursuant to Section 2.2, to be inapplicable to Securities of any Series, the Company shall be deemed to
have paid and discharged the entire indebtedness on all the outstanding Securities of any Series on the 91st day after the date
of the deposit referred to in sub-clause (d) hereof, and the provisions of this Indenture, as it relates to such outstanding Securities
of such Series, shall no longer be in effect (and the Trustee, at the expense of the Company, shall, upon receipt of a Company
Order, execute instruments acknowledging the same), except as to:
(a) the
rights of Holders of Securities of such Series to receive, from the trust funds described in sub-clause (d) hereof, (i) payment
of the principal of and each installment of principal of and interest on the outstanding Securities of such Series on the Maturity
of such principal or installment of principal or interest and (ii) the benefit of any mandatory sinking fund payments applicable
to the Securities of such Series on the day on which such payments are due and payable in accordance with the terms of this Indenture
and the Securities of such Series;
(b) the
provisions of Sections 2.5, 2.8, 2.9, 8.2, 8.3 and 8.5; and
(c) the
rights, powers, trust and immunities of the Trustee hereunder and the Company’s obligations in connection therewith;
provided that, the following conditions shall
have been satisfied:
(d) the
Company shall have deposited or caused to be irrevocably deposited (except as provided in Section 8.2(c)) with the Trustee as trust
funds in trust for the purpose of making the following payments, specifically pledged as security for and dedicated solely to the
benefit of the Holders of such Securities: (i) in the case of Securities of such Series denominated in Dollars, cash in Dollars
and/or U.S. Government Obligations, or (ii) in the case of Securities of such Series denominated in a Foreign Currency (other than
a composite currency), money and/or Foreign Government Obligations, which through the payment of interest and principal in respect
thereof in accordance with their terms (and without reinvestment), will provide, not later than one day before the due date of
any payment of money, an amount in cash, sufficient, in the opinion of a nationally recognized firm of independent public accountants
or investment bank expressed in a written certification thereof delivered to the Trustee, to pay and discharge each installment
of principal of and interest, if any, on and any mandatory sinking fund payments in respect of all the Securities of such Series
on the dates such installments of interest or principal and such sinking fund payments are due;
(e) such
deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement or instrument
to which the Company is a party or by which it is bound;
(f)
no Default or Event of Default with respect to the Securities of such Series shall have
occurred and be continuing on the date of such deposit or during the period ending on the 91st day after such date;
(g) the
Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel to the effect that (i) the
Company has received from, or there has been published by, the Internal Revenue Service a ruling, or (ii) since the date of execution
of this Indenture, there has been a change in the applicable U.S. federal income tax law, in either case to the effect that, and
based thereon such Opinion of Counsel shall confirm that, the Holders of the Securities of such Series will not recognize income,
gain or loss for U.S. federal income tax purposes as a result of such deposit, defeasance and discharge and will be subject to
U.S. federal income tax on the same amount and in the same manner and at the same times as would have been the case if such deposit,
defeasance and discharge had not occurred;
(h) the
Company shall have delivered to the Trustee an Officer’s Certificate stating that the deposit was not made by the Company
with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; and
(i)
the Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of
Counsel, each stating that all conditions precedent provided for relating to the defeasance contemplated by this Section 8.3
have been complied with.
Section 8.4 Covenant
Defeasance.
Unless this Section 8.4
is otherwise specified pursuant to Section 2.2 to be inapplicable to Securities of any Series, the Company may omit to comply with
respect to the Securities of any Series with any term, provision or condition set forth under Sections 4.2 and 4.3, 4.4 and 5.1as
well as any additional covenants specified in a supplemental indenture for such Series of Securities or a Board Resolution or an
Officer’s Certificate delivered pursuant to Section 2.2 (and the failure to comply with any such covenants shall not constitute
a Default or Event of Default with respect to such Series under Section 6.1) and the occurrence of any event specified in a supplemental
indenture for such Series of Securities or a Board Resolution or an Officer’s Certificate delivered pursuant to Section 2.2.18
and designated as an Event of Default shall not constitute a Default or Event of Default hereunder, with respect to the Securities
of such Series, provided that the following conditions shall have been satisfied:
(a) With
reference to this Section 8.4, the Company has deposited or caused to be irrevocably deposited (except as provided in Section 8.2(c))
with the Trustee as trust funds in trust for the purpose of making the following payments specifically pledged as security for,
and dedicated solely to, the benefit of the Holders of such Securities: (i) in the case of Securities of such Series denominated
in Dollars, cash in Dollars and/or U.S. Government Obligations, or (ii) in the case of Securities of such Series denominated in
a Foreign Currency (other than a composite currency), money and/or Foreign Government Obligations, which through the payment of
interest and principal in respect thereof in accordance with their terms (and without reinvestment), will provide, not later than
one day before the due date of any payment of money, an amount in cash, sufficient, in the opinion of a nationally recognized firm
of independent certified public accountants or investment bank expressed in a written certification thereof delivered to the Trustee,
to pay and discharge each installment of principal of and interest, if any, on and any mandatory sinking fund payments in respect
of the Securities of such Series on the dates such installments of interest or principal and such sinking fund payments are due;
(b) Such
deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement or instrument
to which the Company is a party or by which it is bound;
(c) No
Default or Event of Default with respect to the Securities of such Series shall have occurred and be continuing on the date of
such deposit;
(d) The
Company shall have delivered to the Trustee an Opinion of Counsel to the effect that Holders of the Securities of such Series will
not recognize income, gain or loss for U.S. federal income tax purposes as a result of such deposit and covenant defeasance and
will be subject to U.S. federal income tax on the same amounts, in the same manner and at the same times as would have been the
case if such deposit and covenant defeasance had not occurred;
(e) The
Company shall have delivered to the Trustee an Officer’s Certificate stating the deposit was not made by the Company with
the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; and
(f)
The Company shall have delivered to the Trustee an Officer’s Certificate and an
Opinion of Counsel, each stating that all conditions precedent herein provided for relating to the covenant defeasance
contemplated by this Section 8.4 have been complied with.
Section 8.5 Repayment
to Company.
Subject to applicable abandoned
property law, the Trustee and the Paying Agent shall pay to the Company upon request any money held by them for the payment of
principal or interest that remains unclaimed for two years after such principal or interest has become due and payable. After that,
Securityholders entitled to the money must look to the Company for payment as general creditors unless an applicable abandoned
property law designates another person.
Section 8.6 Reinstatement.
If the Trustee or the Paying
Agent is unable to apply any money deposited with respect to Securities of any Series in accordance with Section 8.1 by reason
of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or
otherwise prohibiting such application, the obligations of the Company under this Indenture with respect to the Securities of such
Series and under the Securities of such Series shall be revived and reinstated as though no deposit had occurred pursuant to Section
8.1 until such time as the Trustee or the Paying Agent is permitted to apply all such money in accordance with Section 8.1; provided,
however, that if the Company has made any payment of principal of or interest on any Securities because of the reinstatement of
its obligations, the Company shall be subrogated to the rights of the Holders of such Securities to receive such payment from the
money or U.S. Government Obligations held by the Trustee or Paying Agent after payment in full to the Holders.
ARTICLE IX
AMENDMENTS AND WAIVERS
Section 9.1 Without
Consent of Holders.
The Company and the Trustee
may amend or supplement this Indenture or the Securities of one or more Series without the consent of any Securityholder:
(a) to
add guarantees with respect to any Series of Securities or secure any Series of Securities;
(b) to
surrender any of the Company’s rights or powers under this Indenture;
(c) to
add covenants or Events of Default for the benefit of the Securityholders of any Series of Securities;
(d) to
comply with the applicable rules or procedures of the Depositary;
(e) to
cure any ambiguity, defect or inconsistency, as described in the Officer’s Certificate delivered pursuant to Section 10.4;
(f)
to comply with Article V;
(g) to
provide for uncertificated Securities in addition to or in place of certificated Securities;
(h) to
make any change that does not materially adversely affect the rights of any Securityholder;
(i)
to provide for the issuance of and establish the form and terms and conditions of Securities of any
Series as permitted by this Indenture;
(j)
to evidence and provide for the acceptance of appointment hereunder by a successor Trustee with respect to
the Securities of one or more Series and to add to or change any of the provisions of this Indenture as shall be necessary to
provide for or facilitate the administration of the trusts hereunder by more than one Trustee;
(k) to
comply with requirements of the SEC in order to effect or maintain the qualification of this Indenture under the TIA;
(l) to
comply with the rules or regulations of any securities exchange or automated quotation system on which any of the Securities may
be listed or traded; and
(m) to
change or eliminate any of the provisions of this Indenture, provided that any such change or elimination shall not be effective
with respect to any outstanding Securities of any Series created prior to the execution of such supplemental indenture which is
entitled to the benefit of such provision.
Section 9.2 With
Consent of Holders.
The Company and the Trustee
may enter into a supplemental indenture with the written consent of the Holders of at least a majority in principal amount of the
outstanding Securities of each Series affected by such supplemental indenture (including consents obtained in connection with a
tender offer or exchange offer for the Securities of such Series), for the purpose of adding any provisions to or changing in any
manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying in any manner the
rights of the Securityholders of each such Series. Except as provided in Section 6.13, the Holders of at least a majority in principal
amount of the outstanding Securities of any Series by written notice to the Trustee (including consents obtained in connection
with a tender offer or exchange offer for the Securities of such Series) may waive compliance by the Company with any provision
of this Indenture or the Securities with respect to such Series.
It shall not be necessary
for the consent of the Holders of Securities under this Section 9.2 to approve the particular form of any proposed supplemental
indenture or waiver, but it shall be sufficient if such consent approves the substance thereof. After a supplemental indenture
or waiver under this Section 9.2 becomes effective, the Company shall mail to the Holders of Securities affected thereby, a notice
briefly describing the supplemental indenture or waiver. Any failure by the Company to mail or publish such notice, or any defect
therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture or waiver.
Section 9.3 Limitations.
Without the consent of
each Securityholder affected, an amendment or waiver may not:
(a) reduce
the principal amount of Securities whose Holders must consent to an amendment, supplement or waiver;
(b) reduce
the rate of or extend the time for payment of interest (including default interest) on any Security or that Series;
(c) reduce
the principal of, or change the Stated Maturity of, any Security or reduce the amount of, or postpone the date fixed for, the payment
of any sinking fund or analogous obligation;
(d) reduce
the principal amount of Discount Securities payable upon acceleration of the maturity thereof;
(e) waive
a Default or Event of Default in the payment of the principal of or interest, if any, on any Security (except a rescission of acceleration
of the Securities of any Series by the Holders of at least a majority in principal amount of the then outstanding Securities of
such Series and a waiver of the payment default that resulted from such acceleration);
(f)
make the principal of or interest, if any, on any Security payable in any currency other than
that stated in the Security;
(g) make
any change in Sections 6.8 or 6.13 or this Section 9.3; or
(h) waive
a redemption payment with respect to any Security.
Section 9.4 Compliance
with Trust Indenture Act.
Every amendment to this
Indenture or the Securities of one or more Series shall be set forth in a supplemental indenture hereto that complies with the
TIA as then in effect.
Section 9.5 Revocation
and Effect of Consents.
Until an amendment is set
forth in a supplemental indenture or a waiver becomes effective, a consent to it by a Holder of a Security is a continuing consent
by the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting
Holder’s Security, even if notation of the consent is not made on any Security.
Any amendment or waiver
once effective shall bind every Securityholder of each Series affected by such amendment or waiver unless it is of the type described
in any of sub-clauses (a) through (h) of Section 9.3. In that case, the amendment or waiver shall bind each Holder of a Security
who has consented to it and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the
consenting Holder’s Security.
The Company may, but shall
not be obligated to, fix a record date for the purpose of determining the Holders entitled to give their consent or take any other
action described above or required or permitted to be taken pursuant to this Indenture. If a record date is fixed, then notwithstanding
the immediately preceding paragraph, those Persons who were Holders at such record date (or their duly designated proxies), and
only those persons, shall be entitled to give such consent or to revoke any consent previously given or take any such action, whether
or not such Persons continue to be Holders after such record date. No such consent shall be valid or effective for more than 120
days after such record date.
Section 9.6 Notation
on or Exchange of Securities.
The Company or the Trustee
may place an appropriate notation about an amendment or waiver on any Security of any Series thereafter authenticated. The Company
in exchange for Securities of that Series may issue and the Trustee shall authenticate upon request new Securities of that Series
that reflect the amendment or waiver.
Section 9.7 Trustee
Protected.
In executing, or accepting
the additional trusts created by, any supplemental indenture permitted by this Article or the modifications thereby of the trusts
created by this Indenture, the Trustee shall receive, and (subject to Section 7.1) shall be fully protected in conclusively relying
upon, an Officer’s Certificate or an Opinion of Counsel or both complying with Section 10.4 and stating that the supplemental
indenture is the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms,
subject to customary exceptions. The Trustee shall sign all supplemental indentures upon delivery of such an Officer’s Certificate
or Opinion of Counsel or both, except that the Trustee need not sign any supplemental indenture that, in its sole discretion, adversely
affects its rights.
ARTICLE X
MISCELLANEOUS
Section 10.1 Trust
Indenture Act Controls.
If any provision of this
Indenture limits, qualifies, or conflicts with another provision which is required or deemed to be included in this Indenture by
the TIA, such required or deemed provision shall control.
Section 10.2 Notices.
Any request, demand, notice
or communication by the Company or the Trustee to the other, or by a Holder to the Company or the Trustee, is duly given if in
writing and delivered in person or mailed by first-class mail:
if to the Company:
Galmed Pharmaceuticals Ltd.
if to the Trustee:
Attention:
The Company or the Trustee
by notice to the other may designate additional or different addresses for subsequent notices or communications.
Any notice or communication
to a Securityholder shall be mailed by first-class mail to his address shown on the register kept by the Registrar. Failure to
mail a notice or communication to a Securityholder of any Series or any defect in it shall not affect its sufficiency with respect
to other Securityholders of that or any other Series.
If a notice or communication
is mailed or published in the manner provided above, within the time prescribed, it is duly given, whether or not the Securityholder
receives it.
If the Company mails a
notice or communication to Securityholders, it shall mail a copy to the Trustee and each Agent at the same time.
Notwithstanding any other
provision of this Indenture or any Security, where this Indenture or any Security provides for notice of any event (including any
notice of redemption) to a Holder of a Global Security (whether by mail or otherwise), such notice shall be sufficiently given
to the Depositary for such Security (or its designee) pursuant to the customary procedures of such Depositary.
Section 10.3 Communication
by Holders with Other Holders.
Securityholders of any
Series may communicate pursuant to TIA § 312(b) with other Securityholders of that Series or any other Series with respect
to their rights under this Indenture or the Securities of that Series or all Series. The Company, the Trustee, the Registrar and
anyone else shall have the protection of TIA § 312(c).
Section 10.4 Certificate
and Opinion as to Conditions Precedent.
Upon any request or application
by the Company to the Trustee to take any action under this Indenture, the Company shall furnish to the Trustee:
(a) an
Officer’s Certificate stating that, in the opinion of the signers, all conditions precedent, if any, provided for in this
Indenture relating to the proposed action have been complied with; and
(b) an
Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent have been complied with.
Section 10.5 Statements
Required in Certificate or Opinion.
Each certificate or opinion
with respect to compliance with a condition or covenant provided for in this Indenture (other than a certificate provided pursuant
to TIA § 314(a)(4)) shall comply with the provisions of TIA § 314(e) and shall include:
(a) a
statement that the person making such certificate or opinion has read such covenant or condition;
(b) a
brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained
in such certificate or opinion are based;
(c) a
statement that, in the opinion of such person, he has made such examination or investigation as is necessary to enable him to express
an informed opinion as to whether or not such covenant or condition has been complied with; and
(d) a
statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with.
Section 10.6 Rules
by Trustee and Agents.
The Trustee may make reasonable
rules for action by or a meeting of Securityholders of one or more Series. Any Agent may make reasonable rules and set reasonable
requirements for its functions.
Section 10.7 Legal
Holidays.
Unless otherwise provided
by Board Resolution, Officer’s Certificate or supplemental indenture hereto for a particular Series, a “Legal Holiday”
is any day that is not a Business Day. If a payment date is a Legal Holiday at a place of payment, payment may be made at that
place on the next succeeding day that is not a Legal Holiday, and no interest shall accrue for the intervening period.
Section 10.8 No
Recourse Against Others.
A director, officer, employee
or stockholder (past or present), as such, of the Company shall not have any liability for any obligations of the Company under
the Securities or this Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. Each
Securityholder by accepting a Security waives and releases all such liability. The waiver and release are part of the consideration
for the issue of the Securities.
Section 10.9 Counterparts.
This Indenture may be executed
in any number of counterparts and by the parties hereto in separate counterparts, each of which when so executed shall be deemed
to be an original and all of which taken together shall constitute one and the same agreement. The exchange of copies of this Indenture
and of signature pages by facsimile or PDF transmission shall constitute effective execution and delivery of this Indenture as
to the parties hereto and may be used in lieu of the original Indenture for all purposes. Signatures of the parties hereto transmitted
by facsimile or PDF shall be deemed to be their original signatures for all purposes.
Section 10.10 Governing
Law; Jury Trial Waiver.
THIS INDENTURE AND THE
SECURITIES, INCLUDING ANY CLAIM OR CONTROVERSY ARISING OUT OF OR RELATING TO THIS INDENTURE OR THE SECURITIES, SHALL BE GOVERNED
BY THE LAWS OF THE STATE OF NEW YORK (WITHOUT REGARD TO THE CONFLICTS OF LAWS PROVISIONS THEREOF OTHER THAN SECTION 5-1401 OF THE
GENERAL OBLIGATIONS LAW).
EACH OF THE COMPANY AND
THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN
ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTION CONTEMPLATED HEREBY.
Section 10.11 No
Adverse Interpretation of Other Agreements.
This Indenture may not
be used to interpret another indenture, loan or debt agreement of the Company or a Subsidiary of the Company. Any such indenture,
loan or debt agreement may not be used to interpret this Indenture.
Section 10.12 Successors.
All agreements of the Company
in this Indenture and the Securities shall bind its successor. All agreements of the Trustee in this Indenture shall bind its successor.
Section 10.13 Severability.
In case any provision in
this Indenture or in the Securities shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby.
Section 10.14 Table
of Contents, Headings, Etc.
The Table of Contents,
Cross Reference Table, and headings of the Articles and Sections of this Indenture have been inserted for convenience of reference
only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof.
Section 10.15 Securities
in a Foreign Currency.
Unless otherwise specified
in a Board Resolution, a supplemental indenture hereto or an Officer’s Certificate delivered pursuant to Section 2.2 of this
Indenture with respect to a particular Series of Securities, whenever for purposes of this Indenture any action may be taken by
the Holders of a specified percentage in aggregate principal amount of Securities of all Series or all Series affected by a particular
action at the time outstanding and, at such time, there are outstanding Securities of any Series which are denominated in more
than one currency, then the principal amount of Securities of such Series which shall be deemed to be outstanding for the purpose
of taking such action shall be determined by converting any such other currency into a currency that is designated upon issuance
of any particular Series of Securities. Unless otherwise specified in a Board Resolution, a supplemental indenture hereto or an
Officer’s Certificate delivered pursuant to Section 2.2 of this Indenture with respect to a particular Series of Securities,
such conversion shall be at the spot rate for the purchase of the designated currency as published in The Financial Times in the
“Currency Rates” section (or, if The Financial Times is no longer published, or if such information is no longer available
in The Financial Times, such source as may be selected in good faith by the Company) on any date of determination. The provisions
of this paragraph shall apply in determining the equivalent principal amount in respect of Securities of a Series denominated in
currency other than Dollars in connection with any action taken by Holders of Securities pursuant to the terms of this Indenture.
All decisions and determinations
provided for in the preceding paragraph shall, in the absence of manifest error, to the extent permitted by law, be conclusive
for all purposes and irrevocably binding upon the Trustee and all Holders.
Section 10.16 Judgment
Currency.
The Company agrees, to
the fullest extent that it may effectively do so under applicable law, that (a) if for the purpose of obtaining judgment in any
court it is necessary to convert the sum due in respect of the principal of or interest or other amount on the Securities of any
Series (the “Required Currency”) into a currency in which a judgment will be rendered (the “Judgment
Currency”), the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Trustee
could purchase in The City of New York the Required Currency with the Judgment Currency on the day on which final unappealable
judgment is entered, unless such day is not a Business Day, then the rate of exchange used shall be the rate at which in accordance
with normal banking procedures the Trustee could purchase in The City of New York the Required Currency with the Judgment Currency
on the Business Day preceding the day on which final unappealable judgment is entered and (b) its obligations under this Indenture
to make payments in the Required Currency (i) shall not be discharged or satisfied by any tender, or any recovery pursuant to any
judgment (whether or not entered in accordance with subsection (a)), in any currency other than the Required Currency, except to
the extent that such tender or recovery shall result in the actual receipt, by the payee, of the full amount of the Required Currency
expressed to be payable in respect of such payments, (ii) shall be enforceable as an alternative or additional cause of action
for the purpose of recovering in the Required Currency the amount, if any, by which such actual receipt shall fall short of the
full amount of the Required Currency so expressed to be payable, and (iii) shall not be affected by judgment being obtained for
any other sum due under this Indenture.
Section 10.17 Force
Majeure.
In no event shall the Trustee
be responsible or liable for any failure or delay in the performance of its obligations hereunder arising out of or caused by,
directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war
or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions
of utilities, communications or computer (software and hardware) services, it being understood that the Trustee shall use reasonable
best efforts which are consistent with accepted practices in the banking industry to resume performance as soon as practicable
under the circumstances.
Section 10.18 U.S.A.
Patriot Act.
The parties hereto acknowledge
that in accordance with Section 326 of the U.S.A. Patriot Act, the Trustee, like all financial institutions and in order to help
fight the funding of terrorism and money laundering, is required to obtain, verify, and record information that identifies each
person or legal entity that establishes a relationship or opens an account with the Trustee. The parties to this Indenture agree
that they will provide the Trustee with such information as it may request in order for the Trustee to satisfy the requirements
of the U.S.A. Patriot Act.
ARTICLE XI
SINKING FUNDS
Section 11.1 Applicability
of Article.
The provisions of this
Article shall be applicable to any sinking fund for the retirement of the Securities of a Series if so provided by the terms of
such Securities pursuant to Section 2.2 and except as otherwise permitted or required by any form of Security of such Series issued
pursuant to this Indenture.
The minimum amount of any
sinking fund payment provided for by the terms of the Securities of any Series is herein referred to as a “mandatory sinking
fund payment” and any other amount provided for by the terms of Securities of such Series is herein referred to as an
“optional sinking fund payment.” If provided for by the terms of Securities of any Series, the cash amount of
any sinking fund payment may be subject to reduction as provided in Section 11.2. Each sinking fund payment shall be applied to
the redemption of Securities of any Series as provided for by the terms of the Securities of such Series.
Section 11.2 Satisfaction
of Sinking Fund Payments with Securities.
The Company may, in satisfaction
of all or any part of any sinking fund payment with respect to the Securities of any Series to be made pursuant to the terms of
such Securities (a) deliver outstanding Securities of such Series to which such sinking fund payment is applicable (other than
any of such Securities previously called for mandatory sinking fund redemption) and (b) apply as credit Securities of such Series
to which such sinking fund payment is applicable and which have been repurchased by the Company or redeemed either at the election
of the Company pursuant to the terms of the Securities of such Series (except pursuant to any mandatory sinking fund) or through
the application of permitted optional sinking fund payments or other optional redemptions pursuant to the terms of such Securities,
provided that such Securities have not been previously so credited. Such Securities shall be received by the Trustee, together
with an Officer’s Certificate with respect thereto, not later than 15 days prior to the date on which the Trustee begins
the process of selecting Securities for redemption, and shall be credited for such purpose by the Trustee at the price specified
in such Securities for redemption through operation of the sinking fund and the amount of such sinking fund payment shall be reduced
accordingly. If as a result of the delivery or credit of Securities in lieu of cash payments pursuant to this Section 11.2, the
principal amount of Securities of such Series to be redeemed in order to exhaust the aforesaid cash payment shall be less than
$100,000, the Trustee need not call Securities of such Series for redemption, except upon receipt of a Company Order that such
action be taken, and such cash payment shall be held by the Trustee or a Paying Agent and applied to the next succeeding sinking
fund payment, provided, however, that the Trustee or such Paying Agent shall from time to time upon receipt of a
Company Order pay over and deliver to the Company any cash payment so being held by the Trustee or such Paying Agent upon delivery
by the Company to the Trustee of Securities of that Series purchased by the Company having an unpaid principal amount equal to
the cash payment required to be released to the Company.
Section 11.3 Redemption
of Securities for Sinking Fund.
Not less than 45 days (unless
otherwise indicated in the Board Resolution, supplemental indenture hereto or Officer’s Certificate in respect of a particular
Series of Securities) prior to each sinking fund payment date for any Series of Securities, the Company will deliver to the Trustee
an Officer’s Certificate specifying the amount of the next ensuing mandatory sinking fund payment for that Series pursuant
to the terms of that Series, the portion thereof, if any, which is to be satisfied by payment of cash and the portion thereof,
if any, which is to be satisfied by delivering and crediting of Securities of that Series pursuant to Section 11.2, and the optional
amount, if any, to be added in cash to the next ensuing mandatory sinking fund payment, and the Company shall thereupon be obligated
to pay the amount therein specified. Not less than 30 days (unless otherwise indicated in the Board Resolution, Officer’s
Certificate or supplemental indenture in respect of a particular Series of Securities) before each such sinking fund payment date
the Trustee shall select the Securities to be redeemed upon such sinking fund payment date in the manner specified in Section 3.2
and cause notice of the redemption thereof to be given in the name of and at the expense of the Company in the manner provided
in Section 3.3. Such notice having been duly given, the redemption of such Securities shall be made upon the terms and in
the manner stated in Sections 3.4, 3.5 and 3.6.
[Signature page follows]
IN WITNESS WHEREOF, the
parties hereto have caused this Indenture to be duly executed as of the day and year first above written.
GALMED PHARMACEUTICALS LTD., as Issuer |
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By: |
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Name: |
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Its: |
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, as Trustee |
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By: |
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Name: |
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Its: |
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Exhibit 4.5
GALMED PHARMACEUTICALS LTD.
INDENTURE
Dated as of , 20
[ ]
Trustee
Subordinated Debt Securities
Table
of Contents
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Page |
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ARTICLE I |
DEFINITIONS AND INCORPORATION BY REFERENCE |
1 |
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Section 1.1 |
Definitions |
1 |
Section 1.2 |
Other Definitions |
4 |
Section 1.3 |
Incorporation by Reference of Trust Indenture Act |
5 |
Section 1.4 |
Rules of Construction |
5 |
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ARTICLE II |
THE SECURITIES |
6 |
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Section 2.1 |
Issuable in Series |
6 |
Section 2.2 |
Establishment of Terms of Series of Securities |
6 |
Section 2.3 |
Denominations; Provision for Payment |
8 |
Section 2.4 |
Execution and Authentication |
9 |
Section 2.5 |
Registrar and Paying Agent |
9 |
Section 2.6 |
Paying Agent to Hold Money in Trust |
10 |
Section 2.7 |
Securityholder Lists |
10 |
Section 2.8 |
Transfer and Exchange |
11 |
Section 2.9 |
Mutilated, Destroyed, Lost and Stolen Securities |
11 |
Section 2.10 |
Outstanding Securities |
12 |
Section 2.11 |
Treasury Securities |
12 |
Section 2.12 |
Temporary Securities |
13 |
Section 2.13 |
Cancellation |
13 |
Section 2.14 |
Defaulted Interesthttps://www.sec.gov/Archives/edgar/data/1595353/000149315221006920/ex4-5.htm |
13 |
Section 2.15 |
Global Securities |
13 |
Section 2.16 |
CUSIP Numbers |
15 |
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ARTICLE III |
REDEMPTION |
15 |
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Section 3.1 |
Notice to Trustee |
15 |
Section 3.2 |
Selection of Securities to be Redeemed |
15 |
Section 3.3 |
Notice of Redemption |
15 |
Section 3.4 |
Effect of Notice of Redemption |
16 |
Section 3.5 |
Deposit of Redemption Price |
17 |
Section 3.6 |
Securities Redeemed in Part |
17 |
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ARTICLE IV |
COVENANTS |
17 |
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Section 4.1 |
Payment of Principal and Interest |
17 |
Section 4.2 |
Reports by Company |
18 |
Section 4.3 |
Compliance Certificate |
18 |
Section 4.4 |
Stay, Extension and Usury Laws |
18 |
Section 4.5 |
Corporate Existence |
19 |
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ARTICLE V |
SUCCESSORS |
19 |
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Section 5.1 |
Consolidation, Merger and Sale of Assets |
19 |
Table
of Contents
(continued)
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Page |
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Section 5.2 |
Successor Person Substituted |
19 |
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ARTICLE VI |
DEFAULTS AND REMEDIES |
20 |
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Section 6.1 |
Events of Default |
20 |
Section 6.2 |
Acceleration of Maturity; Rescission and Annulment |
21 |
Section 6.3 |
Collection of Indebtedness and Suits for Enforcement by Trustee |
22 |
Section 6.4 |
Trustee May File Proofs of Claim |
22 |
Section 6.5 |
Trustee May Enforce Claims Without Possession of Securities |
23 |
Section 6.6 |
Application of Money Collected |
23 |
Section 6.7 |
Limitation on Suits |
24 |
Section 6.8 |
Unconditional Right of Holders to Receive Principal and Interest |
24 |
Section 6.9 |
Restoration of Rights and Remedies |
24 |
Section 6.10 |
Rights and Remedies Cumulative |
25 |
Section 6.11 |
Delay or Omission Not Waiver |
25 |
Section 6.12 |
Control by Holders |
25 |
Section 6.13 |
Waiver of Past Defaults |
26 |
Section 6.14 |
Undertaking for Costs |
26 |
|
|
|
ARTICLE VII |
TRUSTEE |
26 |
|
|
|
Section 7.1 |
Duties of Trustee |
26 |
Section 7.2 |
Rights of Trustee |
27 |
Section 7.3 |
Individual Rights of Trustee |
29 |
Section 7.4 |
Trustee’s Disclaimer |
29 |
Section 7.5 |
Notice of Defaults |
29 |
Section 7.6 |
Reports by Trustee to Holders |
29 |
Section 7.7 |
Compensation and Indemnity |
30 |
Section 7.8 |
Replacement of Trustee |
30 |
Section 7.9 |
Successor Trustee by Merger, Etc |
31 |
Section 7.10 |
Eligibility; Disqualification |
31 |
Section 7.11 |
Preferential Collection of Claims Against Company |
32 |
|
|
|
ARTICLE VIII |
SATISFACTION AND DISCHARGE; DEFEASANCE |
32 |
|
|
|
Section 8.1 |
Satisfaction and Discharge of Indenture |
32 |
Section 8.2 |
Application of Trust Funds; Indemnification |
33 |
Section 8.3 |
Legal Defeasance of Securities of any Series |
33 |
Section 8.4 |
Covenant Defeasance |
35 |
Section 8.5 |
Repayment to Company |
36 |
Section 8.6 |
Reinstatement |
36 |
Table
of Contents
(continued)
|
|
Page |
|
|
|
ARTICLE IX |
AMENDMENTS AND WAIVERS |
36 |
|
|
|
Section 9.1 |
Without Consent of Holders |
36 |
Section 9.2 |
With Consent of Holders |
37 |
Section 9.3 |
Limitations |
38 |
Section 9.4 |
Compliance with Trust Indenture Act |
38 |
Section 9.5 |
Revocation and Effect of Consents |
38 |
Section 9.6 |
Notation on or Exchange of Securities |
39 |
Section 9.7 |
Trustee Protected |
39 |
|
|
|
ARTICLE X |
MISCELLANEOUS |
39 |
|
|
|
Section 10.1 |
Trust Indenture Act Controls |
39 |
Section 10.2 |
Notices |
40 |
Section 10.3 |
Communication by Holders with Other Holders |
40 |
Section 10.4 |
Certificate and Opinion as to Conditions Precedent |
41 |
Section 10.5 |
Statements Required in Certificate or Opinion |
41 |
Section 10.6 |
Rules by Trustee and Agents |
41 |
Section 10.7 |
Legal Holidays |
41 |
Section 10.8 |
No Recourse Against Others |
42 |
Section 10.9 |
Counterparts |
42 |
Section 10.10 |
Governing Law; Jury Trial Waiver |
42 |
Section 10.11 |
No Adverse Interpretation of Other Agreements |
42 |
Section 10.12 |
Successors |
42 |
Section 10.13 |
Severability |
43 |
Section 10.14 |
Table of Contents, Headings, Etc |
43 |
Section 10.15 |
Securities in a Foreign Currency |
43 |
Section 10.16 |
Judgment Currency |
43 |
Section 10.17 |
Force Majeure |
44 |
Section 10.18 |
U.S.A. Patriot Act |
44 |
|
|
|
ARTICLE XI |
SINKING FUNDS |
44 |
|
|
|
Section 11.1 |
Applicability of Article |
44 |
Section 11.2 |
Satisfaction of Sinking Fund Payments with Securities |
45 |
Section 11.3 |
Redemption of Securities for Sinking Fund |
45 |
|
|
|
ARTICLE XII |
SUBORDINATION OF SECURITIES |
46 |
|
|
|
Section 12.1 |
Subordination of Terms |
46 |
GALMED PHARMACEUTICALS LTD.
Reconciliation and tie between Trust Indenture
Act of 1939 and
Indenture, dated as of , 20
§ 310(a)(1) |
7.10 |
(a)(2) |
7.10 |
(a)(3) |
Not Applicable |
(a)(4) |
Not Applicable |
(a)(5) |
7.10 |
(b) |
7.10 |
§ 311(a) |
7.11 |
(b) |
7.11 |
§ 312(a) |
2.7 |
(b) |
10.3 |
(c) |
10.3 |
§ 313(a) |
7.6 |
(b)(1) |
7.6 |
(b)(2) |
7.6 |
(c)(1) |
7.6 |
(d) |
7.6 |
§ 314(a) |
4.2, 10.5 |
(b) |
Not Applicable |
(c)(1) |
10.4 |
(c)(2) |
10.4 |
(c)(3) |
Not Applicable |
(d) |
Not Applicable |
(e) |
10.5 |
(f) |
Not Applicable |
§ 315(a) |
7.1 |
(b) |
7.5 |
(c) |
7.1 |
(d) |
7.1 |
(e) |
6.14 |
§ 316(a) |
2.11 |
(a)(1)(A) |
6.12 |
(a)(1)(B) |
6.13 |
(b) |
6.8 |
§ 317(a)(1) |
6.3 |
(a)(2) |
6.4 |
(b) |
2.6 |
§ 318(a) |
10.1 |
Note: This reconciliation and tie shall not,
for any purpose, be deemed to be part of the Indenture.
Indenture dated as of , 20
, between GALMED PHARMACEUTICALS LTD., a company organized under the laws of the State of Israel (“Company”), and ,
as trustee (“Trustee”).
Each party agrees as follows for the benefit
of the other party and for the equal and ratable benefit of the Holders of the Securities issued under this Indenture.
ARTICLE I
DEFINITIONS AND INCORPORATION BY REFERENCE
Section 1.1 Definitions.
“Affiliate”
of any specified person means any other person directly or indirectly controlling or controlled by or under common control with
such specified person. For the purposes of this definition, “control” (including, with correlative meanings, the terms
“controlled by” and “under common control with”), as used with respect to any person, shall mean the possession,
directly or indirectly, of the power to direct or cause the direction of the management or policies of such person, whether through
the ownership of voting securities or by agreement or otherwise.
“Agent”
means any Registrar or Paying Agent.
“Board of Directors”
means the board of directors of the Company or any duly authorized committee thereof.
“Board Resolution”
means a copy of a resolution certified by the Secretary or an Assistant Secretary of the Company to have been adopted by the Board
of Directors or pursuant to authorization by the Board of Directors and to be in full force and effect on the date of the certification
and delivered to the Trustee.
“Business Day”
means, for a particular Series, any day except a Saturday, Sunday or any day, including a legal holiday, on which banking institutions
are authorized or required by law, regulation or executive order to close in The City of New York (or in connection with any payment,
the place of payment).
“Capital Stock”
of any person means any and all shares, interests, participations, rights or other equivalents (however designated) of the equity
of such person.
“Certificated
Securities” means definitive Securities in registered non-global certificated form.
“Company”
means the party named as such above until a successor, which duly assumes the obligations under this Indenture, replaces it and
thereafter means the successor.
“Company Order”
means a written order signed in the name of the Company by an Officer.
“Corporate Trust
Office” means the office of the Trustee at which at any particular time its corporate trust business related to this
Indenture shall be principally administered, which office at the date hereof is located at , Attention: , or
such other address as the Trustee may designate from time to time by notice to the Holders and the Company, or the corporate trust
office of any successor Trustee at which this Indenture shall be administered (or such other address as a successor Trustee may
designate from time to time by notice to the Holders of the Company).
“Default”
means any event which is, or after notice or passage of time or both would be, an Event of Default.
“Depositary”
means, with respect to the Securities of any Series issuable or issued in whole or in part in the form of one or more Global Securities,
the person designated as Depositary for such Series by the Company, which Depositary shall be a clearing agency registered under
the Exchange Act; and if at any time there is more than one such person, “Depositary” as used with respect to
the Securities of any Series shall mean the Depositary with respect to the Securities of such Series.
“Discount Security”
means any Security that provides for an amount less than the stated principal amount thereof to be due and payable upon declaration
of acceleration of the maturity thereof pursuant to Section 6.2.
“Dollars”
and “$” means the currency of The United States of America.
“Exchange Act”
means the Securities Exchange Act of 1934, as amended.
“Foreign Currency”
means any currency or currency unit issued by a government other than the government of The United States of America.
“Foreign Government
Obligations” means, with respect to Securities of any Series that are denominated in a Foreign Currency, direct obligations
of, or obligations guaranteed by, the government that issued or caused to be issued such currency for the payment of which obligations
its full faith and credit is pledged and which are not callable or redeemable at the option of the issuer thereof.
“GAAP”
means accounting principles generally accepted in The United States of America set forth in the opinions and pronouncements of
the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of
the Financial Accounting Standards Board or in such other statements by such other entity as have been approved by a significant
segment of the accounting profession, which are in effect as of the date of determination.
“Global Security”
or “Global Securities” means a Security or Securities, as the case may be, in the form established pursuant
to Section 2.2 evidencing all or part of a Series of Securities, issued to the Depositary for such Series or its nominee, and registered
in the name of such Depositary or nominee.
“Holder”
or “Securityholder” means a person in whose name a Security is registered on the books of the Registrar.
“Indenture”
means this Indenture as amended or supplemented from time to time and shall include the form and terms of particular Series of
Securities established as contemplated hereunder.
“interest”
means, with respect to any Security, any interest on such Security, and with respect to any Discount Security which by its terms
bears interest only after Maturity, interest payable after Maturity.
“Maturity,”
when used with respect to any Security, means the date on which the principal of such Security becomes due and payable as therein
or herein provided, whether at the Stated Maturity or by declaration of acceleration, call for redemption or otherwise.
“Officer”
means the Chairman of the Board of Directors, the Chief Executive Officer, the Chief Financial Officer, the President, any Senior
Vice President or Vice President, the Treasurer, Assistant Treasurer, Secretary or Assistant Secretary of the Company.
“Officer’s
Certificate” means a certificate signed by any Officer (or any person designated in writing by an Officer of the Company
as authorized to execute and deliver Officer’s Certificates) and delivered to the Trustee.
“Opinion of Counsel”
means a written opinion of legal counsel. The counsel may be an employee of or counsel to the Company. Opinions of Counsel required
to be delivered under this Indenture may have qualifications customary for opinions of the type required.
“person”
means any individual, corporation, company, voluntary association, partnership, trust, joint venture, limited liability company,
unincorporated organization or government or any agency, instrumentality or political subdivision thereof.
“principal”
of a Security means the principal of the Security plus, when appropriate, the premium, if any, on the Security.
“Responsible Officer”
means any officer of the Trustee in its Corporate Trust Office having direct responsibility for administration of this Indenture
and also means, with respect to a particular corporate trust matter, any other officer to whom any corporate trust matter is referred
because of his or her knowledge of and familiarity with a particular subject and who shall have direct responsibility for the administration
of this Indenture.
“SEC”
means the Securities and Exchange Commission.
“Securities”
means the subordinated debentures, notes or other debt instruments of the Company of any Series authenticated and delivered under
this Indenture.
“Series”
or “Series of Securities” means each series of debentures, notes or other debt instruments of the Company created
pursuant to Sections 2.1 and 2.2 hereof.
“Stated Maturity”
when used with respect to any Security, means the date specified in such Security as the fixed date on which the principal of such
Security is due and payable.
“Subsidiary”
means, with respect to any person, any corporation, partnership, joint venture, limited liability company or other business entity
of which a majority of the outstanding shares of Capital Stock or other interests having the power to vote in the election of directors,
managers or trustees thereof is at the time directly or indirectly owned or controlled by such person or one or more of the other
Subsidiaries of such person, or a combination thereof.
“TIA”
means the Trust Indenture Act of 1939 (15 U.S. Code §§ 77aaa-77bbbb) as in effect on the date of this Indenture; provided,
however, that in the event the Trust Indenture Act of 1939 is amended after such date, “TIA” means, to the extent required
by any such amendment, the Trust Indenture Act as so amended.
“Trustee”
means the person named as the “Trustee” in the first paragraph of this instrument until a successor Trustee shall have
become such pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall mean or include
each person who is then a Trustee hereunder, and if at any time there is more than one such person, “Trustee” as used
with respect to the Securities of any Series shall mean the Trustee with respect to Securities of that Series.
“United States”
or “U.S.” means The United States of America (including the states thereof and the District of Columbia), its
territories and possessions and other areas subject to its jurisdiction.
“U.S. Government
Obligations” means securities which are direct obligations of, or guaranteed by, The United States of America for the
payment of which its full faith and credit is pledged and which are not callable or redeemable at the option of the issuer thereof,
and shall also include a depository receipt issued by a bank or trust company as custodian with respect to any such U.S. Government
Obligation or a specific payment of interest on or principal of any such U.S. Government Obligation held by such custodian for
the account of the holder of a depository receipt, provided that (except as required by law) such custodian is not authorized to
make any deduction from the amount payable to the holder of such depository receipt from any amount received by the custodian in
respect of the U.S. Government Obligation evidenced by such depository receipt.
Section 1.2 Other
Definitions.
TERM |
DEFINED IN SECTION |
“Bankruptcy Law” |
6.1 |
“Custodian” |
6.1 |
“Event of Default” |
6.1 |
“Judgment Currency” |
10.16 |
“Legal Holiday” |
10.7 |
“mandatory sinking fund payment” |
11.1 |
“optional sinking fund payment” |
11.1 |
“Paying Agent” |
2.5 |
“Registrar” |
2.5 |
“Required Currency” |
10.16 |
“successor person” |
5.1 |
Section 1.3 Incorporation
by Reference of Trust Indenture Act.
Whenever this Indenture
refers to a provision of the TIA, the provision is incorporated by reference in and made a part of this Indenture. The following
TIA terms used in this Indenture have the following meanings:
“Commission”
means the SEC.
“indenture securities”
means the Securities.
“indenture security
holder” means a Securityholder.
“indenture to
be qualified” means this Indenture.
“indenture trustee”
or “institutional trustee” means the Trustee.
“obligor”
on the indenture securities means the Company and any successor obligor upon the Securities.
All other terms used in
this Indenture that are defined by the TIA, defined by TIA reference to another statute or defined by SEC rule under the TIA and
not otherwise defined herein are used herein as so defined.
Section 1.4 Rules
of Construction.
Unless the context otherwise
requires:
(a) a
term has the meaning assigned to it;
(b) an
accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP;
(c) “or”
is not exclusive;
(d) words
in the singular include the plural, and in the plural include the singular; and
(e) provisions
apply to successive events and transactions.
ARTICLE II
THE SECURITIES
Section 2.1 Issuable
in Series.
The aggregate principal
amount of Securities that may be authenticated and delivered under this Indenture is unlimited. The Securities may be issued in
one or more Series. All Securities of a Series shall be identical except as may be set forth or determined in the manner provided
in a Board Resolution, supplemental indenture hereto or Officer’s Certificate establishing the terms of such Series. In the
case of Securities of a Series to be issued from time to time, the Board Resolution, Officer’s Certificate or supplemental
indenture establishing the terms thereof may provide for the method by which specified terms (such as interest rate, maturity date,
record date or date from which interest shall accrue) are to be determined. Securities may differ between Series in respect of
any matters, provided that all Series of Securities shall be equally and ratably entitled to the benefits of this Indenture.
Section 2.2 Establishment
of Terms of Series of Securities.
At or prior to the issuance
of any Securities within a Series, the following shall be established (as to the Series generally, in the case of Subsection 2.2.1
and either as to such Securities within the Series or as to the Series generally in the case of Subsections 2.2.2 through 2.2.24)
by or pursuant to a Board Resolution, and set forth or determined in the manner provided in a Board Resolution, supplemental indenture
hereto or Officer’s Certificate:
2.2.1 the
title (which shall distinguish the Securities of that particular Series from the Securities of any other Series) of the Series;
2.2.2 the
price or prices (expressed as a percentage of the principal amount thereof) at which the Securities of the Series will be issued;
2.2.3 any
limit upon the aggregate principal amount of the Securities of the Series which may be authenticated and delivered under this Indenture
(except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities
of the Series pursuant to Section 2.8, 2.9, 2.12, 3.6 or 9.6);
2.2.4 the
date or dates on which the principal of the Securities of the Series is payable;
2.2.5 the
rate or rates (which may be fixed or variable) per annum or, if applicable, the method used to determine such rate or rates (including,
but not limited to, any commodity, commodity index, stock exchange index or financial index) at which the Securities of the Series
shall bear interest, if any, the date or dates from which such interest, if any, shall accrue, the date or dates on which such
interest, if any, shall commence and be payable and any regular record date for the interest payable on any interest payment date;
2.2.6 the
place or places where the principal of and interest, if any, on the Securities of the Series shall be payable, where the Securities
of such Series may be surrendered for registration of transfer or exchange and where notices and demands to or upon the Company
in respect of the Securities of such Series and this Indenture may be delivered, and the method of such payment, if by wire transfer,
mail or other means;
2.2.7 if
applicable, the period or periods within which, the price or prices at which and the terms and conditions upon which the Securities
of the Series must be redeemed or may be redeemed, in whole or in part, at the option of the Company;
2.2.8 the
obligation, if any, of the Company to redeem or purchase the Securities of the Series pursuant to any sinking fund or analogous
provisions or at the option of a Holder thereof and the period or periods within which, the price or prices at which and the terms
and conditions upon which Securities of the Series shall be redeemed or purchased, in whole or in part, pursuant to such obligation;
2.2.9 the
dates, if any, on which and the price or prices at which the Securities of the Series will be repurchased by the Company at the
option of the Holders thereof and other detailed terms and provisions of such repurchase obligations;
2.2.10 if
other than denominations of $1,000 and integral multiples of $1,000 in excess thereof, the denominations in which the Securities
of the Series shall be issuable;
2.2.11 the
forms of the Securities of the Series and whether the Securities will be issuable as Global Securities;
2.2.12 if
other than the principal amount thereof, the portion of the principal amount of the Securities of the Series that shall be payable
upon declaration of acceleration of the maturity thereof pursuant to Section 6.2;
2.2.13 the
currency of denomination of the Securities of the Series, which may be Dollars or any Foreign Currency, and if such currency of
denomination is a composite currency, the agency or organization, if any, responsible for overseeing such composite currency;
2.2.14 the
designation of the currency, currencies or currency units in which payment of the principal of and interest, if any, on the Securities
of the Series will be made;
2.2.15 if
payments of principal of or interest, if any, on the Securities of the Series are to be made in one or more currencies or currency
units other than that or those in which such Securities are denominated, the manner in which the exchange rate with respect to
such payments will be determined;
2.2.16 the
manner in which the amounts of payment of principal of or interest, if any, on the Securities of the Series will be determined,
if such amounts may be determined by reference to an index based on a currency or currencies or by reference to a commodity, commodity
index, stock exchange index or financial index;
2.2.17 the
provisions, if any, relating to any security provided for the Securities of the Series;
2.2.18 any
addition to, deletion of or change in the Events of Default which applies to any Securities of the Series and any change in the
right of the Trustee or the requisite Holders of such Securities to declare the principal amount thereof due and payable pursuant
to Section 6.2;
2.2.19 any
addition to, deletion of or change in the covenants set forth in Articles IV or V which applies to Securities of the Series;
2.2.20 any
Depositaries, trustees, interest rate calculation agents, exchange rate calculation agents or other agents with respect to Securities
of such Series if other than those appointed herein;
2.2.21 the
provisions, if any, relating to conversion or exchange of any Securities of such Series, including if applicable, the conversion
or exchange price, the conversion or exchange period, the securities or other property into which the Securities will be convertible,
provisions as to whether conversion or exchange will be mandatory, at the option of the Holders thereof or at the option of the
Company, the events requiring an adjustment of the conversion price or exchange price and provisions affecting conversion or exchange
if such Series of Securities are redeemed;
2.2.22 whether
any of the Company’s direct or indirect Subsidiaries will guarantee the Securities of that Series, including the terms of
subordination, if any, of such guarantees;
2.2.23 the
subordination terms of the Securities of the Series; and
2.2.24 any
other terms of the Series (which may supplement, modify or delete any provision of this Indenture insofar as it applies to such
Series), including any terms that may be required under applicable law or regulations or advisable in connection with the marketing
of Securities of that Series.
All Securities of any one
Series need not be issued at the same time and may be issued from time to time, consistent with the terms of this Indenture, if
so provided by or pursuant to the Board Resolution, supplemental indenture hereto or Officer’s Certificate referred to above.
Section 2.3 Denominations;
Provision for Payment.
The Securities of any Series
shall be issuable, except as otherwise provided with respect to Securities of any Series pursuant to Section 2.2, as registered
Securities in the denominations of one thousand Dollars ($1,000) or any integral multiples of $1,000 in excess thereof. Unless
otherwise provided with respect to Securities of any Series pursuant to Section 2.2, the principal of and the interest on the Securities
of any Series, if any, thereon, shall by payable in Dollars at the Corporate Trust Office of the Trustee. Unless otherwise specified
pursuant to Section 2.2 with respect to any Securities of any Series, interest on the Securities of any Series shall be computed
on the basis of a 360-day year consisting of twelve 30-day months.
Section 2.4 Execution
and Authentication.
Two Officers shall sign
the Securities for the Company by manual or facsimile signature.
If an Officer whose signature
is on a Security no longer holds that office at the time the Security is authenticated, the Security shall nevertheless be valid.
A Security shall not be
valid until authenticated by the manual signature of the Trustee or an authenticating agent. The signature shall be conclusive
evidence that the Security has been authenticated under this Indenture.
The Trustee shall at any
time, and from time to time, authenticate Securities for original issue in the principal amount provided in the Board Resolution,
supplemental indenture hereto or Officer’s Certificate, upon receipt by the Trustee of a Company Order. Each Security shall
be dated the date of its authentication.
The aggregate principal
amount of Securities of any Series outstanding at any time may not exceed any limit upon the maximum principal amount for such
Series set forth in the Board Resolution, supplemental indenture hereto or Officer’s Certificate delivered pursuant to Section
2.2, except as provided in Section 2.9.
Prior to the issuance of
Securities of any Series, the Trustee shall have received and (subject to Section 7.1) shall be fully protected in conclusively
relying on: (a) the Board Resolution, supplemental indenture hereto or Officer’s Certificate delivered pursuant to Section
2.2 establishing the form of the Securities of that Series or of Securities within that Series and the terms of the Securities
of that Series or of Securities within that Series, (b) an Officer’s Certificate complying with Section 9.7 (with respect
to the execution of supplemental indentures) and Section 10.4, and (c) an Opinion of Counsel complying with Section 9.7 (with respect
to the execution of supplemental indentures) and Section 10.4.
The Trustee shall have
the right, but not the obligation, to decline to authenticate and deliver any Securities of such Series: (a) if the Trustee, being
advised by counsel, determines that such action may not be taken lawfully; or (b) if the Trustee in good faith determines that
such action would expose the Trustee to personal liability.
The Trustee may appoint
an authenticating agent acceptable to the Company to authenticate Securities. An authenticating agent may authenticate Securities
whenever the Trustee may do so. Each reference in this Indenture to authentication by the Trustee includes authentication by such
agent. An authenticating agent has the same rights as an Agent to deal with the Company or an Affiliate of the Company.
Section 2.5 Registrar
and Paying Agent.
The Company shall maintain,
with respect to each Series of Securities, at the place or places specified with respect to such Series, an office or agency where
Securities of such Series may be presented or surrendered for payment (“Paying Agent”) and where Securities
of such Series may be surrendered for registration of transfer or exchange (“Registrar”). The Registrar shall
keep a register with respect to each Series of Securities and to their transfer and exchange. The Company will give prompt written
notice to the Trustee of the name and address, and any change in the name or address, of each Registrar or Paying Agent. If at
any time the Company shall fail to maintain any such required Registrar or Paying Agent or shall fail to furnish the Trustee with
the name and address thereof, such presentations and surrenders may be made or served at the Corporate Trust Office of the Trustee,
and the Company hereby appoints the Trustee as its agent to receive all such presentations and surrenders.
The Company may also from
time to time designate one or more co-registrars or additional paying agents and may from time to time rescind such designations;
provided, however, that no such designation or rescission shall in any manner relieve the Company of its obligations
to maintain a Registrar or Paying Agent in each place so specified for Securities of any Series for such purposes. The Company
will give prompt written notice to the Trustee of any such designation or rescission and of any change in the name or address of
any such co-registrar or additional paying agent. The term “Registrar” includes any co-registrar; and the term
“Paying Agent” includes any additional paying agent. The Company or any of its Affiliates may serve as Registrar
or Paying Agent.
The Company hereby appoints
the Trustee as the initial Registrar and Paying Agent for each Series unless another Registrar or Paying Agent, as the case may
be, is appointed prior to the time Securities of that Series are first issued.
Section 2.6 Paying
Agent to Hold Money in Trust.
The Company shall require
each Paying Agent other than the Trustee to agree in writing that the Paying Agent will hold in trust, for the benefit of Securityholders
of any Series of Securities, or the Trustee, all money held by the Paying Agent for the payment of principal of or interest on
the Securities of that Series, and will notify the Trustee in writing of any default by the Company in making any such payment.
While any such default continues, the Trustee may require a Paying Agent to pay all money held by it to the Trustee. The Company
at any time may require a Paying Agent to pay all money held by it to the Trustee. Upon payment over to the Trustee, the Paying
Agent (if other than the Company or a Subsidiary of the Company) shall have no further liability for the money. If the Company
or a Subsidiary of the Company acts as Paying Agent, it shall segregate and hold in a separate trust fund for the benefit of Securityholders
of any Series of Securities all money held by it as Paying Agent. Upon any bankruptcy, reorganization or similar proceeding with
respect to the Company, the Trustee shall serve as Paying Agent for the Securities.
Section 2.7 Securityholder
Lists.
The Trustee shall preserve
in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of Securityholders
of each Series of Securities and shall otherwise comply with TIA § 312(a). If the Trustee is not the Registrar, the Company
shall furnish to the Trustee at least ten days before each interest payment date and at such other times as the Trustee may request
in writing a list, in such form and as of such date as the Trustee may reasonably require, of the names and addresses of Securityholders
of each Series of Securities.
Section 2.8 Transfer
and Exchange.
Where Securities of a Series
are presented to the Registrar or a co-registrar with a request to register a transfer or to exchange them for an equal principal
amount of Securities of the same Series, the Registrar shall register the transfer or make the exchange if its requirements for
such transactions are met. To permit registrations of transfers and exchanges, the Trustee shall authenticate Securities at the
Registrar’s request. No service charge shall be made for any registration of transfer or exchange (except as otherwise expressly
permitted herein), but the Company may require payment of a sum sufficient to cover any transfer tax or similar governmental charge
payable in connection therewith (other than any such transfer tax or similar governmental charge payable upon exchanges pursuant
to Sections 2.12, 3.6 or 9.6).
Neither the Company nor
the Registrar shall be required (a) to issue, register the transfer of, or exchange Securities of any Series for the period beginning
at the opening of business fifteen days immediately preceding the mailing of a notice of redemption of Securities of that Series
selected for redemption and ending at the close of business on the day of such mailing, or (b) to register the transfer of or exchange
Securities of any Series selected, called or being called for redemption as a whole or the portion being redeemed of any such Securities
selected, called or being called for redemption in part.
Section 2.9 Mutilated,
Destroyed, Lost and Stolen Securities.
If any mutilated Security
is surrendered to the Trustee, the Company shall execute and the Trustee shall authenticate and deliver in exchange therefor a
new Security of the same Series and of like tenor and principal amount and bearing a number not contemporaneously outstanding.
If there shall be delivered
to the Company and the Trustee (a) evidence to their satisfaction of the destruction, loss or theft of any Security and (b) such
security or indemnity bond as may be required by each of them to hold itself and any of its agents harmless, then, in the absence
of written notice to the Company or the Trustee that such Security has been acquired by a bona fide purchaser, the Company shall
execute and upon receipt of a Company Order the Trustee shall authenticate and make available for delivery, in lieu of any such
destroyed, lost or stolen Security, a new Security of the same Series and of like tenor and principal amount and bearing a number
not contemporaneously outstanding.
In case any such mutilated,
destroyed, lost or stolen Security has become or is about to become due and payable, the Company in its discretion may, instead
of issuing a new Security, pay such Security.
Upon the issuance of any
new Security under this Section 2.9, the Company may require the payment of a sum sufficient to cover any tax or other governmental
charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected
therewith.
Every new Security of any
Series issued pursuant to this Section 2.9 in lieu of any destroyed, lost or stolen Security shall constitute an original additional
contractual obligation of the Company, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by
anyone, and shall be entitled to all the benefits of this Indenture equally and proportionately with any and all other Securities
of that Series duly issued hereunder.
The provisions of this
Section 2.9 are exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement
or payment of mutilated, destroyed, lost or stolen Securities.
Section 2.10 Outstanding
Securities.
The Securities outstanding
at any time are all the Securities authenticated by the Trustee except for those canceled by the Registrar and those described
in this Section 2.10 as not outstanding.
If a Security is replaced
pursuant to Section 2.9, it ceases to be outstanding unless the Trustee receives proof satisfactory to it that the replaced Security
is held by a bona fide purchaser.
If the Paying Agent (other
than the Company, a Subsidiary of the Company or an Affiliate of the Company) holds on the Maturity of Securities of a Series money
sufficient to pay such Securities payable on that date, then on and after that date such Securities of the Series cease to be outstanding
and interest on them ceases to accrue.
The Company may purchase
or otherwise acquire the Securities, whether by open market purchases, negotiated transactions or otherwise. A Security does not
cease to be outstanding because the Company or an Affiliate of the Company holds the Security.
In determining whether
the Holders of the requisite principal amount of outstanding Securities have given any request, demand, authorization, direction,
notice, consent or waiver hereunder, the principal amount of a Discount Security that shall be deemed to be outstanding for such
purposes shall be the amount of the principal thereof that would be due and payable as of the date of such determination upon a
declaration of acceleration of the Maturity thereof pursuant to Section 6.2.
Section 2.11 Treasury
Securities.
In determining whether
the Holders of the required principal amount of Securities of a Series have concurred in any request, demand, authorization, direction,
notice, consent or waiver, Securities of a Series owned by the Company or any Affiliate of the Company shall be disregarded, except
that for the purposes of determining whether the Trustee shall be protected in conclusively relying on any such request, demand,
authorization, direction, notice, consent or waiver, only Securities of a Series that a Responsible Officer of the Trustee actually
knows are so owned shall be so disregarded. Securities so owned which have been pledged in good faith shall not be disregarded
if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right to deliver any such request, demand, authorization,
direction, notice, consent or waiver with respect to the Securities and that the pledgee is not the Company or any other obligor
upon the Securities or any Affiliate of the Company or of such other obligor.
Section 2.12 Temporary
Securities.
Until definitive Securities
are ready for delivery, the Company may prepare and the Trustee shall authenticate temporary Securities upon a Company Order. Temporary
Securities shall be substantially in the form of definitive Securities but may have variations that the Company considers appropriate
for temporary Securities. Without unreasonable delay, the Company shall prepare and the Trustee upon receipt of a Company Order
shall authenticate definitive Securities of the same Series and date of maturity in exchange for temporary Securities. Until so
exchanged, temporary Securities shall have the same rights under this Indenture as the definitive Securities.
Section 2.13 Cancellation.
The Company at any time
may deliver Securities to the Trustee for cancellation. The Registrar and the Paying Agent, if not the Trustee, shall forward to
the Trustee any Securities surrendered to them for registration of transfer, exchange or payment. The Trustee shall cancel all
Securities surrendered for transfer, exchange, payment, replacement, conversion or cancellation and shall dispose of such canceled
Securities (subject to the record retention requirement of the Exchange Act and the Trustee) in accordance with its customary procedures
and deliver a certificate of such cancellation to the Company upon written request of the Company. The Company may not issue new
Securities to replace Securities that it has paid or delivered to the Trustee for cancellation.
Section 2.14 Defaulted
Interest.
If the Company defaults
in a payment of interest on a Series of Securities, it may pay the defaulted interest, plus, to the extent permitted by law, any
interest payable on the defaulted interest, to the persons who are Securityholders of the Series on a subsequent special record
date. The Company shall fix the record date and payment date. At least 10 days before the special record date, the Company shall
mail to the Trustee and to each Securityholder of the Series a notice that states the special record date, the payment date and
the amount of interest to be paid. The Company may pay defaulted interest in any other lawful manner.
Section 2.15 Global
Securities.
2.15.1 Terms
of Securities. A Board Resolution, a supplemental indenture hereto or an Officer’s Certificate shall establish whether
the Securities of a Series shall be issued in whole or in part in the form of one or more Global Securities and the Depositary
for such Global Security or Securities.
2.15.2 Transfer
and Exchange. Notwithstanding any provisions to the contrary contained in Section 2.8 of this Indenture and in addition thereto,
any Global Security shall be exchangeable pursuant to Section 2.8 of this Indenture for Securities registered in the names of Holders
other than the Depositary for such Security or its nominee only if (a) such Depositary notifies the Company that it is unwilling
or unable to continue as Depositary for such Global Security or if at any time such Depositary ceases to be a clearing agency registered
under the Exchange Act, and, in either case, the Company fails to appoint a successor Depositary registered as a clearing agency
under the Exchange Act within 90 days of such event or (b) the Company determines in its sole discretion not to have such Securities
represented by one or more Global Securities and executes and delivers to the Trustee an Officer’s Certificate to the effect
that such Global Security shall be so exchangeable. Any Global Security that is exchangeable pursuant to the preceding sentence
shall be exchangeable for Securities registered in such names as the Depositary shall direct in writing in an aggregate principal
amount equal to the principal amount of the Global Security with like tenor and terms.
Except as provided in this
Section 2.15.2, a Global Security may not be transferred except as a whole by the Depositary with respect to such Global Security
to a nominee of such Depositary, by a nominee of such Depositary to such Depositary or another nominee of such Depositary or by
the Depositary or any such nominee to a successor Depositary or a nominee of such a successor Depositary.
2.15.3 Legend.
Any Global Security issued hereunder shall bear a legend in substantially the following form:
“THIS SECURITY IS
A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITARY OR
A NOMINEE OF THE DEPOSITARY. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY
OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE
DEPOSITARY TO A NOMINEE OF THE DEPOSITARY, BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY,
OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH A SUCCESSOR DEPOSITARY.”
2.15.4 Acts
of Holders. The Depositary, as a Holder, may appoint agents and otherwise authorize participants to give or take any request,
demand, authorization, direction, notice, consent, waiver or other action which a Holder is entitled to give or take under this
Indenture.
2.15.5 Payments.
Notwithstanding the other provisions of this Indenture, unless otherwise specified as contemplated by Section 2.2, payment of the
principal of and interest, if any, on any Global Security shall be made to the Holder thereof, which in the case of a Depositary
therefor will be made in accordance with its applicable procedures.
2.15.6 Consents,
Declaration and Directions. The Company, the Trustee and any Agent shall treat a person as the Holder of such principal amount
of outstanding Securities of such Series represented by a Global Security as shall be specified in a written statement of the Depositary
or by the applicable procedures of such Depositary with respect to such Global Security, for purposes of obtaining any consents,
declarations, waivers or directions required to be given by the Holders pursuant to this Indenture.
Section 2.16 CUSIP
Numbers.
The Company in issuing
the Securities may use “CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP”
numbers in notices of redemption as a convenience to Holders; provided that any such notice may state that no representation is
made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and
that reliance may be placed only on the other elements of identification printed on the Securities, and any such redemption shall
not be affected by any defect in or omission of such numbers. The Trustee shall have no liability for any defect in the “CUSIP”
numbers as they appear on any Security, notice or elsewhere. The Company will promptly notify the Trustee in writing of any change
in the “CUSIP” numbers.
ARTICLE III
REDEMPTION
Section 3.1 Notice
to Trustee.
The Company may, with respect
to any Series of Securities, reserve the right to redeem and pay the Series of Securities or may covenant to redeem and pay the
Series of Securities or any part thereof prior to the Stated Maturity thereof at such time and on such terms as provided for in
such Securities. If a Series of Securities is redeemable and the Company wants or is obligated to redeem prior to the Stated Maturity
thereof all or part of the Series of Securities pursuant to the terms of such Securities, it shall notify the Trustee in writing
of the redemption date and the principal amount of Series of Securities to be redeemed. The Company shall give the notice to the
Trustee at least 45 days before the redemption date, unless a shorter period is satisfactory to the Trustee.
Section 3.2 Selection
of Securities to be Redeemed.
Unless otherwise indicated
for a particular Series by a Board Resolution, a supplemental indenture hereto or an Officer’s Certificate, if less than
all the Securities of a Series are to be redeemed, the Trustee shall select the Securities of the Series to be redeemed in any
manner that the Trustee deems fair and appropriate, including selecting by lot or other method, unless otherwise required by law
or applicable stock exchange requirements, subject, in the case of Global Securities, to the applicable rules and procedures of
the Depositary; provided that the unredeemed portion of the principal amount of any Security shall be in an authorized denomination
(which shall not be less than the minimum authorized denomination) for such Security. The Trustee shall make the selection from
Securities of the Series outstanding not previously called for redemption. Provisions of this Indenture that apply to Securities
of a Series called for redemption also apply to portions of Securities of that Series called for redemption.
Section 3.3 Notice
of Redemption.
Unless otherwise indicated
for a particular Series by Board Resolution, a supplemental indenture hereto or an Officer’s Certificate, at least 30 days
but not more than 60 days before a redemption date, the Company shall mail a notice of redemption by first-class mail to each Holder
whose Securities are to be redeemed.
The notice shall identify
the Securities of the Series to be redeemed and shall state:
(a) the
redemption date;
(b) the
redemption price and the amount of accrued interest, if any, to be paid;
(c) the
name and address of the Paying Agent and, if applicable, the conversion Agent;
(d) for
convertible Securities, the conversion price;
(e) if
any Global Security is being redeemed in part, the portion of the principal amount of such Global Security to be redeemed and that,
after the redemption date upon surrender of such Global Security, the principal amount thereof will be decreased by the portion
thereof redeemed pursuant thereto;
(f)
if any Certificated Security is being redeemed in part, the portion of the principal
amount of such Security to be redeemed, and that, after the redemption date, upon surrender of such Security, a new
Certificated Security in principal amount equal to the unredeemed portion thereof will be issued in the name of the Holder
thereof upon cancellation of the original Certificated Security;
(g) that
Securities of the Series (or portion thereof) called for redemption must be surrendered to the Paying Agent to collect the redemption
price;
(h) that
interest on Securities of the Series called for redemption ceases to accrue on and after the redemption date unless the Company
defaults in the deposit of the redemption price;
(i) the
CUSIP number, if any, and state that no representation is made as to the correctness or accuracy of the CUSIP number, if any, listed
in the SEC’s notice or printed on the Securities; and
(j) any
other information as may be required by the terms of the particular Series or the Securities of a Series being redeemed.
At the Company’s
request, the Trustee shall give the notice of redemption in the Company’s name and at its expense, provided, however, that
the Company has delivered to the Trustee, at least 15 days (unless a shorter time shall be acceptable to the Trustee) prior to
the notice date, an Officer’s Certificate requesting that the Trustee give such notice and setting forth the information
to be stated in such notice.
Section 3.4 Effect
of Notice of Redemption.
Once notice of redemption
is mailed as provided in Section 3.3, Securities of a Series called for redemption become due and payable on the redemption date
and at the redemption price. Except as otherwise provided in the supplemental indenture, Board Resolution or Officer’s Certificate
for a Series, a notice of redemption may not be conditional. Upon surrender to the Paying Agent, such Securities shall be paid
at the redemption price plus accrued interest to the redemption date other than Securities or portions of Securities called for
redemption which have been delivered by the Company to the Registrar for cancellation. The Paying Agent shall return to the Company
any money not required for that purpose.
Unless the Company shall
default in the payment of Securities (and accrued interest) called for redemption, interest on such Securities shall cease to accrue
after the redemption date. Convertible Securities called for redemption shall cease to be convertible after the close of business
on the Business Day immediately preceding the redemption date, unless the Company shall default in the payment of such Securities
on the redemption date, in which event the Securities shall remain convertible until paid (together with accrued interest).
Failure to give notice
of redemption, or any defect in such notice to the Holder of any Security of a Series designated for redemption, in whole or in
part, shall not affect the sufficiency of any notice of redemption with respect to the Holder of any other Security of such Series.
Section 3.5 Deposit
of Redemption Price.
On or before 10:00 a.m.,
New York City time, on the redemption date, the Company shall deposit with the Paying Agent money sufficient to pay the redemption
price of and accrued interest, if any, on all Securities to be redeemed on that date.
Section 3.6 Securities
Redeemed in Part.
Upon surrender of a Certificated
Security that is redeemed in part, the Trustee shall authenticate for the Holder a new Certificated Security of the same Series
and the same maturity equal in principal amount to the unredeemed portion of the Security surrendered and concurrently cancel the
surrendered Certificated Security.
ARTICLE IV
COVENANTS
Section 4.1 Payment
of Principal and Interest.
The Company covenants and
agrees for the benefit of the Holders of each Series of Securities that it will duly and punctually pay the principal of and interest,
if any, on the Securities of that Series in accordance with the terms of such Securities and this Indenture. On or before 10:00
a.m., New York City time, on the applicable payment date, the Company shall deposit with the Paying Agent money sufficient to pay
the principal of and interest, if any, on the Securities of each Series in accordance with the terms of such Securities and this
Indenture. Principal and interest shall be considered paid on the date due if the Paying Agent holds in accordance with this Indenture
on that date money sufficient to pay all principal and interest then due and the Paying Agent is not prohibited from paying such
money to the Holders on such date pursuant to the terms of this Indenture.
Section 4.2 Reports
by Company.
(a) As
long as any Securities are outstanding, the Company shall file with the Trustee, and transmit to the Holders, such information,
documents and other reports, and such summaries thereof, as may be required pursuant to TIA § 314(a). All reports, information
and documents referred to in this Section 4.2 will be deemed to be filed with the Trustee and transmitted to the Holders at the
time such reports, information or documents are publicly filed with the SEC via the SEC’s EDGAR filing system (or any successor
system), it being understood that the Trustee shall have no responsibility whatsoever to determine if such filings have been made.
(b) Delivery
of reports, information and documents to the Trustee under this Section 4.2 are for informational purposes only and shall not constitute
a representation or warranty as to the accuracy or completeness of the reports, information and documents. The Trustee’s
receipt of the foregoing shall not constitute constructive notice of any information contained therein or determinable from information
contained therein, including the Company’s compliance with any of its covenants hereunder (as to which the Trustee is entitled
to rely exclusively on Officer’s Certificates).
Section 4.3 Compliance
Certificate.
To the extent any Securities
of a Series are outstanding, the Company shall deliver to the Trustee, within 120 days after the end of each fiscal year of the
Company, an Officer’s Certificate (which need not contain the statements provided for in Section 10.4) from its principal
executive officer, principal financial officer or principal accounting officer stating that a review of the activities of the Company
and its Subsidiaries during the preceding fiscal year has been made under the supervision of the signing Officer with a view to
determining whether the Company has kept, observed, performed and fulfilled its obligations under this Indenture, and further stating,
as to such Officer signing such certificate, that to his or her knowledge the Company is not in default in the performance or observance
of any of the terms, provisions and conditions hereof (or, if a Default or Event of Default shall have occurred, describing all
such Defaults or Events of Default of which the Officer has knowledge). Such Officer’s Certificate need not include a reference
to any non-compliance that has been fully cured prior to the date as of which such certificate speaks.
Section 4.4 Stay,
Extension and Usury Laws.
The Company covenants (to
the extent that it may lawfully do so) that it will not at any time insist upon, plead, or in any manner whatsoever claim or take
the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, which may
affect the covenants or the performance of this Indenture or the Securities; and the Company (to the extent it may lawfully do
so) hereby expressly waives all benefit or advantage of any such law and covenants that it will not, by resort to any such law,
hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer and permit the execution of every
such power as though no such law has been enacted.
Section 4.5 Corporate
Existence.
Subject to Article V, the
Company will do or cause to be done all things necessary to preserve and keep in full force and effect its corporate existence
and rights (charter and statutory); provided, however, that the Company shall not be required to preserve any such
right if the Board of Directors shall determine that the preservation thereof is no longer desirable in the conduct of the business
of the Company and its Subsidiaries taken as a whole and that the loss thereof is not adverse in any material respect to the Holders.
ARTICLE V
SUCCESSORS
Section 5.1 Consolidation,
Merger and Sale of Assets.
The Company may not consolidate
with or merge with or into, sell, convey, transfer or dispose of all or substantially all of its assets to any other person (a
“successor person”), whether in one transaction or a series of related transactions, unless:
(a) (i)
the Company is the surviving corporation or (ii) the successor person (if other than the Company) (A) is a corporation, limited
liability corporation, partnership or trust organized under the laws of the United States; and (B) expressly assumes, by an indenture
supplemental hereto, the Company’s obligations on the Securities and under this Indenture; and
(b) immediately
after giving effect to the transaction, no Default or Event of Default shall have happened and be continuing.
The Company shall deliver
to the Trustee prior to the consummation of the proposed transaction an Officer’s Certificate to the foregoing effect and
an Opinion of Counsel stating that the proposed transaction and any supplemental indenture comply with Section 5.1 of this Indenture.
Notwithstanding the above,
any Subsidiary of the Company may consolidate with, merge into or transfer all or part of its properties to the Company. Neither
an Officer’s Certificate nor an Opinion of Counsel shall be required to be delivered in connection therewith.
Section 5.2 Successor
Person Substituted.
Upon any consolidation
or merger, or any sale, conveyance, transfer, or lease of all or substantially all of the assets of the Company and its Subsidiaries
in accordance with Section 5.1, the successor person formed by such consolidation or into or with which the Company is merged or
to which such sale, conveyance, transfer, or lease is made shall succeed to, and be substituted for, and may exercise every right
and power of, the Company under this Indenture and the Securities with the same effect as if such successor person has been named
as the Company herein; and, thereafter, the predecessor Company, in the case of a sale, conveyance or transfer (other than a lease),
shall be released from all obligations and covenants under this Indenture and the Securities.
ARTICLE VI
DEFAULTS AND REMEDIES
Section 6.1 Events
of Default.
“Event of Default,”
wherever used herein with respect to Securities of any Series, means any one of the following events, unless in the establishing
Board Resolution, supplemental indenture or Officer’s Certificate, it is provided that such Series shall not have the benefit
of said Event of Default:
(a) failure
to pay any interest on any Security of that Series when it becomes due and payable, and continuance of such default for a period
of 30 days (unless the entire amount of such payment is deposited by the Company with the Trustee or with a Paying Agent prior
to 10:00 a.m., New York City time, on the 30th day of such period);
(b) failure
to pay principal of any Security of that Series at its Maturity;
(c) default
in the performance or breach of any covenant of the Company in this Indenture (other than defaults pursuant to sub-clauses (a)
through (c) above or defaults related to a covenant that has been included in this Indenture solely for the benefit of a Series
of Securities other than that Series), which default continues uncured for a period of 90 days after there has been given, by registered
or certified mail, to the Company by the Trustee or to the Company and the Trustee by the Holders of at least 25% in principal
amount of the outstanding Securities of that Series a written notice specifying such default or breach and requiring it to be remedied
and stating that such notice is a “Notice of Default” hereunder;
(d) the
Company pursuant to or within the meaning of any Bankruptcy Law:
(i) commences
a voluntary case,
(ii) consents
to the entry of an order for relief against it in an involuntary case,
(iii) consents
to the appointment of a Custodian of it or for all or substantially all of its property, or
(iv) makes
a general assignment for the benefit of its creditors;
(e) a
court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:
(i) is
for relief against the Company in an involuntary case,
(ii) appoints
a Custodian of the Company or for all or substantially all of its property, or
(iii) orders
the liquidation of the Company, and the order or decree remains unstayed and in effect for 60 days; or
(f) any
other Event of Default provided with respect to Securities of that Series, which is specified in a Board Resolution, a supplemental
indenture hereto or an Officer’s Certificate, in accordance with Section 2.2.18.
The term “Bankruptcy
Law” means title 11, U.S. Code or any similar federal or state law for the relief of debtors. The term “Custodian”
means any receiver, trustee, assignee, liquidator or similar official under any Bankruptcy Law.
A Default under one Series
of Securities issued under this Indenture will not necessarily be a default under another Series of Securities under this Indenture.
The Company will, so long
as any of the Securities are outstanding, deliver to the Trustee, within 30 days of becoming aware of any Default or Event of Default,
an Officer’s Certificate specifying such Default or Event of Default and what action the Company is taking or proposes to
take with respect thereto.
Section 6.2 Acceleration
of Maturity; Rescission and Annulment.
If an Event of Default
with respect to Securities of any Series at the time outstanding occurs and is continuing (other than an Event of Default referred
to in Section 6.1(d) or (e)) then in every such case the Trustee or the Holders of not less than 25% in principal amount of the
outstanding Securities of that Series may declare the principal amount (or, if any Securities of that Series are Discount Securities,
such portion of the principal amount as may be specified in the terms of such Securities) of and accrued and unpaid interest, if
any, on all of the Securities of that Series to be due and payable immediately, by a notice in writing to the Company (and to the
Trustee if given by Holders), and upon any such declaration such principal amount (or specified amount) and accrued and unpaid
interest, if any, shall become immediately due and payable. If an Event of Default specified in Section 6.1(d) or (e) shall occur,
the principal amount (or specified amount) of and accrued and unpaid interest, if any, on all outstanding Securities shall ipso
facto become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Holder.
At any time after such
a declaration of acceleration with respect to any Series has been made and before a judgment or decree for payment of the money
due has been obtained by the Trustee as hereinafter in this Article provided, the Holders of a majority in principal amount of
the outstanding Securities of that Series, by written notice to the Company and the Trustee, may rescind and annul such declaration
and its consequences if all Events of Default with respect to Securities of that Series, other than the non-payment of the principal
and interest, if any, of Securities of that Series which have become due solely by such declaration of acceleration, have been
cured or waived as provided in Section 6.13.
No such rescission shall
affect any subsequent Default.
Section 6.3 Collection
of Indebtedness and Suits for Enforcement by Trustee.
The Company covenants that
if
(a) default
is made in the payment of any interest on any Security when such interest becomes due and payable and such default continues for
a period of 30 days, or
(b) default
is made in the payment of principal of any Security at the Maturity thereof, or
(c) default
is made in the deposit of any sinking fund payment, if any, when and as due by the terms of a Security,
then, the Company
will, upon demand of the Trustee, pay to it, for the benefit of the Holders of such Securities, the whole amount then due and payable
on such Securities for principal and interest and, to the extent that payment of such interest shall be legally enforceable, interest
on any overdue principal and any overdue interest at the rate or rates prescribed therefor in such Securities, and, in addition
thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation,
expenses, disbursements and advances of the Trustee, its agents and counsel.
If the Company fails to
pay such amounts forthwith upon such demand, the Trustee, in its own name and as trustee of an express trust, may institute a judicial
proceeding for the collection of the sums so due and unpaid, may prosecute such proceeding to judgment or final decree and may
enforce the same against the Company or any other obligor upon such Securities and collect the moneys adjudged or deemed to be
payable in the manner provided by law out of the property of the Company or any other obligor upon such Securities, wherever situated.
If an Event of Default
with respect to any Securities of any Series occurs and is continuing, the Trustee may in its discretion proceed to protect and
enforce its rights and the rights of the Holders of Securities of such Series by such appropriate judicial proceedings as the Trustee
shall deem most effectual to protect and enforce any such rights, whether for the specific enforcement of any covenant or agreement
in this Indenture or in aid of the exercise of any power granted herein, or to enforce any other proper remedy.
Section 6.4 Trustee
May File Proofs of Claim.
In case of the pendency
of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial
proceeding relating to the Company or any other obligor upon the Securities or the property of the Company or of such other obligor
or their creditors, the Trustee (irrespective of whether the principal of the Securities shall then be due and payable as therein
expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand on the Company for
the payment of overdue principal or interest) shall be entitled and empowered, by intervention in such proceeding or otherwise,
(a) to
file and prove a claim for the whole amount of principal and interest owing and unpaid in respect of the Securities and to file
such other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim
for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel) and of the Holders
allowed in such judicial proceeding, and
(b) to
collect and receive any moneys or other property payable or deliverable on any such claims and to distribute the same,
and any custodian, receiver,
assignee, trustee, liquidator, sequestrator or other similar official in any such judicial proceeding is hereby authorized by each
Holder to make such payments to the Trustee and, in the event that the Trustee shall consent to the making of such payments directly
to the Holders, to pay to the Trustee any amount due it for the reasonable compensation, expenses, disbursements and advances of
the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 7.7.
Nothing herein contained
shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan of reorganization,
arrangement, adjustment or composition affecting the Securities or the rights of any Holder thereof or to authorize the Trustee
to vote in respect of the claim of any Holder in any such proceeding.
Section 6.5 Trustee
May Enforce Claims Without Possession of Securities.
All rights of action and
claims under this Indenture or the Securities may be prosecuted and enforced by the Trustee without the possession of any of the
Securities or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the Trustee shall
be brought in its own name as trustee of an express trust, and any recovery of judgment shall, after provision for the payment
of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, be for the ratable
benefit of the Holders of the Securities in respect of which such judgment has been recovered.
Section 6.6 Application
of Money Collected.
Any money or property collected
by the Trustee pursuant to this Article shall be applied in the following order, at the date or dates fixed by the Trustee and,
in case of the distribution of such money or property on account of principal or interest, upon presentation of the Securities
and the notation thereon of the payment if only partially paid and upon surrender thereof if fully paid:
First: To the payment
of all amounts due to the Trustee under this Indenture; and
Second: To the payment
of all indebtedness of the Company to which such Series of Securities is subordinated to the extent required by Article 12 of this
Indenture; and
Third: To the payment
of the amounts then due and unpaid for principal of and interest on the Securities in respect of which or for the benefit of which
such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on
such Securities for principal and interest, respectively; and
Fourth: To the Company.
Section 6.7 Limitation
on Suits.
No Holder of any Security
of any Series shall have any right to institute any proceeding, judicial or otherwise, with respect to this Indenture, or for the
appointment of a receiver or trustee, or for any other remedy hereunder, unless:
(a) such
Holder has previously given written notice to the Trustee of a continuing Event of Default with respect to the Securities of that
Series;
(b) the
Holders of not less than 25% in principal amount of the outstanding Securities of that Series have made written request to the
Trustee to institute proceedings in respect of such Event of Default in its own name as Trustee hereunder;
(c) such
Holder or Holders have offered to the Trustee indemnity or security satisfactory to the Trustee against the costs, expenses and
liabilities which might be incurred by the Trustee in compliance with such request;
(d) the
Trustee has failed to institute any such proceeding for 60 days after its receipt of such notice, request and offer of indemnity;
and
(e) no
direction inconsistent with such written request has been given to the Trustee during such 60-day period by the Holders of a majority
in principal amount of the outstanding Securities of that Series;
it being understood, intended
and expressly covenanted by the Holder of every Security with every other Holder and the Trustee that no one or more of such Holders
shall have any right in any manner whatever by virtue of, or by availing of, any provision of this Indenture to affect, disturb
or prejudice the rights of any other of such Holders, or to obtain or to seek to obtain priority or preference over any other of
such Holders or to enforce any right under this Indenture, except in the manner herein provided and for the equal and ratable benefit
of all such Holders of the applicable Series; provided, however, that the Trustee does not have an affirmative duty to ascertain
whether or not such actions or forbearances are unduly prejudicial to such Holders.
Section 6.8 Unconditional
Right of Holders to Receive Principal and Interest.
Notwithstanding any other
provision in this Indenture, the Holder of any Security has the right, which is absolute and unconditional, to receive payment
of the principal of and interest, if any, on such Security on the Maturity of such Security, including the Stated Maturity expressed
in such Security (or, in the case of redemption, on the redemption date) and to institute suit for the enforcement of any such
payment, and such rights shall not be impaired without the consent of such Holder.
Section 6.9 Restoration
of Rights and Remedies.
If the Trustee or any Holder
has instituted any proceeding to enforce any right or remedy under this Indenture and such proceeding has been discontinued or
abandoned for any reason, or has been determined adversely to the Trustee or to such Holder, then and in every such case, subject
to any determination in such proceeding, the Company, the Trustee and the Holders shall be restored severally and respectively
to their former positions hereunder and thereafter all rights and remedies of the Trustee and the Holders shall continue as though
no such proceeding had been instituted.
Section 6.10 Rights
and Remedies Cumulative.
Except as otherwise provided
with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities in Section 2.9, no right or remedy
herein conferred upon or reserved to the Trustee or to the Holders is intended to be exclusive of any other right or remedy, and
every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right and remedy given
hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder,
or otherwise, shall not, to the extent permitted by law, prevent the concurrent assertion or employment of any other appropriate
right or remedy.
Section 6.11 Delay
or Omission Not Waiver.
No delay or omission of
the Trustee or of any Holder of any Securities to exercise any right or remedy accruing upon any Event of Default shall impair
any such right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy
given by this Article or by law to the Trustee or to the Holders may be exercised from time to time, and as often as may be deemed
expedient, by the Trustee or by the Holders, as the case may be.
Section 6.12 Control
by Holders.
The Holders of a majority
in principal amount of the outstanding Securities of any Series shall have the right to direct the time, method and place of conducting
any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee, with respect
to the Securities of such Series, provided that:
(a) such
direction shall not be in conflict with any rule of law or with this Indenture;
(b) the
Trustee may take any other action deemed proper by the Trustee which is not inconsistent with such direction;
(c) subject
to the provisions of Section 7.1, the Trustee shall have the right to decline to follow any such direction if the Trustee in good
faith shall, by a Responsible Officer of the Trustee, determine that the proceeding so directed would involve the Trustee in personal
liability; and
(d) prior
to taking any action as directed under this Section 6.12, the Trustee shall be entitled to indemnity satisfactory to it against
the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction.
Section 6.13 Waiver
of Past Defaults.
The Holders of not less
than a majority in principal amount of the outstanding Securities of any Series may on behalf of the Holders of all the Securities
of such Series waive any past Default hereunder with respect to such Series and its consequences, except a Default in the payment
of the principal of or interest on any Security of such Series (provided, however, that the Holders of a majority in principal
amount of the outstanding Securities of any Series may rescind an acceleration and its consequences, including any related payment
default that resulted from such acceleration). Upon any such waiver, such Default shall cease to exist, and any Event of Default
arising therefrom shall be deemed to have been cured, for every purpose of this Indenture; but no such waiver shall extend to any
subsequent or other Default.
Section 6.14 Undertaking
for Costs.
All parties to this Indenture
agree, and each Holder of any Security by his acceptance thereof shall be deemed to have agreed, that any court may in its discretion
require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any
action taken, suffered or omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the
costs of such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees
and expenses, against any party litigant in such suit, having due regard to the merits and good faith of the claims or defenses
made by such party litigant; but the provisions of this Section 6.14 shall not apply to any suit instituted by the Company, to
any suit instituted by the Trustee, to any suit instituted by any Holder, or group of Holders, holding in the aggregate more than
10% in principal amount of the outstanding Securities of any Series, or to any suit instituted by any Holder for the enforcement
of the payment of the principal of or interest on any Security on or after the Maturity of such Security, including the Stated
Maturity expressed in such Security (or, in the case of redemption, on the redemption date).
ARTICLE VII
TRUSTEE
Section 7.1 Duties
of Trustee.
(a) If
an Event of Default has occurred and is continuing, the Trustee shall exercise the rights and powers vested in it by this Indenture
and use the same degree of care and skill in their exercise as a prudent person would exercise or use under the circumstances in
the conduct of such person’s own affairs.
(b) Except
during the continuance of an Event of Default:
(i) The
Trustee need perform only those duties that are specifically set forth in this Indenture and no others.
(ii) In
the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness
of the opinions expressed therein, upon Officer’s Certificates or Opinions of Counsel furnished to the Trustee and conforming
to the requirements of this Indenture; however, in the case of any such Officer’s Certificates or Opinions of Counsel which
by any provisions hereof are specifically required to be furnished to the Trustee, the Trustee shall examine such Officer’s
Certificates and Opinions of Counsel to determine whether or not they conform to the requirements of this Indenture (but need not
confirm or investigate the accuracy of mathematical calculations or other facts stated therein).
(c) The
Trustee may not be relieved from liability for its own negligent action, its own negligent failure to act or its own willful misconduct,
except that:
(i) This
sub-clause (c) does not limit the effect of sub-clause (b) of this Section 7.1.
(ii) The
Trustee shall not be liable for any error of judgment made in good faith by a Responsible Officer, unless it is proved that the
Trustee was negligent in ascertaining the pertinent facts.
(iii) The
Trustee shall not be liable with respect to any action taken, suffered or omitted to be taken by it with respect to Securities
of any Series in good faith in accordance with the direction of the Holders of a majority in principal amount of the outstanding
Securities of such Series relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee,
or exercising any trust or power conferred upon the Trustee, under this Indenture with respect to the Securities of such Series
in accordance with Section 6.12.
(d) Every
provision of this Indenture that in any way relates to the Trustee is subject to sub-clauses (a), (b) and (c) of this Section 7.1.
(e) The
Trustee may refuse to perform any duty or exercise any right or power unless it receives indemnity satisfactory to it against the
costs, expenses and liabilities which might be incurred by it in performing such duty or exercising such right or power.
(f) The
Trustee shall not be liable for interest on any money received by it. Money held in trust by the Trustee need not be segregated
from other funds except to the extent required by law.
(g) No
provision of this Indenture shall require the Trustee to risk its own funds or otherwise incur any financial liability in the performance
of any of its duties, or in the exercise of any of its rights or powers, if adequate indemnity against such risk is not assured
to the Trustee in its satisfaction.
(h) The
Paying Agent, the Registrar and any authenticating agent shall be entitled to the protections and immunities as are set forth in
sub-clauses (e), (f) and (g) of this Section 7.1 and in Section 7.2, each with respect to the Trustee.
Section 7.2 Rights
of Trustee.
(a) The
Trustee may conclusively rely on and shall be protected in acting or refraining from acting upon any document (whether in its original
or facsimile form) believed by it to be genuine and to have been signed or presented by the proper person. The Trustee need not
investigate any fact or matter stated in the document.
(b) Before
the Trustee acts or refrains from acting, it shall be entitled to receive an Officer’s Certificate or an Opinion of Counsel
or both. The Trustee shall not be liable for any action it takes or omits to take in good faith in conclusive reliance on such
Officer’s Certificate or Opinion of Counsel.
(c) The
Trustee may act through agents and shall not be responsible for the misconduct or negligence of any agent appointed with due care.
No Depositary shall be deemed an agent of the Trustee and the Trustee shall not be responsible for any act or omission by any Depositary.
(d) The
Trustee shall not be liable for any action it takes or omits to take in good faith which it believes to be authorized or within
its rights or powers, provided that the Trustee’s conduct does not constitute willful misconduct or negligence.
(e) The
Trustee may consult with counsel of its selection and the advice of such counsel or any Opinion of Counsel shall be full and complete
authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in reliance
thereon.
(f) The
Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request or direction
of any of the Holders of Securities unless such Holders shall have offered to the Trustee security or indemnity reasonably satisfactory
to it against the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction.
(g) The
Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement,
instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness
or other paper or document, but the Trustee, in its discretion, may make such further inquiry or investigation into such facts
or matters as it may see fit and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation.
(h) The
Trustee shall not be deemed to have notice of any Default or Event of Default unless a Responsible Officer of the Trustee has actual
knowledge thereof or unless written notice of any event which is in fact such a default is received by a Responsible Officer of
the Trustee at the Corporate Trust Office of the Trustee, and such notice references the Securities generally or the Securities
of a particular Series and this Indenture.
(i) In
no event shall the Trustee be liable to any person for special, punitive, indirect, consequential or incidental loss or damage
of any kind whatsoever (including but not limited to lost profits), even if the Trustee has been advised of the likelihood of such
loss or damage.
(j) The
permissive right of the Trustee to take the actions permitted by this Indenture shall not be construed as an obligation or duty
to do so.
(k) The
rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be indemnified,
are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other
Person employed to act hereunder.
(l) The
Trustee shall not be required to give any bond or surety in respect of the performance of its powers and duties hereunder.
(m) The
Trustee may request that the Company deliver a certificate setting forth the names of individuals and/or titles of officers authorized
at such time to take specified actions pursuant to this Indenture.
Section 7.3 Individual
Rights of Trustee.
The Trustee in its individual
or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or an Affiliate of
the Company with the same rights it would have if it were not Trustee. Any Agent may do the same with like rights. However, the
Trustee is also subject to Sections 7.10 and 7.11 hereof.
Section 7.4 Trustee’s
Disclaimer.
The Trustee makes no representation
as to the validity or adequacy of this Indenture or the Securities, it shall not be accountable for the Company’s use of
the proceeds from the Securities, and it shall not be responsible for any statement in the Securities other than its authentication.
Section 7.5 Notice
of Defaults.
If a Default or Event of
Default occurs and is continuing with respect to the Securities of any Series and if it is actually known to a Responsible Officer
of the Trustee, the Trustee shall mail to each Securityholder of the Securities of that Series notice of a Default or Event of
Default within 90 days after it occurs or, if later, after a Responsible Officer of the Trustee has knowledge of such Default or
Event of Default. Except in the case of a Default or Event of Default in payment of principal of or interest on any Security of
any Series, the Trustee may withhold the notice if and so long as it in good faith determines that withholding the notice is in
the interests of Securityholders of that Series.
Section 7.6 Reports
by Trustee to Holders.
Within 60 days after each
anniversary of the date of this Indenture, the Trustee shall transmit by mail to all Securityholders, as their names and addresses
appear on the register kept by the Registrar, a brief report dated as of such reporting date, in accordance with, and to the extent
required under, TIA § 313.
A copy of each report at
the time of its mailing to Securityholders of any Series shall be filed with the SEC and each national securities exchange on which
the Securities of that Series are listed. The Company shall promptly notify the Trustee in writing when Securities of any Series
are listed on any national securities exchange or of any delisting thereof.
Section 7.7 Compensation
and Indemnity.
The Company shall pay to
the Trustee from time to time compensation for its services as the Company and the Trustee shall from time to time agree upon in
writing. The Trustee’s compensation shall not be limited by any law on compensation of a trustee of an express trust. The
Company shall reimburse the Trustee upon request for all reasonable out of pocket expenses incurred by it. Such expenses shall
include the reasonable compensation and expenses of the Trustee’s agents and counsel.
The Company shall indemnify
each of the Trustee and any predecessor Trustee against any cost, expense, claim (whether asserted by the Company, a Holder or
any other person) or liability (including the cost of defending itself), including taxes (other than taxes based upon, measured
by or determined by the income of the Trustee), incurred by it except as set forth in the next paragraph in the performance of
its duties under this Indenture as Trustee or Agent. The Trustee shall notify the Company promptly of any claim for which it may
seek indemnity. Failure by the Trustee to so notify the Company shall not relieve the Company of its obligations hereunder, unless
and to the extent that the Company is materially prejudiced thereby. The Company shall defend the claim and the Trustee shall cooperate
in the defense. The Trustee may have one separate counsel and the Company shall pay the reasonable fees and expenses of such counsel.
The Company need not pay for any settlement made without its consent, which consent will not be unreasonably withheld. This indemnification
shall apply to officers, directors, employees, shareholders and agents of the Trustee.
The Company need not reimburse
any expense or indemnify against any loss or liability incurred by the Trustee or by any officer, director, employee or shareholder
of the Trustee through willful misconduct or negligence.
To secure the Company’s
payment obligations in this Section 7.7, the Trustee shall have a lien prior to the Securities of any Series on all money or property
held or collected by the Trustee, except that held in trust to pay principal of and interest on particular Securities of that Series.
When the Trustee incurs
expenses or renders services after an Event of Default specified in Section 6.1(f) or (g) occurs, the expenses and the compensation
for the services are intended to constitute expenses of administration under any Bankruptcy Law.
The provisions of this
Section 7.7 shall survive the termination of this Indenture or the resignation or removal of the Trustee.
Section 7.8 Replacement
of Trustee.
A resignation or removal
of the Trustee and appointment of a successor Trustee shall become effective only upon the successor Trustee’s acceptance
of appointment as provided in this Section 7.8.
The Trustee may resign
at any time with respect to the Securities of one or more Series by so notifying the Company at least 30 days prior to the date
of the proposed resignation. The Holders of a majority in principal amount of the Securities of any Series may remove the Trustee
with respect to that Series by so notifying the Trustee and the Company in writing. The Company may remove the Trustee with respect
to Securities of one or more Series if:
(a) the
Trustee fails to comply with Section 7.10;
(b) the
Trustee is adjudged a bankrupt or an insolvent or an order for relief is entered with respect to the Trustee under any Bankruptcy
Law;
(c) a
Custodian or public officer takes charge of the Trustee or its property; or
(d) the
Trustee becomes incapable of acting.
If the Trustee resigns
or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint a successor Trustee.
Within one year after the successor Trustee takes office, the Holders of a majority in principal amount of the then outstanding
Securities may appoint a successor Trustee to replace the successor Trustee appointed by the Company.
If a successor Trustee
with respect to the Securities of any one or more Series does not take office within 30 days after the retiring Trustee resigns
or is removed, the retiring Trustee, the Company or the Holders of at least a majority in principal amount of the Securities of
the applicable Series may petition any court of competent jurisdiction for the appointment of a successor Trustee at the expense
of the Company.
A successor Trustee shall
deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Immediately after that, the retiring
Trustee shall transfer all property held by it as Trustee to the successor Trustee subject to the lien provided for in Section
7.7, the resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all the rights,
powers and duties of the Trustee with respect to each Series of Securities for which it is acting as Trustee under this Indenture.
A successor Trustee shall mail a notice of its succession to each Securityholder of each such Series. Notwithstanding replacement
of the Trustee pursuant to this Section 7.8, the Company’s obligations under Section 7.7 hereof shall continue for the benefit
of the retiring Trustee with respect to expenses and liabilities incurred by it for actions taken or omitted to be taken in accordance
with its rights, powers and duties under this Indenture prior to such replacement.
Section 7.9 Successor
Trustee by Merger, Etc.
If the Trustee consolidates
with, merges or converts into, or transfers all or substantially all of its corporate trust business to, another corporation, the
successor corporation without any further act shall be the successor Trustee, if such successor corporation is eligible and qualified
under Section 7.10.
Section 7.10 Eligibility;
Disqualification.
This Indenture shall always
have a Trustee who satisfies the requirements of TIA § 310(a)(1), (2) and (5). The Trustee shall always have a combined capital
and surplus of at least $25,000,000 as set forth in its most recent published annual report of condition. The Trustee shall comply
with TIA § 310(b).
Section 7.11 Preferential
Collection of Claims Against Company.
The Trustee is subject
to TIA § 311(a), excluding any creditor relationship listed in TIA § 311(b). A Trustee who has resigned or been removed
shall be subject to TIA § 311(a) to the extent indicated.
ARTICLE VIII
SATISFACTION AND DISCHARGE; DEFEASANCE
Section 8.1 Satisfaction
and Discharge of Indenture.
This Indenture shall upon
Company Order cease to be of further effect (except as hereinafter provided in this Section 8.1), and the Trustee, at the expense
of the Company, shall execute instruments acknowledging satisfaction and discharge of this Indenture, when
(a) either
(i) all
Securities theretofore authenticated and delivered (other than Securities that have been destroyed, lost or stolen and that have
been replaced or paid as provided in Section 2.9) have been delivered to the Trustee for cancellation; or
(ii) all
such Securities not theretofore delivered to the Trustee for cancellation:
(1) have
become due and payable, or
(2) will
become due and payable at their Stated Maturity within one year, or
(3) have
been called for redemption or are to be called for redemption within one year under arrangements satisfactory to the Trustee for
the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company;
and the Company, in the
case of (1), (2) or (3) above, has irrevocably deposited or caused to be deposited with the Trustee as trust funds in trust an
amount of money or U.S. Government Obligations sufficient for the purpose of paying and discharging the entire indebtedness on
such Securities not theretofore delivered to the Trustee for cancellation, for principal and interest to the date of such deposit
(in the case of Securities which have become due and payable on or prior to the date of such deposit) or to the Stated Maturity
or redemption date, as the case may be;
(b) the
Company has paid or caused to be paid all other sums payable hereunder by the Company; and
(c) the
Company has delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that all conditions
precedent herein provided for relating to the satisfaction and discharge of this Indenture have been complied with.
Notwithstanding the satisfaction
and discharge of this Indenture, the obligations of the Company to the Trustee under Section 7.7, and, if money shall have been
deposited with the Trustee pursuant to sub-clause (a) of this Section 8.1, the provisions of Sections 2.5, 2.8, 2.9, 8.2 and 8.5
shall survive.
Section 8.2 Application
of Trust Funds; Indemnification.
(a) Subject
to the provisions of Section 8.5, all money or U.S. Government Obligations deposited with the Trustee pursuant to Section 8.1,
all money and U.S. Government Obligations or Foreign Government Obligations deposited with the Trustee pursuant to Section 8.3
or 8.4 and all money received by the Trustee in respect of U.S. Government Obligations or Foreign Government Obligations deposited
with the Trustee pursuant to Section 8.3 or 8.4, shall be held in trust and applied by it, in accordance with the provisions of
the Securities and this Indenture, to the payment, either directly or through any Paying Agent (including the Company acting as
its own Paying Agent) as the Trustee may determine, to the persons entitled thereto, of the principal and interest for whose payment
such money has been deposited with or received by the Trustee or to make mandatory sinking fund payments or analogous payments
as contemplated by Sections 8.3 or 8.4.
(b) The
Company shall pay and shall indemnify the Trustee against any tax, fee or other charge imposed on or assessed against U.S. Government
Obligations or Foreign Government Obligations deposited pursuant to Sections 8.3 or 8.4 or the interest and principal received
in respect of such obligations other than any payable by or on behalf of Holders.
(c) The
Trustee shall deliver or pay to the Company from time to time upon Company Order any U.S. Government Obligations or Foreign Government
Obligations or money held by it as provided in Sections 8.3 or 8.4 which, in the opinion of a nationally recognized firm of independent
certified public accountants or investment bank expressed in a written certification thereof delivered to the Trustee, are then
in excess of the amount thereof which then would have been required to be deposited for the purpose for which such U.S. Government
Obligations or Foreign Government Obligations or money were deposited or received. This provision shall not authorize the sale
by the Trustee of any U.S. Government Obligations or Foreign Government Obligations held under this Indenture.
Section 8.3 Legal
Defeasance of Securities of any Series.
Unless this Section 8.3
is otherwise specified, pursuant to Section 2.2, to be inapplicable to Securities of any Series, the Company shall be deemed to
have paid and discharged the entire indebtedness on all the outstanding Securities of any Series on the 91st day after the date
of the deposit referred to in sub-clause (d) hereof, and the provisions of this Indenture, as it relates to such outstanding Securities
of such Series, shall no longer be in effect (and the Trustee, at the expense of the Company, shall, upon receipt of a Company
Order, execute instruments acknowledging the same), except as to:
(a) the
rights of Holders of Securities of such Series to receive, from the trust funds described in sub-clause (d) hereof, (i) payment
of the principal of and each installment of principal of and interest on the outstanding Securities of such Series on the Maturity
of such principal or installment of principal or interest and (ii) the benefit of any mandatory sinking fund payments applicable
to the Securities of such Series on the day on which such payments are due and payable in accordance with the terms of this Indenture
and the Securities of such Series;
(b) the
provisions of Sections 2.5, 2.8, 2.9, 8.2, 8.3 and 8.5; and
(c) the
rights, powers, trust and immunities of the Trustee hereunder and the Company’s obligations in connection therewith;
provided that, the following
conditions shall have been satisfied:
(d) the
Company shall have deposited or caused to be irrevocably deposited (except as provided in Section 8.2(c)) with the Trustee as trust
funds in trust for the purpose of making the following payments, specifically pledged as security for and dedicated solely to the
benefit of the Holders of such Securities: (i) in the case of Securities of such Series denominated in Dollars, cash in Dollars
and/or U.S. Government Obligations, or (ii) in the case of Securities of such Series denominated in a Foreign Currency (other than
a composite currency), money and/or Foreign Government Obligations, which through the payment of interest and principal in respect
thereof in accordance with their terms (and without reinvestment), will provide, not later than one day before the due date of
any payment of money, an amount in cash, sufficient, in the opinion of a nationally recognized firm of independent public accountants
or investment bank expressed in a written certification thereof delivered to the Trustee, to pay and discharge each installment
of principal of and interest, if any, on and any mandatory sinking fund payments in respect of all the Securities of such Series
on the dates such installments of interest or principal and such sinking fund payments are due;
(e) such
deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement or instrument
to which the Company is a party or by which it is bound;
(f) no
Default or Event of Default with respect to the Securities of such Series shall have occurred and be continuing on the date of
such deposit or during the period ending on the 91st day after such date;
(g) the
Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel to the effect that (i) the
Company has received from, or there has been published by, the Internal Revenue Service a ruling, or (ii) since the date of execution
of this Indenture, there has been a change in the applicable U.S. federal income tax law, in either case to the effect that, and
based thereon such Opinion of Counsel shall confirm that, the Holders of the Securities of such Series will not recognize income,
gain or loss for U.S. federal income tax purposes as a result of such deposit, defeasance and discharge and will be subject to
U.S. federal income tax on the same amount and in the same manner and at the same times as would have been the case if such deposit,
defeasance and discharge had not occurred;
(h) the
Company shall have delivered to the Trustee an Officer’s Certificate stating that the deposit was not made by the Company
with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; and
(i) the
Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that all conditions
precedent provided for relating to the defeasance contemplated by this Section 8.3 have been complied with.
Section 8.4 Covenant
Defeasance.
Unless this Section 8.4
is otherwise specified pursuant to Section 2.2 to be inapplicable to Securities of any Series, the Company may omit to comply with
respect to the Securities of any Series with any term, provision or condition set forth under Sections 4.2 and 4.3, 4.4 and 5.1as
well as any additional covenants specified in a supplemental indenture for such Series of Securities or a Board Resolution or an
Officer’s Certificate delivered pursuant to Section 2.2 (and the failure to comply with any such covenants shall not constitute
a Default or Event of Default with respect to such Series under Section 6.1) and the occurrence of any event specified in a supplemental
indenture for such Series of Securities or a Board Resolution or an Officer’s Certificate delivered pursuant to Section 2.2.18
and designated as an Event of Default shall not constitute a Default or Event of Default hereunder, with respect to the Securities
of such Series, provided that the following conditions shall have been satisfied:
(a) With
reference to this Section 8.4, the Company has deposited or caused to be irrevocably deposited (except as provided in Section 8.2(c))
with the Trustee as trust funds in trust for the purpose of making the following payments specifically pledged as security for,
and dedicated solely to, the benefit of the Holders of such Securities: (i) in the case of Securities of such Series denominated
in Dollars, cash in Dollars and/or U.S. Government Obligations, or (ii) in the case of Securities of such Series denominated in
a Foreign Currency (other than a composite currency), money and/or Foreign Government Obligations, which through the payment of
interest and principal in respect thereof in accordance with their terms (and without reinvestment), will provide, not later than
one day before the due date of any payment of money, an amount in cash, sufficient, in the opinion of a nationally recognized firm
of independent certified public accountants or investment bank expressed in a written certification thereof delivered to the Trustee,
to pay and discharge each installment of principal of and interest, if any, on and any mandatory sinking fund payments in respect
of the Securities of such Series on the dates such installments of interest or principal and such sinking fund payments are due;
(b) Such
deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement or instrument
to which the Company is a party or by which it is bound;
(c) No
Default or Event of Default with respect to the Securities of such Series shall have occurred and be continuing on the date of
such deposit;
(d) The
Company shall have delivered to the Trustee an Opinion of Counsel to the effect that Holders of the Securities of such Series will
not recognize income, gain or loss for U.S. federal income tax purposes as a result of such deposit and covenant defeasance and
will be subject to U.S. federal income tax on the same amounts, in the same manner and at the same times as would have been the
case if such deposit and covenant defeasance had not occurred;
(e) The
Company shall have delivered to the Trustee an Officer’s Certificate stating the deposit was not made by the Company with
the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; and
(f) The
Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that all conditions
precedent herein provided for relating to the covenant defeasance contemplated by this Section 8.4 have been complied with.
Section 8.5 Repayment
to Company.
Subject to applicable abandoned
property law, the Trustee and the Paying Agent shall pay to the Company upon request any money held by them for the payment of
principal or interest that remains unclaimed for two years after such principal or interest has become due and payable. After that,
Securityholders entitled to the money must look to the Company for payment as general creditors unless an applicable abandoned
property law designates another person.
Section 8.6 Reinstatement.
If the Trustee or the Paying
Agent is unable to apply any money deposited with respect to Securities of any Series in accordance with Section 8.1 by reason
of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or
otherwise prohibiting such application, the obligations of the Company under this Indenture with respect to the Securities of such
Series and under the Securities of such Series shall be revived and reinstated as though no deposit had occurred pursuant to Section
8.1 until such time as the Trustee or the Paying Agent is permitted to apply all such money in accordance with Section 8.1; provided,
however, that if the Company has made any payment of principal of or interest on any Securities because of the reinstatement of
its obligations, the Company shall be subrogated to the rights of the Holders of such Securities to receive such payment from the
money or U.S. Government Obligations held by the Trustee or Paying Agent after payment in full to the Holders.
ARTICLE IX
AMENDMENTS AND WAIVERS
Section 9.1 Without
Consent of Holders.
The Company and the Trustee
may amend or supplement this Indenture or the Securities of one or more Series without the consent of any Securityholder:
(a) to
add guarantees with respect to any Series of Securities or secure any Series of Securities;
(b) to
surrender any of the Company’s rights or powers under this Indenture;
(c) to
add covenants or Events of Default for the benefit of the Securityholders of any Series of Securities;
(d) to
comply with the applicable rules or procedures of the Depositary;
(e) to
cure any ambiguity, defect or inconsistency, as described in the Officer’s Certificate delivered pursuant to Section 10.4;
(f)
to comply with Article V;
(g) to
provide for uncertificated Securities in addition to or in place of certificated Securities;
(h) to
make any change that does not materially adversely affect the rights of any Securityholder;
(i)
to provide for the issuance of and establish the form and terms and conditions of Securities of any Series as
permitted by this Indenture;
(j)
to evidence and provide for the acceptance of appointment hereunder by a successor
Trustee with respect to the Securities of one or more Series and to add to or change any of the provisions of this Indenture
as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one Trustee;
(k) to
comply with requirements of the SEC in order to effect or maintain the qualification of this Indenture under the TIA;
(l) to
comply with the rules or regulations of any securities exchange or automated quotation system on which any of the Securities may
be listed or traded; and
(m) to
change or eliminate any of the provisions of this Indenture, provided that any such change or elimination shall not be effective
with respect to any outstanding Securities of any Series created prior to the execution of such supplemental indenture which is
entitled to the benefit of such provision.
Section 9.2 With
Consent of Holders.
The Company and the Trustee
may enter into a supplemental indenture with the written consent of the Holders of at least a majority in principal amount of the
outstanding Securities of each Series affected by such supplemental indenture (including consents obtained in connection with a
tender offer or exchange offer for the Securities of such Series), for the purpose of adding any provisions to or changing in any
manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying in any manner the
rights of the Securityholders of each such Series. Except as provided in Section 6.13, the Holders of at least a majority in principal
amount of the outstanding Securities of any Series by written notice to the Trustee (including consents obtained in connection
with a tender offer or exchange offer for the Securities of such Series) may waive compliance by the Company with any provision
of this Indenture or the Securities with respect to such Series.
It shall not be necessary
for the consent of the Holders of Securities under this Section 9.2 to approve the particular form of any proposed supplemental
indenture or waiver, but it shall be sufficient if such consent approves the substance thereof. After a supplemental indenture
or waiver under this Section 9.2 becomes effective, the Company shall mail to the Holders of Securities affected thereby, a notice
briefly describing the supplemental indenture or waiver. Any failure by the Company to mail or publish such notice, or any defect
therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture or waiver.
Section 9.3 Limitations.
Without the consent of
each Securityholder affected, an amendment or waiver may not:
(a) reduce
the principal amount of Securities whose Holders must consent to an amendment, supplement or waiver;
(b) reduce
the rate of or extend the time for payment of interest (including default interest) on any Security or that Series;
(c) reduce
the principal of, or change the Stated Maturity of, any Security or reduce the amount of, or postpone the date fixed for, the payment
of any sinking fund or analogous obligation;
(d) reduce
the principal amount of Discount Securities payable upon acceleration of the maturity thereof;
(e) waive
a Default or Event of Default in the payment of the principal of or interest, if any, on any Security (except a rescission of acceleration
of the Securities of any Series by the Holders of at least a majority in principal amount of the then outstanding Securities of
such Series and a waiver of the payment default that resulted from such acceleration);
(f)
make the principal of or interest, if any, on any Security payable in any currency other than that stated
in the Security;
(g) make
any change in Sections 6.8 or 6.13 or this Section 9.3; or
(h) waive
a redemption payment with respect to any Security.
Section 9.4 Compliance
with Trust Indenture Act.
Every amendment to this
Indenture or the Securities of one or more Series shall be set forth in a supplemental indenture hereto that complies with the
TIA as then in effect.
Section 9.5 Revocation
and Effect of Consents.
Until an amendment is set
forth in a supplemental indenture or a waiver becomes effective, a consent to it by a Holder of a Security is a continuing consent
by the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting
Holder’s Security, even if notation of the consent is not made on any Security.
Any amendment or waiver
once effective shall bind every Securityholder of each Series affected by such amendment or waiver unless it is of the type described
in any of sub-clauses (a) through (h) of Section 9.3. In that case, the amendment or waiver shall bind each Holder of a Security
who has consented to it and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the
consenting Holder’s Security.
The Company may, but shall
not be obligated to, fix a record date for the purpose of determining the Holders entitled to give their consent or take any other
action described above or required or permitted to be taken pursuant to this Indenture. If a record date is fixed, then notwithstanding
the immediately preceding paragraph, those Persons who were Holders at such record date (or their duly designated proxies), and
only those persons, shall be entitled to give such consent or to revoke any consent previously given or take any such action, whether
or not such Persons continue to be Holders after such record date. No such consent shall be valid or effective for more than 120
days after such record date.
Section 9.6 Notation
on or Exchange of Securities.
The Company or the Trustee
may place an appropriate notation about an amendment or waiver on any Security of any Series thereafter authenticated. The Company
in exchange for Securities of that Series may issue and the Trustee shall authenticate upon request new Securities of that Series
that reflect the amendment or waiver.
Section 9.7 Trustee
Protected.
In executing, or accepting
the additional trusts created by, any supplemental indenture permitted by this Article or the modifications thereby of the trusts
created by this Indenture, the Trustee shall receive, and (subject to Section 7.1) shall be fully protected in conclusively relying
upon, an Officer’s Certificate or an Opinion of Counsel or both complying with Section 10.4 and stating that the supplemental
indenture is the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms,
subject to customary exceptions. The Trustee shall sign all supplemental indentures upon delivery of such an Officer’s Certificate
or Opinion of Counsel or both, except that the Trustee need not sign any supplemental indenture that, in its sole discretion, adversely
affects its rights.
ARTICLE X
MISCELLANEOUS
Section 10.1 Trust
Indenture Act Controls.
If any provision of this
Indenture limits, qualifies, or conflicts with another provision which is required or deemed to be included in this Indenture by
the TIA, such required or deemed provision shall control.
Section 10.2 Notices.
Any request, demand, notice
or communication by the Company or the Trustee to the other, or by a Holder to the Company or the Trustee, is duly given if in
writing and delivered in person or mailed by first-class mail:
if to the Company:
Galmed Pharmaceuticals Ltd.
if to the Trustee:
Attention:
The Company or the Trustee
by notice to the other may designate additional or different addresses for subsequent notices or communications.
Any notice or communication
to a Securityholder shall be mailed by first-class mail to his address shown on the register kept by the Registrar. Failure to
mail a notice or communication to a Securityholder of any Series or any defect in it shall not affect its sufficiency with respect
to other Securityholders of that or any other Series.
If a notice or communication
is mailed or published in the manner provided above, within the time prescribed, it is duly given, whether or not the Securityholder
receives it.
If the Company mails a
notice or communication to Securityholders, it shall mail a copy to the Trustee and each Agent at the same time.
Notwithstanding any other
provision of this Indenture or any Security, where this Indenture or any Security provides for notice of any event (including any
notice of redemption) to a Holder of a Global Security (whether by mail or otherwise), such notice shall be sufficiently given
to the Depositary for such Security (or its designee) pursuant to the customary procedures of such Depositary.
Section 10.3 Communication
by Holders with Other Holders.
Securityholders of any
Series may communicate pursuant to TIA § 312(b) with other Securityholders of that Series or any other Series with respect
to their rights under this Indenture or the Securities of that Series or all Series. The Company, the Trustee, the Registrar and
anyone else shall have the protection of TIA § 312(c).
Section 10.4 Certificate
and Opinion as to Conditions Precedent.
Upon any request or application
by the Company to the Trustee to take any action under this Indenture, the Company shall furnish to the Trustee:
(a) an
Officer’s Certificate stating that, in the opinion of the signers, all conditions precedent, if any, provided for in this
Indenture relating to the proposed action have been complied with; and
(b) an
Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent have been complied with.
Section 10.5 Statements
Required in Certificate or Opinion.
Each certificate or opinion
with respect to compliance with a condition or covenant provided for in this Indenture (other than a certificate provided pursuant
to TIA § 314(a)(4)) shall comply with the provisions of TIA § 314(e) and shall include:
(a) a
statement that the person making such certificate or opinion has read such covenant or condition;
(b) a
brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained
in such certificate or opinion are based;
(c) a
statement that, in the opinion of such person, he has made such examination or investigation as is necessary to enable him to express
an informed opinion as to whether or not such covenant or condition has been complied with; and
(d) a
statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with.
Section 10.6 Rules
by Trustee and Agents.
The Trustee may make reasonable
rules for action by or a meeting of Securityholders of one or more Series. Any Agent may make reasonable rules and set reasonable
requirements for its functions.
Section 10.7 Legal
Holidays.
Unless otherwise provided
by Board Resolution, Officer’s Certificate or supplemental indenture hereto for a particular Series, a “Legal Holiday”
is any day that is not a Business Day. If a payment date is a Legal Holiday at a place of payment, payment may be made at that
place on the next succeeding day that is not a Legal Holiday, and no interest shall accrue for the intervening period.
Section 10.8 No
Recourse Against Others.
A director, officer, employee
or stockholder (past or present), as such, of the Company shall not have any liability for any obligations of the Company under
the Securities or this Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. Each
Securityholder by accepting a Security waives and releases all such liability. The waiver and release are part of the consideration
for the issue of the Securities.
Section 10.9 Counterparts.
This Indenture may be executed
in any number of counterparts and by the parties hereto in separate counterparts, each of which when so executed shall be deemed
to be an original and all of which taken together shall constitute one and the same agreement. The exchange of copies of this Indenture
and of signature pages by facsimile or PDF transmission shall constitute effective execution and delivery of this Indenture as
to the parties hereto and may be used in lieu of the original Indenture for all purposes. Signatures of the parties hereto transmitted
by facsimile or PDF shall be deemed to be their original signatures for all purposes.
Section 10.10 Governing
Law; Jury Trial Waiver.
THIS INDENTURE AND THE
SECURITIES, INCLUDING ANY CLAIM OR CONTROVERSY ARISING OUT OF OR RELATING TO THIS INDENTURE OR THE SECURITIES, SHALL BE GOVERNED
BY THE LAWS OF THE STATE OF NEW YORK (WITHOUT REGARD TO THE CONFLICTS OF LAWS PROVISIONS THEREOF OTHER THAN SECTION 5-1401 OF THE
GENERAL OBLIGATIONS LAW).
EACH OF THE COMPANY
AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY
IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTION CONTEMPLATED HEREBY.
Section 10.11 No
Adverse Interpretation of Other Agreements.
This Indenture may not
be used to interpret another indenture, loan or debt agreement of the Company or a Subsidiary of the Company. Any such indenture,
loan or debt agreement may not be used to interpret this Indenture.
Section 10.12 Successors.
All agreements of the Company
in this Indenture and the Securities shall bind its successor. All agreements of the Trustee in this Indenture shall bind its successor.
Section 10.13 Severability.
In case any provision in
this Indenture or in the Securities shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby.
Section 10.14 Table
of Contents, Headings, Etc.
The Table of Contents,
Cross Reference Table, and headings of the Articles and Sections of this Indenture have been inserted for convenience of reference
only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof.
Section 10.15 Securities
in a Foreign Currency.
Unless otherwise specified
in a Board Resolution, a supplemental indenture hereto or an Officer’s Certificate delivered pursuant to Section 2.2 of this
Indenture with respect to a particular Series of Securities, whenever for purposes of this Indenture any action may be taken by
the Holders of a specified percentage in aggregate principal amount of Securities of all Series or all Series affected by a particular
action at the time outstanding and, at such time, there are outstanding Securities of any Series which are denominated in more
than one currency, then the principal amount of Securities of such Series which shall be deemed to be outstanding for the purpose
of taking such action shall be determined by converting any such other currency into a currency that is designated upon issuance
of any particular Series of Securities. Unless otherwise specified in a Board Resolution, a supplemental indenture hereto or an
Officer’s Certificate delivered pursuant to Section 2.2 of this Indenture with respect to a particular Series of Securities,
such conversion shall be at the spot rate for the purchase of the designated currency as published in The Financial Times in the
“Currency Rates” section (or, if The Financial Times is no longer published, or if such information is no longer available
in The Financial Times, such source as may be selected in good faith by the Company) on any date of determination. The provisions
of this paragraph shall apply in determining the equivalent principal amount in respect of Securities of a Series denominated in
currency other than Dollars in connection with any action taken by Holders of Securities pursuant to the terms of this Indenture.
All decisions and determinations
provided for in the preceding paragraph shall, in the absence of manifest error, to the extent permitted by law, be conclusive
for all purposes and irrevocably binding upon the Trustee and all Holders.
Section 10.16 Judgment
Currency.
The Company agrees, to
the fullest extent that it may effectively do so under applicable law, that (a) if for the purpose of obtaining judgment in any
court it is necessary to convert the sum due in respect of the principal of or interest or other amount on the Securities of any
Series (the “Required Currency”) into a currency in which a judgment will be rendered (the “Judgment
Currency”), the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Trustee
could purchase in The City of New York the Required Currency with the Judgment Currency on the day on which final unappealable
judgment is entered, unless such day is not a Business Day, then the rate of exchange used shall be the rate at which in accordance
with normal banking procedures the Trustee could purchase in The City of New York the Required Currency with the Judgment Currency
on the Business Day preceding the day on which final unappealable judgment is entered and (b) its obligations under this Indenture
to make payments in the Required Currency (i) shall not be discharged or satisfied by any tender, or any recovery pursuant to any
judgment (whether or not entered in accordance with subsection (a)), in any currency other than the Required Currency, except to
the extent that such tender or recovery shall result in the actual receipt, by the payee, of the full amount of the Required Currency
expressed to be payable in respect of such payments, (ii) shall be enforceable as an alternative or additional cause of action
for the purpose of recovering in the Required Currency the amount, if any, by which such actual receipt shall fall short of the
full amount of the Required Currency so expressed to be payable, and (iii) shall not be affected by judgment being obtained for
any other sum due under this Indenture.
Section 10.17 Force
Majeure.
In no event shall the Trustee
be responsible or liable for any failure or delay in the performance of its obligations hereunder arising out of or caused by,
directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war
or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions
of utilities, communications or computer (software and hardware) services, it being understood that the Trustee shall use reasonable
best efforts which are consistent with accepted practices in the banking industry to resume performance as soon as practicable
under the circumstances.
Section 10.18 U.S.A.
Patriot Act.
The parties hereto acknowledge
that in accordance with Section 326 of the U.S.A. Patriot Act, the Trustee, like all financial institutions and in order to help
fight the funding of terrorism and money laundering, is required to obtain, verify, and record information that identifies each
person or legal entity that establishes a relationship or opens an account with the Trustee. The parties to this Indenture agree
that they will provide the Trustee with such information as it may request in order for the Trustee to satisfy the requirements
of the U.S.A. Patriot Act.
ARTICLE XI
SINKING FUNDS
Section 11.1 Applicability
of Article.
The provisions of this
Article shall be applicable to any sinking fund for the retirement of the Securities of a Series if so provided by the terms of
such Securities pursuant to Section 2.2 and except as otherwise permitted or required by any form of Security of such Series issued
pursuant to this Indenture.
The minimum amount of any
sinking fund payment provided for by the terms of the Securities of any Series is herein referred to as a “mandatory sinking
fund payment” and any other amount provided for by the terms of Securities of such Series is herein referred to as an
“optional sinking fund payment.” If provided for by the terms of Securities of any Series, the cash amount of
any sinking fund payment may be subject to reduction as provided in Section 11.2. Each sinking fund payment shall be applied to
the redemption of Securities of any Series as provided for by the terms of the Securities of such Series.
Section 11.2 Satisfaction
of Sinking Fund Payments with Securities.
The Company may, in satisfaction
of all or any part of any sinking fund payment with respect to the Securities of any Series to be made pursuant to the terms of
such Securities (a) deliver outstanding Securities of such Series to which such sinking fund payment is applicable (other than
any of such Securities previously called for mandatory sinking fund redemption) and (b) apply as credit Securities of such Series
to which such sinking fund payment is applicable and which have been repurchased by the Company or redeemed either at the election
of the Company pursuant to the terms of the Securities of such Series (except pursuant to any mandatory sinking fund) or through
the application of permitted optional sinking fund payments or other optional redemptions pursuant to the terms of such Securities,
provided that such Securities have not been previously so credited. Such Securities shall be received by the Trustee, together
with an Officer’s Certificate with respect thereto, not later than 15 days prior to the date on which the Trustee begins
the process of selecting Securities for redemption, and shall be credited for such purpose by the Trustee at the price specified
in such Securities for redemption through operation of the sinking fund and the amount of such sinking fund payment shall be reduced
accordingly. If as a result of the delivery or credit of Securities in lieu of cash payments pursuant to this Section 11.2, the
principal amount of Securities of such Series to be redeemed in order to exhaust the aforesaid cash payment shall be less than
$100,000, the Trustee need not call Securities of such Series for redemption, except upon receipt of a Company Order that such
action be taken, and such cash payment shall be held by the Trustee or a Paying Agent and applied to the next succeeding sinking
fund payment, provided, however, that the Trustee or such Paying Agent shall from time to time upon receipt of a
Company Order pay over and deliver to the Company any cash payment so being held by the Trustee or such Paying Agent upon delivery
by the Company to the Trustee of Securities of that Series purchased by the Company having an unpaid principal amount equal to
the cash payment required to be released to the Company.
Section 11.3 Redemption
of Securities for Sinking Fund.
Not less than 45 days (unless
otherwise indicated in the Board Resolution, supplemental indenture hereto or Officer’s Certificate in respect of a particular
Series of Securities) prior to each sinking fund payment date for any Series of Securities, the Company will deliver to the Trustee
an Officer’s Certificate specifying the amount of the next ensuing mandatory sinking fund payment for that Series pursuant
to the terms of that Series, the portion thereof, if any, which is to be satisfied by payment of cash and the portion thereof,
if any, which is to be satisfied by delivering and crediting of Securities of that Series pursuant to Section 11.2, and the optional
amount, if any, to be added in cash to the next ensuing mandatory sinking fund payment, and the Company shall thereupon be obligated
to pay the amount therein specified. Not less than 30 days (unless otherwise indicated in the Board Resolution, Officer’s
Certificate or supplemental indenture in respect of a particular Series of Securities) before each such sinking fund payment date
the Trustee shall select the Securities to be redeemed upon such sinking fund payment date in the manner specified in Section 3.2
and cause notice of the redemption thereof to be given in the name of and at the expense of the Company in the manner provided
in Section 3.3. Such notice having been duly given, the redemption of such Securities shall be made upon the terms and in the manner
stated in Sections 3.4, 3.5 and 3.6.
ARTICLE XII
SUBORDINATION OF SECURITIES
Section 12.1 Subordination
of Terms.
The payment by the Company
of the principal of, premium, if any, and interest on any Series of Securities issued under this Indenture shall be subordinated
to the extent set forth in a Board Resolution, supplemental indenture hereto or Officer’s Certificate relating to such Series
of Securities.
[Signature page follows]
IN WITNESS WHEREOF, the
parties hereto have caused this Indenture to be duly executed as of the day and year first above written.
GALMED PHARMACEUTICALS LTD., as Issuer |
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By: |
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Name: |
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Its: |
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, as Trustee |
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By: |
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Name: |
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Its: |
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Exhibit
5.1
Galmed
Pharmaceuticals Ltd.
c/o Meitar Law Offices Abba Hillel Silver Rd.,
Ramat Gan 5250608
Israel
November
14, 2024
Re:
Registration Statement on Form F-3
Ladies
and Gentlemen:
We
have acted as Israeli counsel to Galmed Pharmaceuticals Ltd., a company organized under the laws of the State of Israel (the “Company”),
in connection with its filing of a registration statement on Form F-3 (the “Registration Statement”) under the Securities
Act of 1933, as amended (the “Securities Act”), with the U.S. Securities and Exchange Commission (the “Commission”),
which registers the offer, issuance and sale by the Company, from time to time, of up to $200,000,000, in the aggregate, of any one or
more of the following types of securities, individually or in units:
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(a) |
ordinary shares, par value NIS 1.80 per share, of the Company
(“Ordinary Shares” or “Shares”); |
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(b) |
warrants to purchase Ordinary Shares (“Warrants”); |
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(c) |
subscription rights to purchase Ordinary Shares (“Rights”); |
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(d) |
senior or subordinated debt securities of the Company (the
“Debt Securities”) to be issued by the Company pursuant to an indenture (a “Company Indenture”)
to be executed by the Company and the relevant trustee under the Company Indenture; and/or |
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(e) |
units comprised of one or more of the other securities that
may be offered under the Registration Statement (the “Units”) (collectively, the Shares, Warrants, Rights, Debt Securities,
and Units are referred to as the “Securities”). |
We
have also acted as Israeli counsel to the Company in connection with the Capital on Demand™ Sales Agreement, dated as of November
14, 2024 (the “Sales Agreement”), entered into by and between the Company and JonesTrading Institutional Services
LLC (the “Agent”) pursuant to which the Company may offer and sell Ordinary Shares having an aggregate offering price
of up to $8,100,000 (the “ATM Shares”). The ATM Shares will be issued pursuant to the Registration Statement and the
related prospectus contained therein covering the ATM Shares.
This
opinion letter is furnished to you at your request to enable you to fulfill the requirements of Item 601(b)(5) of Regulation S-K under
the Securities Act, in connection with the filing of the Registration Statement.
In
connection herewith, we have examined the originals, or photocopies or copies, certified or otherwise identified to our satisfaction,
of: (i) the form of the Registration Statement, to which this opinion letter is attached as an exhibit; (ii) a copy of the amended and
restated articles of association of the Company, as currently in effect (the “Articles”); (iii) minutes of the meeting
of the board of directors of the Company (the “Board”) at which the filing of the Registration Statement and the actions
to be taken in connection therewith were approved; (iv) minutes of the meeting of the Board at which the execution of the Sales Agreement
and the actions to be taken in connection therewith were approved; and (v) such other corporate records, agreements, documents and other
instruments, and such certificates or comparable documents of public officials and of officers and representatives of the Company as
we have deemed relevant and necessary as a basis for the opinions hereafter set forth. We have also made inquiries of such officers and
representatives as we have deemed relevant and necessary as a basis for the opinions hereafter set forth.
In
such examination, we have assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of all
documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified, confirmed
as photostatic copies and the authenticity of the originals of such latter documents. As to all questions of fact material to these opinions
that have not been independently established, we have relied upon certificates or comparable documents of officers and representatives
of the Company.
We
have also assumed the truth of all facts communicated to us by the Company and that all minutes of meetings of the Board that have been
provided to us are true and accurate and have been properly prepared in accordance with the Articles and all applicable laws. We have
assumed, in addition, that at the time of the execution and delivery of any definitive purchase, underwriting or similar agreement between
the Company and any third party pursuant to which any of the Securities may be issued (a “Securities Agreement”),
the Securities Agreement will be the valid and legally binding obligation of such third party, enforceable against such third party in
accordance with its terms. We have further assumed that at the time of the issuance and sale of any of the Securities, the terms of the
Securities, and their issuance and sale, will have been established so as not to violate any applicable law or result in a default under
or breach of any agreement or instrument binding upon the Company and so as to comply with any requirement or restriction imposed by
any court or governmental body having jurisdiction over the Company.
Based
upon and subject to the foregoing, we are of the opinion that:
|
1. |
With respect to the Shares, assuming (a) the taking of all
necessary corporate action to authorize and approve the issuance of any Shares, the terms of the offering thereof and related matters
(for purposes of this paragraph 1, the “Authorizing Resolutions”), (b) the effectiveness of the Registration Statement,
and any amendments thereto (including any post-effective amendments), and that such effectiveness shall not have been terminated or rescinded,
(c) the delivery and filing of an appropriate prospectus supplement with respect to the offering of the Shares in compliance with the
Securities Act and the applicable rules and regulations thereunder, (d) approval by the Board of, and entry by the Company into, and
performance by the Company under, any applicable Securities Agreement, in the form filed as an exhibit to the Registration Statement,
any post-effective amendment thereto or to a Report on Form 6-K, pursuant to which the Shares may be issued and sold, and (e) receipt
by the Company of the consideration for the Shares as provided for in the Authorizing Resolutions and in accordance with the provisions
of any such Securities Agreement and the applicable convertible Securities, if any, pursuant to which the Shares may be issued, such
Shares, including any Ordinary Shares issued upon exercise or conversion of any Securities, will be validly issued, fully paid and non-assessable. |
|
|
|
|
2. |
With respect to the ATM Shares, assuming that prior to the
issuance of any of ATM Shares under the Sales Agreement, the price, number of ATM Shares and certain other terms of issuance with respect
to any specific placement notice delivered under the Sales Agreement will be authorized and approved by the Board or a pricing committee
of the Board in accordance with Israeli law (for purposes of this paragraph 2, the “Authorizing Resolutions”), all
corporate proceedings necessary for the authorization, issuance and delivery of the ATM Shares shall have been taken and, upon issuance
pursuant to the terms of the Sales Agreement and in accordance with resolutions of the Board related to the offering of the ATM Shares,
the ATM Shares will be validly issued, fully paid and non-assessable. |
You
have informed us that you intend to issue the Securities from time to time on a delayed or continuous basis, and this opinion is limited
to the laws, including the rules and regulations, as in effect on the date hereof. We understand that prior to issuing any Securities
you will afford us an opportunity to review the corporate approval documents and operative documents pursuant to which such Securities
are to be issued (including the Authorizing Resolutions, a Securities Agreement (if applicable) and an appropriate prospectus supplement),
and we will file such supplement or amendment to this opinion (if any) as we may reasonably consider necessary or appropriate by reason
of the terms of such Securities.
With
respect to our opinion as to the Shares, including any Ordinary Shares issued upon exercise or conversion of any Securities and the ATM
Shares, we have assumed that, at the time of issuance and sale and to the extent any such issuance would exceed the maximum share capital
of the Company currently authorized, the number of Ordinary Shares that the Company is authorized to issue shall have been increased
in accordance with the Articles and as described in the Registration Statement such that a sufficient number of Ordinary Shares are authorized
and available for issuance under the Articles.
Members
of our firm are admitted to the Bar in the State of Israel, and we do not express any opinion as to the laws of any other jurisdiction.
This opinion is limited to the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated.
We
consent to the filing of this opinion as an exhibit to the Registration Statement and to the reference to our firm appearing under the
caption “Legal Matters” and “Enforceability of Civil Liabilities” in the prospectus forming part of the Registration
Statement. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under
Section 7 of the Securities Act, the rules and regulations of the Commission promulgated thereunder or Item 509 of the Commission’s
Regulation S-K under the Securities Act.
This
opinion letter is rendered as of the date hereof and we disclaim any obligation to advise you of facts, circumstances, events or developments
that may be brought to our attention after the effective date of the Registration Statement that may alter, affect or modify the opinions
expressed herein.
|
Very truly
yours, |
|
|
|
/s/ Meitar | Law Offices |
|
Meitar | Law Offices |
Exhibit
5.2
November
14, 2024
Galmed
Pharmaceuticals Ltd.
c/o
Meitar Law Offices
Abba
Hillel Silver Rd.,
Ramat
Gan, 5250608
Re:
Galmed Pharmaceuticals Ltd Registration Statement on Form F-3
Ladies
and Gentlemen:
We
have acted as U.S. special counsel to Galmed Pharmaceuticals Ltd., an Israeli company organized under the laws of the State of Israel
(the “Company”), in connection with the filing of a registration statement on Form F-3 (the “Registration Statement”)
to be filed under the Securities Act of 1933, as amended (the “Securities Act”), with the U.S. Securities and Exchange Commission
(the “Commission”). The Registration Statement is being filed for the registration of the following securities which may
subsequently be allotted and issued by the Company up to an aggregate initial offer price of $200,000,000 of (i) ordinary shares of NIS
1.80 par value per share (the “Ordinary Shares”), (ii) debt securities of the Company (“Debt Securities”), (iii)
warrants to purchase Ordinary Shares (the “Warrants”), (iv) rights to purchase Ordinary Shares (“Subscription Rights”)
and (v) units consisting of Ordinary Shares, one or more Debt Securities, Warrants or Subscription Rights, in any combination (“Units”)
(together, the “Securities”).
For
purposes of this opinion letter, we have assumed that the Debt Securities will be either senior debt securities or subordinate debt securities
and will be issued pursuant to a senior debt indenture or a subordinate debt indenture, respectively (collectively, the “Indentures”),
forms of which will be filed as exhibits to the Registration Statement. We have reviewed such documents and made such examination of
matters of fact and questions of law as we have considered appropriate for purposes of this letter.
We
are opining herein only as to the internal laws of the State of New York, and we express no opinion with respect to the applicability
thereto, or the effect thereon, of the laws of any other jurisdiction, or as to any matters of municipal law or the laws of any local
agency within any jurisdiction. With respect to the laws of the State of Israel, we understand that you are relying upon the opinion,
dated the date hereof, of Meitar | Law Offices, counsel to the Company in Israel, and our opinion is subject to the same assumptions,
qualifications and limitations with respect to such law as contained in such opinion of Meitar | Law Offices. We express no opinion herein
regarding the validity or issuance of the Ordinary Shares, Warrants, Subscription Rights or Units, which matters are being addressed
in such opinion of Meitar | Law Offices.
We
have examined signed copies of the Registration Statement and have also examined and relied upon minutes of meetings of the Board of
Directors of the Company as provided to us by the Company, the articles of association of the Company, as restated and/or amended to
date (the “Articles”), and such other documents as we have deemed necessary or appropriate for purposes of rendering the
opinion hereinafter set forth. In addition, we have examined and relied, to the extent we deemed proper, on certificates of officers
of the Company as to factual matters, and on originals or copies certified or otherwise identified to our satisfaction, of all such corporate
records of the Company and such other instruments and certificates of public officials and other persons as we have deemed appropriate.
In our examination, we have assumed the authenticity of all documents submitted to us as originals, the conformity to the original documents
of all documents submitted to us as copies, the genuineness of all signatures on documents reviewed by us and the legal capacity of natural
persons. Other than our examination of the documents indicated above, we have made no other examination in connection with this opinion.
Greenberg
Traurig, P.A. | Attorneys at Law |
Azrieli
Center, Round Tower | 132 Menachem Begin Road, 30th Floor | Tel Aviv, Israel 6701101 | T +1 +972 (0) 3 636 6000 | F +1 +972 (0) 3 636
6010 |
www.gtlaw.com |
We
have assumed (a) that each of the Securities and each applicable agreement pursuant to which such Securities will be issued will be duly
authorized, executed and delivered by the parties thereto in accordance with applicable law, consistent with the procedures and terms
described in the Registration Statement and the applicable Prospectus Supplement and in accordance with the Company’s Articles,
(b) that each of the Securities will be validly issued, fully paid and nonassessable (to the extent applicable), (c) that the Debt Securities,
the Indentures, the Warrants, the Subscription Rights and the Units will constitute legally valid and binding obligations of the parties
thereto (other than the Company), enforceable against each of them in accordance with their respective terms, and (d) that the status
of each of the Debt Securities, the Indentures, the Warrants, the Subscription Rights and the Units as legally valid and binding obligations
of the parties will not be affected by any (i) breaches of, or defaults under, agreements or instruments, (ii) violations of statutes,
rules, regulations or court or governmental orders, or (iii) failures to obtain required consents, approvals or authorizations from,
or to make required registrations, declarations or filings with, governmental authorities.
Subject
to the foregoing and the other matters set forth herein, it is our opinion that as of the date hereof, when (i) the Registration Statement,
as finally amended, is declared or has otherwise become effective under the Securities Act, (ii) the Securities have been duly authorized,
executed and delivered by all necessary corporate action of the Company, (iii) the specific terms of any particular series of Debt Securities
have been duly established in accordance with the Indentures and applicable law and authorized by all necessary corporate action of the
Company (including, without limitation, by the adoption by the board of directors of the Company of resolutions duly authorizing the
issuance and delivery of such Debt Securities), and (iv) any such Debt Securities have been duly executed and issued by the Company,
duly authenticated by the applicable trustee in accordance with the Indentures and duly delivered by or on behalf of the Company against
payment therefor in the manner contemplated by the Registration Statement or the related prospectus and by such corporate action, (1)
the Debt Securities will be valid and binding obligations of the Company, enforceable against the Company in accordance with the terms
of the Indentures, (2) the Warrants will be valid and binding obligations of the Company, enforceable against the Company in accordance
with their terms to the extent governed by New York law, (3) the Subscription Rights will be valid and binding obligations of the Company,
enforceable against the Company in accordance with their terms to the extent governed by New York law, and (4) the Units will be valid
and binding obligations of the Company, enforceable against the Company in accordance with their terms to the extent governed by New
York law.
To
the extent that the obligations of the Company under the applicable indenture governing the Debt Securities may be dependent upon such
matters, we have assumed for purposes of this opinion (i) that the Trustee is duly organized, validly existing and in good standing under
the laws of its jurisdiction of organization and is duly qualified to engage in the activities contemplated by the indenture governing
such Debt Securities and (ii) that the indenture has been duly authorized, executed and delivered by and constitutes the legal, valid
and binding obligation of the Trustee, enforceable against the Trustee in accordance with its terms, except that the enforceability thereof
may be limited by or subject to bankruptcy, reorganization, insolvency, fraudulent conveyance, moratorium or other similar laws now or
hereafter existing that affect the rights and remedies of creditors generally and equitable principles of general applicability.
Our
opinion set forth above is subject to (i) the effects of bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium and
other similar laws relating to or affecting creditors’ rights generally, (ii) general equitable principles (whether considered
in a proceeding in equity or at law), (iii) an implied covenant of good faith and fair dealing and (iv) the effects of the possible application
of foreign laws or foreign governmental or judicial action affecting creditors’ rights.
The
opinion set forth herein is rendered as of the date hereof, and we assume no obligation to update such opinion to reflect any facts or
circumstances which may hereafter come to our attention or any changes in the law which may hereafter occur (which may have retroactive
effect). This opinion is rendered to you in connection with the filing of the Registration Statement referenced above. This opinion may
not be relied upon for any other purpose, or furnished to, quoted or relied upon by any other person, firm or corporation for any purpose,
without our prior written consent.
We
hereby consent to the reference to our firm under the caption “Legal Opinions” in the Registration Statement and to the use
of this opinion as an exhibit to the Registration Statement. In giving this consent, we do not hereby admit that we come within the category
of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission thereunder.
|
Very
truly yours, |
|
|
|
/s/
Greenberg Traurig P.A. |
Exhibit 23.1
Exhibit
107
Calculation
of Filing Fee Tables
Form
F-3
(Form
Type)
Galmed
Pharmaceuticals Ltd.
(Exact
Name of Registrant as Specified in its Charter)
Table
1: Newly Registered Securities and Carry Forward Securities
| |
Security Type | |
Security Class Title | |
Fee Calculation or Carry Forward Rule | | |
Amount
Registered
(1) | | |
Proposed
Maximum Offering
Price Per
Unit
(2)
| | |
Maximum Aggregate Offering Price (3) | | |
Fee Rate | | |
Amount of Registration Fee | |
Fees to Be Paid | |
Equity | |
Ordinary shares, par value NIS 1.80 per share | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Fees to Be Paid | |
Other | |
Warrants | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Fees to Be Paid | |
Other | |
Subscription Rights | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Fees to Be Paid | |
Other | |
Debt Securities | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Fees to Be Paid | |
Unallocated (Universal) Shelf | |
Unallocated (Universal) Shelf | |
| 457 | (o) | |
| (2 | ) | |
| (3 | ) | |
$ | 200,000,000 | | |
| 0.0001531 | | |
$ | 30,620.00 | (4) |
| |
| |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Total Offering Amounts |
$ | 30,620.00 | |
Total Fees Previously Paid |
| — | |
Total Fee Offsets |
$ | 27,631.00 | |
Net Fee Due |
$ | 2,989.00 | (5) |
(1) |
There
are being registered under this registration statement such indeterminate number of ordinary shares, warrants, subscription rights,
debt securities and units, as may be sold by the Registrant from time to time, which collectively shall have an aggregate initial
offering price not to exceed $200,000,000 or, if any securities are issued for consideration denominated in a foreign currency,
such amount as shall result in an aggregate initial offering price equivalent to a maximum of $200,000,000. The securities
registered hereunder also include such indeterminate number of ordinary shares as may be issued upon conversion, exercise or exchange
of warrants that provide for such conversion into, exercise for or exchange into ordinary shares. In addition, pursuant to Rule 416
under the Securities Act of 1933, as amended, or the Securities Act, the ordinary shares being registered hereunder include such
indeterminate number of ordinary shares as may be issuable with respect to the shares being registered hereunder as a result of stock
splits, stock dividends, or similar transactions. |
|
|
(2) |
Not
specified as to each class of securities to be registered pursuant to General Instruction II.C. of Form F-3. |
(3) |
The
proposed maximum offering price per unit of each class of securities will be determined from time to time by the Registrant in connection
with the issuance by the Registrant of the securities registered hereunder and is not specified as to each class of security pursuant
to General Instruction II.D. of Form F-3 under the Securities Act of 1933, as amended (the “Securities Act”). |
(4) |
The
registration fee has been calculated pursuant to Rule 457(o) under the Securities Act on the basis of the maximum aggregate offering
price of the securities listed. |
(6) |
The
Registrant previously filed a Registration Statement on Form F-3 with the Securities and Exchange Commission on March 26, 2021 (File
No. 333-254766), which was declared effective on April 1, 2021 (the “Prior Registration Statement”), that registered
an aggregate of $300,000,000 of an indeterminate number of securities to be offered by the Registrant from time to time. Of the $300,000,000
of securities registered on the Prior Registration Statement, for which the Registrant paid a filing fee of $27,631.00 after giving
effect to a fee offset. In connection therewith, $299,929,500 of the securities remain unsold, leaving $32,722.31 in previously paid
fees available for future offset (calculated at the fee rate in effect on the filing date of the Prior Registration Statement). In
accordance with Rule 457(p) under the Securities Act, the Registrant is using $27,631.00 of the unused filing fees to offset the
filing fee payable in connection with this filing. Accordingly, a registration fee of $2,989.00 is due to be paid at this
time. Concurrently with the effectiveness of this registration statement, any offering of unsold securities pursuant to the Prior
Registration Statement is hereby terminated. |
Table
2: Fee Offset Claims and Sources
| |
Registrant or Filer Name | |
Form or Filing Type | |
File Number | |
Initial Filing Date | |
Filing Date | |
Fee Offset Claimed | | |
Security Type Associated with Fee Offset Claimed | |
Security
Title
Associated
with Fee
Offset
Claimed | | |
Unsold Securities Associated with Fee Offset Claimed | |
Unsold Aggregate Offering Amount Associated with Fee Offset Claimed | |
Fee Paid with Fee Offset Source |
Rule 457(p) |
|
|
|
|
Fee Offset Claims | |
Galmed Pharmaceuticals Ltd. | |
F-3 | |
333-254766 | |
March 26, 2021 | |
| |
$ | 27,631.00 | | |
Unallocated (Universal) Shelf | |
| (1 | ) | |
Unallocated (Universal) Shelf | |
$299,929,500 |
|
|
Fee Offset Sources | |
Galmed Pharmaceuticals Ltd. | |
F-3 | |
333-254766 | |
| |
March 26, 2021 | |
| | | |
| |
| | | |
| |
| |
$27,631.00 |
(1) |
Pursuant
to Rule 457(p) under the Securities Act, the Registrant is offsetting the registration fee due under this registration statement
by $27,631.00, which represents the portion of the registration fee previously paid (after offset) with respect to $299,929,500 of
unsold securities (the “Unsold Offset Securities”) previously registered on the Prior Registration Statement. The offering
of the Unsold Offset Securities pursuant to the Prior Registration Statement associated with the claimed fee offset pursuant to Rule
457(p) have been completed or terminated. |
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