Advanced Proteome Therapeutics Advances its Technological Capability
18 Junho 2018 - 9:30AM
Advanced Proteome Therapeutics Corporation (“APC” or the
“Company”) (TSXV:APC) (FSE:0E8), is pleased to report
continuing progress on its efforts to develop superior antibody
drug conjugates (ADCs).
Proceeding from cytotoxicity studies to the next
phase of testing in animals necessitates scaling up processes by a
significant factor that often requires outsourcing to other
companies at considerable cost and down time. APC can now report
that it has achieved a breakthrough in processing development
candidates for scale up that will allow the Company to
independently supply its partners with material.
The new modified protocol has enabled APC to
progress collaborative programs as with Heidelberg Pharma (HDP)
(Marketwired - January 08, 2018) by producing scaled-up
amounts of antibody-drug conjugates with our proprietary,
time-dependent, site-selective linking process. The Company can now
handle the additional capacity necessary for animal testing,
without resort to outsourcing and provide the requisite amounts of
material at modest cost.
Allen Krantz, Chief Scientific Officer of APC,
stated that “Our progress in reducing the volumes that required
specialized equipment for purifying ADCs will facilitate technology
transfer to our partners. The promising cytotoxicity studies that
we announced in January provided the impetus for successfully
scaling up our conjugative processes to accept a far larger scope
of material necessary for the testing of potency and toxicity on
animal subjects, which we are proud to have achieved in-house. For
example, this technological advance has allowed us to efficiently
produce samples for the HDP collaboration, which has now entered
the animal phase of testing.”
ABOUT THE COMPANY:
Advanced Proteome Therapeutics Corporation is
developing a proprietary technology to directly target cancerous
tumors and avoid destroying normal cells. This type of agent
is capable of greater potency, higher specificity and lower
toxicity than other therapies that can also attack healthy
cells. The Company is working to streamline the process by
which these agents are prepared, which to date, has been extremely
cumbersome, limiting their potential.
FOR FURTHER INFORMATION PLEASE
CONTACT:
Advanced Proteome Therapeutics Corporation Bill
DickiePresident and CEO Tel: 617 358-9777
http://www.advancedproteome.com
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