Filed Pursuant to Rule 424(b)(3)
Registration No. 333-282017
PROSPECTUS SUPPLEMENT NO. 1
(to Prospectus dated September 17, 2024)

15,337,500 Ordinary Shares
This Prospectus Supplement No. 1 updates, amends,
and supplements the prospectus dated September 17, 2024 (as amended and supplemented, the “Prospectus”), which
forms a part of our Registration Statement on Form S-1 (Registration No. 333-282017). Capitalized terms used in this prospectus supplement
and not otherwise defined herein have the meanings specified in the Prospectus.
This prospectus supplement is being filed to
update, amend, and supplement the information in the Prospectus with the information contained in our Current Report on Form 8-K filed
with the Securities and Exchange Commission on September 19, 2024 (the “Report”). Accordingly, we have attached
the Report to this prospectus supplement.
This prospectus supplement is not complete without
the Prospectus. This prospectus supplement should be read in conjunction with the Prospectus, which is to be delivered with this prospectus
supplement, and is qualified by reference thereto, except to the extent that the information in this prospectus supplement updates or
supersedes the information contained in the Prospectus. Please keep this prospectus supplement with your Prospectus for future reference.
New Silexion’s ordinary shares and warrants
are listed on The Nasdaq Stock Market LLC under the symbols “SLXN” and “SLXNW,” respectively. On September 18,
2024, the last reported sales price of the ordinary shares was $0.8528 per share, and on September 18, 2024, the last reported sales price
of the warrants was $0.0363 per warrant.
We are a “smaller reporting company”
as defined in Item 10(f)(1) of Regulation S-K, and an “emerging growth company”, as defined in the Jumpstart Our Business
Startups Act of 2012 and, as such, have elected to comply with certain reduced public company disclosure and reporting obligations. See
“Prospectus Summary — Implications of Being a Smaller Reporting Company and Emerging Growth Company” in the Prospectus
for additional information.
Investing in our securities involves a high
degree of risk. You should review carefully the risks and uncertainties described under the heading “Risk Factors” beginning
on page 7 of the Prospectus, and under similar headings in any amendment or supplements to the Prospectus.
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of the Prospectus
or this prospectus supplement. Any representation to the contrary is a criminal offense.
The date of this prospectus
supplement is September 19, 2024.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM
8-K
CURRENT
REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of report (Date of earliest event reported):
September 19, 2024 (September 16, 2024)
Silexion Therapeutics Corp
(Exact name of registrant as specified in its charter)
Cayman Islands |
|
001-42253 |
|
N/A |
(State or other jurisdiction
of incorporation) |
|
(Commission File Number) |
|
(I.R.S. Employer
Identification No.) |
2 Hama’ayan Street
Modi’in-Maccabim-Reut, Israel |
|
7177871 |
(Address of principal executive offices) |
|
(Zip Code) |
+972-8-6286005 |
(Registrant’s telephone number, including area code) |
|
N/A |
(Former name or former address, if changed since last report) |
Check the appropriate box below if the Form 8-K
is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐ | Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
☐ | Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
☐ | Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
☐ | Pre-commencement
communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b)
of the Act:
Title of each class |
|
Trading Symbol(s) |
|
Name of each exchange on which
registered |
Ordinary Shares, par value $0.0001 per share |
|
SLXN |
|
The Nasdaq Stock Market LLC |
Warrants exercisable for Ordinary Shares at an exercise price of $11.50 per share |
|
SLXNW |
|
The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant is an emerging growth
company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange
Act of 1934 (§240.12b-2 of this chapter).
Emerging
growth company ☒
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 13(a) of the Exchange Act. ☐
Item 5.02 |
Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. |
(b) On September 16, 2024, Ilan Shiloah, an independent director
serving on the board of directors (the “Board”) of Silexion Therapeutics Corp, a Cayman Islands exempted company (the
“Company”), informed the Company that he has resigned from the Board, including from his membership on each of the committees of the Board— the audit committee, the
compensation committee, and the corporate governance and nominating committee— effective immediately. Mr. Shiloah had served as
a director of the Company since the closing of the Company’s business combination transaction on August 15, 2024 pursuant to
the Amended and Restated Business Combination Agreement, dated as of April 3, 2024, by and among the Company, Moringa Acquisition
Corp, a Cayman Islands exempted company, August M.S. Ltd., an Israeli company and a wholly-owned subsidiary of the Company, Moringa Acquisition Merger Sub
Corp, a Cayman Islands exempted company and a wholly-owned subsidiary of the Company, and Silexion Therapeutics Ltd., an
Israeli company
Mr. Shiloah’s decision to resign stemmed
from competing demands on his time, and did not arise or result from any disagreement with the Company on any matter relating to the Company’s
operations, policies or practices.
SIGNATURE
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
|
SILEXION THERAPEUTICS CORP |
|
|
Date: September 19, 2024 |
/s/ Ilan Hadar |
|
Name: |
Ilan Hadar |
|
Title: |
Chief Executive Officer |
Silexion Therapeutics (NASDAQ:SLXNW)
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